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WHAT'S IN CSL'S PANVAX VACCINE? |
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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Posted: September 23 2009 at 9:31pm |
The basic vaccine formulation is as follows:
Monovalent vaccine 15ug of antigen per 0.5mls Unadjuvanted 10ml Multi Dose Vials (containing thiomersal – compound partly composed of mercury and ethylmercury.
- Used to prevent bacterial and fungal contamination of vaccines Other components According to Product Information– Each 0.5mls contains
Sub units of A/California/7/2009 (H1N1) v-like virus 15ug haemagglutinin As stated – 0.01%w/v Thiomersal as a preservative Each 0.5mls also contains
Sodium Chloride 4.1mg Sodium phosphate –dibasic anhydrous 0.3mg Sodium phosphate- monobasic 80ug Potassium chloride 20 ug Potassium phosphate – monobasic 20 ug Calcium chloride 1.5ug Taurodeoxycholate ≤ 5ug (Bile salt-related, anionic detergent) (can give red eyes, blurred vision etc) Ovalbumin ≤ 1.0ug Sucrose <10ug Neomycin ≤ 0.7ug – check for allergies to this antibiotic Polymyxin B sulfate ≤0.11ng– check for allergies to this antibiotic Beta-propiolactone ≤1.4ng Taken From : H1N1 Panvax WA Govt. Training Manual
Comment: Can anyone on the forum tell us in layman's terms what each of these compounds is in there for?
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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Dr D ? Tech ? Med?
Anyone got any ideas? This is important info to find out because the CSL Vaccine is one that will be available in US.
Reading through the whole training manual last night I noticed every person who takes the vaccine in Australia has to sign a consent and liability waiver.
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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thiomersal ... Many Americans don't want it in their vaccines.
It has been banned in many countries.
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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including ours for most purposes .....except in vaccinations.
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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Does anyone know why there are 2 antibiotics in the vaccine? Is that normal?
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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Rick... hi (where are they when you need them?) :)
anyway.. here is what I know.
Biggest Program Ever
CSL Panvax
Free Doses
To all Adults
One shot Vaccine
............................................................
the "other part" from W.H.O.
..........................
Using similar technology, the four vaccines are likely to share similar characteristics of
safety and immunogenicity. To date no results are publicly available.
CSL developed Panvax, a split-virion vaccine (for strict mock-up/pandemic use)
containing 30µgof HA antigen adjuvanted with 0.5mg AlPO4 (aluminium phosphate).
A two-dose regimen 21 days apart induced seroresponses (HI≥1/32) in 59% of adults 6 and in 95-100% of children (aged 6 monthsto 9 years).7 Cross-reactivity in adults and
children to a heterologous clade 2.1 virus(rgA/Indonesia/05/2005) was observed.6,7
A homologous booster dose induced seroresponses(MN≥1/20) in 60% of adult subjects six months after two-dose priming.6
Panvax appeared safe in adults, the elderly and children with no vaccine-related
SAE.6,7 Infants and young children displayed higher frequencies of systemic reactions
than older children.
.............................
Unless there are .. TWO named.... PANVAX Vaccines by CSL... This above is for
H5N1
..............
............Mary008
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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This seems to be the Plan... (H5N1)
Vaccine development and production facilities are being ramped up, and possible pre-pandemic vaccines are being produced and studied. If a human pandemic does
not emerge in the next few years,
its eventual emergence may become almost a non-event
if a very-effective pre-pandemic vaccine has prepared the population with
Indeed, if there is sufficient immunity to stop it at the source,
it will not become pandemic.
As long as the likelihood of protecting the population continues to rise with the passage of time,
that likelihood becomes an increasingly important factor in predicting the loss of
lives and the amount of economic dislocation that will ultimately occur.
In light of human potential to develop herd immunity via vaccination
in advance of a pandemic strain,
the time that it allows us to do so
before it evolves
may become as crucial or more crucial to the measure of damage it causes
than its own lethality and contagiousness.
Among the more attractive alternatives available for reducing mortality
is vaccine stockpiling and
prepandemic vaccination.
"Human H5N1 vaccines are currently available
and can induce heterotypic immunity.
WHO and governments should give urgent consideration to the use of these vaccines
for the priming of individuals or communities who would be at greatest risk of
infection if an H5N1 influenza pandemic were to emerge."[64]
Death associated with
influenza A viruses "is usually mediated by superinfection with bacteria, mainly
Streptococcus pneumoniae."[65], suggesting that lethality may be reduced by
vaccination against pneumonia.
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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Hi Mary
This version of the training manual, ( and I think it is the latest) says the 2 dose vaccination has been replaced by a single unadjuvanted dose. You are probably right, there must be 2 versions of this vaccine.
