Ok..who's first?? Any takers?
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Category: Main Forums
Forum Name: General Discussion
Forum Description: (General discussion regarding the next pandemic)
URL: http://www.avianflutalk.com/forum_posts.asp?TID=31857
Printed Date: April 16 2024 at 2:56pm
Topic: Ok..who's first?? Any takers?
Posted By: coyote
Subject: Ok..who's first?? Any takers?
Date Posted: August 29 2014 at 3:04am
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Ebola vaccine to be tested on British volunteers next month Volunteers in Oxford will be given an experimental vaccine against Ebola in fast-tracked emergency clinical trials to begin in September, it has been announced. At the same time that trials are beginning at Oxford University, up to 10,000 doses will be made to ensure that it can be more widely used quickly if the trials are successful. Initially 60 volunteers will be injected with the vaccine at the Jenner Institute at the University of Oxford and if they show a good immune response with few side effects then a further 40 volunteers will be given the vaccine in Gambia. [link to www.telegraph.co.uk] ------------- Long time lurker since day one to Member. |
Replies:
Posted By: Albert
Date Posted: August 29 2014 at 3:10am
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They need to test it on the folk in Africa. Seems to me they don't have many other choices anyway. Ebola is still mutating and I don't believe they can find a match on it yet. The perfect little killing machine bug. ------------- https://www.facebook.com/Avianflutalk |
Posted By: onefluover
Date Posted: August 29 2014 at 6:49am
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I will "second" that. ------------- "And then there were none." |
Posted By: KiwiMum
Date Posted: August 29 2014 at 3:33pm
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How exactly are they going to test it? Are they going to give it to someone and then give them Ebola and see what happens? I can't believe anyone would sign up to that program! ------------- Those who got it wrong, for whatever reason, may feel defensive and retrench into a position that doesn’t accord with the facts. |
Posted By: Elver
Date Posted: August 29 2014 at 4:23pm
| I want to know if this vaccine is full of live virus or not. |
Posted By: Guests
Date Posted: August 30 2014 at 3:23pm
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They vaccinate with an essential Ebola protein not live or attenuated virus, and 3 weeks later check for protective antibody levels in the serum. They don't give people challenges with Ebola. They have already done animal studies using it. They have to give it to healthy people first. If people who are Ill get it then symptoms can be confused with side effects. Don't think they are testing its safety so much ( it is a basic vaccine recipe ). Think they are more concerned about its antigenicity and hence its effectiveness, seeing if it will generate a good enough response to offer protection. Quote : Results from studies in monkeys suggest a good safety profile from the single ebola virus protein, which produced high levels of antibodies and immune-boosting white blood cells. As it does not contain infectious virus material, it cannot cause a person who is vaccinated to become infected with ebola. The duration of response could only be discovered in ‘real-life’ situations but even if it only lasted a few months it would be enough to contain outbreaks, he said Read more: http://www.dailymail.co.uk/health/article-2736932/Ebola-vaccine-discovered-British-scientists-available-end-year.html#ixzz3BuszBleb Follow us: @MailOnline on Twitter | DailyMail on Facebook |
Posted By: Guests
Date Posted: August 30 2014 at 4:20pm
| I just read an article via Breitbart concerning the mutations in West AfricaThe article is by Awr Hawkins,and the link goes to NPR.It's frankly terrifying. I don't see how an effective vaccine can be made with these rapid mutations.Call me foolish ignorant or whatever, I just don't see and thing useful outcome. |
Posted By: anon54
Date Posted: August 30 2014 at 4:39pm
That should be any productive outcome from vaccine trials,sorry my bad |
anon54 wrote:Posted By: Guests
Date Posted: August 30 2014 at 6:16pm
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Not all parts of the viral genome mutated at the same rate. RNA viruses like Ebola tend to be inherently less stable than say DNA viruses. So you expect changes,especially due to the number of hosts it has passed through, selective pressures etc. However here is the good news, it is whether those changes actually count in the grand scheme. There are many regions depending on their sequences that will stay pretty conserved, stable sequences. The vaccine manufacturers know to look for these sequences and the proteins they relate to. These tend to be in dominant epitope, I.e. pretty stable protein, required for viral entry or replication, and globally immunogenic. So vaccine wise there is some still hope. |
Posted By: Guests
Date Posted: August 30 2014 at 7:23pm
| Thank you for clarifying that Hazelpad.You are right about hope. Can't give that up. |