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PANDEMIC ALERT LEVEL
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Tracking the next pandemic: Avian Flu Talk

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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: October 05 2022 at 10:18pm

DJ, part 1...

Is the OPEC-production cut of 2% linked to the pandemics ? YES !!! It will worsen the pandemic ! Here in NL latest inflation number was 17,1% (year-to-year) so healthcare, consumers, did see their income drop in a major way...It will mean hospitals have less money to spent; decrease of healthcare capacity with an increase-due to the pandemics-of healthcare demand = more serious illness, more (excess) deaths...

There are (by now lots of) stories Ukraine going for a "dirty bomb false flag"...this will increase number of refugees...further escalation of wars is more wounded...In the Ukraine-war a lot of those wounded go to western European hospitals...Refugees are often "not in the best of health"...transport diseases (but still need the best available care !)...More wounded from wars is less healthcare capacity with pandemics getting worse...

Like in wars there are "statisticians" calculating (the best they can) what the effect is of "developments"...Policy can use the info to increase/decrease healthcare capacity..Here in NL we did see a spread of CoViD patients being restarted to get more capacity for new CoViD-hospital cases...We are still in "low numbers" for hospital/ICU but preparing for a worsening that is expected...

Statistics [url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table were supposed to give us info on how the pandemic is developing... Europe-in these statistics-are the only region with an increase of cases...very limited +0,7%...

One of the remarks one can make is the regions being used; Asia has more the half the global population...Oceania just over 0,5%...but still-it can provide some indications..Another aspect most countries stopped daily updates...so the statistics are "eroded"...

Still 68 countries do report an increase of cases...Europe may-again-be a starter for a winterwave...In this worldometers-list UK cases -90%...[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time has UK-self reporting cases-now over 2,5 million...early september it was around 1,5 million...

So...the use of worldometers as even indicator for what the pandemic is doing is "limited" at best...

-From the big picture to the virus;

[url]https://www.coronaheadsup.com/asia/china/china-xinjiang-covid-epidemic-most-difficult-major-public-health-emergency-in-local-history/[/url] or https://www.coronaheadsup.com/asia/china/china-xinjiang-covid-epidemic-most-difficult-major-public-health-emergency-in-local-history/ ;

China’s daily newspaper, the Global Times, is giving prominent coverage today to the ongoing Covid outbreak in Xinjiang, headlining it as the “most difficult major public health emergency in local history”.

The current round of epidemic prevention and control work in Xinjiang has not achieved the goal of “dynamic zero-COVID” for two months not only due to the reasons of strong infectiousness, fast transmission and short incubation period of the Omicron BA.5.2 variant, but also because of some loopholes in the anti-epidemic work.

In a strongly worded article, the Global Times also quotes a local official saying “nucleic acid testing has become the biggest weakness” in Xinjiang.

-

This is, by far, the most critical article on the response to Covid-19 that we have seen in the Chinese press since the beginning of the pandemic. Its tone probably reflects Chinese frustration at the enormous amount of time and effort that has been expended on controlling the virus so far, with seemingly little to show in return.

The question for China, though, is what is the alternative to continuing to try and control the virus?

In response to nearly three years of the pandemic, western capitalist societies have become increasingly relaxed about the value of human life.  The “herd immunity” and “living with Covid” policies have utterly destroyed the initial sense of solidarity built up between ordinary people who were fighting a common enemy. Mitigations and testing have been largely abandoned, millions have died, tens of millions have been disabled, and the functioning of economies and the making of profits remain the top priorities for western leaders.

Living with Covid has been a catastrophe as far as containing the pandemic is concerned. The hands-off approach to Covid-19 has also left weakened populations at risk of new variants, and diseases such as polio, monkeypox, cholera and perhaps even ebola.  Some of these new threats will be far more pathogenic than anything we have had to deal with so far.

To let the virus simply rip in China, as we have seen in the US and Europe, will endanger the lives of tens of millions of people. Is that something that the Chinese leadership are willing to contemplate? We hope not.

The fight against Covid is an existential fight for mankind. There is no living with Covid. There is only dying with Covid.

 

Global TImes: Xinjiang region’s latest epidemic becomes most difficult major public health emergency in local history

DJ...China worldometers cases +1% (1497 this week, 1479 last week) ...Xinjang has an Uyghur-muslim population...I think the statement on "zero CoViD' on "living with CoViD=dying from CoViD" represents more or less my view...

STOP THE SPREAD !!! The alternative we now face is an out of control worst-ever healthcrisis worldwide...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: October 05 2022 at 2:28am

part 4...lots of-bad-news...

DJ-Let me start with the EU...In World War Two Italy managed to be in war with both the allies AND Germany...A major risk for Europe could be we end up-still-in conflict with Russia...but also "not very happy" with what the US is doing...

When you look at the history of Argentina, Lebanon...once very rich countries now in crisis for the last decades...Europe could end up in such a-bad-scenario if there is not "more wisdom",,,

-I was looking for more flu-info [url]https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/960006-study-influenza-a-h6n6-viruses-isolated-from-chickens-replicate-in-mice-and-human-lungs-without-prior-adaptation[/url] or https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/960006-study-influenza-a-h6n6-viruses-isolated-from-chickens-replicate-in-mice-and-human-lungs-without-prior-adaptation ;

When we talk about avian flu viruses with zoonotic (or even pandemic) potential, the various incarnations of H5N1 first come to mind, followed perhaps by China's H7N9 virus. Between them they have caused thousands of infections and hundreds of deaths during the 21st century, but reports of both have declined sharply in recent years.


H5N6, also from China, continues to worry researchers, with 80 cases reported on the Mainland since 2014 (see map below) and a high fatality rate (40%-50%).

LPAI H9N2 has caused roughly 100 known infections (and undoubtedly many more undiagnosed), primarily is Asia, but generally produces mild to moderate illness. To that we can add sporadic human infections by H10Nx and H7N4 viruses in China, H7N2 (infecting cats and humans in NYC), and this year, China reported the first two known infections by avian H3N8 (see IJID: A Review Of The Pandemic Potential Of Avian H3N8).


There are a lot of novel avian flu viruses with zoonotic potential (that, along with swine variant viruses), could spark the next global health crisis.

Including H6 viruses, which don't get a lot of attention, but are common in both wild birds globally and in domesticated poultry in China, and have demonstrated the ability to jump species (to humans, to pigs, and to dogs) as well. Some past blogs include:

But since H6 viruses only rarely produce clinical illness in poultry, and are not legally reportable to the OIE (now WOAH), we are only rarely aware of their presence, or of the potential threat they may pose.


Two years ago, in Nature: Evolution & Pathogenicity of H6 Avian Influenza Viruses, Southern China 2011-2017we looked at study on the evolution of H6 viruses in China, and their growing adaptation to mammalian physiology.


Today we have another study published in the Journal of Virus Eradication, which warns that H6N6 viruses continue to evolve, and are becoming better adapted to human physiology, and that their threat to human health may be increasing.

DJ..more info in the link...see also [url]https://afludiary.blogspot.com/2022/10/study-influenza-h6n6-viruses-isolated.html[/url] or https://afludiary.blogspot.com/2022/10/study-influenza-h6n6-viruses-isolated.html 

-[url]https://www.wormsandgermsblog.com/2022/10/articles/animals/dogs/domestic-animal-monkeypox-surveillance-uk/[/url] or https://www.wormsandgermsblog.com/2022/10/articles/animals/dogs/domestic-animal-monkeypox-surveillance-uk/

The big thing this study suggests is that serious infection with monkeypox virus in pets is unlikely. It doesn’t prove it can’t happen, since the numbers are relatively small, but it shows that transmission to pets and subsequent serious disease is probably uncommon, if it occurs at all.  That’s useful information.

It’s still just one step on our path to understanding more about the potential for human-to-animal (and human-to-animal-back-to-human) transmission, as well the range of species that are susceptible to monkeypox.

DJ, the study did not look for asymptomatic spread...may have missed lots of info-but at least it is a start...

-[url]https://www.thailandmedical.news/news/breaking-chinese-researchers-warn-that-new-sars-cov-2-recombinant-variant-xbb-is-the-most-immune-evasive-strain-that-is-comparable-to-the-sars-cov-1-s[/url] or https://www.thailandmedical.news/news/breaking-chinese-researchers-warn-that-new-sars-cov-2-recombinant-variant-xbb-is-the-most-immune-evasive-strain-that-is-comparable-to-the-sars-cov-1-s train..."Omicron" is seeing a lot of mutations...DJ-I think labs may NOT be able to do all the sequencing that is needed...

Exponential growth will result now in lots of CoViD (sub)variants able to evade immunity and coinfect...

Mixed with the "flu-potential" it is becoming more and more a nightmare scenario...

