Researchers note multiple reassortments in H5N6 avian flu viruses in Japan
Japanese investigators report that five distinct reassortants of H5N6 highly pathogenic avian influenza virus (HPAIV) affected Japanese poultry and wild birds last winter.
In a study in Virology, the researchers analyzed 89 H5N6 viruses belonging to clade 2.3.4.4 obtained from birds. In testing neuraminidase genes, they found three distinct PA genes and two NS genes that originated from distinct H5N6 viruses from China.
The authors conclude, "Japanese H5N6 HPAIVs were generated from an ancestral H5N6 virus, presumably an H5N6 HPAIV that circulated in China, through several reassortment events with other H5N6 HPAIVs or 3 different lineages of AIVs (or both)." They add that their findings highlight the importance of active surveillance.
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