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Tracking the next pandemic: Avian Flu Talk

Bird flu vaccine import gets go-ahead

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    Posted: August 05 2006 at 8:29pm

Bird flu vaccine import gets go-ahead

Yuli Tri Suwarni, The Jakarta Post, Bandung

Despite opposition from critics who fear the move could lead to the development of more virulent strains of the bird flu virus, the government awarded the country's biggest vaccine producer a tender Friday to import the H5N2 vaccine for poultry.

PT Bio Farma president director Marzuki Abdullah said his state-owned firm received the tender from the Agriculture Ministry for its offer of Rp 9.36 billion (US$1.01 million), adding it was the lowest among the competing companies.

Within two weeks from the receipt of the letter, imports can begin from a factory in China.

Almost all of Indonesia's 43 human deaths from bird flu have been traced to contact with infected poultry.

"We're ready to import the vaccine from our partner Qilu, a vaccine producer in China," he said at a press conference ahead of the company's 116th anniversary Sunday.

H5N2 is one of the 15 known strains of the type A influenza virus found in birds. Although milder than H5N1 that has been transmitted to humans, it caused widespread, pathogenic infection in poultry in parts of the United States in the early 1980s and in Mexico from 1992-95.

But some biologists have criticized the plan, saying it could lead to the mutation of an even more lethal form of H5N1 already rife in local chicken populations.

Bio Farma's marketing director Sarimuddin Sulaeman said the company had 50 million doses of the H5N2 vaccine from China but based on the tender, the Agriculture Ministry needed 48 million more to conduct a mass vaccination of poultry stock.

He dismissed reports that the order could not be fulfilled due to the closure of the Qilu factory in China. He said it was undergoing a six-month renovation of its plant, but it had not affected vaccine production.

"Qilu borrows YEBIO Bio Engineer Co. Ltd. of Kingdao to run its vaccine production," he said, adding that the latter was one of seven bird flu vaccine producers granted an official recommendation from the Chinese government.

When asked about the vaccine's quality, he said the choice was made by Agriculture Ministry and the vaccine's content has been directly examined by the ministry's team for livestock medicine consumption.

"So if there's any objection, please ask the Agriculture Ministry why we won the tender," Sarimuddin said.

Bio Farma also is continuing on its project to produce bird flu vaccine for humans by the end of the year. Marzuki met Friday with a team of experts from Biken Kanonji Institute of Japan to prepare for transfer of technology.

Under the plan, Bio Farma would prepare the facilities and equipment to support the production of the vaccine for humans. It is planning to employ a downstream production system, entailing the import of the crude vaccine from a number of foreign companies for common influenza. It would then be modified into a bird flu vaccine for humans.

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H5N2 is a subtype of the species Influenzavirus A (avian influenza virus or bird flu virus).

A highly pathogenic strain of H5N2 caused flu outbreaks with significant spread to numerous farms, resulting in great economic losses in 1983 in Pennsylvania, USA in chickens and turkeys, in 1994 in Mexico in chickens and a minor outbreak in 1997 in Italy in chickens. [1]

It was reported on November 12, 2005 that "One of 2 birds found infected with bird flu in Kuwait has the H5N1 strain of the virus, authorities said. The infected bird was a migrating flamingo found on a Kuwait beach. The other was an imported falcon found to have the milder H5N2 variant."[2]

In China, inactivated H5N2 has been used as a vaccine for H5N1. [3]

Japan's Health Ministry said May 11, 2006 that 93 poultry farm workers near Tokyo may have been exposed to H5N2 (which was not previously known to infect humans) in 2005. "Preliminary tests on the workers were positive for H5N2 antibodies, indicating they were previously exposed, Takimoto said. While exposure carries with it the possibility of infection and illness, he said none had tested positive for the virus itself or had developed flu symptoms. [...] About 5.7 million birds have been destroyed in Ibaraki following the H5N2 outbreaks."[4]

An H5N2 outbreak on a single farm in South Africa resulted in the destruction of all its sixty ostriches. The strain was similar to the one that caused outbreaks in South Africa 2004/2005. [5]

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