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ksc
Adviser Group Joined: February 09 2020 Status: Offline Points: 10995 |
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Posted: January 01 2021 at 6:22am |
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CRS, DrPH
Expert Level Adviser Joined: January 20 2014 Location: Arizona Status: Offline Points: 26660 |
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Thanks, a very helpful compilation! I've mostly been focused upon the mRNA vaccine technology, as this could be a broad platform for many/all RNA viruses, even HIV-AIDS! I'm also glad to see that some (China) are using inactivated virus for vaccines - I could see a combination approach being especially potent (inactivated virus plus mRNA). https://www.nytimes.com/interactive/2020/health/sinovac-covid-19-vaccine.html |
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CRS, DrPH
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Dutch Josh
Adviser Group Joined: May 01 2013 Location: Arnhem-Netherla Status: Online Points: 94017 |
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Cuba, Iran, India are also developing vaccines...over 100 initiatives. As far as I know (and my knowledge on vaccines is very limited) three stategies ? -mRNA (Pfizer, Moderna)-expensive, needs cold (-70C) storage/transport -Adeno virus (AstraZeneca/Oxford, Sputnik-5) cheap, easy storage/transport (fridge) -dead virus parts Vaccinations are not risk-free (as a sort of preventitive intervention). During this-worsening-pandemic it would be good to know; -What vaccine is most effective -What are the side effects (also long term) DJ-Using an adeno-virus-part to create immunity is an old strategy. Practical-since deep-freeze transport also takes much room and costs-my guess is the aden-viruspart vaccines will become the major form of vaccination. (In transport terms 1000 Pfizer vaccines in room may take as much place as 100.000 AstraZeneca-vaccins and the costs for deep-freeze transport, risks of vaccines getting "to hot" may make the logistic-costs for 1000 Pfizer vaccines the same as over 1.000.000 Astra Zeneca vaccines (??) It also would be very welcome to improve communications on vaccines...one of the reasons most developed countries see people getting on average over 80 (in stead of 40 till 1900) may be in vaccinations... |
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We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein |
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Dutch Josh
Adviser Group Joined: May 01 2013 Location: Arnhem-Netherla Status: Online Points: 94017 |
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Will vaccines get mandatory ? DJ-Maybe for some jobs in healthcare ? With-for the moment-not enough vaccines to vaccinate those who DO want to get vaccinated there should be little point in making vaccinations mandatory. Even a registration of vaccines, who did get what vaccine when-has to deal with privacy...There most likely will be legal fights on who has what rights on that kind of information... Countries may ask if people that want to get into a country did have vaccinations. They already ask for a.o. Yellow Fever. The US did not allow people being HIV+ into the country for some years.. But since tourism is a major economic activity in many countries I think a lot of countries will accept proof-of-negative testing (last 48/72 hrs) or test at the airport. Vaccination does not rule out getting infected, spreading the virus..People even may get very ill, die from Covid19 if they were infected just before getting vaccinated or in the first days after vaccination..So recent testing (and what kind of test) may be more usefull then proof of vaccination. Also certificates as proof of vaccination needs an international standard (I can write a certificate claiming someone tested negative, did get vaccinated-has no value but if there is no international policy it could work..). Countries now making laws that transport-companies have to ask their passengers for proof of vaccination/negative testing. That kind of laws may face legal steps-rules. On what legal basis can a private transport company (or (internet) travel agency) ask that kind of information ? How long may they save that info ? Who can see that info ? What are the consequences of misuse ? For now international travel should simply stop ! At this moment any travel is virus-variant transport-so stop that ! |
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We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein |
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ksc
Adviser Group Joined: February 09 2020 Status: Offline Points: 10995 |
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Spain will register people who refuse Covid vaccine, says health ministerDatabase could be shared across Europe, says Salvador Illa |
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Dutch Josh
Adviser Group Joined: May 01 2013 Location: Arnhem-Netherla Status: Online Points: 94017 |
