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Now tracking the new emerging South Africa Omicron Variant

2 common OTC drugs reduce covid replication by 99%

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    Posted: December 13 2021 at 6:52pm

Two Common Over-the-Counter Compounds Reduce COVID-19 Virus Replication by 99% in Early Testing

A pair of over-the-counter compounds has been found in preliminary tests to inhibit the virus that causes COVID-19University of Florida Health researchers have found.

The combination includes diphenhydramine, an antihistamine used for allergy symptoms. When paired with lactoferrin, a protein found in cow and human milk, the compounds were found to hinder the SARS-CoV-2 virus during tests in monkey cells and human lung cells.


The findings by David A. Ostrov, Ph.D., an immunologist and associate professor in the UF College of Medicine’s department of pathology, immunology and laboratory medicine and his colleagues, are published in the journal Pathogens.

“We found out why certain drugs are active against the virus that causes COVID-19. Then, we found an antiviral combination that can be effective, economical, and has a long history of safety,” Ostrov said.

Due to his earlier research with colleagues at UF, Ostrov already knew diphenhydramine was potentially effective against the SARS-CoV-2 virus. The latest discovery has its roots in a routine meeting of scientists with the Global Virus Network’s COVID-19 task force. One researcher presented unpublished data on federally approved compounds that inhibit SARS-CoV-2 activity, including lactoferrin.

Like diphenhydramine, lactoferrin is available without a prescription. Ostrov thought about pairing it with diphenhydramine and ran with the idea. In lab tests on human and monkey cells, the combination was particularly potent: Individually, the two compounds each inhibited SARS-CoV-2 virus replication by about 30%. Together, they reduced virus replication by 99%.

https://scitechdaily.com/two-common-over-the-counter-compounds-reduce-covid-19-virus-replication-by-99-in-early-testing/

"Facts don't care about your feelings" I'M A UNVAXXED DEVIL so kiss my rebel ass.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 7:15pm
Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

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Post Options Post Options   Thanks (0) Thanks(0)   Quote A-I Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 8:03pm

Originally posted by carbon20 carbon20 wrote:

University of Florida....???

Bunch of liar's......


https://www.usatoday.com/story/news/education/2021/12/13/university-florida-investigation-covid-data/6492538001/

Somehow that's all you got out of the article huh. Figures. Is your life really that bad that you have to be negative about something that possibly has the potential to be a positive for everyone?


"Facts don't care about your feelings" I'M A UNVAXXED DEVIL so kiss my rebel ass.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 9:13pm

(carbon20 What is wrong with you ???) [url]https://en.wikipedia.org/wiki/Fluticasone_propionate[/url] or https://en.wikipedia.org/wiki/Fluticasone_propionate is protecting against (severe CoViD0-a Belgian study shows. 

Could not find a link in English so google translate had a job;

Some nasal sprays for asthma, sinusitis and respiratory allergies also protect against corona. Researchers at UZ Leuven have discovered that these sprays prevent the virus from entering the body and making the patient sick. They could therefore also provide extra protection for people with risk contacts.

Doctors feared that people with asthma, chronic sinusitis and respiratory allergies would be the first corona victims. But the opposite turned out to be true, they became just less sick. And this thanks to a component in their daily steroid nasal spray: namely fluticasone propionate. Researchers at UZ Leuven have discovered why.

“On the one hand, because the mucous membrane offers more resistance to the virus, so that the virus can penetrate less well. And, on the other hand, also due to the reduced presence of molecules to which the virus can bind”, says Peter Hellings, professor of nose, throat and ear diseases at UZ Leuven.


DJ There may be lots of effective medications limiting risks (either getting infected or limiting infection) but we may need to link medication with CoViD (and the correct group of patients). 

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 9:23pm

Vaccines are good enough for me,

No  need snake oil  remedies here



I very rarely read anything you post AI.....

Take care all 😷😉💉


Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

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Post Options Post Options   Thanks (0) Thanks(0)   Quote A-I Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 9:38pm

"Facts don't care about your feelings" I'M A UNVAXXED DEVIL so kiss my rebel ass.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 9:41pm






Why would anyone read anything from a Florida University that's under investigation for fraud....

