To date, illness in tigers due to H5N1 infection is of the same severity as that in the H5N1 virus in cats ( http://www.cdc.gov/ncidod/EID/vol11no05/05-0007.htm#1 - 6 ). The serosanguinous nasal discharge seen in the sick tigers before death is likely due to severe thrombocytopenia. Results of laboratory findings, except liver enzyme levels, for the sick tigers were similar to the findings reported earlier in the pediatric cases ( http://www.cdc.gov/ncidod/EID/vol11no05/05-0007.htm#1 - 7 ). Positive staining for the NP protein of influenza A in the nuclei of the hepatocytes might indicate that a heavy virus load had passed through the digestive tract after the infected chicken carcasses were eaten, affecting the liver, particularly the hepatocytes, and possibly causing hepatic failure. Unlike results derived from experiments with cynomolgus monkeys ( http://www.cdc.gov/ncidod/EID/vol11no05/05-0007.htm#1 - 8 ), we were able to demonstrate H5N1 viral antigen in several organs of the infected tigers. The evidence of nonsuppurative encephalitis shown in the previous study ( http://www.cdc.gov/ncidod/EID/vol11no05/05-0007.htm#1 - 2 ) confirmed the involvement of H5N1 virus, as was apparent by using immunohistochemical procedures. H5N1 infection in tigers can induce neurologic signs and encephalitis similar to that observed in other mammals ( http://www.cdc.gov/ncidod/EID/vol11no05/05-0007.htm#1 - 9 ). Neurotropism of the H5N1 virus in mice as part of the pathogenesis subsequent to infection by human influenza virus isolates has been reported ( http://www.cdc.gov/ncidod/EID/vol11no05/05-0007.htm#1 - 10 ). Further studies will be required to elucidate the pathogenesis of the H5N1 virus in felines
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