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Tracking the next pandemic: Avian Flu Talk

New "BATFLU" virus sickens three?

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gnfin View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gnfin Quote  Post ReplyReply Direct Link To This Post Topic: New "BATFLU" virus sickens three?
    Posted: June 28 2007 at 9:25pm
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Originally posted by gnfin gnfin wrote:

New bat virus sickens three in one family

Published: Friday, 29 June, 2007, 01:56 AM Doha Time

HONG KONG: A newly discovered virus that is probably carried by bats has caused acute respiratory disease in three members of the same family in Malaysia, scientists said.

Bats are carriers of a number of viruses, including Sars that killed about 800 people globally in 2003, Nipah that killed more than 100 people in Malaysia in 1999 and the Hendra virus which killed 1 person and 14 horses in Australia in 1994.

Writing in the July issue of the Proceedings of the National Academy of Sciences, scientists in Malaysia and Australia said they isolated a previously unknown virus from a 39-year-old army clerk in Malacca, Malaysia, who fell sick in March 2006.

The issue was published online this week.
The man developed high fever, loss of appetite, fatigue and acute respiratory illness about a week after a bat flew into his home as he was watching television in the living room.

The creature flew frantically for two to three minutes in the living room before flying out the same door through which it entered, the report said.

Two of his five children, an 11-year-old daughter and a 6-year-old son, developed milder symptoms a week after the man fell ill. All three have since recovered.

Virus samples taken from the three of them proved identical and have since been named the Melaka virus. The researchers say it belongs to the family of the reo-viruses, which were first found in humans in the early 1950s.

Melaka virus is a unique ortho-reo-virus capable of infecting and causing disease in humans. The infection of multiple members in the same family and the delayed onset by one week of clinical symptoms of the two children strongly suggest human-to-human transmission, the scientists wrote.

While the researchers have no direct evidence showing that the Melaka virus originates from bats, later analyses found it was closely related to the Pulau virus, another reo-virus isolated in 1999 from fruit bats on Tioman island in Malaysia.

They also detected Melaka virus antibodies in recent tests of serum samples collected between 2001 and 2002, from volunteers from Tioman island, indicating these people had been infected previously by the virus.
The batch of serum was originally collected for surveillance against the Nipah virus.

Looking ahead, the researchers said identification of the Melaka virus would help doctors better diagnose the cause for respiratory tract illnesses (RTI), which are among the symptoms seen in Sars and bird flu patients.

When severe RTI patients (are admitted to) hospital, it is important not only to exclude Sars or highly pathogenic avian influenza, but also to accurately determine the causative agent so that a targeted treatment regimen can be implemented, they said. Reuters    
    
    
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Post Options Post Options   Thanks (0) Thanks(0)   Quote endman Quote  Post ReplyReply Direct Link To This Post Posted: June 29 2007 at 6:36am
Mother Earth is using viruses to fight human infestation
 
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gnfin Quote  Post ReplyReply Direct Link To This Post Posted: June 29 2007 at 8:29am
Wow is this going to be it?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Guests Quote  Post ReplyReply Direct Link To This Post Posted: June 29 2007 at 5:30pm

"...another reo-virus isolated in 1999 from fruit bats on Tioman island in Malaysia...."

.......................................................................................


Bats are mammals....

Genus Orthoreovirus; type species: Mammalian ortho-reovirus

...................

thanks to Google.....


Bat-borne reovirus linked to human respiratory tract illness ...

Research shows bat-borne reoviruses can be transmitted to humans. ... disease in humans provides the first report of an orthoreovirus in association with an ...
www.csiro.au/resources/PNASMelakuVirus.html - 27k - Jun 28, 2007 -


.........

and dogs.....

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TD6-4GDK9S7-1&_user=10&_coverDate=08%2F10%2F2005&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d368b496a4e830fac2704393790f3ccc

Virological and molecular characterization of a mammalian orthoreovirus type 3 strain isolated from
a dog in Italy


......................


from W I K I P D E A ..........

Virus classification
Group: Group III (dsRNA)
Family: Reoviridae
Genera

Orthoreovirus
Orbivirus

Rotavirus
Coltivirus
Aquareovirus
Cypovirus
Fijivirus
Phytoreovirus
Oryzavirus
Idnoreovirus
Mycoreovirus




    * Genus Orthoreovirus; type species: Mammalian orthoreovirus
    * Genus Orbivirus; type species: Bluetongue virus
    * Genus Rotavirus; type species: Rotavirus A (causes diarrhea)


.........................................
http://www.ncbi.nlm.nih.*******sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15116303&dopt=Citation


1: J Infect Dis. 2004 May 1;189(9):1664-75. Epub 2004 Apr 15.Related Articles, < ="1.2">Links
Click here to read


Isolation and molecular characterization of a novel type 3 reovirus 

from a child with meningitis.

Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O'Donnell SM, Valyi-Nagy T, Clarke P, Wetzel JD, Dermody TS.

Department of Neurology, University of Colorado Health Science Center, Denver, Colorado 80262, USA. ken.tyler@uchsc.edu.

Mammalian reoviruses are non-enveloped viruses that contain a segmented, double-stranded RNA genome. Reoviruses infect most mammalian species, although infection with these viruses in humans is usually asymptomatic. 

We report the isolation of a novel reovirus strain from a 6.5-week-old child with meningitis. Hemagglutination and neutralization assays indicated that the isolate is a serotype 3 strain, leading to the

designation T3/Human/Colorado/1996 (T3C/96).