-[url]https://www.thailandmedical.news/news/breaking-u-s-nih-study-warns-of-potetial-human-outbreak-of-a-new-primate-hemorrhagic-fever-causing-arterivirus-from-africa-that-is-far-worse-than-hiv[/url] or https://www.thailandmedical.news/news/breaking-u-s-nih-study-warns-of-potetial-human-outbreak-of-a-new-primate-hemorrhagic-fever-causing-arterivirus-from-africa-that-is-far-worse-than-hiv ;link [url]https://www.cell.com/cell/fulltext/S0092-8674(22)01194-1[/url] or https://www.cell.com/cell/fulltext/S0092-8674(22)01194-1 ;

Highlights

  • SHFV uses an intracellular receptor, CD163, for cellular entry
  • CD163 divergence in primates of some species poses a barrier to SHFV entry
  • All cellular proteins required for SHFV replication are functional in human cells
  • SHFV replication in human cells suggests potential for zoonotic transmission

Summary

Simian arteriviruses are endemic in some African primates and can cause fatal hemorrhagic fevers when they cross into primate hosts of new species. We find that CD163 acts as an intracellular receptor for simian hemorrhagic fever virus (SHFV; a simian arterivirus), a rare mode of virus entry that is shared with other hemorrhagic fever-causing viruses (e.g., Ebola and Lassa viruses). Further, SHFV enters and replicates in human monocytes, indicating full functionality of all of the human cellular proteins required for viral replication. Thus, simian arteriviruses in nature may not require major adaptations to the human host. Given that at least three distinct simian arteriviruses have caused fatal infections in captive macaques after host-switching, and that humans are immunologically naive to this family of viruses, development of serology tests for human surveillance should be a priority.

DJ...see also latest news-new pandemic (Kiwimum had a good link...) [url]https://en.wikipedia.org/wiki/Deltaarterivirus_hemfev[/url] or https://en.wikipedia.org/wiki/Deltaarterivirus_hemfev ;

Deltaarterivirus hemfev

From Wikipedia, the free encyclopedia
(Redirected from Shfv)

Jump to navigationJump to search
Synonyms[1]
Virus classificatione
Deltaarterivirus hemfev
(unranked):Virus
Realm:Riboviria
Kingdom:Orthornavirae
Phylum:Pisuviricota
Class:Pisoniviricetes
Order:Nidovirales
Family:Arteriviridae
Genus:Deltaarterivirus
Subgenus:Hedartevirus
Species:
Deltaarterivirus hemfev

Simian hemorrhagic fever virus

Deltaarterivirus hemfev, formerly Simian hemorrhagic fever virus or simian haemorrhagic fever virus (SHFV), is a highly pathogenic virus in monkeys. It is a positive-stranded RNA virus classified in the family Arteriviridae. It is the only member of the subgenus Hedartevirus.[2]

Hosts[edit]

Patas are believed to be the natural host for the virus since about 50% of wild patas monkeys have antibodies for the virus, while antibodies are much less prevalent in other simian species such as vervets and baboons. In macaques, however, infection with this virus can result in acute severe disease with high mortality. Recently, red colobus monkeys and red-tailed guenons have been identified as natural hosts for SHFV.[3][4]

Symptoms[edit]

Asymptomatic infection of the virus can occur in patas monkeys, vervet monkeys, and baboons, although it is observed primarily in patas monkeys. Infection has a rapid onset with animals developing a high fever, facial edemacyanosisanorexiamelena, and may begin to hemorrhage at the cutaneoussubcutaneous, and retrobulbar levels. Thrombocytopenia will develop soon after. Death usually occurs within 10–15 days after symptoms appear.[5]

...I need a drink....end of part 4...

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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part 3...twitter and this forum are not "mixing well";








The common ancestor from Illinois (from August) appears to be a BA.4 that has picked up K444N. The main difference between is that the Australia/Texas/MOwastewater added N460K. This virus is moving fast mutationally and spatially.


DJ "Double Individual Speculator" also more info on the economic collapse...like;








WTI Oil Rises by 8.8% Past Two Sessions for Largest Two-Day Gain Since April 13

Without an economy there is no healthcare...








At best, molnupiravir (MOV) is a useless drug we’re wasting $$ on. At worst, it could accelerate the emergence of novel variants with unpredictable characteristics. First I’ll explain why MOV is useless. Later, I’ll present evidence I’ve found that it could be dangerous. 1/

See earlier posts...do we invest billions of tax payer money in big pharma strategies making the pandemic even worse ????

DJ-I hate to ask the question-If we had no pharma interventions (vaccines, anti-virals) would we be in a better situation pandemic-wise then we are in now ? My "view" is more Non Pharma Interventions longer and in time could have worked...








Rise in hospitalizations after Oktoberfest: The number of people hospitalized in Munich with Covid increased by 61% to 478 compared to last Tuesday, Bavaria’s capital announced today. Compared to the last day before Oktoberfest hospitalizations rose 137%.

What are we (not) doing ?????






Naomi Wu 机械妖姬

@RealSexyCyborg
·
Replying to @zexpe @Cox_A_R and 3 others
I mean, you killed and disabled millions and convinced them it was unavoidable because actually doing something about it might slightly slow the process of wealth transfer from your poorest citizens to your richest. I stand in awe.

If "governments" fail to do even a basic job-protect their citizens...instead worsen pandemics, inequality and go for more wars it is time for "better governments"...

The "strategy" on CoViD is "much to close" to "genocide by pandemic(s)"....

Josette Schoenmakers

@JosetteSchoenma
·
From the top 10 growing variants that were researched, only BN.1 evaded immunity after 3 CoronaVac + BA.1 infection a bit less than after BA.5 inf.. XBB, CA.1 and BA.2.3.20 evaded BA.1 immunity a bit better, but BQ.1 

From NL...CoViD vaccination/boosters "have a slow start" in NL...no sense of urgency...

On the US; [url]https://www.nber.org/papers/w30512[/url] or https://www.nber.org/papers/w30512 ; Overall, the excess death rate for Republicans was 5.4 percentage points (pp), or 76%, higher than the excess death rate for Democrats. Post- vaccines, the excess death rate gap between Republicans and Democrats widened from 1.6 pp (22% of the Democrat excess death rate) to 10.4 pp (153% of the Democrat excess death rate). The gap in excess death rates between Republicans and Democrats is concentrated in counties with low vaccination rates and only materializes after vaccines became widely available.

DJ...poverty. lack of education, "religion" also increase risk of death/severe disease international...See also [url]https://public.tableau.com/app/profile/raj.rajnarayanan/viz/COVID19UPDATESUSA/COVID19_USA[/url] or https://public.tableau.com/app/profile/raj.rajnarayanan/viz/COVID19UPDATESUSA/COVID19_USA ....


We are now flying blind—The  announced it had ended its #COVID19 country travel health notices as **fewer countries reported enough data for accurate assessments**. Basically, they admit they have no idea how much COVID is worldwide—so forget it? ðŸ¤¦ðŸ»â€â™‚ï¸

"bankruptcy has many faces"....

End of part 3


We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: October 04 2022 at 10:19pm

part 2...

[url]https://www.thailandmedical.news/news/breaking-omicron-variant-and-emerging-sub-lineages-are-decreasing-and-disarming-host-serologic-response-by-reducing-b-cell-antigenicity[/url] or https://www.thailandmedical.news/news/breaking-omicron-variant-and-emerging-sub-lineages-are-decreasing-and-disarming-host-serologic-response-by-reducing-b-cell-antigenicity ...

DJ...new variants "hide" for the immune reaction...or even "undo" the immune response...(link in article)

[url]https://www.thailandmedical.news/news/university-of-wisconsin-study-validates-that-even-the-vaccinated-can-still-shed-and-transmit-infectious-sars-cov-2-virus-when-infected-with-covid-19[/url] or https://www.thailandmedical.news/news/university-of-wisconsin-study-validates-that-even-the-vaccinated-can-still-shed-and-transmit-infectious-sars-cov-2-virus-when-infected-with-covid-19 DJ-A(nother) study indicating vaccines do not bring any change in spread of CoViD...only limit (long term) disease..not much more...So-again-QR-codes for vaccinated create a false sense of safety...

[url]https://www.thailandmedical.news/news/breaking-university-of-oxford-study-shockingly-finds-that-lungs-of-post-covid-19-individuals-displayed-premature-aging-of-more-than-15-years[/url] or https://www.thailandmedical.news/news/breaking-university-of-oxford-study-shockingly-finds-that-lungs-of-post-covid-19-individuals-displayed-premature-aging-of-more-than-15-years on the amount of damage CoViD can bring...

DJ-AGAIN !!!!!

