Now At Level 6

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Posted: September 22 2009 at 9:51pm

http://www.cdc.gov/H1N1flu/vaccination/statelocal/planning_checklist.htm

Public health vaccination clinics

.......................................

(clinics that are conducted, organized or sponsored by public health)

Determine populations that will be targeted for vaccination via large scale/public health sponsored clinics
Identify clinic sites (number, locations, points of contact, alternative sites, accessibility)
Estimate size and type (target and priority groups) of population to be served per site

Determine staffing needs, and sources of staffing
Develop plans for staffing, including identification of sources of volunteers and development of MOAs with relevant organizations.
Initiate contracts with personnel agencies or community vaccinators to provide staff or organize/conduct clinic
Define process to allow healthcare workers from other jurisdictions to vaccinate if necessary

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Posted: September 22 2009 at 10:29pm

What Country Didn't?

that countries will need to adjust their responses to accommodate the

knowledge we now have that this disease is moderate in most cases.

The Australian Government's New Plan-

NEW PANDEMIC PHASE PROTECT

.......................................................

On 17 June 2009, the Federal Minister for Health and Ageing,

Nicola Roxon,

after consultation with State and Territory governments,

announced

that Australia has developed a new response phase to manage the outbreak of

Pandemic (H1N1) 2009 called

PROTECT.

On the advice of the Chief Medical Officer, Professor Jim Bishop,

and the Australian Health Protection Committee,

a new pandemic phase has been created

to guide the ongoing Australian response to the disease.

The new phase recognises that the infection with Pandemic (H1N1) 2009 is not

as severe as originally envisaged when the Australian Health Management Plan for

Pandemic Influenza (AHMPPI) was written in 2008 and that this new disease is mild in

most cases, severe in some and moderate overall.

Pandemic (H1N1) 2009

PROTECT sits alongside CONTAIN and SUSTAIN phases

with a greater focus on treating and caring for people

in whom the disease may be severe.

PROTECT

is a measured, reasonable and proportionate health response

to the risk that the infection poses to the Australian community.

It is consistent with the message from the WHO when it lifted its Pandemic Alert to 6,

that countries will need to adjust their responses to accommodate the

knowledge we now have that this disease is moderate in most cases.

source

http://www.healthemergency.gov.au/internet/healthemergency/publishing.nsf

Also see... "from- Germany... "

http://avianflutalk.com/forum_posts.asp?TID=24452

......................................................

...............................................................

......................................................................

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Posted: September 22 2009 at 10:48pm

What

did they grow in the eggs?

..................................................................

[PDF]
Use of Cell Lines for the Production

File Format: PDF/Adobe Acrobat - View
influenza viruses in eggs generally leads to selection of certain phenotypes, the .... from the original MDCK(dog Kidney) cell line that was initially derived in 1958. All four companies ... At least two of the companies, Novartis and Solvay, have ...
www.who.int/vaccine.../WHO_Flu_Cell_Substrate_Version3.pdf - Similar
...

It led to a pdf-document by Novartis (NVS) on their ("egg-free") influenza ... This MDCK-cell line was optimized for the production of influenza vaccine ...
caps.fool.com/Blogs/ViewPost.aspx?bpid=211483 - Cached - Similar
Flu Vaccines and the Risk of Cancer - The 9/12 Project (New York ...

Sep 22, 2009 ... Cell line technologies, the use of cells and tissues for growing ... for logistical reasons: Flu shots made from cells instead of eggs ... Novartis' EU- approved flu shot, Optaflu, was produced using a ... Dutch giant, Solvay Pharmaceuticals, has been working with MDCK cells since the early 1990s. ...
www.meetup.com/.../boards/thread/7717542/ - 10 hours ago - Similar
mdck cells ebook Download

TAG cell mdck cells dna tumorigenic tumors vaccine influenza vaccines substrates risk assays cell line phenotype the committee agents virus oncogenic egg ...
www.toodoc.com/mdck-cells-ebook.html - Cached - Similar
Flu Vaccines and the Risk of Cancer

Residual egg protein remains within the final vaccine solution and is the ... Novartis' EU-approved flu shot, Optaflu, was produced using a cell line called ... Dutch giant, Solvay Pharmaceuticals, has been working with MDCK cells since ...
www.medicalvoices.org/.../flu-vaccines-and-the-risk-of-cancer.html - Cached - Similar

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Source-
http://www.reuters.com/article/sphereNews/idUKN1039876720070411?sp=true&view=sphere

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Posted: September 22 2009 at 11:34pm

..It is grown in a batch of cells taken from the fall armyworm, a kind of caterpillar.

"The company has actually taken those cells and further fooled around with them to

make them better for making vaccines," Treanor said.

Writing in the Journal of the American Medical Association, Treanor and colleagues...

..............................................

"...taken those cells and further fooled around with them..."

Picture that explanation in the Journal of the American Medical Association?
................................................................................................................................

Safe ... caterpillar cells infected with Baculovirus

.................................................................................................................................

Is this the fooling around part they use?
.....................................................................

Baculovirus
Expression Vector System (BEVS) (Granted May 17, 1988)

...Thousands of laboratories currently use the BEVS technology in their research

programs.

..these viruses have also been found infecting sawflies, mosquitoes, and shrimp. They

are not known to replicate in mammalian or other vertebrate animal cells.

MELT
.............

The extensive lysis of cells frequently causes the host insect to literally melt, thus the

reason for the historic name "wilting disease."

.....................................................

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Posted: September 26 2009 at 9:24am

Week 37
...............

.........................

........................................

Counting ...all... Influenza ... Illness is still fairly moderate in the Nation.
.........................................................................................................................

Two Regions neck in neck...

region 4... AL, FL, GA, KY, MS, NC, SC, TN

region 9.... AZ, CA, Guam, HI, NV

with region 5 a close 3rd ......... IL, IN, MI, MN, OH, WI

9,744 specimens

2,326   Influenza Type A (all types)
        4           "           "    B
..............................................
7, 414      Felt like Flu ... but it was something else. Perhaps we should look into a "cure"

There is only a slight amount of resistance to Tamiflu so far for Swine flu H1N1v.

For seasonal Flu typed and untyped ...making up about 25% of 'Surveillance Cases'

Tamiflu is a no show. No wonder they want to keep it for the very ill.

The Running Total for all Types Influenza Deaths since August 30th across the Nation

..........................................................................................................................................

114

source... FluView

...............................................................................................................................................

News Across The Pond....

Date: Mon 14 Sep 2009

Source: Barcelonareporter.com [edited]
http://www.barcelonareporter.com/index.php?/news/comments/study_involving_21_spanish_hospitals_states_50_of_swine_flu_icu_patients_ha/

excerpt-

...It is estimated that only 0.2 percent of patients suffer serious
complications, according to a calculation based on the experience of
Britain. This means that for every million affected, 2000 suffer
complications, a figure that may overwhelm the capacity of the ICU
departments.

Although the virus primarily affects the lungs, 75 percent of patients
arriving at the ICU in a few days develop multi-organ syndromes. "I
had never seen this type of pneumonia in the 25 years I've been
practising," says Rello.

The study results confirm that obesity and pregnancy are risk factors
for serious complications.

.................

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Posted: September 27 2009 at 8:11am

hi Ruthie.. hope you read the above... (feel better)

only 0.2 percent of patients suffer serious
complications,

.....

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Posted: September 27 2009 at 12:46pm

Congress voting on Bonuses ... with lightening speed

the Nation's Health? .... years.

Waaay Back in 2005 Resistance To Tamiflu
..................................................................................

From The New England Journal Of Medicine
.............................................................................

(Tamiflu) Oseltamivir Resistance - Disabling Our Influenza Defenses

..........................................................................................

Anne Moscona, M.D.

..Why is resistance developing to oseltamivir? Several years ago,structural analysis3 predicted that aspects of the chemical structure of oseltamivir (not present in zanamivir) could facilitate the development of resistance mutations that would permit neuraminidase to function, allowing drug-resistant virus to survive and propagate. This prediction is now being validated by clinical data.

...Like any successful infectious agent, influenza virus will most likely evolve to evade any single drug. By targeting several points in the viral life cycle simultaneously with different drugs, we are more likely to discourage the emergence of viruses that can resist all drugs at once.

But we currently rely solely on the neuraminidase inhibitors - and solely on oseltamivir in many situations, such as in patients who cannot use inhaled medication or in patients infected with H5N1 virus, in whom systemic drug levels may be important. We must not abrogate the usefulness of these drugs by exposing circulating influenza to them in such a way as to facilitate the selection of resistant viruses. The study by de Jong et al. confirms that oseltamivir-resistant H5N1 virus is now a reality.

source
http://content.nejm.org/cgi/content/full/353/25/2633

What do we hear about new antivirals?

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Posted: September 27 2009 at 8:46pm

Please... talk to your Doctor...some schools are giving out flumist vaccine

Not all can take this form of vaccine.

Children under age 10 need 2 swine flu vaccines. some need 4 vaccines.

see www.flu.gov

videos on flu...

.........................

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Posted: September 27 2009 at 9:12pm

What states have A(H1N1) resistance to Tamiflu?

...............

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Posted: September 27 2009 at 9:35pm

Many excellent articles on swine flu here at CIDRAP

.......................................................................................

http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/news/sep1409icaac.html

...............

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Posted: September 28 2009 at 10:24pm

Dr. Richard Daines, New York State health commissioner. must not be aware of all

this...

The Stuff Vaccines are made of... (swine Flu Vaccines)

Take a real good look at the cocktail of strains being used in vaccines... which one are

you getting? A, B, C, or D? The most impprtant "ingredients'

..........................................................................................................................................

excerpt..

Current guidance

As of 20 July 2009, four candidate reassortants have been safety tested in ferrets4.

