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Online Discussion: Tracking new emerging diseases and the next pandemic.

H7N9 virus mutant was found in human cases from Ch

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arirish View Drop Down
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    Posted: February 19 2017 at 2:05pm
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H7N9 virus mutant was found in human cases from China

In January 2017, Guangdong Provincial Center for Disease Control and Disease on the two cases of human infection H7N9 cases were isolated virus gene sequencing analysis, found in the two strains of hemagglutinin link peptide position of the gene insertion mutation occurred, the test results Has been confirmed by the National Center for Viral Disease National Influenza Center.

I center experts to judge and communicate with the relevant experts in the agricultural sector that H7N9 virus in the hemagglutinin link peptide position of the gene insertion mutation, suggesting that the virus mutation to the highly pathogenic virus against birds; the second is based on the virus Sequence analysis results have not yet appeared in the mutant virus that has increased resistance to human infectivity, virulence and interpersonal communication.

Two cases of disease before the incidence of bird exposure history, and in the exposure of poultry birds have occurred in the phenomenon of death. At present, a case has been cured, another case is still in treatment. All the 105 cases of close contact after two weeks of medical observation, were not fever, cough and other symptoms.

H7N9 virus is a influenza virus, one of its main features is prone to gene reassignment and mutation. Some mutations may lead to the virus on the human appeal, virulence and interpersonal communication ability enhancement, so the virus variation has been widely concerned about the domestic and foreign.

It is understood that the agricultural sector laboratory also from Guangdong, four poultry specimens found similar to the variation of the virus. China's health care system will work together with the agricultural sector, the common source of the virus, the scope of the impact of in-depth study, and continue to strengthen the monitoring of H7N9 virus, in time to find any possible variation.

The results have been communicated to the World Health Organization

http://www.cdcp.org.cn/gdsjbyfkzzx/gnwxx001/201702/ce3a2125d5dc46e1b2e906ee42d42c2d.shtml
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: February 19 2017 at 2:53pm
Interesting that they found similar mutations in both humans and poultry. Influenza is an RNA virus, and it's incredibly sloppy when it reproduces. Most of it's "offspring" are such poor copies that they're sometimes classed as quasispieces, and the mutations are such that they're simply not viable. This is significant in that a change has taken place that apparently still leaves it able to infect two different hosts. Thankfully the contacts didn't show signs of infection - with luck, the changes don't move it any closer to a human strain.


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Post Options Post Options   Thanks (0) Thanks(0)   Quote arirish Quote  Post ReplyReply Direct Link To This Post Posted: February 20 2017 at 8:48am


Mutation of H7N9 bird flu strain found in Guangdong patients


Samples taken from patients show genetic change but no sign of higher risk to humans

China has reported the first genetic mutation of the H7N9 bird flu virus with specialists predicting the change will result in more dead poultry.

The Chinese Centre for Disease Control and Prevention ­informed the World Health Organisation that the mutation was found in samples collected from two patients in Guangdong province last month.

The mutation suggested the virus had become deadlier to poultry but there was no indication it posed a greater risk to people, or made transmission among humans more likely, the centre said in a statement released on Sunday.

It came the conclusion after consulting experts with the agricultural ministry. Both patients had been exposed to dead poultry. One had been discharged while the other was still receiving treatment.

China approves human trials of vaccine for deadly bird flu strain(

The centre said 105 people who were in close contact with the patients were being monitored, but none had developed symptoms of bird flu.

Agricultural authorities had also found four poultry samples that might contain the mutation but further study was necessary. The poultry samples were also collected in Guangdong.

Shi Yi, viral infection researcher at the Chinese Academy of Sciences’ Institute of Microbiology, said mutations in bird flu were not uncommon, and the H5N1 virus had undergone a similar change.

“There is no laboratory experiment yet, but based on previous studies on H5N1, it’s possible for the mutated H7N9 to become more [likely to cause disease],” Shi said.

“But there is no proof to suggest any viral changes in existing infection channels or strength.”

Chinese cities shut markets selling live poultry as bird flu deaths surge to 100 this season(

Guan Yi, director of the University of Hong Kong’s State Key Laboratory of Emerging Infectious Diseases and the Centre of Influenza Research, said a H7N9 mutation would kill poultry more readily.

“Before the mutation, the H7N9 virus would only infect poultry intestines and the respiratory tract, but the mutation means the virus can travel to any organ of the chicken,” Guan said.

Such a mutation would kill the chicken “in a few days”.

While there was no indication the mutation would have a greater direct impact on humans, it could lead to more infections in people, given the higher risk of infection among poultry.

More than 100 people have died from bird flu this winter and many provinces have suspended the live poultry trade.




http://www.scmp.com/news/china/society/article/2072454/mutation-h7n9-bird-flu-strain-found-guangdong-patients
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: February 20 2017 at 12:38pm
Being able to attach to receptors in the internal organs of birds might mean it can bring about the "Flubola" effect we've seen other hi path outbreaks. The presence of the virus initiates a cytokine storm that effectively liquifies the bird. Looking on the bright side (if there is one) becoming symptomatic in poultry would definitely make it easier to track, I guess. It's scary that it's expanding it's list of compatible cellular receptors though, because that increases the chances of it being able to find a way into our respiratory tract.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: February 21 2017 at 4:03pm
Anyone know what happened to Niman ?his site not been updated for 2years
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Post Options Post Options   Thanks (0) Thanks(0)   Quote arirish Quote  Post ReplyReply Direct Link To This Post Posted: February 21 2017 at 6:24pm
I heard he gave up the blog and started tweeting!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: February 27 2017 at 1:33pm
shame i dont twit......lol
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Post Options Post Options   Thanks (0) Thanks(0)   Quote arirish Quote  Post ReplyReply Direct Link To This Post Posted: February 27 2017 at 1:47pm
I don't facechat either!
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