According to the manual, Australia will only get the single dose version........I wonder what you guys will get?
Rickster58
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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Rick.... did you read that?
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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Yes I did Mary, but it doesn't make sense to me. This vaccine (or at least the one we are going to get here in Australia from next week) only protects you for 12 months and is only effective for the current strain circulating. It clearly states that in the training manual.
So if herd immunity is the goal how can this work with this vaccine?
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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MELBOURNE, Australia -- June 17, 2008 -- The Australian Therapeutic Goods Administration (TGA) has approved Panvax, an avian influenza vaccine. Panvax is intended for use in the prevention of influenza caused by a pandemic strain of avian influenza virus.
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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.
Interesting wording...
. ...Ms Roxon said the government would negotiate payment to CSL for the vaccine
at the time of any pandemic.
Panvax can only be used
once an influenza pandemic has been officially declared
by the World Health Organization.
"There wouldn't be any benefit to people having the vaccine now if a pandemic hasn't been declared," CSL Biotherapies General Manager Mary Sontrop said.
( hmmm.. )
...............................................................................................................................
Is this sufficient information for a ...... Monovalent Vaccine? Identify (when have I ever seen strains/ingredients listed this way?)
15ug haemagglutinin
...............................................................................................................
Other components According to Product Information Each 0.5mls contains * Sub units of A/California/7/2009 (H1N1) v-like virus * 15ug haemagglutinin * As stated – 0.01%w/v
Thiomersal as a preservative...
................................................................................................................ ...The authors' method involves splicing the hemagglutinin (HA) gene from an avian flu virus into a human adenovirus that has been modified so it can't replicate in the body. Though it can't replicate, it can enter host cells, according to Hoelscher.
Testing experimental bird flu vaccines [Archive] - ZONE GRIPPE ...
The volunteers received doses of 5ug, 10ug, 15ug or 30ug and were ...... Most of them involve the major antigens of the flu virus, hemagglutinin (the H part ... www.zonegrippeaviaire.com/archive/index.php/t-750.html - Cached - Similar |
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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Hi Mary,
My email addy is on my profile. How about you email me and I'll email you back the entire training manual. This is the manual that is currently circulating to doctors and health care professionals so I believe it is reliable.
I still reckon there is two versions of Panvax.
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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I got it :) (thanks)
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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Many Large Pharmas are involved in Pre Pandemic ( H5N1) Vaccine......
urgent consideration to the use of these vaccines
for the priming of individuals or communities |
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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check the date ....... use of H5N1 (inter-Pandemic )
From W. H.O
......................................................................................
Use of licensed H5N1 influenza vaccines in the interpandemic period Report * of the H5N1 SAGE Working Group to theApril 2009 meeting of the Strategic Advisory Group of Experts * 2.8 Ethical considerations on H5N1 vaccination in the interpandemic period
2.8.1 Considerations related to a recommendation on the interpandemic use of licensedhuman H5N1 influenza vaccine (see 3.1, 3.2 and 3.4) |
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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they do not recommend H5N1 use pre pandemc but go on to say...
...................................................................................................................................
3.3 What might be recommended for stockpiled H5N1 influenza vaccines approaching their
expiry date during the interpandemic period? H5N1 vaccine stockpiles have been constituted with the goal to allow vaccination of all or parts of populations immediately after the onset of a potential H5N1 pandemic. Therefore, their use before such an emergency event was not considered at the time of their establishment, excepting for specific research projects. However, calls have been made to reconsider whether vaccine held in stockpiles might be used in the interpandemic period. Holders of a licensed H5N1 vaccine stockpile should therefore be encouraged to gain experience with H5N1 vaccine use, which will provide additional data on safety, immunogenicity, cross-reactivity, priming potential and duration of immunity in order to inform public health policies. Such experience could be acquired through pilot projects, clinical studies and/or limited vaccination of incremental numbers of persons. Studies might start in populations that would be at increased risk of infection in the event of a pandemic (e.g. HCWs ).Additional knowledge could be acquired through pilot projects and/or clinical studies in special population groups (e.g. children, older persons, immunosuppressed and individuals with specific health conditions). In the event that such projects or studies are carried out, it will be important to establish post-licensure or postmarketing surveillance procedures that can collect long-term safety data for ongoing riskbenefit analyses. The results of these studies should be shared promptly with WHO and the 53 international community in order to allow reconsideration, if and when appropriate, of the recommendations. |
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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I've just done a google search on all of the compounds listed in the Panvax Vaccine. I'm no chemist and wouldn't know the first thing about vaccine production or how/why these compounds are in a vaccine but......
