Tracking the next pandemic: Avian Flu Talk |
Is Tamiflu an Antibiotic? - Genericcures |
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Dutch Josh
Adviser Group Joined: May 01 2013 Location: Arnhem-Netherla Status: Offline Points: 95877 |
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Posted: March 21 2024 at 5:05am |
More on Tamiflu; [url]https://afludiary.blogspot.com/2024/03/the-lancet-correspondence-global.html[/url] or https://afludiary.blogspot.com/2024/03/the-lancet-correspondence-global.html ; Twenty years ago Amantadine was the preferred influenza antiviral. It was cheap, plentiful, and worked reasonably well as both a treatment, and a preventative.
By late 2005 Amantadine was beginning to lose its effectiveness against the H3N2 seasonal flu virus and some strains of the H5N1 bird flu. In January of 2006 the CDC issued a warningto doctors not to rely on Amantadine or Rimantadine to treat influenza. Tamiflu (Oseltamivir) - an NAI (neuraminidase inhibitor) - was approved for use in the U.S. in 1999. While far more expensive, it became the new treatment standard. While occasional instances of Oseltamivir resistance were recorded prior to 2007, in nearly every case, it developed after a person was placed on the drug (i.e. `spontaneous mutations’). Although of obvious concern to the patient receiving treatment, it occurred in only about 1% of treated cases, and studies suggested that these resistant strains were `less biologically fit’, and were therefore thought unlikely to spread from human-to-human.
So much so, that by the end of 2008, nearly all of the H1N1 samples tested in the United States were resistant to oseltamivir and the CDC was forced to issue major new guidance for the use of antivirals (see CIDRAP article With H1N1 resistance, CDC changes advice on flu drugs). DJ, "anti-virals work untill they stop working"....Virusses may develop/select mutations getting around antivirals/immunity... |
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