These are:

(a) X-179A virus, a 5:3 reassortant vaccine candidate that possesses the HA, NA and

PB1 genes of A/California/07/2009 (H1N1v) and PA, PB2, NP, M and NS genes of

A/PR/8/34donated from the high-growth reassortant virus NYMC X-157 (A/New

York/55/2004 x A/PR/8/34 (H3N2)). This virus was generated by traditional

reassortment methods.

(b) A/Texas/05/2009(H1N1)-PR8-IDCDC-RG15 virus (RG15), which is a 6:2 modified
reassortant vaccine candidate generated by reverse genetics and possesses the HA and

NA from A/Texas/05/09 (H1N1) with mutation (Q226R) introduced into the HA and six

internal genes from A/PR/8/34.

(c) NIBRG-121 virus, which is a 6:2 reassortant vaccine candidate generated by reverse
genetics that possesses the HA and NA genes of A/California/07/2009 (H1N1)v and PA,

PB1. PB2, NP, M and NS genes of A/PR/8/34.

(d) IVR-153 virus, which is a 6:2 reassortant vaccine candidate generated by traditional
reassortment methods using A/California/7/2009 (H1N1)v and IVR-6. IVR-6 is a 5:3
reassortant of A/Texas/1/77 and A/Puerto Rico/8/34. IVR-153 possesses HA and NA

genes from A/California/07/2009 (H1N1v), the PB1 gene from A/Texas/1/77 and PA,

PB2, NP, M and NS genes of A/PR/8/345.

As a result of testing in ferrets, according to the protocol in Appendix 1, all of the

above viruses are considered (LIVE) attenuated.

source

2107_Biosafety_pandemicA_H1N1_flu_vaccines-Addendum-DRAFTFINAL.pdf

LIVE, ATTENUATED INFLUENZA VIRUS VACCINE (LAIV)
.......................................................................................

...It is approved for healthy (those not at risk

for complications from influenza infection), non-pregnant individuals 2 to 49 years old

but should not be given to children under 5 years of age who have possible reactive

airways disease (for example, a history of recurrent wheezing). It is given nasally and

should provide mucosal, humoral and cell-mediated immunity. It is contraindicated for

children and adolescents on any therapy containing aspirin due to the potential risk of

Reye's syndrome since the virus is a live virus.

source
pathmicro.med.sc.edu/mhunt/flu.htm

How do we know who used what in which vaccines? and ABCD are all....

LIVE, ATTENUATED INFLUENZA VIRUS VACCINE

...the virus is a live virus.

....................................................................................................................................

mutation Q226R (also seen above) why is it in a vaccine strain?

[PDF] INFORMATION FOR THE VACCINES AND RELATED BIOLOGICAL PRODUCTS ...
File Format: PDF/Adobe Acrobat - View as HTML
Q226R. LR- low reactor in HI to. A/Solomon Islands/3/2006. Vaccine Strain. # Egg isolate ..... Increasing proportion of clade 2B nas with H274Y mutation, ...
www.fda.gov/OHRMS/DOCKETS/ac/08/.../2008-4348B2-3.pdf - Similar

Chile/13309/2002
................................

Isolate
............

Chile/13309/2002

passage

E2/E1

collection date
............................

9/24/2002

number of differences
.......................................

position of change
.....................................
V-5A, E82G, E125bG, K166M,
A169V, Q226R, D275G

source
http://www.fda.gov/OHRMS/DOCKETS/ac/03/briefing/3922B1_2.pdf

.....................................................................

Recent H3N2 swine influenza virus with haemagglutinin and nucleoprotein
genes similar to 1975 human strains

interesting factoid
.....................................

Summary: Influenza A(H3N2) Viruses

H3N2 viruses have caused recent outbreaks in Japan, Korea and China
An increasing proportion of recent H3N2 isolates are not well inhibited by post-infecton and post-immunization antiserum

sources-

[PPT]

www.fda.gov/ohrms/dockets/AC/03/slides/3922S_2.ppt

ww.fda.gov/ohrms/dockets/AC/03/slides/3922S_2.ppt
http://vir.sgmjournals.org/cgi/reprint/76/3/697.pdf

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Posted: September 28 2009 at 10:40pm

Johnson & Johnson takes 18 pct stake in Crucell,

boosting vaccine, infectious disease position

......................

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Posted: September 29 2009 at 7:08am

Internal Medicine News

Volume 40, Issue 9, Page 26 (September 2009)

Flu Treatment for Upcoming Season Clarified
.........................................................................................................

..................................................................................................................

..........................................................................................................................

BRUCE JANCIN

VAIL, COLO. - The recommended antiviral therapy during the coming influenza season

will depend on whether a patient has laboratory-confirmed

novel influenza A(H1N1).

In patients with confirmed novel influenza A(H1N1),

or in patients with laboratory-confirmed influenza A(H3N2) or B, the first-line antiviral is

oseltamivir (Tamiflu).

However, in patients with a positive laboratory test for influenza A or seasonal A(H1N1),

the preferred agent is

zanamivir (Relenza),

according to Centers for Disease Control and Prevention recommendations based on

antiviral resistance patterns.

source
http://www.journalofinfection.com

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Posted: September 30 2009 at 10:45pm

Informatiion in Full Here-
.................................................

excerpts-

Antiviral use and the risk of drug resistance

Pandemic (H1N1) 2009 briefing note 12
....................................................................

25 SEPTEMBER 2009 | GENEVA -- Growing international experience in the treatment of pandemic H1N1 virus infections underscores the importance of early treatment with the antiviral drugs, oseltamivir or zanamivir. Early treatment is especially important for patients who are at increased risk of developing complications, those who present with severe illness or those with worsening signs and symptoms.[1]
.................................................................
.......................................................................
...............................................................................

...The risk of resistance is also considered higher in people who receive oseltamivir for

so-called "post-exposure prophylaxis" following exposure to another person with
influenza,

and who then develop(s) illness despite taking oseltamivir. (Tamiflu)

Global Influenza Surveillance Network, ... continues to detect sporadic incidents of

H1N1 pandemic viruses that show resistance to oseltamivir. (Tamiflu)

To date, 28 resistant viruses have been detected and characterized worldwide.[2]

All of these viruses show the same H275Y mutation that confers

resistance to the antiviral oseltamivir, (Tamiflu)

but not to the antiviral zanamivir. Zanamivir remains a treatment

option in symptomatic patients with severe or deteriorating illness due to oseltamivir-

resistant virus.

Twelve of these drug-resistant viruses were associated with the use of oseltamivir for post-exposure prophylaxis.

Six were associated with the use of oseltamivir treatment in patients with severe immunosuppression. Four were isolated from samples from patients receiving oseltamivir treatment.

A further two were isolated from patients who were not taking oseltamivir for either treatment or prophylaxis.

Characterization of the remaining viruses is under way.

These numbers are comparatively small at present.

Worldwide, more than 10,000 clinical specimens (samples and isolates)

of the pandemic H1N1 virus have been tested and found to be sensitive to oseltamivir.

...In general, WHO does not recommend the use of antiviral drugs for prophylactic purposes. For people who have had exposure to an infected person and are at a higher risk of developing severe or complicated illness, an alternative option is close monitoring for symptoms, followed by prompt early antiviral treatment should symptoms develop.

WHO has also recommended against the use of a particular antiviral where the virus is

known or highly likely to be resistant to it.

For this reason, zanamivir is the treatment of

choice for patients who become ill while on oseltamivir (Tamiflu) prophylaxis.

...WHO and its network of collaborating laboratories are closely monitoring the situation
and will issue information and advice on a regular basis as indicated.

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Posted: October 01 2009 at 8:51pm

Flu Thoughts

......................

"By comparing the small genetic differences in flu samples from many patients,

scientists estimate the pandemic strain was already circulating in people

by November 2008."
..................................

LA Times

People in NY had the tell tale hoarseness... inner ear dizziness... in winter 2008.

"...It appears that this flu produces a distinctive "hoarseness" in many victims. The

symptoms, in general, match other flu's; namely, sore throat, body aches, headache,

cough, and fever. Some have all these symptoms, while others may have only one or two."

Marc Gitterle, M.D.

As far as I could see... the summer in NY was the second wave.
..............................................................................................................................

The kids return to school in Sept. is not showing massive illness in NY so far.

Will be interesting to see what the return to school after the Holiday ...

normal February Flu peak brings?

(Additions to Pandemic strain, too simple, but theory of spread is interesting.

Source-
www.latimes.com/.../la-he-virus-qanda14-2009sep14,0,33423.story

By comparing the small genetic differences in flu samples from many patients,

scientists estimate the pandemic strain was already circulating in people by November

2008. The earliest cases to be confirmed in people occurred in Mexico in March.

How did the two strains of swine flu mix?
....................................................................

That remains a mystery, and scientists will probably never know. Relatively few pigs

engage in intercontinental travel, and those that do are strictly quarantined.

But there are theories.

One is that a person in Asia (one? :)

became infected with the Eurasian swine flu, then traveled to North America

and passed it along to a pig here that already had the triple reassortant virus. That

would explain why the outbreak began in Mexico and the United States.

( sounds like a/several, ship(s) of 4,000 seamen? visiting Asia..returning to S. Calif.? )
............................................................................................................................................

Another theory holds that an infected North American pig traveled to Asia

( right )

and passed along its virus to another pig with the Eurasian flu strain.

That pig then infected a person,

who brought the virus back to North America and

spread it to other people.

This would explain why H1N1 has seven out of eight genes in

common with a flu sample taken from a Hong Kong pig in 2004.
...............................................................................................................

( not really... ships do visit Hong Kong ... rather than traveling American and

Eurasian pigs )

...............................................................

Back in July 2009
.................................

Relenza/Zanamivir Injection
..................................................

(Also a later case in Australia)

source-
http://www.medpagetoday.com/Pulmonary/URIstheFlu/15843

Swine Flu Patient Recovers After Last-Ditch Zanamivir Shots
......................................................................................................
......................................................................................................