There are lots of sensible interventions we should do NOW !!!!

-Stop spreading diseases !!!!! Virusses (etc) are still traveling for free around the globe...

-Masks !!!!

-Study/work from home 

-Information/education...know how bad the risks are....

AGAIN !!!! The worst known pandemics may have killed over 50% of the population...In 2022 massive illness and death will cause nuclear, chemical disasters....CoViD most likely does increase risks for all kinds of other diseases...MPX, Ebola, H5N1, Polio etc....

The "present strategy" is like "having a party in a house on fire"....totall madness !!! Denial is NOT a strategy !!!

[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table NL cases +55% in this list...main reason is yesterdays update...Lots of countries/states simply stopped reporting CoViD cases...NL does report twice a week (maybe later on back to daily updates ?) 

[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time UK must be over 2,5 million cases by now...early september it was under 1,5 million cases...

[url]https://nltimes.nl/2022/10/04/dutch-covid-hospital-total-coronavirus-infections-doubled-2-weeks[/url] or https://nltimes.nl/2022/10/04/dutch-covid-hospital-total-coronavirus-infections-doubled-2-weeks ;

The basic reproduction (R) value rose significantly from 1.03 to 1.18. That means that 100 people contagious with the coronavirus on 13 September passed it on to 118 others. They then infected 139 individuals, who were expected to further infect 164 more.

The BA.5 coronavirus variant remained the most common found in germ surveillance. The RIVM noted the appearance of an increase in the BA4.6 and BA2.75 sub-variants, but said there was little changed from last week.

DJ...lots of cases are NOT reported, miss even testing..."living with CoViD" is the "new political disfunction normal" resulting in more spread, more mutations, more variants...

[url]https://nltimes.nl/2022/10/04/45-million-animals-culled-bird-flu-cases-year-4th-case-groningen-3-weeks[/url] or https://nltimes.nl/2022/10/04/45-million-animals-culled-bird-flu-cases-year-4th-case-groningen-3-weeks

Europe is in the midst of the worst bird flu epidemic in 20 years, the European health service ECDC reported. In the Netherlands alone, over 4.5 million chicks and other birds have been culled in the past year, NOS reports.

See also [url]https://thebulletin.org/2022/09/is-the-next-pandemic-brewing-on-the-netherlands-poultry-farms/[/url] or https://thebulletin.org/2022/09/is-the-next-pandemic-brewing-on-the-netherlands-poultry-farms/ DJ-First human "avian Flu" infection in NL this year ? Possibly even a "Flu-Rona" co-infection...resulting in a combined spread ????

-On [url]https://en.wikipedia.org/wiki/Twindemic#%22Flurona%22[/url] or https://en.wikipedia.org/wiki/Twindemic#%22Flurona%22 ;see [url]https://en.wikipedia.org/wiki/Viral_interference[/url] or https://en.wikipedia.org/wiki/Viral_interference ;

Viral interference, also known as superinfection resistance,[1] is the inhibition of viral reproduction caused by previous exposure of cells to another virus.[2] The exact mechanism for viral interference is unknown.[3] Factors that have been implicated are the generation of interferons by infected cells,[4] and the occupation or down-modulation of cellular receptors.[1]

Viral interference was observed as early as the 16th century. An example is the smallpox vaccine which used cowpox to prevent smallpox infection.[5]

DJ...My-non expert-perspective however is new variants of CoVid may not be stopped by a Flu-immune-response...So Flu-patients may catch CoViD on top of the flu...(and it may present itself as a bad flu...certainly when some CoViD variants also escape testing...)....

End of part 2...part 3=high risk twitter...

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: October 04 2022 at 9:21pm

October 5...part 1,


DJ-Let me begin with "good news"; the expected Russian offensive in Ukraine did not start yet...maybe some people somewhere are trying to prevent further escalations...Maybe-in wars-some are facing the very major risks of further escalation...[url]https://www.youtube.com/watch?v=KvBk4atAaq0[/url] or https://www.youtube.com/watch?v=KvBk4atAaq0 "All we are saying is give peace a chance".....

More on wars in non pandemic latest news (later on) ...

-The pandemic picture is getting darker by the hour.....

[url]https://www.coronaheadsup.com/science/variants/omicron/xbb/xbb-and-three-other-sars-cov-2-strains-found-to-be-more-antibody-evasive-than-even-bq-1-1-and-ba-2-75-2/[/url] or https://www.coronaheadsup.com/science/variants/omicron/xbb/xbb-and-three-other-sars-cov-2-strains-found-to-be-more-antibody-evasive-than-even-bq-1-1-and-ba-2-75-2/ ;

The speed with which SARS-CoV-2 is now evolving is quite breathtaking – ever-fitter variants are now being uncovered on an almost daily basis.

Just over one week since we revealed that BA.2.75.2 and BQ.1.1 were approaching SARS-1 levels of escape, those two variants have already been superseded in antibody evasion by no less than FOUR new strains with even more efficient escape mechanisms. Worse still, these four new strains could adopt other mutations to make themselves even fitter yet.

Yunlong Cao, one of the authors of the preprint “Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution“, has continued to test new strains of SARS-CoV-2, and has found four more VOIDs* waiting in the wings.

 

Yunlong Cao: “Updating results regarding convergent variants BU.1, BR.2, BM.1.1.1, CA.1, and XBB. XBB is currently the most antibody-evasive strain tested, and BR.2, BM.1.1.1, CA.1 are more immune evasive than BA.2.75.2 and BQ.1.1.”

DJ more at the link... *VOIDs = Variants of Impending Doom™ See also [url]https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2#Classification_of_variants[/url] or https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2#Classification_of_variants ...WHO "going political" sticking to naming all new variants "Omicron" and "VOC" ...

A related category is "variant of high consequence", used by the CDC if there is clear evidence that the effectiveness of prevention or intervention measures for a particular variant is substantially reduced.[11]

DJ...By not naming VoHC when there are now lots of "Variants of High Consequence" again the WHO, (E)CDC etc fail again...

In short; earlier/present infection may NOT prevent catching the new variants of CoViD...vaccines/treatment "may be of limited use"...again I am NOT an expert but that is what I make of it....

Worse....

[url]https://www.coronaheadsup.com/health/treatment/molnupiravir/multiple-hypermutated-sars-cov-2-sequences-that-may-have-been-created-by-molnupiravir/[/url] or https://www.coronaheadsup.com/health/treatment/molnupiravir/multiple-hypermutated-sars-cov-2-sequences-that-may-have-been-created-by-molnupiravir/ ;

Molnupiravir, a drug used to treat SARS-CoV-2 infections, has received a lot of press attention since its launch, and not all of it has been positive.

Nearly one year ago, in a two part review of molnupiravir, William Haseltine at Forbes.com said “The FDA needs to tread very carefully with molnupiravir, the antiviral currently before them for approval. My misgivings are founded on two key concerns. The first is the drug’s potential mutagenicity, and the possibility that its use could lead to birth defects or cancerous tumors. The second is a danger that is far greater and potentially far deadlier: the drug’s potential to supercharge SARS-CoV-2 mutations and unleash a more virulent variant upon the world.”

Today, Ryan Hisner has posted a long thread on Twitter about molnupiravir that we feel should be preserved publicly in case it is removed from Twitter.  The thread looks at the approval process for the drug, then moves on to the potential for molnupiravir to cause hypermutated SARS-CoV-2 sequences, which is the part that we will focus on here.

It seems that, if this thread is correct, some of William Haseltine’s worst fears about this drug might be being realised.

-

“Molnupiravir is more than just a crap drug. It works by causing random mutations throughout a virus’s genome. Potentially, this could accelerate the evolution of SARS-CoV-2 variants"

DJ...anti-virals resulting in speeding up mutations making CoViD even more hard/impossible to contain...

[url]https://en.wikipedia.org/wiki/List_of_epidemics#By_death_toll[/url] or https://en.wikipedia.org/wiki/List_of_epidemics#By_death_toll the worst known pandemics may have killed more then 50% of the known population...Even the "Spanish Flu" highest estimate of killing 5% of the global population around a 100 years ago is "small" compared to what pandemics can do....

I think there is a need for knowing how big, major, the risks are....Not only from new variants of CoViD but also lots of other diseases (in Spain another a-symptomatic human H5N1 case was detected...)...

STOP THE SPREAD !!!!!!!!!!!!!!!!!!!!!!!

What is wrong with major reduction of air-travel (5% of pre-pandemic level) if we want to "stop" climate collapse, pandemics ????

End of part 1...

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: October 04 2022 at 1:20am

Lets's go for a part 4....

