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Online Discussion: Tracking new emerging diseases and the next pandemic.

H9N2 and 2009 H1N1 reassortants

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arirish View Drop Down
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    Posted: May 04 2017 at 7:49am


Study probes H9N2 and 2009 H1N1 reassortants in pigs

A study of an avian H9N2 and 2009 H1N1 flu virus reassortant in pigs found that after seven serial passages, it gained the ability to transmit more efficiently. Belgian scientists and US researchers from Kansas State University published their findings yesterday in Scientific Reports.

Both viruses can infect both pigs and people, so researchers have been assessing the characteristics of the reassortant. The team that conducted the latest experiments constructed and tested one that contained the hemagglutinin and neuraminidase of H9N2 and the internal proteins of 2009 H1N1.

The initial reassortant only infected cells of the pigs' nasal mucosa, with no virus found in the trachea or lungs. But after seven passages, the virus replicated in the entire respiratory tract. They also looked at transmissibility, comparing the original and seventh-passage reassortants with the 2009 H1N1 virus. For the original reassortant, nasal shedding was noted for only 2 of 6 direct-contact pigs. However, for the seventh passage of the reassortant, 4 of 6 direct-contact pigs showed nasal shedding of the virus, with virus titers similar to 2009 H1N1, which was passed to all six direct-contact pigs.

Genetic studies associated the expanded tissue tropism and increased transmission they saw after repeated passaging with the HA-D225G mutation, which the team said could be a marker for adaptation of H9N2 viruses to pigs. They concluded that the 2009 H1N1 internal genes combined with the serial passages support H9N2 adaptation in pigs.

Abstract:
http://www.nature.com/articles/s41598-017-01512-x

http://www.cidrap.umn.edu/news-perspective/2017/05/news-scan-may-03-2017
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: May 04 2017 at 1:48pm
Originally posted by arirish arirish wrote:

A study of an avian H9N2 and 2009 H1N1 flu virus reassortant in pigs found that after seven serial passages, it gained the ability to transmit more efficiently.


I guess it's lucky that we're not stupid enough to keep pigs close to each other for long periods. No. Wait...



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Post Options Post Options   Thanks (1) Thanks(1)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: May 04 2017 at 3:10pm
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Post Options Post Options   Thanks (1) Thanks(1)   Quote arirish Quote  Post ReplyReply Direct Link To This Post Posted: May 04 2017 at 3:55pm
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