By Michael Smith, North American Correspondent, MedPage Today
Published: September 04, 2009

Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and
Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner

excerpt-

A 22-year-old woman critically ill with H1N1 pandemic influenza survived after her doctors resorted to a last-ditch and unlicensed treatment -- intravenous zanamivir (Relenza).

After 16 days in intensive care -- including 13 days of mechanical ventilation as standard antiviral regimens failed -- the woman was given intravenous zanamivir at 600 milligrams twice a day, according to Michael Kidd, FRCPath, and colleagues from the University College London Hospitals NHS Foundation Trust.

Within 48 hours, the patient's condition improved, and she was able to come off mechanical ventilation five days later. She was discharged to a general ward eight days later, Kidd and colleagues wrote in a case report online in The Lancet.

The physicians cautioned that in a single case report "direct cause and effect cannot be confirmed."

But, they added, "the improvement in clinical status following intravenous zanamivir encourages prompt further investigation."

The woman, who was neutropenic after chemotherapy for Hodgkin's disease, was admitted to the intensive care unit on July 8th. She had increasing shortness of breath, bilateral chest infiltrates, and laboratory-confirmed pandemic H1N1 flu...

interesting article here-
http://www.medpagetoday.com/Pulmonary/URIstheFlu/15843

........................

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Posted: October 02 2009 at 12:56pm

If the FDA allows this.... What else does the FDA Allow?

...Mechanism of Action
The exact mechanisms of protection against influenza following treatment with FluMist
vaccine are not fully understood.

...The individual contribution of the genetic sequences of the six non-glycoprotein MDV
genes ("internal gene segments") to the ca, ts, and att phenotype is not completely understood.

source
http://www.medilexicon.com/drugs/flumist.php

Our current technology, created to help people, while beefing up the coffers of Big Pharma/Research/- exceeds our knowledge of exactly how using novel/experimental
technology in vaccines, plays out in the human body.

The recent 2009 pandemic strategy, smoothly moving from the experimental to the Government approved is a dangerous path. People are now afraid of the unknown contents of what is so forcefully pressed upon them. Get vaccinated or loose your employment.

Why is there a reluctance to make public the particulars of certain antigens used to produce a vaccine? Why not tell people which cell lines are used?

Do you want to know...

Human retinal cells?

Catepillar cells?

Dog kidney cells?

African green monkey cells?

Human embryonic kidney cells?

or details on the method.. caterpillar cells infected with a virus?

What is a DNA vaccine?

When was the last time this many people were so uninformed by something

this important,

(Our bodies) held captive by a knowledgeble few, (Big Pharma Researchers) supported

by Government?

Oh, I remember, It was the Latin Bible, (their minds) known by Clergy, (we know

better than the masses) upheld by Government.

This is as important ... and we know our bodies are as sacred as our minds.

Someone needs to look into the ease in which novel/experimental technology has been

mainstreamed into... vaccines used on our children, right in front of our backs.

New cell technology accepted by the FDA...

MD Consult - Genital Human Papillomavirus Infection: Clinics in ...
Most people who have genital HPV infection do not know that they are infected. ... HPV is necessary, but not sufficient, to cause cervical cancer. .... The odds ratio for cervical cancer was 435 for infection with HPV 16 and 248 for ... the SCJ epithelium and vasculature of the uterine cervix, lower genital tract, ...

How much of this do you understand?
.................................................................

Current developments in viral DNA vaccines: shall they solve the unsolved?
................................................................................................................................

excerpt-

...since the immunised subject is already a viral DNA (or provirus) carrier.

The DNA-based immunisation strategies may overcome several problems of classical viral vaccines.

Novel DNA vaccines could induce immunity against multiple viral epitopes including
the conservative type common ones,

which do not undergo antigenic drifts.

Within the immunised host, they mimic the effect of live attenuated viral vaccines when
continuously expressing the polypeptide in question.

source
http://www3.interscience.wiley.com/journal/110488991/abstract?CRETRY=1&SRETRY=0

...................

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Posted: October 02 2009 at 1:15pm

Company: MedImmune

What were they doing

back in 2003?
..........................

All are called Flumist but...

Which FluMist is it?
................................

FluMist (Influenza Virus Vaccine Live) Intranasal is a live trivalent nasally administered

vaccine intended for active immunization for the prevention of influenza. The vaccine

contains live attenuated influenza viruses that replicate in the nasopharynx of the

recipient and are shed in respiratory secretions.

..Each of the three influenza virus strains contained in FluMist is a genetic reassortant of a

Master Donor Virus (MDV) and a wild-type influenza virus.

...................................

A wild-type influenza virus is being shed (sneezed) onto people who never (before this)

came into contact with this No Name Wild Influenza Virus?

I feel totally safe...

...................................

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Posted: October 02 2009 at 7:46pm

my take on...

Week 38
...................
..............................
........................................

Counting ...all... Influenza ... Illness is higher in some areas of the the Nation.
.....................................................................................................................................

9,314 specimens
2,119 Influenza Type A (all types)
7 " " B
..............................................
7, 188 Felt like Flu ... but it was something else. Perhaps we should look into a "cure"

52.7% of positive Flu A cases were ... 2009 H1N1v 1,116 cases

(45.3%) A (subtyping not performed) 959 cases

(1.7%) A (unable to subtype) 35 cases

observed proportion of deaths

attributed to pneumonia or influenza
...................................................................

"epidemic threshold," i.e., the point at which the observed proportion of deaths

attributed to pneumonia or influenza was significantly higher than would be expected at
that time of the year ...

for week 38.... (the) percentage

was below
..................

the epidemic threshold of 6.4%.

"..rare sporadic cases of oseltamivir resistant 2009 influenza A (H1N1) viruses have

been detected worldwide, including 11 cases in the United States ..."

Cases of All Influenza in all Regions
................................................................

(in relation to one another)

Highest 4: AL, FL, GA, KY, MS, NC, SC, TN, 6: AR, LA, NM, OK, TX

High 5: IL, IN, MI, MN, OH, WI, 9: AZ, CA, Guam, HI, NV

Moderate 1: CT, ME, MA, NH, RI, VT, 3: DE, DC, MD, PA, VA, WV

Milder 2: NJ, NY, Puerto Rico, 7: IA, KS, MO, NE, 8: CO, MT, ND, SD, UT, WY,
10: AK, ID, OR, WA

source... FluView

http://www.cdc.gov/h1n1flu/updates/us/

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http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5834a1.htm

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Posted: October 03 2009 at 10:12pm

Note that numbers are small... (for deaths)

Neurodevelopmental condition	22	(61)
Chronic pulmonary condition	10	(28)

Reported CDC

September 4, 2009

......................................

April--August 2009 cases

high-risk medical condition
children whose deaths were associated with

2009 pandemic influenza (H1N1) virus infection

.........................................................................................................................................

University of Richmond Health Center: Health Alerts

About 2009 H1N1 Influenza (previously referred to as novel Influenza A ... While rare, complications can be severe, including meningitis, encephalitis, ...
healthcenter.richmond.edu/alert.html - Cached - Similar

This is fairly uncommon... But.... Be Alert Anyway....

Meningitis

Meningitis is inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges.[1] The inflammation may be caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs.[2] Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord; therefore the condition is classified as a medical emergency.[1][3]

The most common symptoms of meningitis are

headache and

neck stiffness associated with fever,

confusion or altered consciousness,

vomiting, and an

inability to tolerate light (photophobia)

or loud noises (phonophobia).

Sometimes, especially in small children, only nonspecific symptoms may be present,
.............................................................................................................................................

such as irritability and drowsiness.
...........................................................

If a rash is present, it may indicate a particular
..............................................................................
cause of meningitis;

for instance, meningitis caused by

meningococcal bacteria

may be

accompanied by a characteristic rash.[1][4]

baby/child/ adult does not react normally... I would call ..... Doc/911

Pneumococcal conjugate vaccines

PCV7 is recommended for all children aged less than 5 years; national coverage among 19-35 month olds with 3 or more PCV7 doses is currently > 90% (National Immunization Survey, July 2007-June 2008). PCV7 coverage estimates are available at: http://www.cdc.gov/vaccines/stats-surv/nis/data/tables_0708.htm .

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Posted: October 05 2009 at 6:49pm

Swine flu science update: 5 October 2009

Carol Campbell

5 October 2009

Genetic similarities between the swine flu virus - influenza A(H1N1) - and other circulating viruses may explain the unexpected effectiveness of a single dose pandemic vaccine.

...........

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Posted: October 05 2009 at 7:30pm

this is what worries me... misinformation
.......................................................................

Patricia means well... but the information for pregnant women is incorrect.
...............................................................................................................................

Swine flu shots due October 5, 2009 - Decision Time

September 28, 8:44 AM
Atlanta Faith & Family Examiner

excerpt-

This first round of the nasal vaccine is designated for the following: pregnant women, health care workers, young people and parents/caregivers of infants younger than 6 months. The report of USA Today did not indicate that this nasal mist would be available to the elderly or those with chronic diseases.

...........................................

FluMist is LAIV
..........................

The CDC wants Parents to be aware of Vaccine Safety....

They have a special PDF .... Please read All of it and know what members of your family

should not have certain vaccines.

Not everyone should have all vaccines.... read the PDF...

http://www.cdc.gov/vaccines/recs/vac-admin/downloads/contraindications_guide.pdf

CDC

Who... should not .. be vaccinated with the nasal-spray flu vaccine LAIV (FluMist)?
..........................................................................................................................................

People less than 2 years of age

People 50 years of age and over

People with a medical condition that places them at high risk for complications from
influenza, including those with chronic heart or lung disease, such as asthma or reactive
airways disease;

people with medical conditions such as diabetes

or kidney failure;

or people with illnesses that weaken the immune system,

or who take medications that can weaken the immune system.