-Economic backgrounds;

[url]https://www.moonofalabama.org/2022/10/the-expected-financial-crash-is-finally-here.html[/url] or https://www.moonofalabama.org/2022/10/the-expected-financial-crash-is-finally-here.html ,

[url]https://southfront.org/british-economy-is-collapsing-its-the-energy-stupid/[/url] or https://southfront.org/british-economy-is-collapsing-its-the-energy-stupid/ should not be ignored...

One aspect making the economic outlook very likely WORSE then 1929...[url]https://tass.com/politics/1516893[/url] or https://tass.com/politics/1516893 is the economic warfare part..."de-dollar-ization"...Euro/pound now even under 1US$...is not a sign of US strength...only a sign of European collapse going even faster...

Without an economy forget about healthcare....I-in this part of the forum-leave it up to you to decide on the wisdom of no longer buying energy from your main supplier and NOT expecting it will hurt your economy...To me it is like a shop-owner without a bank...maybe on a small scale it may work...

Presented without comment! WSJ: U.N. Calls On Fed, Other Central Banks to Halt Interest-Rate Increases: A U.N. agency warns that further policy tightening risks a global economic downturn

link;[url]https://www.wsj.com/articles/u-n-calls-on-fed-other-central-banks-to-halt-interest-rate-increases-11664809202[/url] or https://www.wsj.com/articles/u-n-calls-on-fed-other-central-banks-to-halt-interest-rate-increases-11664809202 

Another aspect of wars is refugees...here in NL very likely linked to Afghan/Pakistan refugees polio(vaccine related) virus parts were detected...

-So far polio seems to remain limited. CoViD likely will go exponential...a horror show, this winter...

MPX  

Genomic accordions may hold the key to Monkeypox Clade IIb's increased transmissibility (H/T )

link [url]https://www.biorxiv.org/content/10.1101/2022.09.30.510261v2[/url] or https://www.biorxiv.org/content/10.1101/2022.09.30.510261v2 

As I noted in part 2 (Bird)Flu risks are also increasing...[url]https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/959892-ecdc-guidance-for-testing-identification-of-zoonotic-influenza-infections-in-humans-in-the-eu-eaa[/url] or https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/959892-ecdc-guidance-for-testing-identification-of-zoonotic-influenza-infections-in-humans-in-the-eu-eaa 

and what about Ebola...[url]https://flutrackers.com/forum/forum/africa/ebola-forums/959915-media-south-sudan-sends-samples-of-suspected-ebola-cases-to-south-africa-for-testing-october-3-2022[/url] or https://flutrackers.com/forum/forum/africa/ebola-forums/959915-media-south-sudan-sends-samples-of-suspected-ebola-cases-to-south-africa-for-testing-october-3-2022 5 possible Ebola cases (detected september 30-Central Equatoria-province) in South Sudan...[url]https://en.wikipedia.org/wiki/Central_Equatoria[/url] or https://en.wikipedia.org/wiki/Central_Equatoria bordering Uganda...

-Let me go back in time; [url]https://en.wikipedia.org/wiki/Plague_of_Cyprian#Epidemiology[/url] or https://en.wikipedia.org/wiki/Plague_of_Cyprian#Epidemiology ;

The severe devastation to the European population from the two plagues may indicate that the people had no previous exposure or immunity to the plague's cause. The historian William Hardy McNeill asserts that both the earlier Antonine Plague (166–180) and the Plague of Cyprian (251–270) were the first transfers from animal hosts to humanity of two different diseases, one of smallpox and one of measles, but not necessarily in that order. Dionysios Stathakopoulos asserts that both outbreaks were of smallpox.[15]

According to the historian Kyle Harper, the symptoms attributed by ancient sources to the Plague of Cyprian better match a viral disease causing a hemorrhagic fever, such as ebola, rather than smallpox. (Conversely, Harper believes that the Antonine Plague was caused by smallpox.)[1][2][14]

Legacy[edit]

According to Harper, the plague nearly saw the end of the Roman Empire, and in the period between AD 248 and 268, "the history of Rome is a confusing tangle of violent failures. The structural integrity of the imperial machine burst apart. The frontier system crumbled. The collapse of legitimacy invited one usurper after another to try for the throne. The empire fragmented and only the dramatic success of later emperors in putting the pieces back together prevented this moment from being the final act of Roman imperial history."[2]

Both the threat of imminent death from the plague and the unwavering conviction among many of the Christian clergy in the face of it won many converts to that religion.[16]

-

[url]https://en.wikipedia.org/wiki/Consequences_of_the_Black_Death[/url] or https://en.wikipedia.org/wiki/Consequences_of_the_Black_Death ;

The Black Death peaked in Europe between 1348 and 1350 with an estimated one-third of the continent's population ultimately succumbing to the disease. Often simply referred to as "The Plague", the Black Death had both immediate and long-term effects on human population across the world as one of the most devastating pandemics in human history. These included a series of biological, social, economic, political and religious upheavals which had profound effects on the course of world history, especially the history of Europe. Symptoms of the bubonic plague included painful and enlarged or swollen lymph nodes, headaches, chills, fatigue, vomiting, and fevers, and within 3–5 days, 80% of the victims would be dead.[1] Historians estimate that it reduced the total world population from 475 million to between 350 and 375 million. In most parts of Europe, it took nearly 80 years for population sizes to recover, and in some areas more than 150 years.[citation needed]

From the perspective of many of the survivors, the effect of the plague may have been ultimately favorable, as the massive reduction of the workforce meant their labor was suddenly in higher demand. R. H. Hilton has argued that those English peasants who survived found their situation to be much improved. For many Europeans, the 15th century was a golden age of prosperity and new opportunities. The land was plentiful, wages high, and serfdom had all but disappeared. A century later, as population growth resumed, the lower classes once again faced deprivation and famine.[2][3][4]

DJ...of course you need survivors to claim "progress"...

Do we see major pandemics in a sort of cycle-every 800-1,000 years ? [url]https://en.wikipedia.org/wiki/List_of_epidemics#Chronology[/url] or https://en.wikipedia.org/wiki/List_of_epidemics#Chronology mentions [url]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123324/[/url] or https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123324/ ;

Abstract

Dr. Norrie provides a summary of the fifteen currently accepted causes for the end of the Bronze Age in the Near East and then goes on to discuss the sixteenth reason—infectious disease epidemics. These are the real reason that the end of the Bronze Age in the Near East was called either the “catastrophe” or the “collapse” due to its short time frame of 50 years, the mass migration of the general population and the “Sea Peoples” plus the abandonment of cities such as Hattusa, the capital of the Hittite Empire c.1200 bce. The diseases most likely to cause this collapse are smallpox, bubonic plague and tularemia.

DJ...of course a major pandemic in 2022 is different from the-often less global-pandemics in human history. 

Some aspects;

-CoViD and MPX are allready global..."polio in sewage" detected in Asia, Europe, North America...Ebola keeps returning in Africa...lots of other diseases very likely "have potential"..

-The present pandemic is "beyond twindemic", it is not only CoViD and MPX...[url]https://en.wikipedia.org/wiki/Epidemiology_of_HIV/AIDS[/url] or https://en.wikipedia.org/wiki/Epidemiology_of_HIV/AIDS is not over...TB(C) may become very hard to limit...

-In 2018-2020 we had a global African Swine Fever pandemic in pigs...in 2019 CoViD started spreading in humans...in 2022 Avian Flu did not stop spreading during summer-spread to more regions then ever before...infecting also a.o. foxes [url]https://flutrackers.com/forum/forum/europe/h5n1-tracking/ireland/959899-ireland-1-new-outbreak-of-highly-pathogenic-avian-influenza-h5n1-in-a-red-fox-in-rathankar-woah-september-30-2022[/url] or https://flutrackers.com/forum/forum/europe/h5n1-tracking/ireland/959899-ireland-1-new-outbreak-of-highly-pathogenic-avian-influenza-h5n1-in-a-red-fox-in-rathankar-woah-september-30-2022 

-CoViD detected in 100 species...bats (a.o.) may have lots of other corona-virusses...

Of course diseases have been around all the time...however air-travel is spreading disease...we now have close to 8 billion people-most living in mega-cities...

DJ-The least we could do is face the potential risks and try to limit them;

-A major reduction in travel=a major reduction in spreading diseases

-Increase of testing/sequencing may bring early detection-limiting spread

-Better information/education on the risks may increase public support for limiting these major risks

Non of this is happening now...and these steps are allready late...

End of part 4

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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DJ, since the situation is that serious-part 3, 

[url]https://www.thailandmedical.news/news/warning-next-covid-19-surges-will-be-lead-not-by-a-one-or-a-couple-of-new-variants-but-by-a-multitude-of-sub-lineages-with-convergent-rbd-escape-mutat[/url] or https://www.thailandmedical.news/news/warning-next-covid-19-surges-will-be-lead-not-by-a-one-or-a-couple-of-new-variants-but-by-a-multitude-of-sub-lineages-with-convergent-rbd-escape-mutat giving a good description of what CoViD-9sub)variants will bring us...in part 2 I did mention "bird flu" variants very likely to jump species...

