Click to Translate to English Click to Translate to French  Click to Translate to Spanish  Click to Translate to German  Click to Translate to Italian  Click to Translate to Japanese  Click to Translate to Chinese Simplified  Click to Translate to Korean  Click to Translate to Arabic  Click to Translate to Russian  Click to Translate to Portuguese  Click to Translate to Myanmar (Burmese)

PANDEMIC ALERT LEVEL
123456
Forum Home Forum Home > Main Forums > General Discussion
  New Posts New Posts RSS Feed - Swine flu genes circulated undetected for years
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Tracking the next pandemic: Avian Flu Talk

Swine flu genes circulated undetected for years

 Post Reply Post Reply
Author
Message
July View Drop Down
Valued Member
Valued Member
Avatar

Joined: May 24 2006
Status: Offline
Points: 1660
Post Options Post Options   Thanks (0) Thanks(0)   Quote July Quote  Post ReplyReply Direct Link To This Post Topic: Swine flu genes circulated undetected for years
    Posted: May 22 2009 at 1:57pm

Swine flu genes circulated undetected for years

Friday, May 22, 2009
The Associated Press
By RANDOLPH E. SCHMID
AP Science Writer
In this photo taken April 27, 2009, Victor Calderon, General Director of Granjas Carroll de Mexico, stands next to pigs at one of the company's farms on the outskirts of Xicaltepec in Mexico's Veracruz state. Scientists are returning to La Gloria, a pig-farming village in the Veracruz mountains where Mexico's earliest confirmed case of swine flu was identified. They hope to learn where the epidemic began by taking fresh blood samples from villagers and pigs, and looking for antibodies that could suggest exposure to previous swine flu infections. (AP Photo/Alexandre Meneghini)

Genes included in the new swine flu may have been circulating undetected in pigs for at least a decade, according to researchers who have sequenced the genomes of more than 50 samples of the virus.

The findings suggest that pig populations need to be more closely monitored in the future for emerging influenza viruses, said a team led by Rebecca Garten of the Centers for Disease Control and Prevention in a report released Friday by the journal Science.

First detected last month, at least 42 countries now have confirmed the new virus in more than 11,000 people — although those are only the cases tested, and authorities say many more have been sickened. Mexico has reported 75 swine flu deaths, the U.S. 10 and Canada and Costa Rica one each.

How the new flu originated has taken a back burner to the more pressing work of treating the sick and trying to create a vaccine. But almost immediately, the CDC learned that the novel flu's parents were some older swine viruses — one of them a combination of pig, bird and human strains — that had mixed genes in a new way.

Friday's report takes a closer look at all of the virus' genetic material, and found the closest ancestor for all eight gene segments is of swine origin. That suggests this new virus might have been infecting pigs somewhere in the world for years, even if the infected pigs didn't appear sick.

In fact, viruses with genes that most resembled the new swine virus — known scientifically as part of the H1N1 flu family — were identified on average 10 years ago.

Flu viruses of any origin very easily swap genetic material with each other. So each time two or more viruses come into contact in a species, they have an opportunity to mix and create new strains that can be more dangerous or more easily transmitted to each other or another species.

The new work doesn't shed any light on where this new virus made its jump from pigs to people. Some of the genetic ancestors come from a virus that first hit U.S. pig farms in 1998. Others are traced to pig viruses in Europe and Asia.

But scientists haven't yet found the key genetic clue: What made this virus able to easily spread from person to person?

On the good side, CDC reiterated that none of its genes show any of the markers of extra virulence or high transmissibility that have been found in some other influenza A viruses.

While the journal Science normally publishes on Thursday, the new study was released immediately because of the widespread interest in the topic.

On the Net:

Science: http://www.sciencemag.org

Back to Top
 Post Reply Post Reply
  Share Topic   

Forum Jump Forum Permissions View Drop Down