A simple google searech turned up the following:
Calcium chloride, CaCl2, is a common salt. It behaves as a typical ionic halide, and is solid at room temperature. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in concrete. The anhydrous salt is also widely used as a desiccant, where it will absorb so much water that it will eventually dissolve in its own crystal lattice water. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, the anhydrous form must be kept in tightly-sealed containers. It is used to turn kelp into a solid
Sodium phosphates are used as food additives. Sodium phosphates are added to many foods as an emulsifier to prevent oil separation. Some examples are processed cheeses, processed meats, ready-made meals and tinned (canned) soups. Sodium phosphates are also commonly added to powdered soups, boullions and gravy mixtures.
Sodium phosphates can also be used as a leavening agent. Some examples of these foods include the batter coating on breaded fish or chicken, and commercially baked cakes.
Adding sodium phosphates to food increases the shelf life of the food; maintaining the texture and appearance of the food.
Sodium Phosphate (trisodium phosphate) is also an ingredient of cleaning products; e.g. Sugar soap.
The majority of the potassium chloride produced is used for making fertilizer, since the growth of many plants is limited by their potassium intake. As a chemical feedstock it is used for the manufacture of potassium hydroxide and potassium metal. It is also used in medicine, scientific applications, food processing, and as a sodium-free substitute for table salt (sodium chloride). Potassium chloride is used as the third of a three -drug combination in lethal injection. Additionally, KCl is used (albeit rarely) in fetal intracardiac injections in second- and third-trimester induced abortions.
Monopotassium phosphate (also potassium dihydrogen phosphate, KDP, or monobasic potassium phosphate, MKP) -- KH2PO4 -- is a soluble salt which is used as a fertilizer, a food additive and a fungicide. It is a source of phosphorus and potassium. It is also a buffering agent. When used in fertilizer mixtures with urea and ammonium phosphates, it minimizes escape of ammonia by keeping the pH at a relatively low level. Sodium taurodeoxycholate hydrate Bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins.
Neomycin is an aminoglycoside antibiotic that is found in many topical medications such as creams, ointments and eyedrops. Neomycin is overwhelmingly used as a topical preparation, such as Neosporin. It can also be given orally, where it is usually combined with other antibiotics. Neomycin is not absorbed from the gastrointestinal tract, and has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. By killing bacteria in the intestinal tract, it keeps ammonia levels low and prevents hepatic encephalopathy, especially prior to GI surgery. It has also been used to treat small intestinal bacterial overgrowth. It is not given intravenously, as neomycin is extremely nephrotoxic (causes kidney damage), especially compared to other aminoglycosides. The exception is when neomycin is included, in very small quantities, as a preservative in some vaccines - typically 0.025 mg per dose. Polymyxin B is an antibiotic primarily used for resistant gram negative infections. Polymyxins bind to the cell membrane and alter its structure making it more permeable. The resulting water uptake leads to cell death. They are cationic, basic proteins that act like detergents(surfactants}. Side effects include neurotoxicity and acute renal tubular necrosis. it is commonly used in the topical first aid preparation Neosporin.
Family of polypeptides with attached fatty acid; cationic detergent at physiological pH, both hydrophilic and hydrophobic properties Bactericidal for gram-negative; little to no effect on gram-positive since cell wall is too thick to permit access to membrane β-Propiolactone is "reasonably expected to be a human carcinogen" (IARC, 1999).[1] It was once widely used in the manufacture of acrylic acid and its esters, but its use has been mostly phased out in favor of safer and less expensive alternatives. β-Propiolactone is a disinfectant and has been used to sterilize blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes.[1] The principal current use of propiolactone is an intermediate in the synthesis of other chemical compounds.
β-Propiolactone will slowly react with water and hydrolyse to produce 3-hydroxypropionic acid (hydracryclic acid). Would you take this mix?
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Technologist
Admin Group Joined: May 05 2009 Location: California Status: Offline Points: 1192 |
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That batch doesn't sound like it's for the US. In the US they would call that preservative Thimerosal not Thiomersal. That's the ingredient that bothers me as it has small quantity of mercury in it. Most likely about 25 micrograms of mercury are inside. Eating 8-9 ounces of tuna will give you roughly the same amount of mercury. The stabilizers, PH balancers and antibiotics are not a big deal as they are extremely low in quantity's. ug should be labeled in mcg for Micrograms or one millionth (1/1,000,000) gram ng is nanogram or one billionth (1/1,000,000,000) gram Neomycin 0.7ug Polymyxin B sulfate Remember one ng or Nanogram is .0000000000357 ounces Or 1/28th of one billionth of one ounce. These are extremely tiny amounts used to keep the vaccine sterile. One millionth or one billionth the typical oral dosage when you are prescribed antibiotics. Just applying an over the counter triple antibiotic ointment or an antibiotic BAND-AID will have 1000's of times that amount absorbed into your skin. |
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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Rick.. it doesen't bother you... that a group advising WHO thinks it's ok to use expiring H5N1 Vaccine ... prior to... an H5N1 Pandemic.... in order to gain knowledge and experience in vaccine use by.... priming.... certain populations and or age groups? (like.... Now...."interpandemic "... "3" .... for H5N1 )
or parts of populations immediately after the onset of a potential H5N1 pandemic. Therefore, their use before such an emergency event was not considered at the time of
and duration of immunity in order to inform public health policies.