On top of that we have never been this close to nuclear-all out-war...

Since I have "limited room for decission" I will limit my (allready very limited...) social contacts further...I expect to be invited for a CoViD/Flu vaccination this month...hope the risks are smaller then the benefits...My main "tool" is trying to stay informed...

And-yes-I go for "hopium"...hope me-my "loved ones" will be able to have a "happy future" not be dead within a few years...There are major risks-it is our duty to limit those risks....

So-what can YOU do ? Contact politicians there is NO excuse ever for nuclear all out war....It is MAD !

Tell politicians they failed to do their job in protecting us from major healthrisks...they have to do more !

Why flying -kerosine- still is tax free [url]https://en.wikipedia.org/wiki/Chicago_Convention_on_International_Civil_Aviation[/url] or https://en.wikipedia.org/wiki/Chicago_Convention_on_International_Civil_Aviation and [url]https://en.wikipedia.org/wiki/Kerosene_tax[/url] or https://en.wikipedia.org/wiki/Kerosene_tax 

Again, if you want to limit climate change, pandemics, limit air travel....

[url]https://www.thailandmedical.news/news/sars-cov-2-is-different-from-all-other-betacoronaviruses-in-that-it-only-partially-activates-the-ire1-alpha-xbp1-endoplasmic-reticulum-stress-pathway[/url] or https://www.thailandmedical.news/news/sars-cov-2-is-different-from-all-other-betacoronaviruses-in-that-it-only-partially-activates-the-ire1-alpha-xbp1-endoplasmic-reticulum-stress-pathway 

and [url]https://www.thailandmedical.news/news/university-of-virginia-study-finds-that-sars-cov-2-infections-triggers-reduction-in-circulating-monocytes-that-leads-to-persistent-post-covid-pulmonar[/url] or https://www.thailandmedical.news/news/university-of-virginia-study-finds-that-sars-cov-2-infections-triggers-reduction-in-circulating-monocytes-that-leads-to-persistent-post-covid-pulmonar both further underline the very major risks of CoViD infections....

We have been-de facto-in this pandemic maybe up to three years...the picture is only getting worse...So we need another strategy (if we had a strategy to begin with...).

Again the main problem is political...like in climate collapse politics simply fail to do their job...protect you and me !








The last 5 times the spread between New Orders and Inventories in the ISM Manufacturing Index was this negative, the US was already in a recession. The 2001 and 1990-91 recessions never had readings this low. 

DJ, "politics" claim they "protected the economy" ...the economy is now moving into depression...very likely WORSE then after 1929...

Enough ! End of part 3...

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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part 2,

[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time self reporting of symptoms in the UK may give better info.

[url]https://nltimes.nl/2022/10/03/covid-hospital-total-shows-sharpest-weekend-increase-since-march[/url] or https://nltimes.nl/2022/10/03/covid-hospital-total-shows-sharpest-weekend-increase-since-march ;

Hospitals are seeing an increase in the number of patients in care who have tested positive for the coronavirus. They are currently treating 842 people who are infected with the virus, a 40 percent increase in a week, said patient coordination service LCPS. That is the highest number since 5 August, almost two months ago.

Since Friday, the number of people admitted into care with the infection increased by 146. That is the largest increase over a weekend since 14 March. The LCPS stopped updating hospital figures over the weekends and holidays in mid-April.


Last Monday, there were 601 patients who tested positive, and 466 the Monday before that. That means that the occupancy has increased by just over 80 percent in two weeks. If this rate of increase continues, hospitals will be treating more than a thousand people with the coronavirus in just a few days’ time.

The LCPS figures do not distinguish between people who were admitted because of symptoms caused by Covid-19, and people who were being treated for other health ailments and also happened to be infected. The National Institute for Public Health and the Environment (RIVM) does make that distinction, and also observed more admissions due to Covid-19. The institute said it appears the autumn coronavirus wave has started.


Since Sunday afternoon, 149 people with a coronavirus infection were admitted to a hospital. That is the largest influx since July 26. On the other hand, people also exit hospitalized care, due to death or because they have recovered sufficiently, which resulted in a net increase.

It is especially busy in the regular care wards, where there are 798 positively-tested people. That is 143 more than Friday and 230 more than last Monday. Some 44 patients with coronavirus are now in intensive care units, three more than Friday

DJ, In NL on tuesday and friday we get new statistics on CoViD...I hope they soon will provide more -and daily- info. There may be regional differences both in variants and-with that-what (age) groups are most at risk. 

[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table due to not reporting most cases in the weekend in statistics only Africa has a growth of cases +4%, Europe -1%....NOT REPORTING CASES IN TIME IS KILLING PEOPLE !!!!!

US cases would be -39%, Canada -41%, Mexico -25%...coherent regional picture...it looks like CoViD is still limited in North America...

In Europe Germany (now) +15%, France +31%, Italy +59% still delay in reporting is giving wrong statistics...

When there is a risk of flooding you need most recent numbers...not numbers that go back hours or even a day...Again-this winterwave most likely will be the worst-by far-so far in this pandemic...There are now 66 countries reporting an increase of cases (from all around the globe...)

[url]https://www.thailandmedical.news/news/warning-next-covid-19-surges-will-be-lead-not-by-a-one-or-a-couple-of-new-variants-but-by-a-multitude-of-sub-lineages-with-convergent-rbd-escape-mutat[/url] or https://www.thailandmedical.news/news/warning-next-covid-19-surges-will-be-lead-not-by-a-one-or-a-couple-of-new-variants-but-by-a-multitude-of-sub-lineages-with-convergent-rbd-escape-mutat TMN has lots of links warning for re/co-infections, vaccines/anti-virals no longer able to help much...

[url]https://flutrackers.com/forum/forum/europe/h5n1-tracking/959895-avian-flu-an-unprecedented-number-of-cases-this-summer-in-europe-efsa-october-3-2022[/url] or https://flutrackers.com/forum/forum/europe/h5n1-tracking/959895-avian-flu-an-unprecedented-number-of-cases-this-summer-in-europe-efsa-october-3-2022 ;

An unprecedented number of detections of the highly pathogenic avian influenza (HPAI) virus were reported in wild and domestic birds from June to September in Europe, according to the latest report compiled by EFSA, the European Center for Prevention and for disease control and the EU reference laboratory. In previous years, none or only a few cases had been detected during the summer period. The entire 2021-2022 HPAI season therefore generated the largest outbreak observed to date in Europe.

Between 11 June and 9 September 2022, 788 HPAI virus detections were reported in 16 EU/EEA countries and the UK, including 56 in poultry and 22 and 710 in captive birds respectively and wild. The unusual persistence of the virus in wild birds continued throughout the summer and was observed in 15 European countries. The virus has reached seabird breeding colonies on the northern Atlantic coast, causing mass mortality, particularly in Germany, France, the Netherlands and the United Kingdom.

Heavily infected wild birds also posed a permanent risk of infection to domestic birds. From June to September, the number of outbreaks in domestic birds decreased compared to previous months but was more than five times higher compared to the same period the previous year.

“With cases detected in poultry and wild birds through September, the current outbreak is clearly still ongoing. As the autumn migration begins and the number of wild birds wintering in Europe increases, they are likely to be at higher risk of becoming infected with HPAI than in previous years, due to the persistence of the virus in Europe,” said Guilhem de Seze, head of the department in charge of risk assessment at EFSA.

-

Low risk to humans


The European Center for Disease Prevention and Control (ECDC), which also contributed to the report, concludes that the risk of infection for the general human population in the EU/EEA is low, and that it is low to medium. for occupationally exposed persons. There is, however, a great deal of uncertainty in these conclusions due to the wide diversity of avian influenza viruses circulating in bird populations. The risk of transmission to humans via exposure to contaminated poultry products is considered negligible.

ECDC has also published a technical report entitled " Testing and detection of zoonotic infections of avian influenza in humans in the EU/EEA ", to which EFSA, the EU reference laboratory and the European Agency for Safety and Health at Work also contributed.

and;

[url]https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/959892-ecdc-guidance-for-testing-identification-of-zoonotic-influenza-infections-in-humans-in-the-eu-eaa[/url] or https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/959892-ecdc-guidance-for-testing-identification-of-zoonotic-influenza-infections-in-humans-in-the-eu-eaa ;

Oct 1st begins the 2022-2023 flu season, and as the chart above illustrates, the last 12 months have produced Europe's worst avian flu outbreak on record. Unlike in previous outbreak years, summer offered little respite and we've seen increasing evidence of mammalian adaptation of these viruses (see herehere, and here), making EU officials quite concerned over what the next 12 months will bring.


