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Online Discussion: Tracking new emerging diseases and the next pandemic; Now tracking the Aussie Flu.

Zikavirus and Guillain-Barré-Syndrom

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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Topic: Zikavirus and Guillain-BarrĂ©-Syndrom
    Posted: February 09 2016 at 6:03am
http://time.com/4209612/zika-guillain-barre-syndrome-cdc/

The Brazil Ministry of Health has reported higher than normal cases of GBS, which kicked off the investigation. Some experts knew that amid a Zika outbreak, they should be on the lookout for GBS. Dr. James Sejvar, a neuroepidemiologist at the CDC, told TIME in an interview that back in 2013, the CDC and other public health groups like the World Health Organization started hearing reports of Zika in the South Pacific. In French Polynesia, Sevjar said, clinicians were also seeing an uptick in GBS cases.

The findings are still preliminary, but so far, Sejvar said researchers have observed an interesting pattern. Typically, the incidence of GBS increases with age. While the disorder is rare on its own, it’s especially rare among people in their 20’s and 30’s and is more common among people in their 60’s and 70’s. But what experts are seeing is unusual. “One thing that has struck us is the cases have tended to be disproportionally young and relatively healthy,” Sejvar said. “We are seeing quite a few 20, 30, 40 year olds who are otherwise healthy.”

In addition, the cases appear particularly severe. “Over time people often get better, but one thing that we have noticed is that even among otherwise healthy people, six months later they are still having neurological problems,” Sejvar said. “Some can’t go to work or need help with daily activities. That’s something we found peculiar.”

Que sera, sera, Whatever will be, will be, The future is not ours to see, Que sera, sera !
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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: February 09 2016 at 6:08am
Or is GBS related to pesticides used against the mosquitoes ? 

http://www.ncbi.nlm.nih.gov/pubmed/16599005

2004 Nov;59(11):575-80.

Guillain-Barre syndrome in a rural farming district in South Africa: a possible relationship to environmental organophosphate exposure.

Abstract

Although organophosphate (OP) insecticides have been recognized as having neuropathic potential, a relationship with Guillain-Barre syndrome (GBS) has not been previously confirmed. A cluster of 7 cases of GBS was noted over an 11-yr period in an isolated farming region in the Northern Cape Province of South Africa, an area subject to intensive aerial application of OP insecticides. Observed cases were more than 4 times higher than expected based on a Poisson probability distribution. Four cases were clustered in an area where the topography showed a marked hollow, and where spray drift of aerial OP insecticides was anticipated. The rate of GBS in this subcluster was more than 14 times higher than expected. The authors explored the hypothesis that aerial OP insecticide application was related to the raised incidence of GBS in this area and made suggestions for future research.

Que sera, sera, Whatever will be, will be, The future is not ours to see, Que sera, sera !
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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: February 09 2016 at 6:12am
In the former Dutch colony Surinam the last two months four people died who were infected with the zika-virus. The were all male 58-76, had other illnes (diabetes) that may have worsened. The Paramaribo University Hospital is still doing research with people from Erasmus University from Rotterdam.

In the Netherlands there are over 20 (imported) Zika-cases.
Que sera, sera, Whatever will be, will be, The future is not ours to see, Que sera, sera !
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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: February 21 2016 at 3:28am
http://www.who.int/emergencies/zika-virus/situation-report/19-february-2016/en/

Six countries/territories (Brazil, French Polynesia, El Salvador, Venezuela, Colombia and
Suriname) have reported an increase in the incidence of cases of microcephaly and/or
Guillain-Barré syndrome (GBS) following a Zika virus outbreak. Microcephaly has so far
been reported only from Brazil and French Polynesia. Puerto Rico and Martinique have
also reported cases of GBS associated with Zika virus infection, but without evidence of
an overall increase in the incidence of GBS.
 Evidence that neurological disorders, including microcephaly and GBS, are linked to Zika
virus infection remains circumstantial, but a growing body of clinical and epidemiological
data points towards a causal role for Zika virus.
Que sera, sera, Whatever will be, will be, The future is not ours to see, Que sera, sera !
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EdwinSm, View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote EdwinSm, Quote  Post ReplyReply Direct Link To This Post Posted: February 29 2016 at 9:59pm
They predict there could be one case of Guillain-Barré among every 4,000 people falling ill with Zika

Originally posted by BBC BBC wrote:

New research gives the first evidence that Zika virus might cause a severe neurological disorder called Guillain-Barré syndrome.

The study was carried out using blood samples from 42 patients who became ill in a previous outbreak.

The Lancet authors say they developed the neurological problems around six days after Zika infection.

Leading scientists described the study as "compelling".

....

Researchers analysed the blood of patients who developed the disorder during a Zika outbreak in French Polynesia in the Pacific two years ago.

From this work, they predict there could be one case of Guillain-Barré among every 4,000 people falling ill with Zika.

The lead author Professor Arnaud Fontanet, from the Institut Pasteur in Paris, said: "These patients tended to deteriorate more rapidly than we usually see with Guillain-Barré.

"But once they were over the acute phase of the illness, their recovery tended to be better."

None of the 42 patients died but some still needed help walking, several months after they became ill.

....

Dr Jeremy Farrar, director of the Wellcome Trust, said: "This study provides the most compelling evidence to date of a causative link between Zika and Guillain-Barré syndrome."


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