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Recomb:H5N1 Bird Flu Migrates to Ningxia China

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    Posted: July 01 2006 at 7:27am
H5N1 Bird Flu Migrates to Ningxia China

Recombinomics Commentary
July 1, 2006

China has found the H5N1 avian influenza virus in birds in the northwestern region of Ningxia, the Agriculture Ministry said, suggesting a fresh outbreak.

The National Bird Flu Reference Laboratory identified the virus on Thursday in samples taken from the town of Xuanhe in Ningxia's Zhongwei city, the ministry said late on Friday on its Web site (www.agri.gov.cn).


The above confirmed H5N1 bird flu outbreak in China provides additional evidence of an expanded H5N1 presence.  The strain of H5N1 was first noted at Qinghai Lake in May, 2005.  This outbreak was followed by outbreaks on farms in northwest Xinjiang province in June, and outbreaks in Russia, Kazakhstan, and Mongolia that were initially reported in mid-July in the region around Chany Lake.

This year there are more reports at the locations from 2005 as well as nearby regions.  H5N1 appeared at
Qinghai Lake almost exactly on year after the initial outbreak.  However, much large outbreaks were reported in southern Qinghai Province as well as the adjacent area in northern Tibet.  These locations are about 300 miles southwest of  Qinghai Lake.  The Ningxia outbreak above is near the Inner Mongolian board and about 200 miles northeast of Qinghai Lake.  This outbreak was preceded by an outbreak in Shanxi, about 500 miles east of Qinghai Lake as well as Xinjiang Province again..

In addition to the outbreaks in China, Russia has reported outbreaks near Chany Lake again as well as adjacent
Tomsk, but there is also a major die-off to the east in Tuva and across the southern border in northern Mongolia.  A recent presentation on bird flu in Qinghai showed that the 2006 isolates were most closely related to isolates in Novosibirsk and Mongolia.  As this H5N1 migrates further north, new H5N1 from earlier infections in China, southeast Asia, India, Africa, Middle East, and Europe, will converge in southern Siberia, which additional recombination will generate new gene sequences.

Thus, the widespread reports of H5N1 in the spring suggest movement of H5N1 in the fall will generate significant problems

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New bird flu outbreak in China

Beijing (dpa) - China on Saturday reported a new outbreak of H5N1 avian influenza among birds in a town in the northwestern region of Ningxia.

The national avian influenza laboratory tested samples from the town of Zhongwei and confirmed the presence of the H5N1 virus on Thursday, the agriculture ministry said.

Agriculture and health officials set up emergency vaccination and quarantine procedures in the affected area of Zhongwei, the ministry said in a brief statement posted on its website.

The statement gave no details of what kind of birds were infected or how many had died.

China has reported dozens of cases of H5N1 bird flu in wild birds and poultry in the last two years.

It has recorded 19 human infections and 12 deaths from H5N1 bird flu in China, though some experts believe that many more cases may have gone undetected.

The World Health Organization has asked for an investigation of a claim last week by Chinese scientists that China's first human infection with bird flu may have appeared in November 2003, two years before the government reported any cases.

The WHO had recorded 228 human infections with bird flu worldwide, including 130 deaths, by June 20.
 
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21 Bird Flu Outbreaks In China This Year, Crisis To Get Worse: Official
 
 
Beijing (AFP) Nov 22, 2005
 

China said Tuesday three new outbreaks of deadly bird flu had been detected, bringing the total number of confirmed outbreaks in the country to 24 this year.

One outbreak each struck in northwest China's Xinjiang and Ningxia regions while a third hit Yunnan province in the southwest, the state-run news agency said late Tuesday.

In the Xinjiang outbreak, 38 birds were discovered dead near Urumqi city on November 16 with the disease confirmed by a national laboratory, Xinhua said, citing a Ministry of Agriculture statement.

On November 17, 230 birds were found dead in Yinchuan, the capital of Ningxia, while another 2,500 poultry were discovered dead in Chuxiong city in Yunnan on the same day.

Ministry officials have ordered the culls of all poultry within a radius of three kilometers (1.9 miles) of each outbreak, with 8,388 fowls destroyed in Xinjiang, 99,400 in Yunnan and 66,800 in Ningxia.

The news came one day after China announced the bird flu crisis in the country was "severe" and set to worsen in the winter months.

