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Online Discussion: Tracking new emerging diseases and the next pandemic

Out of Left field Deadly Nipah kills Nine

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: May 26 2018 at 10:43am
Just for once, it was't the bats..........  I am sorry, the article resists being copied.  You can findit here:

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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: May 26 2018 at 4:07pm
even if it wasnt the bats ,if they were using that well and Some got infected,

and its been covered where will the Infected bats go to get a drink,and will that  water source become "unclean" ??

i am afraid the Geine is out of the bottle on this one ,

do i trust the Indian government to tell the truth ??

Errr NO,panic would happen


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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: May 26 2018 at 4:11pm

maybe with a tweak this could be a vaccine that could help this situation..


The Hendra vaccine

The Equivac® HeV vaccine became available to horse owners on 1 November 2012. It is an animal medicine, fully registered by the Australian Pesticides and Veterinary Medicines Authority (APVMA.)  The vaccine has been declared as safe and effective (Source: Qld Parliament Report into the Hendra Vaccine; October 2016.)  The vaccine was initially released to high-risk areas in Australia and then to all horse owners soon afterwards.

The vaccine was the result of scientific and collaborative efforts between the Uniformed Services University of the Health Sciences in Maryland USA, the Henry M Jackson for the Advancement of Military Medicine in Maryland USA,  Pfizer Animal Health (now Zoetis), and CSIRO's Australian Animal Health Laboratory.

A timeline from 1994 to 2012 (the year the Hendra virus vaccine was released) has been developed to provide a summary of the research that has improved our knowledge of the deadly disease and contributed to the development of the vaccine. Download vaccine timeline

A review by Professor C Broder, Dr D Weir and Dr P Reid of the development of active and passive Hendra virus and Nipah virus animal vaccines has recently been published June 2016 in the internationally renowned journal Vaccine. Available online here.

The current scheduling protocol for healthy microchipped horses over four months of age is two initial vaccinations administered three to six weeks apart, followed by a booster at 6 months, followed by annual boosters, with all vaccinations recorded in a central database register. The vaccine should not be used in sick or immunocompromised animals. As no animal or human vaccines are regarded as 100% effective in all individuals, appropriate PPE, good personal hygiene and biosecurity practices should always be used when dealing with sick, vaccinated or unvaccinated horses.

The vaccine is only available to veterinarians. The reasoning behind this is based on the fact that because Hendra is such a lethal disease, the vaccine needs therefore to be handled, stored and administered by veterinary professionals, to ensure adherence to correct administration protocols in order to protect animal and human health, in line with the best international standards for preventive medical care.  In addition, the record of  horse vaccination is entered into a central database which can be used to used by veterinarians to check the horse's current vaccination status.

No vaccinated horses have ever contracted Hendra virus, whilst 20 laboratory confirmed HeV infections in horses have occurred in Queensland and NSW since vaccine release in November 2012.

The vaccine is the single most effective way of reducing the risk of Hendra virus infection and provides a work health and safety as well as a public health benefit and there is a high level of confidence in the vaccine held by veterinarians and by both Queensland and NSW State Governments and the Australian Government through the Animal Health Committee. This has been evidenced in outbreak situations since the vaccine became available.

From 2013-2015 there were seven horse deaths in NSW. Of the seven NSW properties affected there were 19 horses in contact with the HeV positive cases which had not been vaccinated. These 19 in contact with horses were then vaccinated and subsequently did not become infected. In an outbreak in Queensland on the Atherton Tablelands in July 2015 where one horse died from HeV, there were also six vaccinated horses and three unvaccinated horses on a property. These six vaccinated horses were regarded by QDAF’s Biosecurity Queensland as “low interest” horses and subsequently released early from quarantine in line with national Animal Health Committee policy.  

 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: May 27 2018 at 4:33am
Let's hope so, Carbon.  I think the research stands a better chance of being persued than in the past, because, for once, people actually seem to be paying attention*.    It makes a nice change. 

Quite a bit of research goes on in India these days as well.  They seem to be rather good at it despite the country's poverty.  Brains will out!  -  Upon which note, they seem to be taking a very proactive approach too**.


*Officials: Deadly Nipah virus has not spread in south India

May 25, 2018, 9:20 AM  http://uk.businessinsider.com/ap-officials-deadly-nipah-virus-has-not-spread-in-south-india-2018-5
and

No Trace Of Nipah Virus In Himachal Pradesh, No Need To Panic: Officer

 Updated: May 27, 2018 05:48 IST  https://www.ndtv.com/india-news/nipah-virus-no-trace-of-nipah-virus-in-himachal-pradesh-no-need-to-panic-bk-aggarwal-1858141


**Bihar government issues Nipah virus alert

The government has issued an alert of Nipah virus (NiV) in view of its outbreak in Kerala that has claimed 10 lives and created panic.   http://www.newindianexpress.com/nation/2018/may/26/bihar-government-issues-nipah-virus-alert-1819789.html


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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: May 28 2018 at 3:58am
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WORLD NEWS
29/05/2018 13:57 BST

Nipah Virus Outbreak: Death Toll Rises In India As Brain-Damaging Disease Spreads

As the rare virus claims more lives in the Indian state of Kerala, concerns have been raised about the potential of Nipah to become a global health emergency.