Your the clown.....

Take care all 😷😉💉

Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 9:59pm

A-I, carbon20...we are in a very serious crisis, with all respect please stick to info !

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (1) Thanks(1)   Quote A-I Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 10:30pm

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells



1
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
2
Department of Geography, University of Florida College of Liberal Arts and Sciences, Gainesville, FL 32611, USA
3
Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
4
Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
5
Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
6
Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada
7
Cancer Research Department, Saskatchewan Cancer Agency, Saskatoon, SK S7N 5E5, Canada
8
Department of Medicinal Chemistry, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
9
Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
10
Translational Drug Development Core, University of Florida Clinical and Translational Sciences Institute, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Lawrence S. Young
Pathogens 2021, 10(11), 1514; https://doi.org/10.3390/pathogens10111514
Received: 14 October 2021 / Revised: 10 November 2021 / Accepted: 17 November 2021 / Published: 20 November 2021

Abstract

(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interactions with non-structural SARS-CoV-2 proteins present in the replication complex. (2) Methods: In this work, highly specific sigma receptor ligands were investigated for their ability to inhibit both SARS-CoV-2 genome replication and virus induced cellular toxicity. This study found antiviral activity associated with agonism of the sigma-1 receptor (e.g., SA4503), ligation of the sigma-2 receptor (e.g., CM398), and a combination of the two pathways (e.g., AZ66). (3) Results: Intermolecular contacts between these ligands and sigma receptors were identified by structural modeling. (4) Conclusions: Sigma receptor ligands and drugs with off-target sigma receptor binding characteristics were effective at inhibiting SARS-CoV-2 infection in primate and human cells, representing a potential therapeutic avenue for COVID-19 prevention and treatment.

Full study link.

https://www.mdpi.com/2076-0817/10/11/1514/htm

What's additionally interesting is the potential for this therapeutic for prevention and treatment of ALL variants.



"Facts don't care about your feelings" I'M A UNVAXXED DEVIL so kiss my rebel ass.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 11:29pm






I'm not in a serious situation,it's hunky dory here in WA,no covid,no lockdown,no masks mandates....

It's all a powderpuff......

Lol.....

I still say vaccines are the way out ,not snake oil remedies.....

Seems ai ,who is totally against vaccines ,will jump onto any ,sudoscience,

To justify not taking a vaccine,

 governments all over the world are imploring people to take,

Why would I listen to or read something from someone who is so anti Vax.......??


Or from a university that's under investigation for fraud ?.....

Nah I'm no clown......

Take care all 😷😉💉


Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
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Post Options Post Options   Thanks (0) Thanks(0)   Quote A-I Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 11:36pm

Originally posted by carbon20 carbon20 wrote:

I'm not in a serious situation,it's hunky dory here in WA,no covid,no lockdown,no masks mandates....

It's all a powderpuff......

Lol.....

I still say vaccines are the way out ,not snake oil remedies.....

Seems ai ,who is totally against vaccines ,will jump onto any ,sudoscience,

To justify not taking a vaccine,

 governments all over the world are imploring people to take,

Why would I listen to or read something from someone who is so anti Vax.......??


Or from a university that's under investigation for fraud ?.....

Nah I'm no clown......

Take care all 😷😉💉


Careful Carbon your intelligence level is showing. Here's a novel idea for you, if you don't like what I post then stay off the threads I post and don't post on them. All it takes is self control. Something else I seriously think you lack. 

"Facts don't care about your feelings" I'M A UNVAXXED DEVIL so kiss my rebel ass.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: December 13 2021 at 11:51pm

DJ, I do welcome news/info on treatments that limit infection/disease. 

Bickering and insults do damage (to) this forum. Stop it !!!

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Littlesmile Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 5:53am

Good find, thank you AI :-)

Antihistamine would 'calm' the immune system so that actually makes sense. 

My daughter has celiac and say she accidentally eats wheat. If we are quick enough with antihistamine her symptoms are greatly reduced.

