Tracking the next pandemic: Avian Flu Talk |
mosquitos coronavirus vector? |
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Pixie
Admin Group Joined: June 05 2006 Location: United States Status: Offline Points: 19668 |
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Posted: May 29 2013 at 8:00am |
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Novel Corona Virus (SARS-2): The Unknown VectorNovel Coronavirus 2012 (nCoV), Human Coronavirus-Erasmus Medical Center (hCoV-EMC) orSARS-2, the tentative name of this recently discovered Corona Virus, now seems to be able to spread from human to human. But where did it originate?
The first known cluster of SARS-2 occurred in April 2012 in Jordan, while the second occurred a few months later in Saudi Arabia. Were these cases related? The genomic structure of this deadly virus has been determined and the virus seems[1] very similar to those reported for bats-derived Coronaviruses of the 2c subgroup: the Bat-CoV HKU4 and HKU5 stains. Research has also demonstrated that Corona viruses have the potential to undergo rapid genetic change as they adapt to new hosts[2].
Thus the question remains how the virus managed to jump from bats to humans. The unknown vector seems elusive but the answer may be easy: mosquitoes.
This could indicate that mosquitoes could first feed on the blood of an infected bat and when it subsequently feeds on the blood of a human, it will infect the human with Coronavirus. [1] Lu et al: SARS-like virus in the Middle East: a truly bat-related coronavirus causing human diseases in Protein & Cell - 2012 |
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Albert
Admin Joined: April 24 2006 Status: Offline Points: 47746 |
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So I guess the new name is SARS-2?
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jacksdad
Executive Admin Joined: September 08 2007 Location: San Diego Status: Offline Points: 47251 |
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Erasmus shouldn't get to name it after patenting the viral gene sequence in the underhanded manner they did. Saudi might not like it but MERS works just fine for me.
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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary. |
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jacksdad
Executive Admin Joined: September 08 2007 Location: San Diego Status: Offline Points: 47251 |
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Something this fatal spread by mosquitoes would be a nightmare scenario for public health agencies and vector control. Scary thought. And H2H?
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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary. |
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Rors
Adviser Group Joined: May 12 2013 Location: Lebanon Status: Offline Points: 465 |
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Has it been definitively determined that bats are the original reservoir? Did they isolate the virus in bats?
The mosquito vector theory seems borderline "guessing". Temperatures in the region have climbed to the thirties Celsius (that's 86F and above) and mosquitoes are brewing everywhere, I would think there would be more cases if mosquitoes were involved in the transmission. I'm not sure what to think of this article, but if it turns out to be valid, then we're in for a tough ride |
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EdwinSm,
Moderator Joined: April 03 2013 Status: Offline Points: 24065 |
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Given the names used this seems to be an old article, but no one has come up with a vector that sounds reasonable, so maybe it is those pesky little insects - direct transfusion to the blood system - Help!
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Pixie
Admin Group Joined: June 05 2006 Location: United States Status: Offline Points: 19668 |
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I've been digging around , looking for a possible vector...anything is a possibility at this point. Haven't found anything solid. Just broad gum shoe searches.
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jacksdad
Executive Admin Joined: September 08 2007 Location: San Diego Status: Offline Points: 47251 |
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It could be that mosquitoes are an emerging vector - as yet there probably isn't a significant animal reservoir for them to tap into and spread the virus, but that might change if it continues to develop and move into other countries. Fingers crossed that it doesn't play out that way and they don't have a role in spreading MERS - a mosquito borne disease that kills half of it's victims would be like a biblical plague.
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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary. |
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debbiencusa
Adviser Group Joined: April 25 2013 Location: nc Status: Offline Points: 2100 |
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All knowledge at this stage saves lives. In my opinion post it if you have considered it. I have wondered about this myself, as another commonality is both bats and mosquitos are nocturnal. I can comfortably say, I do not want to be bit by a mosquito that has been biting on a bat or another human with Mers. This ten day incubation period is what concerns me. Lots of time to spread.
What we can do is make sure we have no areas where mosquito's breed, we can spray the yard during the day and kill off a lot of them, stay away from lakes, ponds, rivers where the bug is in abundance. Stay in during the times they are out, use the best repellent liberally. Bring animals in before the bug comes out. Be aware that CATS kill and eat BATS. I have four cats that live out doors, they will keep the bats at bay, but I will feed and water them, keep my distance. What we could do is begin to use DDT as a emergency stop gap.
