Now tracking the new emerging South Africa Omicron Variant |
Ok..who's first?? Any takers? |
Post Reply |
Author | |
coyote
Admin Group Joined: April 25 2007 Location: United States Status: Offline Points: 8395 |
Post Options
Thanks(0)
Posted: August 29 2014 at 3:04am |
Ebola vaccine to be tested on British volunteers next month
Volunteers in Oxford will be given an experimental vaccine against Ebola in fast-tracked emergency clinical trials to begin in September, it has been announced. At the same time that trials are beginning at Oxford University, up to 10,000 doses will be made to ensure that it can be more widely used quickly if the trials are successful. Initially 60 volunteers will be injected with the vaccine at the Jenner Institute at the University of Oxford and if they show a good immune response with few side effects then a further 40 volunteers will be given the vaccine in Gambia. [link to www.telegraph.co.uk] |
|
Long time lurker since day one to Member.
|
|
Albert
Admin Joined: April 24 2006 Status: Offline Points: 47746 |
Post Options
Thanks(0)
|
They need to test it on the folk in Africa. Seems to me they don't have many other choices anyway.
Ebola is still mutating and I don't believe they can find a match on it yet. The perfect little killing machine bug. |
|
https://www.facebook.com/Avianflutalk
|
|
onefluover
Admin Group Joined: April 21 2013 Location: Death Valleyish Status: Offline Points: 20151 |
Post Options
Thanks(0)
|
I will "second" that.
|
|
"And then there were none."
|
|
KiwiMum
Moderator Joined: May 29 2013 Status: Offline Points: 29640 |
Post Options
Thanks(0)
|
How exactly are they going to test it? Are they going to give it to someone and then give them Ebola and see what happens? I can't believe anyone would sign up to that program!
|
|
Those who got it wrong, for whatever reason, may feel defensive and retrench into a position that doesn’t accord with the facts.
|
|
Elver
Valued Member Joined: June 14 2008 Status: Offline Points: 7778 |
Post Options
Thanks(0)
|
I want to know if this vaccine is full of live virus or not.
|
|
hazelpad
Guest Group |
Post Options
Thanks(0)
|
They vaccinate with an essential Ebola protein not live or attenuated virus, and 3 weeks later check for protective antibody levels in the serum. They don't give people challenges with Ebola. They have already done animal studies using it.
They have to give it to healthy people first. If people who are Ill get it then symptoms can be confused with side effects. Don't think they are testing its safety so much ( it is a basic vaccine recipe ). Think they are more concerned about its antigenicity and hence its effectiveness, seeing if it will generate a good enough response to offer protection. Quote : Results from studies in monkeys suggest a good safety profile from the single ebola virus protein, which produced high levels of antibodies and immune-boosting white blood cells. As it does not contain infectious virus material, it cannot cause a person who is vaccinated to become infected with ebola. The duration of response could only be discovered in ‘real-life’ situations but even if it only lasted a few months it would be enough to contain outbreaks, he said Read more: http://www.dailymail.co.uk/health/article-2736932/Ebola-vaccine-discovered-British-scientists-available-end-year.html#ixzz3BuszBleb Follow us: @MailOnline on Twitter | DailyMail on Facebook |
|
anon54
Guest Group |
Post Options
Thanks(0)
|
I just read an article via Breitbart concerning the mutations in West AfricaThe article is by Awr Hawkins,and the link goes to NPR.It's frankly terrifying. I don't see how an effective vaccine can be made with these rapid mutations.Call me foolish ignorant or whatever, I just don't see and thing useful outcome.
|
|
anon54
V.I.P. Member Joined: May 03 2007 Status: Offline Points: 309 |
Post Options
Thanks(0)
|
That should be any productive outcome from vaccine trials,sorry my bad |
|
hazelpad
Guest Group |
Post Options
Thanks(0)
|
Not all parts of the viral genome mutated at the same rate. RNA viruses like Ebola tend to be inherently less stable than say DNA viruses. So you expect changes,especially due to the number of hosts it has passed through, selective pressures etc.
However here is the good news, it is whether those changes actually count in the grand scheme. There are many regions depending on their sequences that will stay pretty conserved, stable sequences. The vaccine manufacturers know to look for these sequences and the proteins they relate to. These tend to be in dominant epitope, I.e. pretty stable protein, required for viral entry or replication, and globally immunogenic. So vaccine wise there is some still hope. |
|
anon54
Guest Group |
Post Options
Thanks(0)
|
Thank you for clarifying that Hazelpad.You are right about hope. Can't give that up.
|
|
Post Reply | |
Tweet
|
Forum Jump | Forum Permissions You cannot post new topics in this forum You cannot reply to topics in this forum You cannot delete your posts in this forum You cannot edit your posts in this forum You cannot create polls in this forum You can vote in polls in this forum |