Obviously I wouldn't use it alone lol but I think it might help.

:-)
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Post Options Post Options   Thanks (1) Thanks(1)   Quote ViQueen24 Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 7:48am

I (who am double-vaxxed and due in Jan/Feb to be boosted) think that if I were to contract Covid, I would want all available tools to be utilized to lessen its impact/save my life, or address whatever condition I was in.

Here are some studies going on into repurposing some common meds for off-label use to address Covid:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713548/

https://www.nih.gov/research-training/medical-research-initiatives/activ/covid-19-therapeutics-prioritized-testing-clinical-trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354566/

If the science supports the safety/effectiveness, and I trusted the doctor who was treating me, I would take any of these treatments.  Diphenhydramine and Fluticasone are already a part of my toolkit for allergies/asthma, and it may interest some that Fluticasone has been used to treat some forms of lymphoma.

I am the DZ Queen, and I approve this message.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiminNM Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 11:26am

Originally posted by ViQueen24 ViQueen24 wrote:

I (who am double-vaxxed and due in Jan/Feb to be boosted) think that if I were to contract Covid, I would want all available tools to be utilized to lessen its impact/save my life, or address whatever condition I was in.

Here are some studies going on into repurposing some common meds for off-label use to address Covid:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713548/

https://www.nih.gov/research-training/medical-research-initiatives/activ/covid-19-therapeutics-prioritized-testing-clinical-trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354566/

If the science supports the safety/effectiveness, and I trusted the doctor who was treating me, I would take any of these treatments.  Diphenhydramine and Fluticasone are already a part of my toolkit for allergies/asthma, and it may interest some that Fluticasone has been used to treat some forms of lymphoma.



Thank you! I take Fluticasone for asthma and allergies (both inhaled oral and sinus) and I take diphenhydramine every 4 hours for allergies. I will take every tiny possible advantage I can get!

 


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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 1:13pm

Originally posted by A-I A-I wrote:

Originally posted by carbon20 carbon20 wrote:

I'm not in a serious situation,it's hunky dory here in WA,no covid,no lockdown,no masks mandates....

It's all a powderpuff......

Lol.....

I still say vaccines are the way out ,not snake oil remedies.....

Seems ai ,who is totally against vaccines ,will jump onto any ,sudoscience,

To justify not taking a vaccine,

 governments all over the world are imploring people to take,

Why would I listen to or read something from someone who is so anti Vax.......??


Or from a university that's under investigation for fraud ?.....

Nah I'm no clown......

Take care all 😷😉💉


Careful Carbon your intelligence level is showing. Here's a novel idea for you, if you don't like what I post then stay off the threads I post and don't post on them. All it takes is self control. Something else I seriously think you lack. 

Why should I....????

You don't ... Your quick enough to rubbish/belittle someone's post.......

Your quick to put up juvenile pictures makinge out me to be a clown or lacking intelligence ,how old are you 5yrs? 

You need to grow up.....

Practice what you preach.......

Lmao ......

Take care all 😷😉💉

PS .

DNA ..... SMALLPOX....



Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
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Post Options Post Options   Thanks (0) Thanks(0)   Quote A-I Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 2:38pm

Originally posted by carbon20 carbon20 wrote:

Originally posted by A-I A-I wrote:

Originally posted by carbon20 carbon20 wrote:

I'm not in a serious situation,it's hunky dory here in WA,no covid,no lockdown,no masks mandates....

It's all a powderpuff......

Lol.....

I still say vaccines are the way out ,not snake oil remedies.....

Seems ai ,who is totally against vaccines ,will jump onto any ,sudoscience,

To justify not taking a vaccine,

 governments all over the world are imploring people to take,

Why would I listen to or read something from someone who is so anti Vax.......??


Or from a university that's under investigation for fraud ?.....

Nah I'm no clown......

Take care all 😷😉💉


Careful Carbon your intelligence level is showing. Here's a novel idea for you, if you don't like what I post then stay off the threads I post and don't post on them. All it takes is self control. Something else I seriously think you lack. 