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In India [url]https://en.wikipedia.org/wiki/Bharat_Biotech[/url] or https://en.wikipedia.org/wiki/Bharat_Biotech vaccines will be part of a vaccination campain starting the coming week India also will use the AstraZeneca/Oxford vaccine. On [url]https://www.bharatbiotech.com/covaxin.html[/url] or https://www.bharatbiotech.com/covaxin.html ; (from wikipedia) In September 2020, the company announced that it was going to manufacture the novel chimp-adenovirus, a single dose intranasal vaccine for COVID-19 being developed in collaboration with the Washington University School of Medicine in St Louis, Missouri. It is currently under clinical trials. DJ-That would be a new way to give a covid-vaccine... [url]https://www.bbc.com/news/world-asia-india-55520658[/url] or https://www.bbc.com/news/world-asia-india-55520658 ; India has formally approved the emergency use of two coronavirus vaccines as it prepares for one of the world's biggest inoculation drives. The drugs regulatory authority gave the green light to the jabs developed by AstraZeneca with Oxford University and by local firm Bharat Biotech. - India plans to inoculate some 300 million people on a priority list this year. It has recorded the second-highest number of infections in the world, with more than 10.3 million confirmed cases to date. Nearly 150,000 people have died. On Saturday India held nationwide drills to prepare more than 90,000 health care workers to administer vaccines across the country, which has a population of 1.3 billion people. DJ-The real number of infections in India must be in the tens of millions. Variants could "destroy" India (etc) one only can hope massive vaccination may limit the damage...The AZ/O vaccine will be produced in Pune-50 million doses per month, BharatBiotech will produce 100 million doses per mont in Hyderabad. The Bharat vaccine is based on inactivated virus [url]https://en.wikipedia.org/wiki/BBV152[/url] or https://en.wikipedia.org/wiki/BBV152 (=Covaxin) Both vaccines may offer a lot of protection (after a few days) after first vaccination-a second vaccination can wait up to 12 weeks...giving room for a lot of vaccination. With 150 million vaccines produced in India per month and over 90.000 people to do the vaccination a lot of work can be done... |
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We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein |
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AndyPOW
V.I.P. Member Joined: December 31 2020 Status: Offline Points: 675 |
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I'm curious why the Moderna and Pfizer vaccines need to be stored at -70C and -20C when it is possible to store RNA vaccines at 4C? https://www.future-science.com/doi/10.2144/000112593 "The results of this study provide support for the future potential of RNA vaccines. Using the disaccharide sugar, trehalose, as a stabilizing agent, DNA-free and protein-free RNA, stored for 10 months at 4°C, retained its function. As many of the viruses for which new vaccines are urgently required are transmitted by arthropod vectors in tropical countries (31), our novel findings will allow RNA vaccines to be considered as a viable option, even in developing countries where the cold chain may be restricted to 4°C." |
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"Every thing looks great, until you think." Dr. Al Bartlett
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Dutch Josh
Adviser Group Joined: May 01 2013 Location: Arnhem-Netherla Status: Online Points: 94017 |
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DJ- With Pakistan going for the single shot (!!!!!) Chinese CanSino adeno-5 vaccine it would be good if western media/interner had more info then this december 21 news item [url]https://www.reuters.com/article/us-health-coronavirus-vaccine-cansinobio-idUSKBN28V1N8[/url] or https://www.reuters.com/article/us-health-coronavirus-vaccine-cansinobio-idUSKBN28V1N8 ; The candidate, known as Ad5-nCoV or Convidecia, which CanSinoBIO is jointly developing with a research institute backed by the Chinese military, is among the five vaccines China has moved into Phase 3 clinical trials to test their efficacy. - Phase 3 trials for CanSinoBIO's candidate, which are planned to involve 40,000 participants in total, have begun enrolling participants in Pakistan, Russia, Mexico and Chile, the latest clinical trial registration data showed. bit.ly/3mHzt8R The candidate also has trials lined up in Argentina, and has secured a supply deal with Mexico. The one-dose vaccine had been given to about 40,000-50,000 people in emergency use since it obtained approval to be used in military personnel in June, CanSinoBIO Chief Executive Yu Xuefeng said in an industrial event on Nov. 28. DJ From China Global Television Network CGTN; [url]https://news.cgtn.com/news/2020-12-10/Mexico-to-buy-35-million-doses-of-China-s-CanSino-COVID-19-vaccine-W6uyiFBPAk/index.html[/url] or https://news.cgtn.com/news/2020-12-10/Mexico-to-buy-35-million-doses-of-China-s-CanSino-COVID-19-vaccine-W6uyiFBPAk/index.html (december 10) In China Covid19 is becoming something of a "dark recent past" while for most of the world it is still making headlines. In China vaccination campains are on their way...partly to be able to restart tourism, make more economic growth... |
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We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein |
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