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Is Tamiflu Effective Against H1N1?

Printed From: Avian Flu Talk
Category: Main Forums
Forum Name: General Discussion
Forum Description: (General discussion regarding the next pandemic)
URL: http://www.avianflutalk.com/forum_posts.asp?TID=30548
Printed Date: April 27 2024 at 3:00am


Topic: Is Tamiflu Effective Against H1N1?
Posted By: Guests
Subject: Is Tamiflu Effective Against H1N1?
Date Posted: December 28 2013 at 7:48pm
Ok you guys that are experts is Tamiflu effective against H1N1? I am not seeing anything on this subject.


Replies:
Posted By: Medclinician2013
Date Posted: December 28 2013 at 11:03pm
http://www.webmd.com/cold-and-flu/news/20090707/tamiflu-resistant-swine-flu-in-us%20 - http://www.webmd.com/cold-and-flu/news/20090707/tamiflu-resistant-swine-flu-in-us

This was in 2009. H1N1 was already developing resistance.

July 7, 2009 -- Is http://www.webmd.com/drugs/mono-5294-OSELTAMIVIR+-+ORAL.aspx?drugid=17765&drugname=tamiflu+oral - Tamiflu -resistant http://www.webmd.com/cold-and-flu/swine-flu/default.htm - swine flu spreading in the U.S.?

A 16-year-old girl traveling from San Francisco was found to be infected with Tamiflu-resistant swine http://www.webmd.com/cold-and-flu/default.htm - flu after triggering a temperature-monitoring device in the Hong Kong airport. That has set off a West Coast search for others who might be carrying the drug-resistant virus.

http://www.cbsnews.com/news/tamiflu-resistant-h1n1-cluster-reported/ - http://www.cbsnews.com/news/tamiflu-resistant-h1n1-cluster-reported/

March 2013


http://www.theguardian.com/world/2013/mar/18/swine-flu-resistant-tamiflu-scientists - http://www.theguardian.com/world/2013/mar/18/swine-flu-resistant-tamiflu-scientists

Increasing numbers of cases of http://www.theguardian.com/world/swine-flu - swine flu are being detected that are resistant to Tamiflu, the drug the UK and rest of the world stockpiled to fight a pandemic, according to scientists calling for greater global monitoring.

Even more worryingly, these strains of flu are appearing in patients who have never been treated with the drug, which means the strains are able to pass from one human to another.

Tamiflu, generic name oseltamivir, is one of the few treatments available for pandemic swine flu, although it is thought to be of limited effectiveness. The reluctance of the manufacturer Roche to release all the trial data has made it difficult to ascertain how limited. Nonetheless the drug can save lives if used early in the course of the illness.

Resistance to the drug has been shown before, but the new Australian data on its steady growth and the apparently easy transfer from one person to another of Tamiflu-resistant flu strains will alarm public health experts.

http://www.bloomberg.com/news/2013-03-18/tamiflu-resistance-in-2-of-h1n1-flu-cases-globally-study-finds.html - http://www.bloomberg.com/news/2013-03-18/tamiflu-resistance-in-2-of-h1n1-flu-cases-globally-study-finds.html

http://www.bloomberg.com/news/2013-03-18/tamiflu-resistance-in-2-of-h1n1-flu-cases-globally-study-finds.html - Tamiflu-resistant swine flu is turning up in about 2 percent of cases globally, researchers in http://topics.bloomberg.com/australia/ - Australia found, raising the risk that http://www.bloomberg.com/quote/ROG:VX - Roche Holding AG (ROG) ’s pill may become ineffective in fighting the pandemic H1N1 virus.

Shades of never speaking the name of Moses (Ten Commandments) Henry N. is still alive and beating the bushes with his recombo stuff.

This is interesting though...

The CDC released a series of H1N1 sequences, which were largely from the first three weeks of November. Included were two sequences with H274Y, which correlates with the two Tamiflu resistance cases announce in the week 47 FluView. One of these sequences, A/Louisiana/13/2013 is closely related to the three earlier resistant sequences from Louisiana (A/Louisiana/07/2013, A/Louisiana/08/2013, A/Louisiana/10/2013), which signA cluster of seven people infected with a Tamiflu-resistant strain of pandemic H1N1 influenza has been identified by researchers in Vietnam and reported in the New England Journal of Medicine.

comment: Interesting question. It appears there might be a greater resistance than is currently known and this topic definitely merits more research.

Med


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Medclinician - not if but when - original

Posted By: Guests
Date Posted: December 29 2013 at 4:37pm
Thanks Med, I will use my Tamiflu if I get it or my son gets it! Better than nothing!

Posted By: Guests
Date Posted: December 29 2013 at 5:41pm
Tamiflu is almost useless. 98% of influenza A/H1N1 in North America is resistant to Tamiflu. They still give it to patients as it has a mild effect

Relenza is the go. Its made to combat H1 and specifically H274Y. 

Funny thing is Tamiflu was originally made for H2/H9 but was also found to be useful on H1. It had the strange effect of rearranging the virus to fit the drug. Gotta get lucky sometimes.

I have Relenza stockpiled. Its expensive a hell, but i see it as an insurance policy. You should also stockpile Tamiflu as its still effective against H2 and H9.

Relenza a very unusual drug. Its a pill which is inserted into an inhaler devise. Its similar to the newer asthma inhalers. This delivery method gets the drug deep into the lungs where its most effective. Its akin to inhaling a tea spoon of talcum powder.

Posted By: Guests
Date Posted: December 31 2013 at 6:45pm
cobber how did you get the Relenza? I have to get a script from my doc for the Tamiflu and that is not easy.

Posted By: Johnray1
Date Posted: December 31 2013 at 7:02pm
FluMom,change doctors. Johnray1

Posted By: Guests
Date Posted: January 02 2014 at 4:48am
Tell your doctor you are flying to Asia and are concerned about birdflu. That's what i did. (i actually went)

Your doctors really shouldn't limit your access to drugs if you make a reasonable request. Just tell them you have an emergency kit and want certain supplies. Most doctors i know love dealing out the drugs.

If they are cool with that then also hit em up for antibiotics too. ;)

Posted By: Guests
Date Posted: January 02 2014 at 4:50am
PS: Some doctors are wankers and will lecture you. Pissthem off and find a new doctor.

Posted By: jacksdad
Date Posted: January 02 2014 at 6:52am
FluMom - Relenza is prescription only but it is still believed to be effective against H1N1 whereas widespread resistance to Tamiflu is starting to show up.


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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.

Posted By: Guests
Date Posted: February 26 2014 at 9:22am
Though I received the seasonal flu vaccine, I was infected with H1N1 in November. It was within 48 hours of my initial symptoms and the urgent care physician prescribed Tamiflu. It had no discernible effect and I was quite ill for two weeks. I just recently acquired Type B and was prescribed Tamiflu. This time, I recovered within a few days and my overall symptoms were minimal.

Posted By: Kilt2
Date Posted: February 26 2014 at 5:04pm
Tamiflu and Relenza are Neuraminidase inhibitors.

The death rate (RoM) with those in hospitals with H5N1 and H7N9 would be a lot higher without them.

They help - they are not a magic bullet.

The virus will mutate around them.


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And I looked, and behold a pale horse: and his name that sat on him was Death, and Hell followed with him.


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