Children <5 years old with a history of recurrent wheezing

Children or adolescents receiving aspirin

People with a history of Guillain-Barré syndrome, a rare disorder of the nervous system

Pregnant women

People who have a severe allergy to chicken eggs

or who are allergic to any of the nasal spray vaccine components.

........

Please read the Entire CDC PDF>>>>>

http://www.cdc.gov/vaccines/recs/vac-admin/downloads/contraindications_guide.pdf

..........

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Posted: October 06 2009 at 8:59am

the original essay in northern Germany's

"Schleswig-Holsteinischer Zeitungsverlag (sh:z)

Dr. Wolfgang Wodarg

.....................................

statements on the so called "swine-flu" and on new methods of the production of vaccines has lead to many echoes in different media.

Germany's Boulevard-Newspaper BILD published the following Report:

Doctor Kent Holtorf

....................................

http://www.youtube.com/watch?v=E1z7KSEnyxw&feature=player_embedded#

............

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Posted: October 08 2009 at 9:16pm

........................................

It's been a long time coming...

http://www.usaha.org/committees/reports/2008/report-sd-2008.pdf
.......................................................................................................................

excerpts-

Swine Influenza Update was presented by Dr. Amy Vincent, National Animal Disease Center. Dr. Vincent presented a background on the rise of influenza virus infections in swine. H1N1, H1N2, and H3N2 viruses are currently circulating in the U.S. swine population. Emerge via drift, shift, interspecies transmission, or re-emergence. Double and triple reassortants emerged in 1997-1998.

In 2003-2005, a human-like H1N1 emerged. H1N1 viruses have predominated since 2007. New genetic cluster of influenza viruses have been detected in the U.S. Two separate introductions of human H1 viruses have occurred containing the TRIG cassette which has been highly successful in swine. Limited serum cross-reactivity with swine H1. Zoonotic potential is unknown.

An H2N3 virus has been detected from two swine farms in Missouri with some changes suggesting adaptation from avian to mammal receptor binding. No human illness has been reported. No evidence that the virus is still circulating.

During the 2007 Ohio county fair, pigs and people had flu-like symptoms. A swine H1N1 from the pigs was detected. Clinical signs were reproduced in pigs at the National Animal Disease Center (NADC).

These produced more severe clinical signs then normally observed with influenza alone. They also produced severe lung lesions.

Genetically there is nothing different about this group of viruses, but has increased virulence, increased shedding, potential to infect people, poor cross-reactivity with other H1 strains.

We need: better vaccines for pigs and people including modified live viruses (MLV), personal protective equipment (PPE) for people, and minimize contact between swine and avian species.

wondering how this adds to ...taste.

Seven U.S. states with direct flights from Hispaniola allow garbage feeding. Approximately 70,000 passengers are found yearly with meat products (3.5 percent of passengers). DR passengers are twice as likely to travel with meat products than travelers from other countries.

The risk of introduction of foot-and-mouth disease (FMD) is a great concern particularly due to the high number of United Nations forces in the country – a number of which come from countries positive for FMD.

Dr. Patrick Webb, National Pork Board (NPB) gave a presentation on Waste Feeding. In the U.S. there are an total of 67,280 premises with more than 70 percent having a premises identification.

In 2008, 113 million market hogs were harvested, including 7 million feeder pigs from Canada.

Webb summarized waste feeding statistics in the U.S.:

160,000 head of market swine are currently fed waste products

600 pounds of feed to a 40-pound pig to 240 pounds.

............................

Mary's old thread...

(still thinking about H9N2)

Disturbing, H9N2/H1N1-2/H3N2/H5N1 and SWINE

Posted: April 14 2009 at 10:04am
http://www.avianflutalk.com/forum_posts.asp?TID=22192&KW=porc&PN=1

Posted: April 14 2009 at 10:38am
.
How 'Silent' is H9N2?

China and Hong Kong seem to be rather open on the DANGER of H9N2
....................................................................................................................

Excerpt from Yahoo Hong Kong

Wednesday, April 15

24Â°C 88 % Temperature 24 Â° C Humidity 88%

......................................

Ming Pao Daily News,

a newsletter with his family a long time girl living in Shenzhen, Hong Kong Tuen Mun Hospital due to a doctor, was diagnosed with avian influenza H9N2 infection.

...Experts advise:

Do not underestimate the threat of H9N2

Experts believe that the world's attention to the focus of bird flu, mostly on high pathogenicity, mortality of the H5N1 virus, the threat of H9N2 had not been sufficient attention.

Professor Wei Bosi in July this year attended a seminar in Hong Kong, warning of the

greater risk of H9N2, which is a silent virus, more easily transmitted.

H9N2 avian influenza virus characteristics, are considered more "human" and more capable

than the impact of H5N1 human cell receptors, so that the virus easier to invasive cells.

Now on the H5N1 bird flu worldwide, there are more comprehensive measures to deal

with, but experts believe that the world should be on guard against the same H9N2 bird flu

Experts believe that the world's attention to the focus of bird flu, mostly on high

pathogenicity, mortality of the H5N1 virus, the threat of H9N2 had not been sufficient

attention. Professor Wei Bosi in July this year attended a seminar in Hong Kong, warning of

the greater risk of H9N2, which is a silent virus, more easily transmitted.

H9N2 avian influenza virus characteristics, are considered more "human" and more capable

than the impact of H5N1 human cell receptors, so that the virus easier to invasive cells.

Now on the H5N1 bird flu worldwide, there are more comprehensive measures to deal

with, but experts believe that the world should be on guard against the same H9N2 bird flu

Welcome to respond to
editorial@mingpao.com

article here-
http://translate.google.com/translate?hl=en&sl=zh-TW&u=http://hk.news.yahoo.com/article/081230/4/9zbi.html&ei=iMfkSYugDp6clQeknqzgDg

&sa=X&oi=translate&resnum=10&ct=result&prev=/search%3Fq%3D2009%25E5%25B9%25B44%25E6%259C%2588%2BH9N2%26hl%3Den%26sa%3DN%26start%3D10

...........................

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Posted: October 09 2009 at 3:57pm

Week 39 ending October 3, 2009

Week 39
...................
..............................
........................................

10,816 specimens
2,959   Influenza Type A (all types)
         9           "           "    B
..............................................
7, 848      Felt like Flu ... but it was something else. Perhaps we should look into a "cure"

52.3% of positive Flu A cases were ... 2009 H1N1v 1,549 cases (proir week 1,116)

(46.2%) A (subtyping not performed) 959 cases

(1.4%) A (unable to subtype) 40 cases

"..rare sporadic cases of oseltamivir resistant 2009 influenza A (H1N1) viruses have

been detected worldwide, including 12 cases in the United States ..."

Cases of All Influenza by Region
................................................................

REGION 1 & 2 (CT, ME, MA, NH, RI, VT) (NJ, NY) no change, not much flu.

REGION 6 ( AR, LA, NM, OK, TX ) Big drop in Flu cases to less than half.

REGION 9 (AZ, CA, HI, NV) Much less flu here ...less than half of week prior.

REGION 5 (IL, IN, MI, MN, OH, WI) fair amount of flu, similar to week prior.

REGION 3 (DE, DC, MD, PA, VA, WV) fair amount of flu here, increasing a bit each wk.

REGION 4 (AL, FL, GA, KY, MS, NC, SC, TN) Still has High Flu but less than week prior.

REGION 10 (AK, ID, OR, WA) Fair amount of flu, little less than week prior.

REGION 7 & 8 (IA, KS, MO, NE) (CO, MT, ND, SD, UT, WY)

Flu Ballooning in these states ... double that of reg flu season in 8, almost double in 7.

See Region Graphs here-

http://www.cdc.gov/flu/weekly/regions2008-2009/hhswhousmap.htm
.......................................................................................................................................

....................................................................

observed proportion of deaths
attributed to pneumonia or influenza
...................................................................

"epidemic threshold," i.e., the point at which the observed proportion of deaths

attributed to pneumonia or influenza was significantly higher than would be expected at

that time of the year ...

for week 38.... (the) percentage

was below
..................

the epidemic threshold of 6.4%.

for week 39

percentage was at the epidemic threshold of 6.5%

source... FluView

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Posted: October 10 2009 at 8:10am

Flu in these states is similar to what NYS had in spring/summer...

we have little flu now...

INFLUENZA ISOLATES FROM THE HHS REGION 8

(CO, MT, ND, SD, UT, WY)

Reported By WHO/NREVSS Collaborating Laboratories
2008-2009 Season

%20Region%20Chart%20of%20Influenza%20Positive%20Tests%20Reported%20to%20CDC%20by%20U.S.%20WHO/NREVSS%20Collaborating%20Laboratories

INFLUENZA ISOLATES FROM THE HHSREGION 2 (NJ, NY)
Reported By WHO/NREVSS Collaborating Laboratories
2008-2009 Season

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Posted: October 10 2009 at 5:08pm

Rob, that headline might sell more papers... but the truth is-

Five otherwise healthy children died, some after immune systems were weakened by flu. (no flu type was specified )
.....................................................................................................

Saturday, October 10, 2009 - Page updated at 05:00 p.m.

19 children, teens die in a week as swine flu escalates across U.S.

By Rob Stein

The Washington Post

excerpt-

...While most children who died had other health problems that made them particularly vulnerable, such as asthma, muscular dystrophy and cerebral palsy, 20 to 30 percent (of the 19 ) were otherwise healthy, Schuc h a t said. Many of the deaths resulted from bacterial infections after immune systems were weakened by flu.

source
http://seattletimes.nwsource.com/text/2010036066.html

.................................

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Posted: October 11 2009 at 3:34pm

FDA.gov

................

