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Online Discussion: Tracking new emerging diseases and the next pandemic.

H10N8 Bird Flu claims its First Human Victim

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rickster58 View Drop Down
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    Posted: February 04 2014 at 5:35pm
New and deadly form of bird flu claims its first human victim prompting fears of a pandemic

A woman in China died after contracting a new sub-strain of H10N8
She is thought to have picked up the illness at a live poultry market
She died despite antibiotic and antiviral treatment in hospital
At least one other person in China is also believe to have been infected
A new and potentially deadly form of bird flu has claimed its first confirmed victim.

Tests revealed that a previously unknown sub-strain of the H10N8 virus killed a woman who was admitted to hospital in China with fever and pneumonia.

The woman, from Nanchang City in Jiangxi province, died nine days after becoming ill despite antibiotic and antiviral treatment.

Experts believe the strain spread from poultry and may pose the threat of a pandemic.

The dead woman had visited a live poultry market a few days prior to her illness, suggesting an incubation time of around four days - similar to that of other bird flu strains.

Reports suggest the victim was not an isolated case. At least one other person is believed to have been infected by the same strain in Jiangxi Province.

Dr Yuelong Shu, from the Chinese Centre for Disease Control and Prevention in Beijing, said: ‘A genetic analysis of the H10N8 virus shows a virus that is distinct from previously reported H10N8 viruses, having evolved some genetic characteristics that may allow it to replicate efficiently in humans.’

The strain is thought to have emerged from multiple re-assortments of genes from different bird flu viruses.

Notably, it shares genes with three other bird flu strains, H9N2, H7N9 and H5N1, the last two of which have spread to humans.

Scientists conducted tests on swab samples taken from the woman victim's windpipe.

more at .....

http://www.dailymail.co.uk/health/article-2551679/New-bird-flu-claims-human-victim-prompting-fears-pandemic.html
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rickster58 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote rickster58 Quote  Post ReplyReply Direct Link To This Post Posted: February 04 2014 at 5:45pm
More reports on this at ....

http://www.wantchinatimes.com/news-subclass-cnt.aspx?id=20131218000148&cid=1103

http://home.bt.com/news/worldnews/new-bird-flu-kills-first-victim-11363873234756
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Post Options Post Options   Thanks (0) Thanks(0)   Quote guests Quote  Post ReplyReply Direct Link To This Post Posted: February 04 2014 at 5:55pm
This victim died December 6th I believe.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote rickster58 Quote  Post ReplyReply Direct Link To This Post Posted: February 04 2014 at 7:02pm
That is correct, however it is only now being reported as H10N8 - a previously unknown strain, so it seems.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote EdwinSm, Quote  Post ReplyReply Direct Link To This Post Posted: February 04 2014 at 9:40pm
This made front page of the BBC internet news. 

Quote:  "Scientists who have studied the new H10N8 virus say it has evolved some genetic characteristics that may allow it to replicate efficiently in humans."
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: February 04 2014 at 9:49pm
"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: February 05 2014 at 6:09am

Chinese scientists sound warning over new bird flu virus

Avian flu viruses pass from infected birds to humans in close proximity but typically do not transmit easily between humans

Potentially fatal strain of avian influenza virus may have passed between people for the first time in China, experts believe.
Most cases of avian influenza virus have been among people visiting markets selling live birds or among those who had contact with live poultry  Photo: AP

8:28AM GMT 05 Feb 2014

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Chinese scientists have sounded the alarm after a new bird flu virus, H10N8, killed an elderly woman in December and infected another individual last month.

The fifth novel influenza strain to emerge in 17 years, the virus has a worrying genetic profile and should be closely monitored, they reported in The Lancet medical journal.

It appears to be able to infect tissue deep in the lung and may have features allowing it to spread efficiently among humans, they said.

"The pandemic potential of this novel virus should not be underestimated," said the team headed by Yuelong Shu from the Chinese Centre for Disease Control and Prevention (CDC) in Beijing.

The warning stems from analysis of a virus sample taken from a 73-year-old woman who died in Nanchang, in southeastern Jiangxi province, on December 6 after being diagnosed with severe pneumonia and respiratory failure.

The Chinese authorities announced her death from H10N8 on December 18.

The Lancet study disclosed that a second case of H10N8 was recorded in Nanchang, on January 26. It did not give further details.

They are the first known human cases of H10N8, a virus that has been found only twice before in China - once in a water sample from a lake in Hunan in 2007, and the second time in live poultry in Guangdong province in 2012.

But this particular strain is different from the ones found in those two samples, the study said.

The big contributors to its genome are reshuffled genes from the H9N2 virus, the authors said.

This is a bird virus that erupted in Hong Kong in 1999 and has also contributed to the dangerous H5N1 and H7N9 flu viruses, the probe said.

Avian flu viruses pass from infected birds to humans in close proximity but typically do not transmit easily between humans.

The worry for health watchdogs is their potential to acquire an ability to jump easily from person to person.

H7N9, which emerged last year, has led to 159 human infections in China, including 71 deaths, according to a combined toll of official figures and an AFP tally of reports by local authorities.

H5N1, which first occurred among humans in Hong Kong in 1997, has caused 648 infections with 384 deaths since 2003, according to figures cited in The Lancet study.

The genome of H10N8, it said, pointed to a mutation in its so-called PB2 protein that, previous research has found, suggests an ability to adapt to mammals.

The virus also has a mutation in its haemagglutinin protein - a spike on the virus surface that enables it to latch onto other cells - that suggests it can infect deep in the lung, like H5N1, rather than the upper respiratory tract, the trachea.

Lab tests on the sample showed it could be attacked by Tamiflu, the frontline anti-viral drug.

Many questions remain, including how the woman was infected.

She had bought a live chicken at a poultry market several days before falling sick.

But she may have become infected beforehand, the scientists said. She did not handle the bird and no virus traces were found in poultry at the market.

In addition, the woman may have been an easy target for the virus because of poor health - she had coronary heart disease, high blood pressure and a muscle-weakening disease called myasthenia gravis.

Tests on people who had been in close contact with her concluded that no one else had been infected.

The second case of H10N8 "is of great concern", said co-author Mingbin Liu of the Nanchang branch of China's CDC.

"It reveals that the H10N8 virus has continued to circulate and may cause more human infections in the future."

12 monkeys!!!!!
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