Tracking the next pandemic: Avian Flu Talk |
Immunity? |
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BeachMama
V.I.P. Member Joined: January 25 2020 Location: Southwest US Status: Offline Points: 3080 |
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Posted: June 21 2020 at 6:02pm |
Excellent article. Thanks so much for sharing this. My mom was just talking about how she had seen something the other day regarding the fact that immunity to this virus was in question after contracting it — I’m glad I’ll be able to share this with her. |
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Tabitha111
Adviser Group Joined: January 11 2020 Location: Virginia Status: Offline Points: 11640 |
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Regarding "Immunity Passports" Thu 18 Jun 2020 Source: Newsweek https://www.newsweek.com/coronavirus-antibodies-lost-10-wuhan-study-patients-within-21-days-1511850 Chinese scientists have cast doubt over whether we have long-lasting immunity to the coronavirus in 2 studies released this week, prompting them to question the use of immunity certificates. [...] According to the scientists, the around 10% of COVID-19 patients in their pre-print study who didn't have antibodies 21 days after their symptoms started likely "lost" them after they recovered. In contrast, patients with severe acute respiratory syndrome (SARS) have been known to carry antibodies for up to 210 days, the researcher said. [...] They said, "Very few healthcare providers had IgG [virus-specific] antibodies to SARS-CoV-2 [the COVID-19 coronavirus], though a significant proportion of them had been infected with the virus. After SARS-CoV-2 infection, people are unlikely to produce long-lasting protective antibodies against this virus." [...] Symptomatic patients had significantly higher levels of virus-specific antibodies than the asymptomatic during the period when the virus could still be detected in their respiratory tracts. Eight weeks after the patients were discharged from hospitals, 81% of asymptomatic patients saw levels of their neutralizing antibodies drop compared with 62% of symptomatic patients. [...] Echoing their concerns, the medRxiv researchers said, "As infected people do not develop long-lasting protecting antibodies against SARS-CoV-2, the idea of immune certificate for recovered COVID-19 patients is invalid." Weak immune response in asymptomatic cases Date: Fri 19 Jun 2020 Source: Genetic Engineering & Biotechnology News Asymptomatic COVID-19 Cases May Have Weaker Immune Responses [...] ...other infections remain asymptomatic. Neither the clinical features nor the immune responses of asymptomatic cases have been well described. [...] . Now, a small study performed by a group from Chongqing Medical University in Chongqing, China, found that people who fail to develop COVID-19 symptoms may have a weaker immune response to the virus. They also found that people's antibody response to SARS-CoV-2 may diminish rapidly after infection, which may have implications for the interpretation of negative serological results. [...] Of the 37 asymptomatic patients -- identified in a group of 178 people with SARS-CoV-2 infection -- 22 were female and 15 were male, with ages ranging from 8-75 years (median age, 41 years). The authors found that these patients had a significantly longer duration of viral shedding, with median duration of viral shedding of 19 days, compared with 14 days in a group of 37 symptomatic patients. Levels of virus-specific IgG antibodies were significantly lower in the asymptomatic group than in the symptomatic group during the acute phase of infection, when the virus could be detected in the respiratory tract. Eight weeks after the patients were discharged from the hospital, antibody levels were measured. Of asymptomatic individuals, 93.3% and 81.1% had a reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% and 62.2% of symptomatic patients. In addition, asymptomatic patients had lower levels of 18 pro- and anti-inflammatory cytokines. The authors suggest that this indicates that the asymptomatic patients may have had a weaker immune response to SARS-CoV-2 infection. The authors also observed that IgG levels began to diminish within 2-3 months of infection in a large proportion of the asymptomatic patients [...] They argue that this finding, along with previous analyses of neutralizing antibodies in patients recovering from COVID-19, highlights the potential risks of using "immunity passports" and supports the continuation of public-health interventions and widespread testing. [,,,] |
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