Vaccines and Related Biological Products Advisory Committee Meeting

July 23, 2009

Pandemic Influenza A (H1N1)
Virology Update

Nancy Cox, PhD
Alexander Klimov, PhD
Influenza Division
National Center for Immunizations and Respiratory Diseases
Centers for Disease Control and Prevention

unity

Immunity TO 2009 H1N1 VIRUS RESULTING FROM PRIOR INFLUENZA INFECTION OR VACCINATION WITH SEASONAL INFLUENZA VACCINE IN DIFFERENT AGE GROUPS

(NEJM submitted)

Less than 4% of individuals born during or after 1980 exhibited preexisting, cross-reactive, neutralizing antibody titers of â‰¥40 to the pandemic virus, whereas 34% of individuals born prior to 1950 had titers of - or > 80 (at or above 80 )

source

oodVaccinesandOtherBiologics/VaccinesandRelatedBiologicalProductsAdvisoryCommittee/UCM1

74056.

ppt

Note:

The World Health Organization (WHO) defines a positive test result as a microneutralization antibody titer for influenza virus ... of >80 with a confirmatory ELISA or Western blot assay[3,4]

wikipedia

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Posted: October 11 2009 at 7:44pm

... promising countermeasures ... as in ..... experimental vaccines

Which many would welcome ... if the situation were very extreme..

August 21, 2009

*If an emerging public health threat is identified for which no licensed or approved
product exists,

the Project BioShield Act of 2004

authorizes the Food and Drug Administration commissioner to issue (an) Emergency Use Authorization
so promising countermeasures can be disseminated quickly
to protect the safety of the U.S. population.

As of July 31, 2009, the median age of hospitalizedpersons with laboratory-confirmed
novel influenza A (H1N1)virus infection was 20 years,

and

the incidence of hospitalization was highest among young children aged <4 years
(11;CDC, unpublished data, 2009).

Only

282 (5%) of 5,514hospitalizations

and

29 (8%) of the 353 reported deaths

had occurred among persons aged >65 years

(CDC, unpublisheddata, 2009).

..The median age among persons who died

with novel influenza A (H1N1) virus infection was 37 years.

Current studies indicate the risk for infection among persons aged >65 years is less than the risk for persons in younger age groups. Expanding vaccination recommendations to include adults aged >65 years is recommended only after assessment of vaccine availability and demand at the local level.

Once demand for vaccine among younger age groups is being met, vaccination should be expanded to all persons aged >65 years.

This recommendation might need to be reassessed as new epidemiologic,
immunologic, or clinical trial data warrant and in the context of global need for vaccine.

sources

http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5808a1.htm?s_cid=rr5808a1_e

...........................

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Posted: October 11 2009 at 7:50pm

Mary that NJ and NY chart is weird. It's almost like it infected everyone then vanished. I'm wondering if that's the end of it in those states?

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source
http://www.novartis.com/newsroom/media-releases/en/2009/1339223.shtml

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Posted: October 11 2009 at 10:53pm

ON Pandemic Vaccine....

H1N1 Flu Vaccine

The H1N1 influenza vaccine will be available in an inactivated, injectable formulation
and a nasal-spray, live attenuated formulation.

Neither is an experimental vaccine.

The2009 H1N1 influenza vaccines are made employing the same methods and facilities usedannually to produce seasonal influenza vaccine. The vaccines are undergoing additionalclinical trials at this time to determine the size of the dose and the number of doses that will be needed for protection.

source-
http://www.co.gila.az.us/DepartmentFiles/Health/Nursing/Vaccines.pdf

NIAID
..............

National Institute of Allergy and Infectious Diseases (NIAID)

... is sponsoring two major ongoing studies. The first was received by the U.S. National
Institutes of Health on July 21, 2009 for a

Sanofi Pasteur experimental H1N1 vaccine

and the other was received on August, 20, 2009 for a

CSL experimental vaccine.

(just as they said... studies done to check dosage levels for immunogenicity

and... tolerability.)

Sanofi Pandemic Vaccine
................................................

Sanofi H1N1 Influenza Vaccine Administered at Two Dose Levels in Adult and Elderly Populations

The purpose of this study is to assess the safety and the body's immune response (body's defense against disease)

to an experimental H1N1 influenza vaccine

in healthy adult and elderly populations. The study will enroll up to 450 healthy adults ages 18 and older with no history of H1N1 infection or vaccination. Two hundred individuals will be 18-64 years old, and the other 200 will be greater than or equal to 65 years of age. Participants will be randomly assigned to 1 of 2 possible vaccine groups: group 1 will receive 15 mcg of H1N1 vaccine; group 2 will receive 30 mcg of H1N1 vaccine. Both groups will receive vaccine injections on days 0 and 21 in the arm muscle.

source
http://clinicaltrials.gov/ct2/show/NCT00943631

Novartis
..................

The trial evaluated the tolerability and immunogenicity of the vaccine. Different schedules and timing between vaccinations were tested. The vaccine schedule comprised one or two doses of 7.5µg MF-59 adjuvanted surface-antigen A/California/2009 vaccine derived from

cell-culture.

The cost of growing mammalian cell cultures is high, so research is underway to

produce such complex proteins in insect cells or in higher plants.

Established human cell lines
.....................................................

One of the earliest human cell lines, descended from Henrietta Lacks, who died of the
cancer that those cells originated from, the cultured HeLa cells shown here have been
stained with Hoechst turning their nuclei blue.

Cell lines that originate with humans have been somewhat controversial in bioethics, as they may outlive their parent organism and later be used in the discovery of lucrative medical treatments. In the pioneering decision in this area, the Supreme Court of

California held in Moore v. Regents of the University of California that human patients

have no property rights in cell lines derived from organs removed with their consent. [13]

source
http://en.wikipedia.org/wiki/Cell_culture#Cell_line_cross-contamination

Baculovirus Expression Vector System

..........................................................

PSC utilizes a proprietary Baculovirus Expression Vector System (BEVS) for development of all its products and services. The platform leverages a natural infection process of insect cells with an engineered baculovirus that specifically infects and re-programs the insect cell to produce the recombinant protein(s) desired

http://www.proteinsciences.com/

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Posted: October 12 2009 at 10:18pm

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Posted: October 13 2009 at 8:18pm

A/H1N1 Pandemic Vaccines
.............................................................

Novartis successfully demonstrates capabilities of cell-based technology for production
of A(H1N1) vaccine
.........................................................................

June 12, 2009

First results achieved with A(H1N1) wild type strain

shows significant time savings of cell-based production over egg-based manufacturing

approach confirming its value in pandemic situations.

Based on this success Novartis expects to be able to achieve rapid production and scale

up of influenza A(H1N1) vaccine manufacture with reassortant seed.

More than thirty governments have made influenza A(H1N1) vaccine supply requests to

Novartis for cell-based and egg-based antigen and MF59.

Experimental adjuvants
......................................

An increasing number of vaccines with squalene and phosphate adjuvants are being

tested on humans.[12] The compound QS21 is under investigation as a possible

immunological adjuvant[13] as is Novartis' (formerly Chiron) MF59.[14]

(wikipedia)

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Posted: October 13 2009 at 10:43pm

. German soldiers to receive SPECIAL swine flu vaccine

..............................................................

Baxter
.................

Celvapan
..................

The vaccine has been tested in Mice, but not in humans.
...................................................................................................

source

excerpts...

contains...

Trometamol (see below)

uses a vero cell line... green monkey cells

multi dose vial. The vaccine is an off-white, opalescent, translucent suspension.

There is currently no clinical experience with Celvapan (H1N1) in adults, elderly, children or adolescents.

There are currently no data available on the use of Celvapan in pregnancy.

One dose of 0.5 ml at an elected date.

A second dose of vaccine should be given after an interval of at least three weeks.

There are no safety, immunogenicity or efficacy data to support interchangeability of

Celvapan with other H1N1 pandemic vaccines.

Within each frequency grouping, adverse reactions are presented in the order of

(showing here... common only... see source... for uncommon and complete info)

decreasing seriousness.

Common: nasopharyngitis

Common: headache, dizziness

Common: vertigo

Common: pharyngolaryngeal pain

Common: hyperhidrosis

Common: arthralgia, myalgia

Very common: injection site pain

Common: pyrexia, chills, fatigue, malaise, induration, erythema, swelling and

haemorrhage at the injection site

............................................................................

Other names TRIS, Tris, Tris base, Tris buffer,
TrizmaTM, Trisamine, THAM,
Tromethamine, Trometamol, Tromethane

Appearance White crystalline powder

Medical

Tris (usually known as THAM in this context) is used as alternative to sodium
bicarbonate in the treatment of metabolic acidosis.[5]

Buffer details

It is toxic to mammalian cells.

wikipedia

...................................................................................

Acidosis: Too much acid in the body, a distinctly abnormal condition resulting from the accumulation of acid or from the depletion of alkaline reserves. In acidosis, the pH of the blood is abnormally low. Acidosis is associated with diabetic ketoacidosis, lung disease, and severe kidney disease. The opposite of acidosis is alkalosis in which there is too high a pH due to excess base or insufficient acid in the body.

www.medterms.com/script/main/art.asp?articlekey=6846

......................................................

The Treatment of Acidosis in Acute Lung Injury with Tris-Hydroxymethyl Aminomethane (THAM)

excerpt...

Patients consisted of all patients with ALI who received THAM between March 1, 1994 and March 1, 1999 at San Francisco General Hospital.

The patients were not part of a randomized, prospective study, and the decision to administer THAM was made by the patient's treating physician; therefore, informed consent was not sought. THAM (0.3 M solution; Abbott Laboratories, Abbott Park, IL) was used to treat severe acidosis during either eucapnic ventilation or permissive hypercapnic ventilation in patients with ALI.

http://ajrccm.atsjournals.org/cgi/content/full/161/4/1149

In six of these patients adequate control of pH could not be achieved with sodium bicarbonate therapy. We have summarized the clinical circumstances and laboratory findings that compelled us to use THAM in these patients (Table 1), along with the severity of their ALI (Table 2). Lung injury scores were computed using the method described by Murray and colleagues (14)

................