Beijing also revealed there had been 21 outbreaks in the world's most populous country this year.

The outbreaks had occurred in nine provinces in mainland China, affecting 45 villages and causing the deaths of 144,624 birds, while a further 21.1 million have been culled, Vice Agriculture Minister Yin Chengjie said.

With the world's biggest poultry industry -- 14 billion fowls produced each year -- China faces a crisis that is far from over, Yin warned.

He made the grim assessment after China's cabinet, the State Council, adopted tough emergency laws requiring local governments and people to respond quickly to bird flu and other animal diseases.

Bird flu has killed more than 60 people in Southeast Asia since 2003. China reported its first human fatality this month.

Hong Kong late Tuesday suspended poultry meat imports from Ningxia and Yunnan, said a Health, Welfare and Food Bureau spokesman. Imports from Xinjiang had been suspended since an outbreak in June.

"Of the three regions, there were only a small quantity of frozen poultry meats imported to Hong Kong from Ningxia," the spokesman said. "We will keep a close watch on the development in the three regions in the next few weeks."

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China reviews death in 2003 for bird flu

By Associate Press
Published July 1, 2006

BEIJING - China's Health Ministry is investigating whether a man initially thought to have SARS actually died of bird flu in 2003, two years before Beijing reported its first human case of the disease, the World Health Organization said Friday.

The man's case was brought to light in a letter Chinese scientists published in the June 22 issue of the New England Journal of Medicine, said Roy Wadia, a WHO spokesman in Beijing.

The Health Ministry said it was not aware of the case and would do its own internal investigation, Wadia said.

He said tests were being conducted on samples from the man.

The ministry did not respond to telephone and faxed requests for comment.

The case raises troubling questions about China's ability to track emerging diseases and cooperate with international organizations like WHO. It also raises the possibility that other cases attributed to severe acute respiratory syndrome, or SARS, may actually have been infections by the deadly H5N1 bird virus.

Wadia said the man died in November 2003 at a military hospital in Beijing. Military hospitals, which answer to the secretive People's Liberation Army, figured prominently in a coverup of the spread of SARS in Beijing in the spring of 2003.

[Last modified June 30, 2006, 23:34:43]
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As this H5N1 migrates further north, new H5N1 from earlier infections in China, southeast Asia, India, Africa, Middle East, and Europe, will converge in southern Siberia, which additional recombination will generate new gene sequences.
 

THE deadly H5N1 strain of bird flu has appeared in remote Taraba state in eastern Nigeria, but in most other parts of Africa's most populous country the spread of the virus is slow, officials said overnight. The first African country to be hit by bird flu, Nigeria has not reported any human cases of the disease although experts warn surveillance may not be completely effective and cases may have gone undetected. The detection of the virus in Taraba means bird flu is now present in 14 of Nigeria's 36 states and in the Federal Capital Territory. The state that had most recently joined the list was Lagos in April. "We have identified it in three places in Taraba, one commercial farm and two places where there are backyard poultry," said Lami Lombin, director of the National Veterinary Research Institute which tests for bird flu. "There are a few places in Plateau and Kaduna where we are still getting new outbreaks. Elsewhere all the samples we're getting are negative," said Mr Lombin. Plateau and Kaduna, which form a strip of north-central Nigeria, were among the first four states where H5N1 was detected in February. Taraba borders Plateau to the east. In the first few weeks after the first cases were found, bird flu spread rapidly in poultry across the country despite measures to contain it such as culling and quarantine. Veterinary officials say it would not be safe to consider the disease contained, but recent evidence suggests measures to prevent its spread are working better than at the start.
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More than 25 children have died of suspected encephalitis in Bihar, India in the past few days. The dead in the Muzaffarpur district of Bihar reported sudden light fever in the early morning and then bouts of unconsciousness and convulsion before their death. The Muzaffarpur district administration has sounded a high alert to check the spread of the killer disease after doctors confirmed the deaths of the children due to suspected encephalitis. Muzaffarpur-based S.K. Medical College and Hospital superintendent G.K. Thakur has urged health experts to visit Muzaffarpur to study the cause of spread of the disease and preventive measures. The World Health Organization (WHO) has also expressed serious concern over the recurrence of encephalitis in Muzaffarpure. This is the third time in seven years that encephalitis has hit Muzaffarpur. Last year over 30 children died of the disease in the district.
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PonyGirl,
I believe that I read some where that Encephalitis and several other diseases where rearing up at the time of the 1918 pandemic. Do you think that this could be a repeat? Definately something to watch. Jo
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Yes encephalitis is a signal of a possible bird flu case. Its a red flag that hospitals are being asked to watch for.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Jhetta Quote  Post ReplyReply Direct Link To This Post Posted: July 02 2006 at 9:38am
Originally posted by PonyGirl PonyGirl wrote:

Yes encephalitis is a signal of a possible bird flu case. Its a red flag that hospitals are being asked to watch for.
 
PonyGirl do you have a link for this info?  I am aware that encephalitis can be involved in H5N1... http://www.avianflutalk.com/forum_posts.asp?TID=9749&KW=encephalitis&PID=83284#83284
 
However I have not read any info regarding H5N1 and hospitals screening for encephalitis.
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Encephalitis lethargica

Encephalitis lethargica is an atypical form of encephalitis which caused an epidemic from 1917 to 1928. There have only been a small number of isolated cases since, though in recent years a few patients have shown very similar symptoms. The cause is now thought to be a bacterial agent or an autoimmune response following infection. As depicted in the book Awakenings by doctor Oliver Sacks, which was made into the film starring Robin Williams and Robert De Niro, the disease sometimes caused catatonia which could persist for decades.

 
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I have two clients and both want me to go to China with them this year for bronze casting. I'm quaking in my sandles over this because I can't get out of going without breaking our contracts. I guess I'm packing my N95 masks and gloves.
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Jhetta we had this conversation before and posted the link to you. Believe it was on a PEI thread not long ago.  The hospitals in Canada looking for the disease as surveillence for possible BF. It was noted on their website as a clinical sign to watch for in suspect patients.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Jhetta Quote  Post ReplyReply Direct Link To This Post Posted: July 02 2006 at 7:59pm
Originally posted by PonyGirl PonyGirl wrote:

Jhetta we had this conversation before and posted the link to you. Believe it was on a PEI thread not long ago.  The hospitals in Canada looking for the disease as surveillence for possible BF. It was noted on their website as a clinical sign to watch for in suspect patients.
 
After 20 minutes of searching both our posts for PEI, encephalitis, Canada, Surveillance, etc I may have found the conversation you are referring to in the thread "Suspect Cases Possibly Not Being Reported" by searching for the word link and finally links.  Guess I was confused because the surveillance you referenced was not specific to H5N1.... Instead it referenced: Influenza-like illness (ILI)
 
 
 
Thank you!
 
 
Originally posted by PonyGirl PonyGirl wrote:

Influenza-like illness (ILI) in the general population (FluWatch national case definition): Acute onset of respiratory illness with fever and cough and with one or more of the following - sore throat, arthralgia, myalgia, or prostration which could be due to influenza virus. In children under 5, gastrointestinal symptoms may also be present. In patients under 5 or 65 and older, fever may not be prominent.
Severe ILI may include complications such as: pneumonia, Acute Respiratory Distress Syndrome (ARDS), encephalitis and other severe and life threatening complications requiring hospitalization or resulting in death of otherwise healthy individuals.
Originally posted by Jhetta Jhetta wrote:


Links
Originally posted by PonyGirl PonyGirl wrote:

One link is posted above.
 
Here is the disease description link:
 
http://www.phac-aspc.gc.ca/h5n1/index.html
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Post Options Post Options   Thanks (0) Thanks(0)   Quote pugmom Quote  Post ReplyReply Direct Link To This Post Posted: July 03 2006 at 9:19am
[QUOTE Recombinomics Commentary
July 1, 2006

" As this H5N1 migrates further north, new H5N1 from earlier infections in China, southeast Asia, India, Africa, Middle East, and Europe, will converge in southern Siberia, which additional recombination will generate new gene sequences.

Thus, the widespread reports of H5N1 in the spring suggest movement of H5N1 in the fall will generate significant problems."

Media Sources

Phylogenetic Trees
[/QUOTE]
 
New gene sequences??  The blasted WHO and CDC and St. Jude's haven't even released the old gene sequences yet!!  How far behind the eight ball do they intend for the world's scientists to be??
jpc
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