jacksdad wrote: For a virus that we've known about since 1947 and has demonstrated only limited ability to spread, this thing certainly stepped up it's game recently. Mutation does seem to be the most logical explanation, but maybe it was waiting for a bigger petri dish. I guess while we were worrying about the possibility of Ebola making it to a Brazilian favela, we forgot to watch out for all the other bugs that were looking for a chance to hone their skills on a larger population. uploads/3156/favela.jpg

That is one big petri dish.

When you look at the numbers over the last 90 days with the explosion in cases, one can't help but to think that Zika mutated and became more adaptable to humans.   If that's the case, it would be good to know what mutations and if the virus is still changing.  This could be the next generation of pandemics that redefines them all.

The Zika Virus Takes A Frightening Turn — And Raises Many Questions

Something new — and quite frightening — appears to be happening with the Zika virus.

For decades Zika was a virus that turned up in monkeys and occasionally in humans in Africa and Southeast Asia. Its symptoms were mild and the number of confirmed human cases was low.

Things began to change last year. The virus, which is spread by mosquitoes, turned up in Brazil. There have been at least half a million cases there and the virus has appeared in many other countries in Latin America and the Caribbean.

Why is this virus spreading so rapidly?

"We do still know so little about this virus and the harm that it can cause," says Albert Ko, an epidemiologist from Yale who has been working with the Brazilian Ministry of Health to investigate the Zika outbreak. "This is really a relatively new pathogen." Indeed, the virus was first identified in 1947 in a rhesus monkey in Uganda's Zika forest (which gave the disease its name).

Ko says it may be that the Americas are fertile ground for the virus — this hemisphere has the right type of mosquitoes to transmit Zika and people have no immunity to it.

Or it may be that the virus has mutated.

"This may be a new strain that's traveling very quickly but we really don't know," says Ko.

And along with the increase in numbers has come a disturbing development. In October, Brazilian health authorities noticed a surge in the number of babies born with a birth defect called microcephaly, characterized by smaller than normal heads and severe brain damage. Could the birth defect be linked to instances of Zika in the mother when she was pregnant?

The link between Zika and microcephaly, the condition where a baby's brain and head don't fully develop, still hasn't been proved definitely. But health officials are operating under the assumption that there is one. Brazil reported only 150 cases of microcephaly in 2014 before the virus arrived yet has recorded nearly 4,000 cases of the birth defect since October.

Officials in Brazil and Colombia have taken the extraordinary step of asking women to not get pregnant. The risk to pregnant women is thought to be greatest if she contracts the virus during the first trimester of pregnancy.

Marcie Treadwell is a fetal medicine physician at the University of Michigan in Ann Arbor. She says it's possible that in many more babies the virus is causing less severe forms of brain damage that will only become apparent later: "We don't know the full range of the impact of the virus."

Indeed, there are many unanswered questions. Since many people who get infected with Zika don't get sick at all, she says, "there may be a whole host of women who have had the virus while pregnant who have kids who are completely normal — or [who may] appear completely normal [but will] develop mental issues as these kids get older. We just don't know."

Currently there's no treatment for Zika. Nor is there a vaccine. All the experts can say is that pregnant women should avoid mosquitoes, says Dr. Denise Jamieson, a medical officer with the CDC in Atlanta.

She adds: "There's no intervention that we have to prevent the development of microcephaly."

About a half-dozen cases of Zika have turned up in the U.S. over the past two weeks — all in travelers returning from parts of Latin America and the Caribbean where the outbreak is raging. CDC officials predict any outbreaks in the U.S. mainland will be localized and relatively small because Americans have better access to screens and air-conditioning to protect themselves from mosquitoes.

http://www.npr.org/sections/goatsandsoda/2016/01/22/463974869/the-zika-virus-takes-a-frightening-turn-and-raises-many-questions