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God Bless
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Kyle
Adviser Group Joined: May 29 2013 Location: Colorado, USA Status: Offline Points: 5800 |
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My concern is a West Nile virus infected mosquito also being infected with MERS. That could be deadly also
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Pixie
Admin Group Joined: June 05 2006 Location: United States Status: Offline Points: 19668 |
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Roof rats were suspect in large infection of apartment building...Another theory.
Rats may have played role in Hong Kong SARS outbreak Aug 18, 2003 (CIDRAP News) – The vector in the SARS (severe acute respiratory syndrome) outbreak at the Amoy Gardens housing complex in Hong Kong last spring may have been roof rats, hypothesizes Stephen K. C. Ng of Columbia University School of Public Health in an article published in the Aug 16 issue of The Lancet. How the infection spread from the index case to more than 300 residents of the complex very rapidly has remained a mystery. Amoy Gardens has no communal facilities; no common food or water source was identified; and airborne transmission was determined by a World Health Organization investigative team to be unlikely. The index case was found to be a 33-year-old healthcare worker who stayed overnight with his brother, a resident of Amoy Gardens, on Mar 14 and 19. He became ill on Mar 14; SARS virus was later isolated from his blood, urine, and stool. Between Mar 21 and Apr 1, 267 residents of the complex became ill. Ng proposes that a rat could have come in contact with infectious material (eg, used tissue, leftover food, excreta) Mar 14 in the apartment stayed at by the index case. That rat, Ng says, would have become contagious about Mar 19. The rat then could have spread the virus to other rats and the rats to humans by means of leaving contaminants (droppings, urine, and saliva—all of which contain large amounts of virus and are highly contagious) in other apartments. The rats also could have spread the virus by coming into contact with clothing hanging on clotheslines outside bathroom windows of the complex that have become "bridges" for the rats as they forage for food. Three factors in the outbreak—dose, timing, and spatial distribution—have not been adequately explained by other theories on the outbreak but may fit with Ng's rat-vector explanation. As for dose, Ng explains that a sole source of contamination is unlikely, because to infect more than 200 people, "the index patient would have needed to excrete a tremendous amount of virus into the environment." Regarding timing of illness spread, Ng says delivery of the virus to more than 200 people within 1 or 2 days would have been required because of the "finite window of infectiousness" of the index patient, again arguing against a sole source. Finally, SARS cases occurred on upper rather than lower levels of the complex with particular concentration on certain floors; roof rats are known to look for food in elevated areas above ground and to behave habitually, using the same routes over and over and visiting and revisiting the same areas. Among his theory's weaknesses, says Ng, is the fact that no rodent model has been established for SARS. "The rat vector hypothesis is a strong possibility that needs to be further explored," he concludes. Among his suggestions are epidemiological case-control studies to look for behavioral risk factors and mechanisms for rat-to-human spread, detailed comparisons of SARS cases in Amoy Gardens with SARS cases elsewhere, and viral studies of isolates from Amoy patients to see whether mutation has occurred. Ng SKC. Possible role of an animal vector in the SARS outbreak at Amoy Gardens. Lancet 2003 Aug 16; 362(9383):570-2 [Abstract] See also: Previous CIDRAP News stories about the Amoy Gardens SARS outbreak: March 31, April 2 |
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Pixie
Admin Group Joined: June 05 2006 Location: United States Status: Offline Points: 19668 |
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Old article about possible rats as vector.
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debbiencusa
Adviser Group Joined: April 25 2013 Location: nc Status: Offline Points: 2100 |
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Rats nest and pee in their nests, I saw a program called infestation on the Animal planet station, where a beautiful home was rat infested how they found out was a large urine stain that continued to spread, until the whole ceiling became soggy. Rats this program said also mark their territory with urine. So that would be a cotangent.
Also remember. 1. They also eat rats in China (could be sick ones were easier caught and consumed. 2. They do not have separate pipes for waste water between apartments, but one large pipe that empties out to open sewers. If there are cracks in the sewer pipe this could spread from apt. to apt. 3. Since the virus is in the excrement both urine and fecal, rats make a mess in each apt. they visit it could have become airborne easily, if you sweep the floor it is mixed with dust allowing even easier air exposure in fine dust particles. 4. Any animal that consumes a dead infected rat could then get sick and pass it to humans.
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God Bless
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debbiencusa
Adviser Group Joined: April 25 2013 Location: nc Status: Offline Points: 2100 |
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Mosquito and fleas and ticks would also bite rats and then humans, maybe even roaches could eat feces then eat on human food. I think there could be multiple modes of passage.
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God Bless
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