Why should I....????

You don't ... Your quick enough to rubbish/belittle someone's post.......

Your quick to put up juvenile pictures makinge out me to be a clown or lacking intelligence ,how old are you 5yrs? 

You need to grow up.....

Practice what you preach.......

Lmao ......

Take care all 😷😉💉

PS .

DNA ..... SMALLPOX....



Carbon have you ever heard of the term "low hanging fruit"? I think you show the forum your intelligence level as well as your level of negativity quite well all on your own. There is no need for me to pick your abundant low hanging fruit.

"Facts don't care about your feelings" I'M A UNVAXXED DEVIL so kiss my rebel ass.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote A-I Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 4:09pm

Imagine if this study leads to a 99% effective, economical preventive and treatment of covid which has the added benefit of a long history of the components being safe. Think Sudafed type like for a cold.  Covid would be knocked out in short order. I think it's a very positive thing and a promising study and bears watching further developments.

"Facts don't care about your feelings" I'M A UNVAXXED DEVIL so kiss my rebel ass.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiwiMum Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 4:28pm

I had a conversation a few years ago with our GP who told me that many medicines had well known secondary uses. She was prescribing a cream for a rash one of my children had and told me that this cream was the best on the market for burns. So now I make a point of asking what the alternative uses for them are. I've kept all our old medications, just in case.

"Once you've decided that something's absolutely true, you've closed your mind on it, and a closed mind doesn't go anywhere. Question everything. That's what education's all about." ~ David Eddings
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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiminNM Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 4:33pm

Originally posted by KiwiMum KiwiMum wrote:

I had a conversation a few years ago with our GP who told me that many medicines had well known secondary uses. She was prescribing a cream for a rash one of my children had and told me that this cream was the best on the market for burns. So now I make a point of asking what the alternative uses for them are. I've kept all our old medications, just in case.


Smart question to ask!! 

I also keep all my old medicines, and all my cats old medications, just in case.  

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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiwiMum Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 5:26pm

Originally posted by KiminNM KiminNM wrote:

Originally posted by KiwiMum KiwiMum wrote:

I had a conversation a few years ago with our GP who told me that many medicines had well known secondary uses. She was prescribing a cream for a rash one of my children had and told me that this cream was the best on the market for burns. So now I make a point of asking what the alternative uses for them are. I've kept all our old medications, just in case.


Smart question to ask!!

I also keep all my old medicines, and all my cats old medications, just in case.  

Ha ha. I have 2 large shoeboxes in my cold room full of old cat, dog and chicken medications and a third one full of syringes and needles of all kinds right up to huge cattle beast needles. I keep them all just in case.

"Once you've decided that something's absolutely true, you've closed your mind on it, and a closed mind doesn't go anywhere. Question everything. That's what education's all about." ~ David Eddings
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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiminNM Quote  Post ReplyReply Direct Link To This Post Posted: December 14 2021 at 5:37pm

Originally posted by KiwiMum KiwiMum wrote:

Originally posted by KiminNM KiminNM wrote:

Originally posted by KiwiMum KiwiMum wrote:

I had a conversation a few years ago with our GP who told me that many medicines had well known secondary uses. She was prescribing a cream for a rash one of my children had and told me that this cream was the best on the market for burns. So now I make a point of asking what the alternative uses for them are. I've kept all our old medications, just in case.


Smart question to ask!!

I also keep all my old medicines, and all my cats old medications, just in case.  

Ha ha. I have 2 large shoeboxes in my cold room full of old cat, dog and chicken medications and a third one full of syringes and needles of all kinds right up to huge cattle beast needles. I keep them all just in case.


Yes! I have the needles and syringes too.  It's come in handy more than once... 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Littlesmile Quote  Post ReplyReply Direct Link To This Post Posted: December 15 2021 at 1:44am

ViQueen thank you for links. Very interesting... And I agree with others that most medicines can have many uses :-)


*I am double  vaccinated too but have never been one to rely on something fully. 

:-)
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