While the immediate concern is HPAI H5Nx clade 2.3.4.4b, which has ravaged wild birds and poultry both in Europe and North America, we are also watching zoonotic H5N6, H9N2, H10N3, and H3N8 avian viruses (along with a similar number of swine variant viruses).

Late last week the ECDC released their quarterly Avian influenza overview June – September 2022as a highly detailed 58 page PDFThe Executive Summary from the ECDC follows:


The 2021–2022 highly pathogenic avian influenza (HPAI) epidemic season is the largest HPAI epidemic so far observed in Europe, with a total of 2,467 outbreaks in poultry, 47.7 million birds culled in the affected establishments, 187 outbreaks in captive birds, and 3,573 HPAI virus detections in wild birds with an unprecedent geographical extent reaching from Svalbard islands to South Portugal and Ukraine, affecting 37 European countries.

Between 11 June and 9 September 2022, 788 HPAI virus detections were reported in 16 European countries in poultry (56), captive (22) and wild birds (710). Several colony-breeding seabird species exhibited widespread and massive mortality from HPAI A(H5N1) virus along the northwest coast of Europe.

This resulted in an unprecedentedly high level of HPAI virus detections in wild birds between June and August 2022 and represents an ongoing risk of infection for domestic birds. HPAI outbreaks were still observed in poultry from June to September with five-fold more infected premises than observed during the same period in 2021 and mostly distributed along the Atlantic coast.

Response options to this new epidemiological situation include the definition and rapid implementation of suitable and sustainable HPAI mitigation strategies such as appropriate biosecurity measures and surveillance strategies for early detection in the different poultry production systems.

The viruses currently circulating in Europe belong to clade 2.3.4.4b with seven genotypes, three of which identified for the first time during this time period, being detected during summer. HPAI A(H5) viruses were also detected in wild mammal species in Europe and North America and showed genetic markers of adaptation to replication in mammals.

Since the last report, two A(H5N6), two A(H9N2) and one A(H10N3) human infections were reported in China. The risk of infection is assessed as low for the general population in the EU/EEA, and low to medium for occupationally exposed people.


While primarily a threat to wild and domesticated birds, these viruses are continually evolving, and in the past few years we've seen disturbing evidence of increased spillover from birds to mammals, with many of these infections resulting in severe neurological manifestations and death

-

While we've seen guidance documents before on zoonotic flu from the ECDC (and the CDC), the level of concern in this document is clearly elevated going into this new flu season.


Granted, it is far from certain that an H5 virus can spark a human pandemic (see Are Influenza Pandemic Viruses Members Of An Exclusive Club?). However, the same could have been said about a coronavirus only a few years ago. And it is not as if H5Nx is the only novel threat before us.


Admittedly, we've stood on the viral precipice before with Asian H5N1 (primarily in Indonesia and Egypt), and H7N9 (in China), and each time the threat has receded. Maybe we get lucky again.

But I can't recall any time in the past 17 years of writing this blog where we've had so many plausible zoonotic threats circulating simultaneously - and as widely distributed - around the world.

DJ...Flutrackers also following Ebola in Africa (spread to Sudan from Uganda ???) 

CoViD-infection-even mild/without symptoms-may limit immunity against other diseases. Risk of a sort of Avian/Bird-flu spread in humans (maybe via another host) did increase...

"Flu-rona", "Twindemic" [url]https://en.wikipedia.org/wiki/Twindemic#%22Flurona%22[/url] or https://en.wikipedia.org/wiki/Twindemic#%22Flurona%22 ;

Twindemic is a term used during the COVID-19 pandemic, referring to the possibility of a severe flu season happening alongside an increase in cases of COVID-19 during the fall and winter of 2020 and 2021.[1][2][3][4][5] A consequence of a twindemic may be a mixture of two different infections in the same person at the same time.[6] The term twindemic is a portmanteau of "twin" and "pandemic".[3]

-

In April 2022, Apoorva Mandavilli of The New York Times speculated that a twindemic has not occurred because "exposure to one respiratory virus may put the body's immune defenses on high alert, barring other intruders from gaining entry into the airways. This biological phenomenon, called viral interference, may cap the amount of respiratory virus circulating in a region at any given time."[8] In the United States, flu cases, hospitalizations and deaths were up from the previous flu season, but were still lower than the pre-pandemic average.[8]

In January 2022, Israel reported, for the first time, a mixture of COVID-19 and influenza infections, colloquially known as "flurona".[9][10][11][12] In Brazil, four cases of the double infection have been identified, including a 16-year-old male from Rio de Janeiro. In Fortaleza of Ceará state, two children, including a one-year-old child tested positive without complications, and also a 52-year-old man who did not need hospitalization.[13] In São Paulo, the Secretariat of Health announced that its state had 110 cases in 2021.[14]

Flurona infections have also been reported in the United States, the Philippines and Hungary.[11]

DJ...we are already in a "twindemic" with both CoViD and Monkeypox...H3N2 may became a major "normal" flu (with some swine H3N2v also in humans....). 

Again -the perspective, outlook is BAD !!!!

Stop the spread !!! 

...politics going for more war, fiat currencies bringing hyperinflation...

Music; R.E.M. [url]https://www.youtube.com/watch?v=Z0GFRcFm-aY[/url] or https://www.youtube.com/watch?v=Z0GFRcFm-aY ;

REMASTERED IN HD!! Official Music Video for It's The End Of The World As We Know It (And I Feel Fine) performed by R.E.M. 

DJ...I was also thinking of [url]https://www.youtube.com/watch?v=d-diB65scQU[/url] or https://www.youtube.com/watch?v=d-diB65scQU Don't worry, Be happy...Bobby Mc. Ferrin..."Into each live some rain must fall"....time for more coffee !

We cannot solve our problems with the same thinking we used when we created them.
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DJ, part 1

-international situation/war; 

I expect/hope there are lots of talks on de-escalation. If these talks fail we may see major escalation-possibly into a world War Thee/Nuclear War scenario this week.

I will try to write my update on it in latest-non pandemic-news. Economy-wise a major crisis is unfolding allthough there is not yet news on a major bank collapse. Protests in Europe will escalate...Most European/western governments are NO longer supported by most of the public. 

-Pandemics;

[url]https://www.coronaheadsup.com/science/variants/omicron/bq-1-1/growth-advantage-for-bq-1-1-is-above-100-per-week/[/url] or https://www.coronaheadsup.com/science/variants/omicron/bq-1-1/growth-advantage-for-bq-1-1-is-above-100-per-week/ ;

The Omicron variant BQ.1.1 appears to be in a prime position to drive the coming winter wave in Europe.

Bioinformatics scientist and variant watcher Cornelius Roemer has published several updates on BQ.1.1 since we first published details on the variant in this post.

On the 21st September, Cornelius Roemer said that “BQ.1.1 is showing quite some growth, especially in England where the first sample was submitted 9 days ago and now there are already 28 sequences. I hope there is some sort of biased sampling going on. Otherwise this doesn’t look good.”

Today’s updates give further details of the growth advantage of BQ.1.1, which is now above 100% per week.

 

“2-3 more days of GISAID data have just appeared on @GenSpectrum. This is a worldwide view, but biased by major uploaders i.e. Europe/North America Growth advantage for BQ.1.1 is stably above 100% per week. BA.2.3.20, mostly Asia so far, can possibly compete.”

 

The latest update shows that, on the 3rd October 2022, that figure of 28 sequences had grown to 200 sequences.

“With 11 days more data, it is becoming quite clear that BQ.1.1 will drive a variant wave in Europe and North America before the end of November Its relative share has kept more than doubling every week It has taken just 19 days to grow 8-fold from 5 sequences to 200 sequences.”

 

Some bad news regarding BQ.1.1 is that it escapes all available monoclonal antibody cocktails, even those that are still working against BA.5 Now looks like a pretty good time to get a booster dose if one is eligible. I got mine a week ago.

 

A week ago, @TWenseleers estimated a growth advantage of ~14% per day for BQ.1 over BA.5 This may be a slight overestimate. But note this was for BQ.1 not BQ.1.1 which has a few extra % pts Evidence quite strong that BQ.1.1 will have >10%/day advantage.

 

For comparison:
Alpha had ~7%/day growth advantage
Delta had ~11%/day over Alpha
BA.1 Omicron had ~20-25%/day over Delta
BA.2 had ~11%/day over BA.1
BA.4/5 had ~11%/day over BA.2
Looks like BQ.1.1 is less drastic than Omicron vs Delta but comparable to Delta, BA.2 & BA.4/5 waves

 

The growth advantage for BQ.1.1 is roughly similar to Delta, BA.2 and BA.5 at this point in time:

 

While BQ.1.1 is significantly faster than BA.2.75.2, it could still happen that XBB, BS.1.1 or another BA.2.75* offshoot will be able to keep up with BQ.1.1, but this would not make wave dynamics better, only worse.

