Possible Cure for Swine Flu-datam Medclinician - Event Date: September 21 2009

Don’t do this at home kids. This is a published research item.

It needs more research- and I am posting it here first of all blogs (well almost first)  -

Remember- see a doctor- do not self medicate- this substance has a zillion side effects and is not to be used WITHOUT AN M.D. and even then it is NOT APPROVED FOR USE with Swine Flu.

The chemical data here needs to be utilized - tested as per research laws. This drug for no reason is to be given to pregnant women, and read all side effect, even if you have a script.

This I hope will be picked up by drug companies- and used to create a drug that will save millions of lives. So-

(1) Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Room 2D-57, Bethesda, MD 20892, USA

Received: 17 December 2008 Accepted: 11 February 2009 Published online: 4 March 2009

Abstract In addition to regulating blood pressure, Angiotensin II (Ang II) exerts powerful pro-inflammatory effects in hypertension through stimulation of its AT1 receptors, most clearly demonstrated in peripheral arteries and in the cerebral vasculature. Administration of Ang II receptor blockers (ARBs) decreases hypertension-related vascular inflammation in peripheral organs. In rodent models of genetic hypertension, ARBs reverse the inflammation in the cerebral microcirculation. We hypothesized that ARBs could be effective in inflammatory conditions beyond hypertension. Our more recent studies, summarized here, indicate that this is indeed the case. We used the model of systemic administration of the bacterial endotoxin lipopolysaccharide (LPS). LPS produces a robust initial inflammatory reaction, the innate immune response, in peripheral organs and in the brain. Pretreatment with the ARB candesartan significantly diminishes the response to LPS, including reduction of pro-inflammatory cytokine release to the general circulation and decreased production and release of the pro-inflammatory adrenal hormone aldosterone. In addition, the ARB very significantly decreased the LPS-induced gene expression of pro-inflammatory cytokines and microglia activation in the brain. Our results demonstrate that AT1 receptor activity is essential for the unrestricted development of full-scale innate immune response in the periphery and in the brain. ARBs, due to their immune response-limiting properties, may be considered as therapeutically useful in a number of inflammatory diseases of the peripheral organs and the brain.

datamined by J. aka Medclinician

usual Med rambling...

for the world…

thank you for the inspiration

Dr. John, Dr. D

and Carah formerly of Shiny Toy Guns

its so contagious

http://www.youtube.com/watch?v=pnaRUpar_bY

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you are the one

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