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Tracking the next pandemic: Avian Flu Talk

Is Tubercin a possible cure for Ebola

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waterboy View Drop Down
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    Posted: October 06 2014 at 12:14pm
http://www.artec-inc.net/continue.html
This drug was in a trial for AIDS/HIV/Cancer a few years ago. Whatever happened to it?
TUBERCIN/WELME

If first link doesn't work try this. www.artec-inc.net
.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 06 2014 at 3:41pm
Sorry this isnt news.It should of been posted in discussions.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Jen147 Quote  Post ReplyReply Direct Link To This Post Posted: October 06 2014 at 4:26pm
I moved it for you waterboy.  You are doing an awesome job.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 06 2014 at 5:16pm
Thank you Jenn
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 07 2014 at 8:23am
How are you?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 07 2014 at 9:41am
artec-inc.net
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 07 2014 at 9:44am
http://www.artec-inc.net/Abstract.pdf
Read this...
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Hazelpad Quote  Post ReplyReply Direct Link To This Post Posted: October 07 2014 at 5:04pm
Don't know this drug. Basically from what you say the drug strengthens the T cell Receptor interaction with its target cell by increasing its adhesion artificially.

Problem is during activation T cells need transient interactions, it is not a process that can usually be skipped and you cant go straight in with a strong interaction. T cells crawl all over antigen presenting cells, and do not make initial strong interations for a good reason, i.e. it require numerous transient contacts with the antigen presenting cell, each contact varies in duration and adds to the signalling cascades, building up a profile of adhesion molecules on the surface. Once a specific threshold of activation is reached the chemokines and adhesion molecules are at the right concentration to create lipid rafts which then allows for a more focused interaction. After getting or delivering a hit the T cell has to disengage and move on. Fluidity in interaction strengths and duration is critical in shaping the T cells response.

Many drugs that aimed to increase contact strength, can caused non specific interactions which could lead to uncontrolled stimulation. inappropriate activation, ( such as autoimmunity), or even the opposite effect of creating immunotolerance ( T cell receptor engagment in the abscence of costimulation). In addition if interactions between T cell and target cell are too strong the massive Ca2+ influx can be toxic to T cell. Lastly messing with costimulation strength is tricky. In 2006 all 6 healthy controls ended up in intensive care with cytokine storm after taking a trial antibody designed to stimulate accessory molecules on T cells ( CD28 which acts with TCR to increase adhesion, cell signalling and response).   http://www.medscape.com/viewarticle/538531

Perhaps you know more about this drug, I don't know about its trials specifically as an immunostimulant, is it FDA approved, or close to it.   

Interesting topic.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 07 2014 at 9:49pm
Originally posted by Hazelpad Hazelpad wrote:

Don't know this drug. Basically from what you say the drug strengthens the T cell Receptor interaction with its target cell by increasing its adhesion artificially.

Problem is during activation T cells need transient interactions, it is not a process that can usually be skipped and you cant go straight in with a strong interaction. T cells crawl all over antigen presenting cells, and do not make initial strong interations for a good reason, i.e. it require numerous transient contacts with the antigen presenting cell, each contact varies in duration and adds to the signalling cascades, building up a profile of adhesion molecules on the surface. Once a specific threshold of activation is reached the chemokines and adhesion molecules are at the right concentration to create lipid rafts which then allows for a more focused interaction. After getting or delivering a hit the T cell has to disengage and move on. Fluidity in interaction strengths and duration is critical in shaping the T cells response.

Many drugs that aimed to increase contact strength, can caused non specific interactions which could lead to uncontrolled stimulation. inappropriate activation, ( such as autoimmunity), or even the opposite effect of creating immunotolerance ( T cell receptor engagment in the abscence of costimulation). In addition if interactions between T cell and target cell are too strong the massive Ca2+ influx can be toxic to T cell. Lastly messing with costimulation strength is tricky. In 2006 all 6 healthy controls ended up in intensive care with cytokine storm after taking a trial antibody designed to stimulate accessory molecules on T cells ( CD28 which acts with TCR to increase adhesion, cell signalling and response).   http://www.medscape.com/viewarticle/538531

Perhaps you know more about this drug, I don't know about its trials specifically as an immunostimulant, is it FDA approved, or close to it.   

Interesting topic.


No it's not FDA approved. I feel it needs to be fasttracked to help build the immune system of those infected with any virolent diseases.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 1:04pm

CDC is talking now on Foxnews


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http://www.artec-inc.net/tubercin.htm
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 5:14pm
Tubercin/Welme
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Albert Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 5:19pm
Waterboy I know you're hyping your stock dude.  If you think people should load up then spit it out.  What's it at?  Or symbol.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 5:26pm
Originally posted by Albert Albert wrote:

Waterboy I know you're hyping your stock dude.  If you think people should load up then spit it out.  What's it at?  Or symbol.



P.S. I wonder if it will help our colds?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Albert Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 5:27pm
Before I started my first forum in 2002 lol, I used to participate on my first ever message board called ragingbull.com for stocks, penny stocks, etc....  Pretty ruthless place in my youth.  Home of the pump and dumps.   Better see what waterboys is trading at first, the float, etc..
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Albert Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 5:28pm
Okay waterboy thanks for being honest.  We go back a long time.  Don't hype it too much so I can load up.  I'm kidding.  

I would have to research it a little first.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 5:31pm
  

I would have to research it a little first.


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Post Options Post Options   Thanks (0) Thanks(0)   Quote Albert Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 5:44pm
I've been out of the game for a few years now.  Can you sum it up?  Is it a pink sheet, otcbb, or what? 

Dang dude at .003 it's a day trader stock.  GNFIN... are you being a naughty boy?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 5:48pm
[QUOTE=Albert] I've been out of the game for a few years now.  Can you sum it up?  Is it a pink sheet, otcbb, or what? 
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Albert Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 6:10pm
You had the price the first time as .003 instead of .03. Big difference. You never know though. I once hit one that was mind boggling. Anyway, I'll hold off but good luck. You can post about it in OT. So I don't get into too much trouble we'll probably move this thread to off topic forum

Good luck
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 6:18pm
Good luck
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: October 08 2014 at 7:38pm
Not poking fun or belittling or bragging but dern. I made more money than that every two months in the tattoo business. Every two months for decades. And only worked two hours a month to hold it all together. 5 to 25k an hour. Income. Not gross. But I'm not stupid though, WB. If it really works and takes off then you're a very rich man and I will envy you in my meager misery. You are already rich in Heavenly Father but if the drug works it will move up fantastically and you will have certainly earned that earthly reward.
"And then there were none."
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 11 2014 at 5:57pm
Who knows
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 13 2014 at 8:59pm
Thank you
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 14 2014 at 7:55pm
Good product?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Jen147 Quote  Post ReplyReply Direct Link To This Post Posted: October 14 2014 at 8:37pm
waterboy please stop posting this in Latest News or General Discussion.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote waterboy Quote  Post ReplyReply Direct Link To This Post Posted: October 22 2014 at 2:59pm
Let's focus on Ebola
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