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Did H7N9 mix with H1N1 in Russia ? |
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Dutch Josh
Adviser Group Joined: May 01 2013 Location: Arnhem-Netherla Status: Online Points: 95827 |
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Posted: December 26 2013 at 3:32am |
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http://pf11.blogspot.nl/search/label/225G
2013-09-26Emergent H7N9 Homology in Fatal Human pH1N1 Case Near Caspian SeaSequences discussed in this analysis are variously stored publicly at GenBank and at GISAID. We gratefully acknowledge the authors, originating and submitting laboratories of the sequences from GenBank and from GISAID’s EpiFlu™ Database on which this research is based. A GISAID-generated list is detailed in a linked Excel workbook for completeness in citation. Publish Date : 2013-09-26 Last Update : 2013-11-04
On 2013-09-25, the Rospotrebnadzor of Moscow, Russia released a set of human pH1N1 sequences without age or gender at GISAID, including 6 Fatal cases. The Neuraminidase segments were not released. One HA segment sampled in late January 2013 from Astrakhan [map], near the Caspian Sea, [EPI471830] strongly suggests Emergent H7N9 involvement. This Astrakhan H7N9-related viral Hemagglutinin displays a standardEmergent H7N9 amino at 179V on a pH1N1 Clade2:188T background. The HA 179V is Novel to pH1N1 after more than 4 years of pH1N1 circulation in humans. HA 89G, found in the H7N9 reservoir, is co-located on this same pH1N1 sequence. Polymorphisms at two antigenic amino positions practically adjacent, HA 129Q and HA 131L, provide grist for the Host-Transition mill. Contemporary sequences from Spain carry homology as well as an unusual change adjacent to these odd aa129 andaa131 positions from the Russian Federation:
HA 219T, also seen in the H7N9 reservoir, is demonstrated in Kazan [map], [EPI471827]. HA 225G continues to inform Fatal pH1N1 cases: |
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cobber
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Its an interesting observation. I was just reading this myself in another blog
This recombo with HA 225G is not good. I'm yet to see all the gene codes coming out of Texas. Maybe this is the culprit.
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