As health workers in India scramble to contain an ongoing outbreak of Nipah, a rare and deadly virus with no known cure, concerns have been raised about the disease’s potential to become the next global health emergency.

At least 13 people in the Indian state of Kerala have died from the Nipah virus in the recent outbreak. On Monday, The Hindu newspaper reported that a patient with Nipah-like symptoms was under observation in a hospital in Goa, a state in western India. If diagnosed with the disease, the patient — reportedly a 20-year-old man who’d traveled to Goa from Kerala — could be the first case of Nipah infection outside Kerala since the recent outbreak began earlier this month.

The Nipah virus, which was first identified in 1999 after an outbreak in Malaysia and Singapore, is a disease thought to be transmitted by bats, pigs or other animals to humans. The virus, which has a mortality rate of up to 70 percent, can cause encephalitis, or inflammation of the brain, as well as severe respiratory symptoms, according to the World Health Organization. There is currently no cure or vaccine for Nipah, though research into a possible vaccine is reportedly underway.

As health workers in India scramble to contain an ongoing outbreak of Nipah, a rare and deadly virus with no known cure, concerns have been raised about the disease’s potential to become the next global health emergency.

At least 13 people in the Indian state of Kerala have died from the Nipah virus in the recent outbreak. On Monday, The Hindu newspaper reported that a patient with Nipah-like symptoms was under observation in a hospital in Goa, a state in western India. If diagnosed with the disease, the patient — reportedly a 20-year-old man who’d traveled to Goa from Kerala — could be the first case of Nipah infection outside Kerala since the recent outbreak began earlier this month.

The Nipah virus, which was first identified in 1999 after an outbreak in Malaysia and Singapore, is a disease thought to be transmitted by bats, pigs or other animals to humans. The virus, which has a mortality rate of up to 70 percent, can cause encephalitis, or inflammation of the brain, as well as severe respiratory symptoms, according to the World Health Organization. There is currently no cure or vaccine for Nipah, though research into a possible vaccine is reportedly underway.

The Nipah virus was listed this year on the WHO’s priority list of emerging diseases that could cause a global health emergency. Ebola and Zika were also on the 2018 list, which the WHO said identifies diseases that “pose a public health risk because of their epidemic potential and for which there are no, or insufficient, countermeasures.”

Stanford epidemiologist and Nipah expert Stephen Luby said recently that Nipah could conceivably become a “global pandemic threat” if there emerged a strain of the disease that could efficiently be transmitted from person to person. 

“It is conceivable that there is currently a strain of Nipah virus circulating among bats that, if it infected people, would efficiently transmit from person to person,” Luby told the Stanford Report, though noting that “so far, we have not identified such a strain.”

“Characteristics that might increase the risk of person-to-person transmission would be a virus that has a stronger tendency to move to the respiratory tract in high numbers,” he said. “It is conceivable that the virus could acquire a mutation that would enhance this capacity. One concern is that anytime a virus infects a human, it is in an environment that selects for survival in that context.”

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Albert Quote  Post ReplyReply Direct Link To This Post Posted: May 30 2018 at 5:46am
Are these people getting infected solely from bats or do we have limited person-to-person infections?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: May 30 2018 at 5:49am
Your guess is as good as mine, Boss.  I suspet the health workers were h2h and the initial cases were zoonotic.  After that, who knows?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: May 30 2018 at 3:10pm
i just wonder how it got to India when the last cases were in Maylasia,so my guess is limited H2H ,and there has probably been more cases but put down to other  viruses,IE......
  • The infection was first identified in 1999 during an outbreak of encephalitis and respiratory illness among pig farmers and people with close contact with pigs in Malaysia and Singapore,
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KOZHIKODE:  Another person died of Nipah virus in Kerala's Kozhikode taking the death toll to 14.

Madhusudhanan, 55, of Nellikode in Kozhikode district died tonight, according to health department sources.

He was undergoing treatment at a private hospital, they said, adding that Madhusudhanan had tested positive of the virus.
The number of confirmed Nipah virus cases has risen to 17 with the National Institute of Virology, Pune, finding its presence in the blood sample of a 28-year-old person from Karassery, the sources said.

 

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15 now.

Nipah Virus Claims 2 More Lives In Kerala's Kozhikode; 15 Deaths Till Now

Two more people have died in Kerala of Nipah virus

All India | Reported by | Updated: May 31, 2018 09:06 IST

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Albert Quote  Post ReplyReply Direct Link To This Post Posted: May 31 2018 at 5:55am
Limited human spread by close contact is not good.
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Last Updated : May 31, 2018 06:52 PM IST | Source: Moneycontrol.com

Bangladesh strain of Nipah virus responsible for outbreak in Kerala, death toll reaches to 15

First identification of Nipah virus as a cause of an outbreak of encephalitis was reported in 2001 in Meherpur district of Bangladesh.


