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Not a Recommendation but an Explanation

Printed From: Avian Flu Talk
Category: Pandemic Prepping Forums
Forum Name: Medical Intervention & Prevention
Forum Description: (Medical interventions & natural remedies for potential pandemic causing viruses)
URL: http://www.avianflutalk.com/forum_posts.asp?TID=819
Printed Date: May 01 2024 at 10:38pm


Topic: Not a Recommendation but an Explanation
Posted By: Guests
Subject: Not a Recommendation but an Explanation
Date Posted: January 23 2006 at 9:31pm

I am not recommending this to anyone but this is why I have Curcumin in my Pandemic Flu Stash.

As we all should know by now H5N1 appears to produce a "Cytokine Storm".  In my language that means the body turns on its immune system balls-to-the-wall and ends up literally killing what it is trying to save.  I am going to post a PubMed description of a cytokine storm.  Stay with me because the particulars (the bits) are important.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8940690&dopt=Abstract - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&a mp;db=PubMed&list_uids=8940690&dopt=Abstract

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[Cytokine storm in the pathogenesis of multiple organ dysfunction syndrome associated with surgical insults]

[Article in Japanese]

Aikawa N.

Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan.

Multiple organ dysfunction syndrome (MODS) is a critical condition developing in the patients under overwhelming surgical insults such as a major surgery, severe trauma, extensive burn, and systemic sepsis. The host response to those surgical insults is the main pathogenetic factor contributing to the development of shock and MODS seen in surgical patients. The proinflammatory cytokines, TNF-alpha (TNF) and interleukin-1 beta (IL-1), are known to play a pivotal role in the pathogenetic mechanisms of MODS. In response to surgical insults, macrophages produce and release TNF and IL-1 which subsequently induce the production of other cytokines (IL-6, IL-8, etc.) and other endogenous chemical mediators (growth factors, adhesion molecules, complement cleavage products, thrombin, eicosanoids, PAF, nitric oxides, oxygen-free radicals, granulocyte elastase, etc.) The resultant systemic inflammation may develop into shock and MODS when the primary insults are overwhelming (early MODS) or a second inflammatory insult such as sepsis triggers an exaggerated inflammation. In the patients suffering from MODS, a systemic release of various cytokines is not properly regulated, and the high blood levels of the proinflammatory cytokines induce an autodestructive generalized inflammatory reaction. This condition is termed "Cytokine Storm" by the author. In the cytokine storm, not only proinflammatory cytokines but also anti-inflammatory cytokines are elevated in the blood stream. With the recent understanding of the biological and pathological roles of cytokines and other mediators, a new therapeutic strategy has been developed. In addition to the reduction of the surgical insults, a variety of anti-cytokine therapy and anti-mediator therapy has been tested in an attempt to prevent or treat the life-threatening MODS.

Publication Types:
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PMID: 8940690 [PubMed - indexed for MEDLINE]

Now for the benefits of Curcumin:

https://enzy.com/abstracts/display.asp?id=1961 - https://enzy.com/abstracts/display.asp?id=1961

Medical Abstract Title:

Curcumin Inhibition of Inflammatory Cytokine Production by Human Peripheral Blood Monocytes and Alveolar Macrophages
 

Author:

Abe Y, Hashimoto S, Horie T
 

Source:

Pharmacol Res. 1999;39:41-47.
 

Abstract:

Curcumin, a dietary pigment responsible for the yellow colour of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects such as anti-inflammatory activity. The mechanism in anti-inflammatory activity of curcumin has been investigated; however, little is known about the effect of curcumin on cytokine production by human peripheral blood monocytes and alveolar macrophages. In the present study, we shed light on the effect of curcumin on inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. To this end, we determined the concentrations of interleukin-8 (IL-8), monocyte inflammatory protein-1(MIP-1alpha), monocyte chemotactic protein-1 (MCP-1), interleukin-1beta (IL-1beta), and tumour necrosis factor-alpha (TNF-alpha) in the culture supernatants from phorbor ester, 4beta phorbor 12beta-myristate-13alpha acetate (PMA)- or lipo-polysaccharide (LPS)-stimulated monocytes and alveolar macrophages in the presence or absence of curcumin. Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner. These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar (lung stuff*sz) macrophages.

Now, remember I ain't recommending this for you or yours.  I expect you to trust in our medical community to be there, in full faith and force, if you find yourself in the terrible, beyond imagining, position of being exposed to or infected with Avian Influenza and not having a ready and handy stash of Tamiflu, the only recognized and medically sanctioned drug therapy for Avian Influenza. 


Replies:
Posted By: Rocky
Date Posted: January 24 2006 at 3:54pm
Hi Sophie,
Can you venture to guess how much curcumin would be appropriate for
someone exhibiting signs of avian flu?


Thanks. Rocky

-------------
Prepare for the Unexpected!
Rocky http://www.homeemergencyusa.com - http://www.homeemergencyusa.com

Posted By: Guests
Date Posted: January 24 2006 at 4:13pm

There's the rub!  Since it hasn't been tested as a treatment for H5N1 there is NO recommended amount to take.  It's one big SWAG and that's one of the things the medical community finds so offensive about these alternative therapies.

I should have also mentioned that I only buy curcumin with peperine in it.  This facilitates the absorption of the curcumin, without it most of the curcumin passes right through your system without being absorbed.

Posted By: bruss01
Date Posted: January 26 2006 at 11:00am

SophiaZoe - Wow, thanks for that!  My wife has used curcumin as an anti-inflamatory before, with good results, but I never translated that into it being effective against BF.  Thank you Thank you THANK YOU!.

Also thanks for the head's up on peperine.  I know there are some herbals that are poor in absorbtion unless they have help, St. John's Wort being among them.


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