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Approaches to Combat Antibiotic Resistance

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    Posted: August 11 2018 at 6:52am
Rescuing antibiotics' effectiveness in face of drug-resistant bacteria

Date:
    August 10, 2018
Source:
    Beth Israel Deaconess Medical Center
Summary:
    Bacteria -- especially Gram-negative strains -- are becoming increasingly resistant to current antibiotic drugs, and the development of new classes of antibiotics has slowed. Faced with these challenges, investigators are studying the potential of combination therapy, in which two or more drugs are used together to increase or restore the efficacy of both drugs against a resistant bacterial pathogen. Now new research indicates that such synergy may work even when bacteria become resistant to colistin, which is considered a treatment agent of last resort.
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BIDMC Research Briefs showcase groundbreaking scientific advances that are transforming medical care.

Bacteria -- especially Gram-negative strains -- are becoming increasingly resistant to current antibiotic drugs, and the development of new classes of antibiotics has slowed. Faced with these challenges, investigators are studying the potential of combination therapy, in which two or more drugs are used together to increase or restore the efficacy of both drugs against a resistant bacterial pathogen. Now new research indicates that such synergy may work even when bacteria become resistant to colistin, which is considered a treatment agent of last resort.

The findings are especially promising because recent evidence indicates the potential for rapid worldwide spread of colistin resistance. "For an infected patient, if the multidrug-resistant Gram-negative bacterial pathogen is resistant to colistin, then there is a big problem," said senior author James Kirby, MD, Director of the Clinical Microbiology Laboratory at BIDMC.

In their Antimicrobial Agents and Chemotherapy study, Kirby and his colleagues Thea Brennan-Krohn, MD and Alejandro Pironti, PhD screened 19 different antibiotics for synergy with colistin. The team discovered several combinations where synergy was present and infections with resistant pathogens could potentially be treated with the combination therapy.

Of particular interest, colistin demonstrated high rates of synergy with linezolid, fusidic acid, and clindamycin, which are protein synthesis inhibitor antibiotics that individually have no activity against Gram-negative bacteria. "It was remarkable to see two drugs, each of which is inactive on its own against these bacteria, inhibiting them in combination," notes Brennan-Krohn. "These findings suggest that colistin retains sub-lethal activity against colistin-resistant bacteria, which may enable drugs like linezolid to reach their targets."

"Faced with highly resistant pathogens, clinicians often currently treat with multiple antibiotics without knowing the benefit the combinations may provide," said Kirby. "This study now provides some scientific underpinning for these choices and direction for future investigation." He added that combination therapy may also allow clinicians to use lower effective doses of colistin and other drugs, which would help avoid toxicities associated with the medications as well as slow the development of antibiotic resistance.

This work was funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, and the Department of Health and Human Services.

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Materials provided by Beth Israel Deaconess Medical Center. Note: Content may be edited for style and length.


Beth Israel Deaconess Medical Center. "Rescuing antibiotics' effectiveness in face of drug-resistant bacteria." ScienceDaily. ScienceDaily, 10 August 2018. <www.sciencedaily.com/releases/2018/08/180810132602.htm>.

My Source:   https://www.sciencedaily.com/releases/2018/08/180810132602.htm
Absence of proof is not proof of absence.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: August 11 2018 at 3:36pm
i'v been trying to tell people for 30 odd years we in a crisis ,

but they still take antibiotics for the slightest thing......

and the farmers use them as if they going out of fashion....

guess what .....

they are .............

12 Monkeys...............
1995 ‧ Science fiction film/Thriller ‧ 2h 11m a must for AFT
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: August 11 2018 at 3:37pm
phages were supposed to save us ,but that lead nowhere............
12 Monkeys...............
1995 ‧ Science fiction film/Thriller ‧ 2h 11m a must for AFT
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Post Options Post Options   Thanks (0) Thanks(0)   Quote FluMom Quote  Post ReplyReply Direct Link To This Post Posted: August 11 2018 at 6:17pm
Hope this works I believe we will be doomed unless something happens with antibiotics.
Always Be Prepared
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