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Posted: October 14 2009 at 9:53am

Because the information is different...

If you want your children to have a vaccination PLEASE know the difference between

Seasonal Vaccine dosage info

and

Influenza A (H1N1) 2009
Monovalent Vaccine Live, Intranasal (FluMist)

(swine flu)

ASK
..........
..................

Is it Seasonal Flu Vaccine? (different dose info see bottom for Seasonal FluMist)

Is it

Influenza A (H1N1) 2009
Monovalent Vaccine Live, Intranasal (FluMist) ?
.......................................................................................

Do Not let School /medical personnel
................................................................

tell you

dosage Info for SEASONAL FluMist
............................................................

when giving your child

Influenza A (H1N1) 2009
Monovalent Vaccine Live, Intranasal (FluMist) (under age 2 No )
...................................................................................

..........................................................

2.1 Dosing Information Clinical studies are ongoing with Influenza A (H1N1) 2009

Monovalent Vaccine Live, Intranasal to determine the optimal number of doses.

Available data

show that children 9 years of age and younger are largely serologically

naive to the pandemic (H1N1) 2009 virus [1].

Based upon these data

Influenza A (H1N1) 2009Monovalent Vaccine Live, Intranasal
should be administered as follows:

Age Group Dosage Schedule

................................................

( Influenza A (H1N1) 2009
Monovalent Vaccine Live, Intranasal (FluMist)

(swine flu) )

Children age 2 years through 9 years 2 doses (0.2 mL* each,
........................................................................................................
....................................................................................................................
..................................................................................................................................

approximately 1 month apart)
...................................................
......................................................

Children, adolescents andadults age 10 through 49 years (over 50 No )

1 dose (0.2 mL*) âˆ— Administer as 0.1 mL per nostril.

Each 0.2 mL dose is administered as 0.1 mL per nostril.2.2 Administration Instructions

Each sprayer contains a single dose; approximately one-half of the contents should

beadministered into each nostril. Refer to the administration diagram (Figure 1) for step

-bystep administration instructions. Once the vaccine has been administered, the

sprayershould be disposed of according to the standard procedures for medical waste

(e.g.,sharps container or biohazard containe

...............................................................................................

PS....

If your kid sneezes while the mist is being administered...

The Mist should NOT be readministered
........................................................................

1st nostral...sneezes... go to the second nostril and administer . done

1st... fine.... after 2nd nostril administered sneezes.... done.

...............................................................................................................................

Seasonal FluMist Vaccination
....................................................
..........................................................
..................................................................

Special Instructions for Children Being Vaccinated Against Seasonal Flu for the First

Time:

Children 6 months up to 9 years of age getting a flu vaccine for the first time will need

two doses of vaccine the first year they are vaccinated.

If possible, the first dose should be given as soon as vaccine becomes available. The

second dose should be given 28 or more days after the first dose.

The first dose "primes" the immune system; the second dose provides immune

protection.

Children who only get one dose but need two doses can have reduced or no protection

from a single dose of flu vaccine.

Two doses are necessary to protect these children.

If your child needs two doses, begin the process early, so that children are protected

before influenza starts circulating in your community. Be sure to follow up to get your

child a second dose if they need one. It usually takes about two weeks after the second

dose for protection to begin.

............................................................................

Seasonal

2009-2010 Formula
.....................................
FOR INTRANASAL ADMINISTRATION BY A HEALTH CARE PROVIDER
.......................................................................................................................

2.1 Dosing Information
FluMist should be administered according to the following schedule:
Age Group Vaccination Status Dosage Schedule
Children age 2 years through Not previously vaccinated 2 doses (0.2 mL* each,
8 years with influenza vaccine at least 1 month apart)
Children age 2 years through Previously vaccinated with 1 dose (0.2 mL*)
8 years influenza vaccine
Children, adolescents and Not applicable 1 dose (0.2 mL*)
adults age 9 through 49 years
* Administer as 0.1 mL per nostril.

For children age 2 years through 8 years who have not previously received influenza

vaccine, the
recommended dosage schedule for nasal administration is one 0.2 mL dose (0.1 mL per

nostril)
followed by a second 0.2 mL dose (0.1 mL per nostril) given at least 1 month later.
For all other individuals, including children age 2-8 years who have previously received

influenza
vaccine, the recommended schedule is one 0.2 mL dose (0.1 mL per nostril).
FluMist should be administered prior to exposure to influenza. Annual revaccination

with influenza
vaccine is recommended.

2.2 Administration Instructions
Each sprayer contains a single dose of FluMist; approximately one-half of the contents

should be
administered into each nostril. Refer to the administration diagram (Figure 1) for step-

by-step
administration instructions. Once FluMist has been administered, the sprayer should

be disposed of
according to the standard procedures for medical waste (e.g., sharps container or

biohazard container).

http://www.medimmune.com/pdf/products/flumist_pi.pdf
...........................................................................................................

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Posted: October 15 2009 at 11:25pm

Vaccine - H1N1 Flu Press Conference (CDC): 10/06/2009

VIDEO

............

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Posted: October 15 2009 at 11:31pm

CDC: Injectable Swine Flu Vaccines Ready

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Posted: October 17 2009 at 8:32pm

my take on..

Week 40 ending October 10, 2009

Week 40
.....................
..............................
........................................

Counting ...all... Influenza ...like Illness ... high in some areas of the the Nation.
..............................................................................................................................

13,921 specimens
4,093   Influenza Type A (all types)
       15           "           "    B
..............................................

9,813    Felt like Flu ... but it was something else. Perhaps we should look into a "cure"

61.4% of positive Flu A cases were ... 2009 H1N1v 2,505 cases (proir week 1,549)

(38.2%) A (subtyping not performed) 1,556 cases

(0.4%) A (unable to subtype) 17 cases

"..rare sporadic cases of oseltamivir resistant 2009 influenza A (H1N1) viruses have

been detected worldwide, including 13 cases in the United States ..."

Cases Of Influenza Like Illness For All Regions
....................................................................................

Highest

............

Region 6 AR, LA, NM, OK, TX

High

........

Region 4
AL, FL, GA, KY, MS, NC, SC, TN

Region 10
AK, ID, OR, WA

Moderate
.................

Region 7
IA, KS, MO, NE

Region 9
AZ, CA, HI, NV

Fair
.......

Region 3
DE, DC, MD, PA, VA, WV

Region 8
CO, MT, ND, SD, UT, WY

Low
........

Region 1
CT, ME, MA, NH, RI, VT

Region 2
NJ, NY

Region 5
IL, IN, MI, MN, OH, WI

See Region Graphs here-
http://www.cdc.gov/flu/weekly/regions2008-2009/hhssenusmap.htm
.......................................................................................................................................

....................................................................

observed proportion of deaths
attributed to pneumonia or influenza
...................................................................

"epidemic threshold," i.e., the point at which the observed proportion of deaths
attributed to pneumonia or influenza was significantly higher than would be expected at
that time of the year ...

for week 38.... (the) percentage
was below
..................
the epidemic threshold of 6.4%.

for week 39 was ......   at the epidemic threshold of 6.5%

For week 40.............    above the epidemic threshold of 6.5% f

source... FluView
http://www.cdc.gov/h1n1flu/updates/us/
http://www.cdc.gov/flu/weekly/

...........................

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Posted: October 18 2009 at 7:59pm

Reporters need to do the homework :)

Does the New York Times Have A Medical/Health Reporter?
........................................................................................................

Article here-
http://www.nytimes.com/2009/10/16/health/16vaccine.html

Swine Flu Shots Revive a Debate About Vaccines

By JENNIFER STEINHAUER
Published: October 15, 2009

.....................................................................................................................................

"the vaccine"

Is this Reporter unaware? ... of the many different companies and methods of antigen

preperation that make up several varieties of 'the vaccine?'

Newly formed? is that a code for... new technology?

Quickly distributed? you betcha..

Fast tracked into becoming a .. normal strain change...for future vaccine...smooth move.

............................

The most common complaint is that the vaccine

has been newly formed

and quickly distributed

without the benefit of clinical trials; in fact, the swine flu vaccine was made using the same

techniques as seasonal flu shots over the last two decades,

(does this Reporter know what clinical trials are? Dosage and..... Safety? )

and

a small number of clinical trials

were conducted this year

to determine the

adequate dose.

.................................................

(that's not > safety trials )

in fact, the swine flu vaccine was made using the same

techniques as seasonal flu shots over the last two decades,

( yes that one vaccine... ) "The Vaccine" made using the same techniques...

cell technology... with human, animal and Insects...they want tio try ...plants.

Could the Reporter tell us why they were termed "experimental vaccines?"

Working on experimental vaccines for decades? oh... that's ok then...

...............

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Posted: October 19 2009 at 7:29pm

This shows us that errors are made in Dosage.... Please... check the Dosage for your child.

Know the Name of the vaccine given and the Name of the Manufacturer.

Then Look at the file to see what the dosage is... write it down or copy it off.

Take it with you ... or call the school and ask questions.

The time is worth it :)

..................

DOSAGE ERRORS

..........................

Vaccine Problems

VAERS ID:	229930	Vaccination Date:	2004-10-26
Age:	25.0	Onset Date:	2004-10-26 Days later: 0
Gender:	Female	Submitted:	2004-10-28
State:	Maryland	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? No

ER or Doctor Visit? No

Hospitalized? No

Current Illness:

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: NONE

Preexisting Conditions:

CDC 'Split Type': MEDI0002350

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	IN500336P	0	IN

Administered by: Other Purchased by: Other

Symptoms: Medication error

Write-up: This is a non serious spontaneous case from a nurse of a medication error. The reporter causality was not provided to Flumist. A nurse reported a series of medication errors. The nurse misunderstood the dosing instructions for FluMist and administered a double dose of vaccine to seven pt's . Prior to the administration of the vaccine she removed the dose divider clip thereby giving 0.50ml per nostril versus the prescribed dose of 0.25 ml per nostril. On 26Oct04, at 4:00 in the afternoon, the reporter gave a double dose of FluMist to a 25 year old female pt whose medical history was not reported. The reporter stated the pt had no adverse events. No further information is available.

