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Online Discussion: Tracking new emerging diseases and the next pandemic

Ebola Information And Updates

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onefluover View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: August 08 2014 at 1:39pm
FDA lifts hold on experimental Ebola drug

Published August 08, 2014
Associated Press
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People walk past a billboard encouraging people suffering from symptoms linked to Ebola to present themselves at a health facility for treatment in Freetown, Sierra Leone, Thursday, Aug. 7, 2014. While the Ebola virus outbreak has now reached four countries, Liberia and Sierra Leone account for more than 60 percent of the deaths, according to the World Health Organization. The outbreak that emerged in March has claimed at least 932 lives. (AP Photo/ Michael Duff)
WASHINGTON – U.S. health authorities have eased safety restrictions on an experimental drug to treat Ebola, a move that could clear the way for its use in patients infected with the deadly virus.

Canadian drugmaker Tekmira Pharmaceuticals Corp. said the U.S. Food and Drug Administration modified a hold recently placed on the company's drug after safety issues emerged in human testing.

The company has a $140 million contract with the U.S. government to develop its drug, TKM-Ebola, which targets the genetic material of Ebola. But last month the FDA halted a small study of the injection in adults to request additional safety information.

Tekmira said Thursday the agency "verbally confirmed" changes to the hold that may allow the company to make the drug available, although it has yet to be proven as safe and effective.

Two Americans diagnosed with Ebola recently received a different experimental drug called ZMapp, made by Mapp Biopharmaceutical Inc. of San Diego. It is aimed at boosting the immune system's efforts to fight off Ebola and is made from antibodies produced by lab animals exposed to parts of the virus.

The U.S. aid workers were first treated in Liberia. And while the FDA must grant permission to use experimental treatments in the United States, it does not have authority over the use of such a drugs in other countries.

The FDA's move Thursday comes amid an Ebola outbreak in West Africa that health officials warn could sicken more people than all previous outbreaks of the disease combined. More than 1,700 people have been sickened in the current outbreak, which began in March. Nearly 1,000 have died, according to the World Health Organization.

Currently, there are no licensed drugs or vaccines for the deadly disease. Several are in various stages of development, but none have been rigorously tested in humans.

The FDA in March granted Tekmira "fast track" status for its Ebola drug, a designation designed to speed up approval of high-priority drugs by granting companies extra meetings with FDA scientists. Early studies of TKM-Ebola in monkeys suggested it could block high doses of the Ebola virus. But on July 21, the company based in Vancouver, British Columbia, announced the FDA had halted a small dosing study of the drug in 28 healthy adults. The company said regulators had questions about a type of drug reaction that can cause nausea, chills, low blood pressure and shortness of breath.

Tekmira's CEO Mark Murray praised the FDA for modifying the restriction on Thursday.

"We have been closely watching the Ebola virus outbreak and its consequences, and we are willing to assist with any responsible use of TKM-Ebola," Murray said. "The foresight shown by the FDA removes one potential roadblock to doing so."

FDA spokeswoman Stephanie Yao said she could not confirm the company's announcement since FDA regulations bar the agency from disclosing information about experimental drugs. She did note that the agency places clinical holds on studies based on the risks and benefits to patients. Patients in the Tekmira study were healthy volunteers.

Tekmira's U.S.-traded shares jumped 89 cents, or 6.7 percent, to close at $14.27 in regular trading. They climbed another $1.18 cents, or 8.3 percent, to $15.45 in afterhours trading.

"And then there were none."
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Kilt2 View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Kilt2 Quote  Post ReplyReply Direct Link To This Post Posted: August 08 2014 at 2:32pm
here is a pandemic we have been prepping for

And I looked, and behold a pale horse: and his name that sat on him was Death, and Hell followed with him.
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CRS, DrPH View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote CRS, DrPH Quote  Post ReplyReply Direct Link To This Post Posted: August 08 2014 at 3:17pm
Originally posted by Kilt2 Kilt2 wrote:

here is a pandemic we have been prepping for

Isaacs of Samaritan's Purse said that a huge problem will be persuading African communities to abandon the traditional practice of washing the body and kissing the corpse immediately after death, when the body is most infectious.

 He said aid workers have been attacked when trying to intervene, and that some physicians in Liberia even mocked the existence of the Ebola virus, shunning protection around patients.


This thing won't end anytime soon, but I really don't see it spreading beyond Africa, except for sporadic cases.  

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sleusha View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote sleusha Quote  Post ReplyReply Direct Link To This Post Posted: August 08 2014 at 4:53pm
I just dug up this interesting tidbit of information:

"Men who have recovered from the disease can still transmit the virus through their semen for up to 7 weeks after recovery from illness."

I found it here:
Be the positive change that you want to see. Live it, be it, push for it.
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Krystar View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Krystar Quote  Post ReplyReply Direct Link To This Post Posted: August 08 2014 at 6:00pm
If EVD arrives in dense populated city such as New York city, the hospitals could be overwhelmed and not sure if health care workers will choose to serve the public or run to the hills?...

If we don't implement restrictions on flights from west Africa and also implement scanning measures for incoming flights, then it is only a matter of has to fight this disease one way or other....there in Africa or here in usa...
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atheris View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote atheris Quote  Post ReplyReply Direct Link To This Post Posted: August 13 2014 at 11:17am

Aug 13 (Reuters) - The World Health Organisation (WHO) on Wednesday reported 128 new Ebola cases and 56 deaths in West Africa in the two days to August 11, raising the death toll from the worst ever outbreak of the disease to 1,069.

Since the outbreak was identified in March, there have been a total of 1,975 confirmed, probable and suspected Ebola cases in Guinea, Liberia, Sierra Leone and Nigeria, the United Nations health agency said in a statement. (Reporting by Stephanie Nebehay; Editing by Daniel Flynn)

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