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Tracking the next pandemic: Avian Flu Talk

CFR vs IFR

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EdwinSm, View Drop Down
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    Posted: February 20 2020 at 12:42am
The latest Situation Report from WHO [Report # 30] contains two terms that initially seem to mean the same thing.

As with many discussions that end at cross purposes one should look carefully at the definitions of words.

Originally posted by WHO WHO wrote:

case fatality ratio (CFR, the proportion of cases who die),
infection fatality ratio (IFR, the portion of all of those infected who die),

In my understanding if you are infected with SARS-Cov2 then you have a case of Corvid-19, so the two terms should mean the same thing.

Later on in the report there is further clarification,  in that for WHO whenever you read CFR you should automatically translated it to CCFR (Confirmed CFR).  The following also implies to me  (but it is not clearly stated) that a "case" might only be counted if symptoms show.


Quote The confirmed case fatality ratio, or CFR, is the total number of deaths divided by the total number of confirmed cases at one point in time. Within China, the confirmed CFR, as reported by the Chinese Center for Disease Control and Prevention,9 is 2.3%. This is based on 1023 deaths amongst 44 415 laboratory-confirmed cases as of 11 February. This CFR does not include the number of more mild infections that may be missed from current surveillance, which has largely focused on patients with pneumonia requiring hospitalization; nor does it account for the fact that recently confirmed cases may yet develop severe disease, and some may die. As the outbreak continues, the confirmed CFR may change. Outside of China, CFR estimates among confirmed cases reported is lower than reported from within China. However, it is too early to draw conclusions as to whether there are real differences in the CFR inside and outside of China, as final outcome data (that is, who will recover and who will die) for the majority of cases reported from outside China are not yet known.

Modeling is a helpful tool to try to account for missed cases, such as those that are mild cases potentially missed in current surveillance activities, and the time lag between onset and death. Using an estimated number of total infections, the Infection Fatality Ratio can be calculated. This represents the fraction of all infections (both diagnosed and undiagnosed) that result in death. Based on these available analyses, current IFR estimates10,11,12 range from 0.3% to 1%. Without population-based serologic studies, it is not yet possible to know what proportion of the population has been infected with COVID-19.

Lesson: While I consider WHO to be accurate in the figures that they give, they are based on a very narrow definition, and so give an inaccurate over all position.  It is a clever political move that plays into the hands of those governments who what to suppress some of the data. 

Note: from the differences between the CCFR and the IFR quoted above, WHO is saying that the estimated actual rate of infection is between 3 and 10 times larger than the information published by China.  
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carbon20 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: February 20 2020 at 12:46am
Smoke and mirrors.......



Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

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pheasant View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote pheasant Quote  Post ReplyReply Direct Link To This Post Posted: February 20 2020 at 2:31am
100% smoke and mirrors, they are double dipping and moving the goal post.

   And still not addressing the un-diagnosed death equation.

   
The only thing we have to fear, is fear itself......FDR
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Pixie Quote  Post ReplyReply Direct Link To This Post Posted: February 20 2020 at 1:06pm



Today there was a change in statement. If the highest is 1% .94% is not that comforting


Since the publication of modeling estimates in yesterday’s ‘Subject in Focus’, one research group (Ref. 12) has provided a correction of their estimate of the Infection-Fatality Ratio (IFR), with the new estimate being 0.94% (95% confidence interval 0.37-2.9). This replaces the lowest estimate of IFR of 0.33%, but remains below the highest estimate of 1.0% (Ref. 11). 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Pixie Quote  Post ReplyReply Direct Link To This Post Posted: February 20 2020 at 1:40pm

If .07% and.23% is smaller than a CFR of4.06% what does this revision to .94% imply?


Background: Since the first cluster of cases was identified in Wuhan City, China, in December, 2019, 2019-nCoV has rapidly spread across China as well as caused multiple introductions in 25 countries as of February, 2020. Despite the scarcity of publicly available data, scientists around the world have made strides in estimating the magnitude of the epidemic, the basic reproduction number, and transmission patterns. Recently more evidence suggests that a substantial fraction of the infected individuals with the novel coronavirus show little if any symptoms, which suggest the need to reassess the transmission potential of emerging disease. The present study aimed to estimates of the transmissibility and virulence of 2019-nCov in Wuhan City, China, by reconstructing the underlying transmission dynamics. 


Methods: We employ statistical methods and publicly available epidemiological datasets to jointly derive estimates of transmissibility and severity associated with the novel coronavirus. For estimation, the daily series of laboratory-confirmed nCov cases and deaths in Wuhan City and epidemiological data of Japanese evacuees from Wuhan City on board government-chartered flights were used.

 Results: We found that our posterior estimates of basic reproduction number (R) in Wuhan City, China in 2019-2020 is calculated to be as high as 7.05 (95%CrI: 6.11-8.18) and the enhanced public health intervention after January 23rd in 2020 has declined R to 3.24 (95%CrI: 3.16-3.32), with the total number of infections (i.e. cumulative infections) estimated at 983006 (95%CrI: 759475-1296258) in Wuhan City, raising the proportion of infected individuals to 9.8% (95%CrI: 7.6-13.0%)

https://www.medrxiv.org/content/10.1101/2020.02.12.20022434v1
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. We also found that most recent crude infection fatality ratio (IFR) and time-delay adjusted IFR is estimated to be 0.07% (95% CrI: 0.05%-0.09%) and 0.23% (95%CrI: 0.17-0.30%), which is several orders of magnitude smaller than the crude CFR at 4.06% 
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Post Options Post Options   Thanks (1) Thanks(1)   Quote CRS, DrPH Quote  Post ReplyReply Direct Link To This Post Posted: February 20 2020 at 1:41pm
They all mean the same thing.  In the US, we use "case fatality rate" more than "case fatality ratio," but they are the same.   Being a confirmed case is implied. 

Case fatality rate, also called case fatality ratio, in epidemiology, the proportion of people who die from a specified disease among all individuals diagnosed with the disease over a certain period of time. Case fatality rate typically is used as a measure of disease severity and is often used for prognosis (predicting disease course or outcome), where comparatively high rates are indicative of relatively poor outcomes. It also can be used to evaluate the effect of new treatments, with measures decreasing as treatments improve. Case fatality rates are not constant; they can vary between populations and over time, depending on the interplay between the causative agent of disease, the host, and the environment as well as available treatments and quality of patient care.
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