 

Raj Rajnarayanan has posted that the Covid bellwether state of New York is seeing growth in BQ lineages.

 

 

Lastly, we have this fantastic diagram by Marc Johnson showing the convergent evolution that has led to the lineages we have been discussing, including BQ.1.1. Click on the image to expand.

 

 

 

 

DJ [url]https://www.thailandmedical.news/news/warning-next-covid-19-surges-will-be-lead-not-by-a-one-or-a-couple-of-new-variants-but-by-a-multitude-of-sub-lineages-with-convergent-rbd-escape-mutat[/url] or https://www.thailandmedical.news/news/warning-next-covid-19-surges-will-be-lead-not-by-a-one-or-a-couple-of-new-variants-but-by-a-multitude-of-sub-lineages-with-convergent-rbd-escape-mutat ions

We are (also) on the eve of a major worsening of the global-ongoing-pandemic. STOP THE SPREAD would help...Good information would help...

But the US president, top of WHO came up recently with "the pandemic is (as good as) over....There are lots of tools (Non Pharma Interventions);

-work/study from home

-mask up

-social distance

-test when ill

-wastewater/sewage samples can give good info-try to be on top of it...

Again-this pandemic looks like it will get much worse...protect yourself now governments do not protect you (but they protect profits...) 

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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part 2, twitter;








Some bad news regarding BQ.1.1 is that it escapes all available monoclonal antibody cocktails, even those that are still working against BA.5 Now looks like a pretty good time to get a booster dose if one is eligible. I got mine a week ago.

and

Yunlong Richard Cao

@yunlong_cao
·
As expected, BQ.1.1 escapes Evusheld and bebtelovimab, making all clinically available antibody drugs ineffective. BQ.1.1 and BA.2.75.2 both displayed sufficient hACE2 binding capability. (3/4)

DJ, I expect an invitation for both CoViD-vax/booster and Flu-vax this month...I will accept both in the hope it will offer some protection...








Cornelius Roemer

@CorneliusRoemer
·
With 11 days more data, it is becoming quite clear that BQ.1.1 will drive a variant wave in Europe and North America before the end of November Its relative share has kept more than doubling every week It has taken just 19 days to grow 8-fold from 5 sequences to 200 sequences 1/  twitter.com/CorneliusRoeme…

I admit...I stopped following names...I could write something on pandemic history...how "the plague" killed 100% of the population in some parts of Europe..but also never reached other parts of Europe in the 14th century...After the (major) pandemic shortage of workers did result in higher wages...giving the economy a boost...but that was "then and there" not "here and now"...the outlook now may be a lot worse...There are links between [url]https://en.wikipedia.org/wiki/Mongol_Empire[/url] or https://en.wikipedia.org/wiki/Mongol_Empire and the plague [url]https://en.wikipedia.org/wiki/Theories_of_the_Black_Death[/url] or https://en.wikipedia.org/wiki/Theories_of_the_Black_Death but there are also lots of questions...

[url]https://en.wikipedia.org/wiki/Black_Death_migration#European_outbreak[/url] or https://en.wikipedia.org/wiki/Black_Death_migration#European_outbreak ;

In 1345 the Mongols under Khan Jani Berg of the Golden Horde besieged Caffa. Suffering from an outbreak of black plague, the Mongols placed plague-infected corpses in catapults and threw them into the city. In October 1347, a fleet of Genoese trading ships fleeing Caffa reached the port of Messina in Sicily.[28] By the time the fleet reached Messina, all the crew members were either infected or dead. It is presumed that the ships also carried infected rats and/or fleas. Some ships were found grounded on shorelines, with no one aboard remaining alive.

Looting of these lost ships also helped spread the disease. From there, the plague spread to Genoa and Venice by the turn of 1347–1348, spreading across Italy.

From Italy the disease spread northwest across Europe, striking France, the Crown of Aragon, the Crown of CastilePortugal and England by June 1348, then turned and spread east through Germany and Scandinavia from 1348 to 1350. It was introduced in Norway in 1349 when a ship landed at Askøy, then proceeded to spread to Bjørgvin (modern Bergen). From Norway it continued to Sweden, by which point it had already spread around Denmark.

Finally it spread to north-eastern Russia in 1351; however, the plague largely spared some parts of Europe, including the Kingdom of Poland, isolated parts of Belgium and the NetherlandsMilan and the modern-day France-Spain border.

At SienaAgnolo di Tura wrote:

"They died by the hundreds, both day and night, and all were thrown in ... ditches and covered with earth. And as soon as those ditches were filled, more were dug. And I, Agnolo di Tura … buried my five children with my own hands … And so many died that all believed it was the end of the world."[29]

DJ...[url]https://en.wikipedia.org/wiki/List_of_epidemics[/url] or https://en.wikipedia.org/wiki/List_of_epidemics ...in many ways pandemics are NOT that abnormal...we did live in a very "ab-normal" time, certainly since 1945...limited wars, climate disasters, diseases....In 1900 average life expectency was 40...something like 10 years extra compared to Roman times...in about a 100 years life expectency increased to 80...[url]https://en.wikipedia.org/wiki/Life_expectancy[/url] or https://en.wikipedia.org/wiki/Life_expectancy ; Until the middle of the 20th century, infant mortality was approximately 40–60% of the total mortality. Excluding child mortality, the average life expectancy during the 12th–19th centuries was approximately 55 years. If a medieval person survived childhood, they had about a 50% chance of living 50–55 years, instead of only 25–40 years.[5]

-

Life expectancy increases with age as the individual survives the higher mortality rates associated with childhood. For instance, the table gives the life expectancy at birth among 13th-century English nobles at 30. Having survived to the age of 21, a male member of the English aristocracy in this period could expect to live:[41]

  • 1200–1300: to age 64
  • 1300–1400: to age 45 (because of the bubonic plague)
  • 1400–1500: to age 69
  • 1500–1550: to age 71

17th-century English life expectancy was only about 35 years, largely because infant and child mortality remained high. Life expectancy was under 25 years in the early Colony of Virginia,[52] and in seventeenth-century New England, about 40 percent died before reaching adulthood.[53] During the Industrial Revolution, the life expectancy of children increased dramatically.[54] The under-5 mortality rate in London decreased from 74.5% in 1730–1749 to 31.8% in 1810–1829.[55][56]

Public health measures are credited with much of the recent increase in life expectancy. During the 20th century, despite a brief drop due to the 1918 flu pandemic[57] starting around that time the average lifespan in the United States increased by more than 30 years, of which 25 years can be attributed to advances in public health.[58]

The life expectancy for people reaching adulthood is greater, — ignoring infant and child mortality. For instance, 16th Century English and Welsh women at 15 years may have had an life expectancy of around 35 more years (50 total).[43]

DJ...in many ways one could claim we had "seven golden decades" from 1950 to 2020....but being very lucky was-in history terms-NOT "normal"...

Well this story may have cheered you up ;-) ! 

Music...another of my French favorites; Michel Fugain et le Big Bazar, Les Printemps (Spring...) 1976 [url]https://www.youtube.com/watch?v=Qbk9iDL6txE[/url] or https://www.youtube.com/watch?v=Qbk9iDL6txE ...

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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DJ, 

We expect a bit of [url]https://en.wikipedia.org/wiki/Indian_summer[/url] or https://en.wikipedia.org/wiki/Indian_summer here in NL ...(in Dutch [url]https://nl.wikipedia.org/wiki/Nazomer[/url] or https://nl.wikipedia.org/wiki/Nazomer Old Women Summer...an -old-name also showing up in Germany etc...) Music; [url]https://www.youtube.com/watch?v=cN-OCHlfRTU[/url] or https://www.youtube.com/watch?v=cN-OCHlfRTU , L'ete Indien - Joe Dassin 1975....(mmm...not the best version...but not a remix...)

I start with music because "the rest" does simply look bad....

"Politics" has been kicking lots of cans down the road..."solving" all problems by printing more money..."Vision", setting goals-just like "public spending" or "tax"were "dirty words"...privatize everything...profits first...

In the crisis we now face we need a very strong public sector...but it has been destroyed by neo-liberal phantasies...So the next banking crisis [url]https://en.wikipedia.org/wiki/Credit_Suisse#Drug_money_laundering_scandal,_2022[/url] or https://en.wikipedia.org/wiki/Credit_Suisse#Drug_money_laundering_scandal,_2022 may be close to collapse....will hit countries very hard...

