Click to Translate to English Click to Translate to French  Click to Translate to Spanish  Click to Translate to German  Click to Translate to Italian  Click to Translate to Japanese  Click to Translate to Chinese Simplified  Click to Translate to Korean  Click to Translate to Arabic  Click to Translate to Russian  Click to Translate to Portuguese


Forum Home Forum Home > General Discussion > General Discussion
  New Posts New Posts RSS Feed - Vaccine improvement for RSV
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Online Discussion: Tracking new emerging diseases and the next pandemic; Now tracking the Aussie Flu.

Vaccine improvement for RSV

 Post Reply Post Reply
Author
Message
Technophobe View Drop Down
Senior Moderator
Senior Moderator
Avatar

Joined: January 16 2014
Location: Scotland
Status: Offline
Points: 31550
Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Topic: Vaccine improvement for RSV
    Posted: October 23 2017 at 8:37am
The vaccine for Respiratory Synctal Virus produced unacceptable levels of 'bad reactions' in children.  A solution has been found.  

Virus-like Particle Vaccine Protects Against RSV Vaccine-Enhanced Respiratory Disease, Study Finds

OCTOBER 23, 2017

Doctor pediatrician injecting vaccine to cute young girl
Media Contact
LaTina Emerson

Public Relations Coordinator 
Georgia State University

404-413-1353
lemerson1@gsu.edu

ATLANTA—Researchers have discovered that a virus-like particle vaccine can prime the body’s immune response and prevent the severe respiratory disease that results when patients given an early form of a vaccine for respiratory syncytial virus (RSV) are exposed to RSV, according to a study led by Georgia State University.

This study offers a solution to the formalin inactivated respiratory syncytial virus (FI-RSV) vaccine that did not protect children, but rather caused severe respiratory illness, vaccine-enhanced respiratory disease (ERD), after infection with RSV.

The researchers found immunizing mice with virus-like particles containing RSV fusion proteins before administering the FI-RSV vaccine and exposing mice to RSV prevented FI-RSV vaccine-enhanced lung inflammation and the invasion of eosinophils, which are disease-fighting white blood cells. The study’s findings are published in the journal Virology.

ERD that results from FI-RSV vaccination has led to hospitalization in 80 percent of patients and the deaths of two children. It is characterized by mucus production in the airways, severe lung inflammation, immune responses by T helper type 2 (Th2) cells and infiltrations of eosinophils into the lining of the respiratory tract.

RSV, the original disease that scientists were working to prevent, is a common respiratory virus that causes mild, cold-like symptoms, but it can be serious for infants and older adults. It is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children under one year of age in the United States. RSV is also a major cause of respiratory illness in older adults, according to the Centers for Disease Control and Prevention.

“This study provides insight into mechanisms responsible for ERD caused by FI-RSV vaccination and developing safe RSV vaccines,” said Dr. Sang-Moo Kang, lead author and professor in the Institute for Biomedical Sciences at Georgia State. “We demonstrated that priming mice with virus-like particles that present RSV fusion proteins shifted immune response and resulted in preventing ERD. A vaccine that primes protective innate and adaptive immune responses that prevent ERD still remains to be developed, but our findings could pave the way to creating a safe vaccine with these capabilities.”

The researchers used control mice and two groups of mice that were immunized in different ways. The immunized mice received one of two primers before receiving the FI-RSV boost vaccine. One group of mice was primed with the FI-RSV vaccine and then given the FI-RSV boost. Another group was first primed with vaccine-like particles containing RSV fusion proteins and then given the FI-RSV boost. Blood samples were collected at three weeks after these immunizations.

After 15 weeks, the control mice and mice from the two immunization groups were infected with RSV to determine the efficacy of protection against RSV and assess ERD. Body weight changes were monitored, bronchoalveolar lavage fluids were collected for viral titers and lung tissue was obtained for histology and cellular analysis.

Co-authors of the study include Drs. Young-Tae Lee, Ki-Hye Kim, Eun-Ju Ko and Young-Man Kwon, Ph.D. student Youri Lee of Georgia State and Dr. Hye Suk Hwang of both Georgia State and Chonnam National University Medical School in the Republic of Korea.

The study is funded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health.

Featured Researcher

sangmoo3-300x300

Sang-Moo Kang
Professor
Center for Inflammation Immunity and Infection

Sang-Moo Kang, professor at Georgia State University, is focused on research to design and develop effective vaccines against viral diseases such as influenza virus and respiratory syncytial virus, to better understand vaccine-induced protective immune mechanisms, to study pathogen-induced inflammation and to develop anti-inflammatory therapeutics.


Source:   http://news.gsu.edu/2017/10/23/virus-like-particle-vaccine-protects-rsv-vaccine-enhanced-respiratory-disease-study-finds/

Absence of proof is not proof of absence.
Back to Top
 Post Reply Post Reply
  Share Topic   

Forum Jump Forum Permissions View Drop Down