Sequence analysis of the T3C/96 S1 gene segment, which encodes the viral attachment protein, sigma 1, confirmed the serotype assignment for this strain and indicated that T3C/96 is a novel reovirus isolate. T3C/96 is capable of systemic spread in newborn mice after peroral inoculation and produces lethal encephalitis. These results suggest that serotype 3

reoviruses can cause meningitis in humans.

Publication Types:
MeSH Terms:
Substances:
Secondary Source ID:
Grant Support:
PMID: 15116303 [PubMed - indexed for MEDLINE]

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.................thanks to GOOGLE...


[PDF]

"Reoviruses". In: Encyclopedia of Life Sciences

File Format: PDF/Adobe Acrobat
Many of these agents are. pathogenic, either in humans (e.g. rotaviruses and coltivi-. ruses), or in animals (e.g. orbiviruses, avian reoviruses and ...
doi.wiley.com/10.1038/npg.els.0001084 - Similar pages

JSTOR: The History of Avian Reovirus

Avian reoviruses III. Infectivity and egg transmission. Avian Dis. ... Avian reoviruses IV. Relationship to human reoviruses. Avian Dis. 13:16-22. 1969. 6. ...
links.jstor.org/sici?sici=0005-2086(200007%2F09)44%3A3%3C638%3ATHOAR%3E2.0.CO%3B2-D - Similar pages

JSTOR: Intestinal Cryptosporidiosis and Reovirus Isolation from ...

Cryptosporidial infections in humans and an- imals have often been associated with immu- nodeficiency (20). Recent work indicates that avian reoviruses may ...
links.jstor.org/sici?sici=0005-2086(198607%2F09)30%3A3%3C603%3AICARIF%3E2.0.CO%3B2-R - Similar pages

Avian Reovirus Infections - Poultry Articles from The Poultry Site

These viruses have also been isolated from humans and in fact the name reovirus is a ... Avian reoviruses, in the past, have been associated with viral ...
www.thepoultrysite.com/articles/96/avian-reovirus-infections - 28k - Cached - Similar pages



read in full here....

http://www.thepoultrysite.com/articles/96/avian-reovirus-infections

Avian Reovirus Infections

By F. Dustan Clark, Extension Poultry Health Veterinarian at the University of Arkansas's Avian Advice -

Reoviruses are widespread in nature and have been isolated from a variety of animals. These viruses have also been isolated from humans and in fact the name reovirus is a mnemonic for respiratory (r) enteric (e) orphan (o) since the virus was isolated from the human respiratory and enteric tract, but was not associated with disease. In some species of mammals (primarily mice) these viruses have caused liver, pancreatic, lung, and heart disease and central nervous system symptoms.

More on the Author
Dr. Dustan Clark
Extension Poultry Health Veterinarian
Introduction

Avian reoviruses, in the past, have been associated with viral arthritis/tenosynovitis, malabsorption syndrome, stunting/runting syndromes, enteric disease, immunosuppression, and respiratory disease.

Recently, there have been reports from the field and isolations of reoviruses from chickens exhibiting neurological signs.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Guests Quote  Post ReplyReply Direct Link To This Post Posted: June 29 2007 at 8:06pm


interesting site...


http://www.iah.bbsrc.ac.uk/dsRNA_virus_proteins/




The dsRNA genome segments and



proteins of mammalian

 

 orthoreovirus-3 (MRV-3)

 

(genus Orthoreovirus: family


Reoviridae )




........................




read in full here....


http://216.239.51.104/search?q=cache:-c8hxAuhiXgJ:cstl-csm.semo.edu/cfrazier/virologyongoing/virology/protected/pp04/REOVIRUS04.ppt+Orthoreovirus,+Orbivirus,+Coltivirus,+and+Rotavirus+species+infect+humans&hl=en&ct=clnk&cd=6&gl=us



excerpt....


Family Reoviridae

 
 
 
 
 
  • Family: Birnaviridae (Bisegmented dsRNA Virus Group)
    • Genus: Aquabirnavirus
    • Type species: Infectious Pancreatic Necrosis Virus
    • 2 segments of ds RNA
    • Genus: Avibirnavirus
      • Type species: Infectious bursal disease virus
    • Genus: Entomobirnavirus
      • Type species: Drosophila X virus
  • Family: Totiviridae (Monopartite dsRNA mycovirus group)
    • Genus: Totivirus
      • Type species: Saccharomyces cerevisiae Virus L‑A
      • 1 segment of ds RNA, 4.6 ‑ 6.7 kbp
    • Genus: Giardiavirus
      • Type species: Giardia Lamblia Virus
      • 1 segment of ds RNA, 7 kbp
    • Genus: Leishmaniavirus
      • Type species: Leishmania RNA virus
      • 1‑1 1 segement of ds RNA, 5.3 kbp
 
 
 
 
 



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gnfin View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gnfin Quote  Post ReplyReply Direct Link To This Post Posted: June 29 2007 at 9:30pm
What?
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.

While the researchers have no direct evidence showing that the Melaka virus originates from bats, later analyses found it was closely related to the Pulau virus, another reo-virus isolated in 1999 from fruit bats on Tioman island in Malaysia.
..........................................................................

reoviruses can cause meningitis in humans
.............................


Primary host
- Insects



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Post Options Post Options   Thanks (0) Thanks(0)   Quote gnfin Quote  Post ReplyReply Direct Link To This Post Posted: July 01 2007 at 9:20pm

HMNN..

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