AND

Efforts are also underway to procure the cell line which Australia used to develop the antibody. Once ICMR gets the cell line, India can start manufacturing it.

Thursday, May 31, 2018 - 20:15


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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: May 31 2018 at 2:52pm
I would say that its something to do with  Hendra virus , ( see my earlier post) that Australia has flown in ,

must be getting people worried.............
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Nipah Deaths In Kerala Rise To 16, Minister Warns Of Second Outbreak

The staff, including nurses and four doctors of the hospital where the two patients died in the last two days, has been asked to go on leave for a week as a precautionary measure

Kerala | Reported by , Edited by | Updated: June 01, 2018 18:48 IST

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Post Options Post Options   Thanks (0) Thanks(0)   Quote EdwinSm, Quote  Post ReplyReply Direct Link To This Post Posted: June 01 2018 at 10:42pm
With nurses and doctors going on leave, this could create a situation where the lack of medical staff could cause other non-Nipah deaths as fewer people could be treated at hospitals.


It is this knock-on effect that worries me about pandemics, or disasters Such as estimates of over 4 000 deaths in Puerto Rico from the hurricane instead of the 82 'officially related' deaths.  About 1/3rd of the deaths are attributed to people not getting medical care they needed.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: June 02 2018 at 3:38am
the hospital staff "going on leave" is a bit worry.........
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ICMR may soon be able to neutralise the effects of Nipah virus using anti-body developed in Australia; death toll rises to 16

The Indian Council for Medical Research (ICMR) may soon be able to neutralise the effects of the Nipah Virus which has killed 16 people in Kerala.

The ICMR had earlier reached out to the the University of Queensland, Australia, which has developed an antibody to combat and 'neutralise' the virus. The antibody was expected to reach India on Thursday.

"The Human Monoclonal Antibody (M 102.4) is a non-patented drug, developed by Dr Christopher C Broder from Australia. The antibody is still referred by a number and not a name as clinical trials are yet to be completed. This is an antibody and not a vaccine, which can neutralise the effects of the Nipah Virus," says The News Minute.

The antibody has not been tested on humans so far.

"We have asked them to give their monoclonal antibody for conducting a test in India to find out if it can neutralise the Nipah virus in humans. In Australia, it has only been tried in vitro (happening outside the body in artificial conditions, often in a test tube) and has been found to be effective. But it has not been tested on humans," Dr Balram Bhargava, ICMR Director General, said while clarifying that it will not lead to creation of vaccine

ICMR is the apex body in India for the formulation, coordination and promotion of biomedical research. "We are preparing a dossier on what will be methodology and what would be the regulatory process so that we can fast track the process," he said.

"Efforts are also underway to procure the cell line which Australia had used to develop the antibody. Once the ICMR gets the cell line, India can start manufacturing the antibodies," The News Minute reported.

According to Dr Bhargava, Australia is ready to share as it will help generate data on the efficacy of the antibody. "It is not yet sure how much it will be effective," he said, adding the infection caused by Nipah virus has a high mortality rate (50-70 percent).

According to National Vector Borne Disease Control Programme, a drug named ribavirin has been shown to be effective against the viruses in vitro, but human investigations to date have been inconclusive and the clinical usefulness of the drug remains uncertain.

The death toll due to outbreak of Nipah virus rose to 16 in Kerala, with one more person succumbing to the deadly virus in Kozhikode on Thursday morning, reports said.

Meanwhile, there are reports of dead bats being found on the premises of a government school in Himachal Pradesh, samples of which have been sent for testing to NIV, Pune, to ascertain the reason behind their deaths

Nipah virus (NiV) infection is a newly emerging zoonosis that causes severe disease in both animals and humans. The natural host of the virus are fruit bats of the Pteropodidae Family, Pteropus genus. Currently, there is no vaccine or drug for the treatment of the NIV infection. The treatment for human cases is supportive and management treatment along with intensive supportive care

The virus spreads through close contact with people's secretions and excretions. Eating food which may have the droplets of saliva and urine of infected bats can lead to the transmission of the virus. Earlier, cases of Nipah virus were reported from Siliguri in 2001 and Nadia in 2007 in the eastern state of West Bengal and around 47 deaths were reported.

With inputs from PTI


Updated Date: Jun 01, 2018 13:44 PM


Source:   https://www.firstpost.com/india/icmr-may-soon-be-able-to-neutralise-the-effects-of-nipah-virus-using-anti-body-developed-in-australia-death-toll-rises-to-16-4490979.html

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The Kerala Health Department said that apart from the 18 positive cases of Nipah virus, no new cases were reported on Monday.

Tuesday, June 05, 2018 - 11:17

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Nipah death toll rises to 16, but end of outbreak might be near

Updated 1336 GMT (2136 HKT) June 5, 2018

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