VAERS ID:	229931	Vaccination Date:	2004-10-26
Age:	41.0	Onset Date:	2004-10-26 Days later: 0
Gender:	Female	Submitted:	2004-10-28
State:	Maryland	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? No

ER or Doctor Visit? No

Hospitalized? No

Current Illness:

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: NONE

Preexisting Conditions:

CDC 'Split Type': MEDI0002351

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	IN500336P	0	IN

Administered by: Other Purchased by: Other

Symptoms: Medication error

Write-up: This is a non serious spontaneous case from a nurse of a medication error. The reporter causality was not provided to Flumist. A nurse reported a series of medication errors. The nurse misunderstood the dosing instructions for FluMist and administered a double dose of vaccine to seven pt's . Prior to the administration of the vaccine she removed the dose divider clip thereby giving 0.50ml per nostril versus the prescribed dose of 0.25 ml per nostril. On 26Oct04, at 12:00 in the afternoon, the reporter gave a double dose of FluMist to a 41 year old female pt whose medical history was not reported. The reporter stated the pt had no adverse events. No further information is available.

VAERS ID:	229932	Vaccination Date:	2004-10-26
Age:	47.0	Onset Date:	2004-10-26 Days later: 0
Gender:	Female	Submitted:	2004-10-28
State:	Maryland	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? No

ER or Doctor Visit? No

Hospitalized? No

Current Illness:

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: NONE

Preexisting Conditions:

CDC 'Split Type': MEDI0002352

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	IN500336P	0	IN

Administered by: Other Purchased by: Other

Symptoms: Medication error

Write-up: This is a non serious spontaneous case from a nurse of a medication error. The reporter causality was not provided to Flumist. A nurse reported a series of medication errors. The nurse misunderstood the dosing instructions for FluMist and administered a double dose of vaccine to seven pt's . Prior to the administration of the vaccine she removed the dose divider clip thereby giving 0.50ml per nostril versus the prescribed dose of 0.25 ml per nostril. On 26Oct04, at 11:00 in the morning, the reporter gave a double dose of FluMist to a 47 year old female pt whose medical history was not reported. The reporter stated the pt had no adverse events. No further information is available.

VAERS ID:	229933	Vaccination Date:	2004-10-26
Age:	34.0	Onset Date:	2004-10-26 Days later: 0
Gender:	Female	Submitted:	2004-10-28
State:	Maryland	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? No

ER or Doctor Visit? No

Hospitalized? No

Current Illness:

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: NONE

Preexisting Conditions:

CDC 'Split Type': MEDI0002353

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	IN500336P	0	IN

Administered by: Other Purchased by: Other

Symptoms: Medication error

Write-up: This is a non serious spontaneous case from a nurse of a medication error. The reporter causality was not provided to Flumist. A nurse reported a series of medication errors. The nurse misunderstood the dosing instructions for FluMist and administered a double dose of vaccine to seven pt's . Prior to the administration of the vaccine she removed the dose divider clip thereby giving 0.50ml per nostril versus the prescribed dose of 0.25 ml per nostril. On 26Oct04, at 10:00 in the morning, the reporter gave a double dose of FluMist to a 34 year old female pt whose medical history was not reported. The reporter stated the pt had no adverse events. No further information is available.

VAERS ID:	229934	Vaccination Date:	2004-10-28
Age:	38.0	Onset Date:	2004-10-29 Days later: 1
Gender:	Female	Submitted:	2004-11-01
State:	Texas	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? No

ER or Doctor Visit? No

Hospitalized? No

Current Illness:

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: NONE

Preexisting Conditions: NONE

CDC 'Split Type': MEDI0002362

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	IN500333P	0	IN

Administered by: Other Purchased by: Private

Symptoms: Headache, Rhinorrhoea

Write-up: This is a not serious spontaneous case from a pharmacist of headache. The reporter causality is not provided to FluMist. A health professional reported headache, runny nose, nasal and head congestion after receiving her first dose of FluMist on 28Oct04. On the morning of 29Oct04 the reporter stated she had a headache, runny nose, and congestion. The reporter took ibuprofen for treatment and had some relief. The symptoms continue. No further information is available.

VAERS ID:	229935	Vaccination Date:	2004-10-21
Age:	50.0	Onset Date:	2004-10-22 Days later: 1
Gender:	Female	Submitted:	2004-11-01
State:	California	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? No

ER or Doctor Visit? No

Hospitalized? No

Current Illness:

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: NONE

Preexisting Conditions: NONE

CDC 'Split Type': MEDI0002364

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	IN500335P		IN

Administered by: Other Purchased by: Private

Symptoms: Cough, Eye irritation, Laryngitis, Pharyngolaryngeal pain, Rhinorrhoea

Write-up: This is a non serious spontaneous case from a pharmacist of Burning Sensation in Eye. The reporter causality was not provided to FluMist. A pharmacist reported loss of voice, sore throat, runny nose, cough, the burning sensation in the left nostril, and eye area in a 50 year old female after receiving her first FluMist dose on 21Oct04. The reporter would not disclose the pt's history or contact information. On 26Oct04 the pt stated to the reporter that one day after receiving FluMist she had a burning sensation in her left nostril. She also had a runny nose and congestion which subsided by 29Oct04. On 29Oct04 the pt complained of cough, sore throat and loss of voice. The burning sensation in her nostril remained and had spread to her eye area. No further information is available.

VAERS ID:	229936	Vaccination Date:	2004-11-02
Age:	49.0	Onset Date:	2004-11-03 Days later: 1
Gender:	Male	Submitted:	2004-11-11
State:	Tennessee	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? No

ER or Doctor Visit? No

Hospitalized? No

Current Illness:

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: Cholesterol Medication

Preexisting Conditions: NONE

CDC 'Split Type': MEDI0002401

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	IN50033P	0	IN

Administered by: Other Purchased by: Other

Symptoms: Headache

Write-up: This is a not serious spontaneous case from a pharmacist of throbbing head. The reporter causality is not provided to FluMist. A pharmacist reported the complaint of a throbbing in the head in a 49 year old pt one day after receiving FluMist. The pt received FluMist on 02Nov04 at 8:30AM. The reporter stated the pt's head throbbing started at an unspecified time on 03Nov04 and has continued for almost a week. The pt's head would throb in five minute episodes.

VAERS ID:	229937	Vaccination Date:	2004-11-04
Age:	51.0	Onset Date:	2004-11-06 Days later: 2
Gender:	Female	Submitted:	2004-11-16
State:	North Carolina	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? Yes

ER or Doctor Visit? No

Hospitalized? No

Current Illness:

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: Allergy Med

Preexisting Conditions: Pollen Allergy, allergy shots within 4 weeks of receiving FluMist.

CDC 'Split Type': MEDI0002435

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC			IN

Administered by: Private Purchased by: Other

Symptoms: Influenza like illness

Write-up: This is a non serious spontaneous case from a physician who reports a pt experienced influenza like symptoms after receiving FluMist. The reporter did not provide causality between events and FluMist. A female pt experienced flu like symptoms within 48 hours of receiving FluMist IN (date unknown). The pt recovered one week after the start of the events. The reporter did not provide causality between event and FluMist vaccination. Follow up 03/07/05: Lot number for vaccine not recorded.

VAERS ID:	229938	Vaccination Date:	2004-11-08
Age:	42.0	Onset Date:	2004-11-11 Days later: 3
Gender:	Female	Submitted:	2004-11-18
State:	Texas	Entered:	2004-12-02

Life Threatening Illness? No

Died? No

Disability? No

Recovered? Yes

ER or Doctor Visit? No

Hospitalized? No

Current Illness: Methicillin resistant, staphylococcal culture

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: Flonase, Prozac, Klonopin, Birth control pills, Guaifenesin

Preexisting Conditions: S. aureus carrier, methicillin resistant, staphylococcus aureus (MRSA), past disease: endocarditis.

CDC 'Split Type': MEDI0002440

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	IN500337P		IN

Administered by: Private Purchased by: Private

Symptoms: Ageusia, Anosmia, Pharyngolaryngeal pain, Sinusitis

Write-up: This is a not serious spontaneous case from a consumer involving loss of smell. The reporter causality is not related to FluMist. A 41 year old female reported the loss of smell, loss of taste, and a sore throat three days after receiving one dose of FluMist. This female with the history of MRSA (Methicillin Resistant Staphylococcus aureus) infection and endocarditis received FluMist on 08Nov04 at 5:00PM. She had taken one dose of fluticasone propionate on the morning of 08Nov04. Her physician instructed her to discontinue the use of fluticasone propionate for one week after receiving FluMist. On 11Nov04 by 6:00PM, the reporter was not able to smell or taste anything. On 15Nov04, around lunch the reporter regained the ability to smell and taste without intervention. She stated on 15Nov04 she had a mild sore throat that she believed was due to sinus drainage. On 16Nov04 the reporter continued fluticasone propionate usage. She stated that the events were due to the discontinuance of the fluticasone propionate. No further information available.