Such experience could be acquired through pilot projects, clinical
start in populations that would be at increased risk of infection in the event of a pandemic (e.g. HCWs).
special population groups (e.g. children, older persons, immunosuppressed and individuals with specific health conditions).
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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Hi Mary,
I must have missed the bit about using expired H5N1 vaccines......will re-read and comment
Rickster58
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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hi... there is a lot there. I highlighted...sorry...for many just skim the wordy posts ( I do it myself :) It may catch the notice of people passing through... it should be noticed.
I think i would feel a whole lot different about Heroic actions... on warding off massive illness (they do get worked up) if they were more up front... safer vaccines.... and not legislating Mandated Vaccinations.
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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Very interesting... looking into ingredients. I wanted to focus on it, but found the H5N1 info...and got interested in it. (20 directiions at once :)
This is from... Vaccine Igredients..
(some in my Fam use it as a salt substitute :O
The findings suggest that potassium supplements should be used with caution in the elderly, in those with uremia and in patients receiving diuretics. Wide variations in the frequency of potassium use amongst the monitored hospitals suggest that this drug may be used more than is necessary and that a reduction in its use in hospitals might lead to a decreased mortality and morbidity, particularly among elderly individuals.
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Technologist
Admin Group Joined: May 05 2009 Location: California Status: Offline Points: 1192 |
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Mary, The amount of potassium in the vaccine mentioned above is 40 micrograms or .00004 grams. One cup of carrot juice has about 700 milligrams of potassium or 17,500 times the potassium.
One drop of carrot juice has much more potassium in it then the vaccine. Potassium is necessary for life and almost every food we eat has loads of it in it. |
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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hi Tech... I was mentioning it in the form of .. supplements... as some of my family uses it instead of salt ... (wondering how safe it is...some use a lot of "salt" )
The findings suggest that potassium supplements
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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Tech... what is your take on the "advice" of S.A.G.E. over at W.H.O.... to use H5N1 Vacs before they expire... to gain knowledge? Who shall we try it out on?
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Technologist
Admin Group Joined: May 05 2009 Location: California Status: Offline Points: 1192 |
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Mary this was a Vaccine thread so someone drifted off topic.
Most people eat way too much salt. If they have kidney, renal problems they should cut salt down to under 2,000mg's a day. Salt substitutes have potassium chloride in them so those should be avoided also if you're battling with high potassium levels. Anyone dealing with Ascites, CHF, high blood pressure or using diuretics should be cutting salt down. One easy way to cut salt out is to never eat anything where the mgs of salt is greater then the calories per serving. On a typical 2000-2500 calories per day diet this is very simple to do. Unfortunately most people will do the wrong things until they die regardless what they are told. It can be done without even thinking using this method: Campbell's Chicken Noodle Soup: Calories 70 Sodium 870 mg Sodium is higher then the calories so it's a NO. Kettle Brand® Potato Chips lightly salted: Calories 150 Sodium 115mg Sodium is lower then the calories so it's a YES on eating. It's not that healthy but at least you get an idea what I'm getting at. In all realty people should be eating lot's of fresh healthy Fruits and vegetables and exercising and you'll find people might not need the diuretics or blood pressure meds with a doctors help. |
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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great info.... I will look into the salt substitute.. guys in the fam use it. amazing the salt contenti in food. I use all the Ms Dash and many Indian spices. the Mayo site says chips are very bad... the oils heated at high temp. I keep alot of fresh veggies in the fridge. I'll remember that mgs of salt no greater than calories rule, easy to follow.
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rickster58
Moderator Joined: March 09 2009 Location: Sydney Status: Offline Points: 4875 |
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Tech,
Thanks for the info on how miniscule these quantities are in the vaccine but I still have questions about
Potassium chloride Potassium phosphate
Taurodeoxycholate Polymyxin B sulfate Beta-propiolactone
Especially the last 2. Why are these substances in there?
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Mary008
V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769 |
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potassium chloride (KCl) is a metal halide salt and Potassium phosphate used to disinfect the biologicaal sample. .. i.e. >> 15ug of antigen per 0.5mls
now. they have to preserve protien...you'don't want to be injected with rancid egg whites
antigen.. sounds nicer... (the expensive -part of the mix)
..l....
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