VAERS ID:	229961	Vaccination Date:	2004-11-19
Age:	48.0	Onset Date:	2004-11-20 Days later: 1
Gender:	Female	Submitted:	2004-12-03
State:	Maryland	Entered:	2004-12-03

Life Threatening Illness? No

Died? No

Disability? No

Recovered? Yes

ER or Doctor Visit? No

Hospitalized? No

Current Illness: none

Diagnostic Lab Data:

Previous Vaccinations:

Other Medications: none

Preexisting Conditions: none

CDC 'Split Type':

Vaccination	Manufacturer	Lot	Dose	Route	Site
FLUN	MEDIMMUNE, INC./WYETH LABORATORIES, INC	500340P	0	IN

Administered by: Unknown Purchased by: Unknown

Symptoms: Ear pain, Feeling hot, Myalgia, Nasal congestion, Pyrexia, Urticaria

Write-up: Symptoms developed the morning of 11/20/04 and lasted until 11/23/04. Pt c/o congestion, earache, muscle aches and low grade fever. Pt developed hives on Saturday afternoon. Pt reports taking Benadryl and the hives subsided 1 hour later. Pt reports hives reoccurred on Sunday am 11/21/04 and again subsided after taking Benadryl. Pt reports feeling "heat" behind knees and on elbows which lasted approx. 2 hours. Pt reports that symptoms

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Posted: October 22 2009 at 1:34pm

Mary008's take ... on..

Senate Hearing on "H1N1 Flu: Monitoring the Nation's Response"
Wednesday

Due to delays in production, health officials announced that between 28 and 30 million doses of H1N1 vaccine will be delivered by the end of the month, as opposed to the expected 40 million. Secretaries Napolitano (DHS), Sebelius (HHS) & Duncan (Education) testified on this and other issues before the Senate Homeland Security Cmte.

ng+the+Nations+Response.a

spx

Dept. Of HomeLand Security is in Charge... Health and Human services is Leading the medical.

H1N1 is widespread.

2,300 people have died in the country since April. (abt 6 months)

Highly Infective.

pediatric deaths are ... mentioned as from H1N1... but it is>>> All Influenza Like Illness

28 deaths of pregnant women (very sad..). ...but out of 300 million is >>very low.

Then they go on to talk about the vaccine... not enough. (heaven help us if they roll out

the experimental vaccine... because of "quiet desparation" )

Then the senator talks about Bioterrorism...

27 states could exceed hospital bed capacity...

Numbers fly around... (almost as if everyone in a state could all become ill at the same

time... :/ Wild thought.)

Barda Program... farsighted... breakthrough antivirals by intervenous application... have

not completed all the trials... used via FDA's compasionate usage authorization.

(If you ask me 30% of the country ....is becoming infected... and we are not seeing a lot of

deaths as yet...good news....effecting most mildly... questioning if it will get ahead of

our capacity to deal with it.)

(During the summer Wisconsin ..and NY state were... highly infected... and they dealt

with it....( near by states are ready to assist eachother with resources.)

Millions of Americans are worried about the vaccine.

Gov. bought 250 million doses...

(but not all of those purchased were conventional

egg basesed vaccine)

40 million were to be available... 25% fewer doses than

projected...

(Did the Govt. know what they were purchasing? ie... how 'experimental'

some of the the vaccines are? ... I think not)

She (senator) says she is interested on hearing about the shortage of the vaccine...

Janet Napolitano... is addressing the committee... Dept of Homeland sec....is the lead

Coordinater HSPD5... is the lead for HSPD5 ....Dept of Health and Human services and

CDC... lead on vaccine... planning assumed there would be a gap between the flu

spiking and vaccine availability. ...Simple actions...washing hands and coughing

properly help slow the transmission of this virus.

Since April.. planning.... prep and response... mission critical ... etc...etc....

Fema reviewed ...planning during a pandemic...business of the country...

... software updates on picture of H1N1... daily... Training teams...for states that say...

we need help... Robust system of communicating.... (but) ....not at a local and state

level...lessons learned... ongoing meetings... surge before vaccine available.. keep

critical infrastructure going...steps Companies can take... Mexico...Canada... working

with them... reviewing Emergency info...we will work our way through this...vaccine

would not be commonly available...Vaccine addressed by Sebilious... 3 billion shared for

hospital surge planning... planning for care outside hospitals...

Health and Human Services...

Secretary Sebelius... speaks... vaccine...

science based advice... situational updates twice a week... (?) .... flu.gov...5 million hits

a week.... we have some good news ...virus has not changed significantly since April...

More illness than in a typical flu season.... 86 lab confirmed pediatric H1N1 deaths

since April... 1/2 of Flu Like Hopitalizations are are under age 25.

(small percentage) Deaths... 90% people under 65 ....90% over 65 is usual...

Intensely monitoring the world... (still waiting to hear about vaccine shortage)

Vaccination program is underway... production is slower... in context... identified in

April...has a robust vaccine.... 5 producers of vaccine...11 million doses ordered by

states... 150,000 sites where vaccine is automatically delivered.... We are relying on

their numbers...... early delays due to 2 issues...

antigen yielding lower results than anticipated...yields more robust now...new

production lines...glitches...fill and finish... corrected....number growing ....by early

November vaccine will be more widely available... there is enough vaccine and will

be ....

lessons we've learned....too dependant on vaccine production in other countries...we are

using old technology...we are still still using egg based technology ...

we are committed

to developing cell basedand newer technology....very focused on that....cell technology

we need to make all aspects of the vaccine manufacturing process more appropriate for

the 21st century ... very focused on that....safety is essential.... lingering questions....

taken enough time for clinical trials?....This vaccine is being made the way seasonal flu

vaccine is made... excelleration of production of antiviral... scientists will lead our

recommendations.... coughing and sneezing etc etc... Seseme St... Elmo.... YouTube...

getting the message out.

..................

..... Unplannned closure (of schools) lead to loss of meals...income of parents...kids

home alone...good hygene...decks further apart...new school dismissal system...

Schools should not close unless there is a Magnitude... of personnel and teachers ill....
....................................................................................................................................................

Comment
.........................

Used NY as an example of less school closures in fall...

stating the number closed in spring as compared to the number open in the fall...

(there is little flu in NYS this fall )

(My take is...Because the flu illness is fairly moderate in over 99% of the population.. it

is better to keep the schools open unless massive numbers are ill because it is too

disruptive to close them.... they are hoping for herd immunity through

vaccination...hoping it will move ahead of the spread of the disease)

The demand is ahead.... of the yield... (of traditionally produced vaccine?)

Only one of the 5 producers of the vaccines..... is in the US. (Sanofi in Sweetwater PA)

(have to go out....more later)

real quick...senator is asking if...vaccine is going to be too late to protect people...

Sec Sebelius says ...

even if you had it in the spring or fall...get the vaccine (scientists encourage)

....As different strains develope ...it will likely immunise them for what is to come.

What kind of amazing vaccine is this?

............

have a look at the video... thoughts?

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Posted: October 22 2009 at 4:56pm

Wow Maryoo8 that is extremely detailed info on the vaccines

Thanks

"In a time of universal deceit, telling the truth is a revolutionary act." G Orwell

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Posted: October 23 2009 at 11:23am

senator is asking if...vaccine is going to be too late to protect people...

Sec Sebelius says ...

even if you had it in the spring or fall...get the vaccine (scientists encourage)

....As different strains develope ...it will likely immunise them for what is to come.

What kind of amazing vaccine is this?

............

Infection with a virus of one subtype confers little or no protection against viruses of other

subtypes. {02} {05} Furthermore, over time, antigenic variation (antigenic drift) within a

subtype may be so marked that infection or vaccination with one strain may not induce

immunity to distantly related strains of the same subtype. {02} {05}

{2}
Centers for Disease Control and Prevention (CDC). Prevention and control of influenza: recommendations

of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1996; 45(RR-5): 1-24.

{5}
Centers for Disease Control and Prevention (CDC). Prevention and control of influenza: recommendations

of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1997; 46(RR-9): 1-25.

...........................................

Does that seem conflicting to anyone?

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http://www.novartis.com/newsroom/media-releases/en/2009/1345850.shtml

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Posted: October 23 2009 at 1:55pm

Novartis Fluvirin...Info... lets people know that...

Immunocompromised persons may have a reduced immune response to Influenza A

(H1N1) 2009 monovalent vaccine.

That means... If you had your spleen removed or ar otherwised deemed

immunocompromised by your Doctor... you may have a reduced immune response

to the (H1N1) 2009 monovalent vaccine.

So ... discuss with your Doctor ... other ways you can protect yourself.

................................................................................................................

Other conditions, such as certain cancers and genetic disorders, can also cause a person

to become immunocompromised. Immunocompromised individuals can sometimes be prone

to more serious infections and/or complications than healthy people. They are also more

prone to getting opportunistic infections, which are infections that do not normally afflict

healthy individuals.

Causes for Immunodeficiency:
....................................................

Genetic - inherited genetic defects

Acquired - infections, such as HIV, and certain cancers, including leukemia, lymphoma, or multiple myleoma

Chronic diseases - such as end stage renal disease and dialysis, diabetes, cirrhosis

Medications - such as steroids, chemotherapy, radiation, immunosuppressive post-transplant medications

Physical State - such as pregnancy

It is important to note that not all immunodeficiencies result in the same risk for infection.

................

Patients who undergo splenectomy (removal of the spleen)

are at increased risk for infection.

The spleen acts as a filter and manufactures important antibodies (components of

immune system that fight specific antigens [infectious agents]).

sources for above-

www.stjude.org/stjude/v/index.jsp?vgnextoid

http://infectiousdiseases.about.com/od/glossary/g/immunocompromised.htm

..................

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Posted: October 23 2009 at 10:16pm

Line%20Charts%20of%20Percentage%20of%20Visits%20for%20Influenza-like%20Illness%20%28ILI%29%20Reported%20by%20
the%20U.S.%20Outpatient%20Influenza-like%20Illness%20Surveillance%20Network%20%28ILINet%29

Posted: 30 September 2009 at 11:25pm

Region 5.

Is something odd in the drawing above?

Has anyone noticed it does not match the summer severity shown in the Region 5 graph below?

Region 5 had about twice the summer flu that was seen in New York, which is region 2.

The second Mountain above should be higher than the first, it isn't

INFLUENZA ISOLATES FROM THE HHS REGION V (IL, IN, MI, MN, OH, WI)
Reported By WHO/NREVSS Collaborating Laboratories
2008-2009 Season

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