[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table Europe cases +9%, Africa +8%...bad statistics-72 countries now reporting an increase of cases...however lots of countries/states simply stopped reporting...More "bird flu" cases have been detected-so far no spread into humans this year...Cholera killing people again in Haïti...Ebola-Uganda [url]https://www.coronaheadsup.com/health/ebola/ebola-the-risk-of-international-spread-cannot-be-ruled/[/url] or https://www.coronaheadsup.com/health/ebola/ebola-the-risk-of-international-spread-cannot-be-ruled/ ...

"No news is good news" is "hopium" polio, MPX cases may simply not get reported...[url]https://www.cdc.gov/poxvirus/monkeypox/cases-data/technical-report/report-3.html[/url] or https://www.cdc.gov/poxvirus/monkeypox/cases-data/technical-report/report-3.html US-CDC reporting once every four weeks...in that report CDC states 24,846 US cases...[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory has 25,851 US cases (last update september 30)...global cases moving towards 74,000 but reporting is "very poor"...just like with CoViD-cases...[url]https://www.coronaheadsup.com/europe/uk/uk-the-covid-19-enquiry-cover-up-begins/[/url] or https://www.coronaheadsup.com/europe/uk/uk-the-covid-19-enquiry-cover-up-begins/ criminal governments simply do not want to know...

"Politics" did mix with "banksters" (financing drugs, trade in weapons, humans, organs...) the military industrial complex (more war) ...Maybe "politicians" simply did not (want to) know who their partners were...

"Saving the economy=profits" during the pandemic not only worsened the pandemic...it also destroyed the economy...

[url]https://www.thailandmedical.news/news/breaking-early-data-shows-that-ba-2-75-2-and-bq-1-1-is-causing-varied-strange-symptoms-that-are-debilitating-in-many-that-are-infected[/url] or https://www.thailandmedical.news/news/breaking-early-data-shows-that-ba-2-75-2-and-bq-1-1-is-causing-varied-strange-symptoms-that-are-debilitating-in-many-that-are-infected 

[url]https://www.thailandmedical.news/news/breaking-according-to-insurance-claims,-lyme-disease-diagnoses-in-the-united-states-have-exponentially-increased-to-over-357-percent-in-rural-location[/url] or https://www.thailandmedical.news/news/breaking-according-to-insurance-claims,-lyme-disease-diagnoses-in-the-united-states-have-exponentially-increased-to-over-357-percent-in-rural-location 

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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The MoA Week In Review - (Not Ukraine) OT 2022-163

Last week's posts on Moon of Alabama:

bigger

> The US views the sabotage of the Nord Stream gas pipelines as a “tremendous opportunity” to wean the continent off of Russian energy, Secretary of State Antony Blinken told reporters on Friday. With winter approaching, Blinken said that the US wants Europe to decrease its fuel use. <

Beguiling the traitors:

Secretary Antony Blinken @SecBlinken - 15:59 UTC · Sep 29, 2022

Congratulations to my friend and German Foreign Minister @ABaerbock on being named to @TIME Magazine’s 2022 #TIME100 Next List. Thank you for your steadfast support for democracy, freedom, and human rights during challenging times.
2022 TIME100 Next: Annalena Baerbock


DJ...The Duran [url]https://www.youtube.com/watch?v=oMWtgKP2ZdM[/url] or https://www.youtube.com/watch?v=oMWtgKP2ZdM on the collapse of the Euro, UK pound...Hungary planning to jump out of NATO/EU "Titanic"...lack of any US leadership, vision, plan...

Related [url]https://www.coronaheadsup.com/europe/uk/uk-the-covid-19-enquiry-cover-up-begins/[/url] or https://www.coronaheadsup.com/europe/uk/uk-the-covid-19-enquiry-cover-up-begins/ ;

“The inquiry is becoming a farce and an exercise in cover-up.”.

After the complete shipshow that was the British government’s response to Covid-19, plans are afoot to ensure that the Covid-19 inquiry doesn’t reach any useful conclusions by excluding witnesses from giving evidence about the care that their relatives received, writes The Guardian.

DJ...there is music to love...[url]https://www.youtube.com/watch?v=ALlkMv21a7s[/url] or https://www.youtube.com/watch?v=ALlkMv21a7s it is "religious"...religion is the basis for any totalitarianism..."people speaking in the name of a (self created) "god"....still good-relaxing, hypnotizing music...from another world...

Stay safe & sane...

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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twitter problems...









Create a financial crash by tax cuts for the rich & then ask the public to 'prepare for a new age of austerity' This isn't incompetence- it's a plan to enrich Tories/Tory allies, deregulate business, strip public services, welfare, destroy the environment, and privatise the NHS

-

Have no doubt- in this plan inequalities will rise even further, healthcare & education will be further devastated, and those with the least protections will struggle & suffer - with food and fuel poverty. While the top 1% get richer on the backs of the most disadvantaged.

and








🚨 TODAY ðŸš¨ The largest wave of simultaneous protest in Britain in years. 50 towns and cities will take to the streets against this government. We say #EnoughIsEnough ðŸ‘Š Join us: http://wesayenough.co.uk/oct1

DJ...no doubt state/billionaire owned "media" mostly will ignore protests...

In the US;








U.S. COVID update: More than 600 new deaths - New cases: 90,483 - Average: 49,689 (-650) - States reporting: 28/50 - In hospital: 28,257 (-167) - In ICU: 3,455 (-29) - New deaths: 616 - Average: 451 (-22)

DJ...so 22 US states simply stopped reporting CoViD cases...

Australia;


Australia will be a nice one to keep an eye on, because they have the top 5 of fastest growing variants. The last week is still prelimary. And numbers are still low, but that might change quickly. Data from GISAID.

and

Replying to 
One wonders about AU advisers. How does a decision get made that says if you do nothing it will outweigh by orders of magnitude cost of simple NPIs, further will⬆ï¸hospitalisation, long covid & death?🤦â€â™€ï¸#RespsOn #CovidisAirborne #CovidIsNotOver #SimpleNPIs #PrecautionaryPrinciple

end of this part 3b...it is nice weather outside...

We cannot solve our problems with the same thinking we used when we created them.
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Let me go for a part 3...

UK [url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time self reporting CoViD symptoms now over 2,3 million (out of UK population of 68,5 million...) 


Shaun Lintern

@ShaunLintern
·
NHS England has identified 10 areas including big city regions like Brimingham and Leicester, which it fears could see a 'system failure' this winter when 999, A&E, hospitals and social care all collapse. twitter.com/ShaunLintern/s…

and 








Royal Liverpool hospital said it had very limited space in emergency departments and St George’s hospital in London asked people to go to A&E only in serious situations.

DJ....protests can become mass spread events....








Some more highlights from an astonishing  poll for  - Tory supporters, look away now: The PM’s net approval rating has fallen from -9 to -37 in a week. It’s a worse net rating than the -28 that Johnson registered in the final poll before his removal.

And 


Mike Galsworthy

@mikegalsworthy
·
It’s an important point that Truss & Kwarteng have no mandate from the British people for the hugely destructive actions they are taking. It’s worth registering this through the current surging petition—> https://petition.parliament.uk/petitions/619781







🔥This has now clocked past a quarter of a million signatures. ðŸ”¥ Do sign and share...
Quote Tweet







Mike Galsworthy

@mikegalsworthy
·
It’s an important point that Truss & Kwarteng have no mandate from the British people for the hugely destructive actions they are taking. It’s worth registering this through the current surging petition—> https://petition.parliament.uk/petitions/619781
Show this thread


Image

96

1,402

2,236



Again...western countries sinking into a major political crisis....








I guess we have different definitions of what constitutes the beginning of a wave? Maybe we just have different definitions of autumn?

DJ...UK Office of National Statistics state UK cases going up-however "not sign of a new wave".....

We cannot solve our problems with the same thinking we used when we created them.
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part 2

[url]https://www.wpc.ncep.noaa.gov/qpf/excessive_rainfall_outlook_ero.php[/url] or https://www.wpc.ncep.noaa.gov/qpf/excessive_rainfall_outlook_ero.php DJ-"Ian" did claim lots of lives...cause massive damage/flooding in a.o. Florida...[url]https://en.wikipedia.org/wiki/2022_Atlantic_hurricane_season#Season_effects[/url] or https://en.wikipedia.org/wiki/2022_Atlantic_hurricane_season#Season_effects "Fiona" did bring damage/flooding to a.o. Puerto Rico, Eastern Canada..."Julia" is now forming but most likely will stay on the Atlantic...Worldwide climate disasters worsen the pandemic perspectives....

Economy;








OPEC+ CONFIRMS IN-PERSON MEETING IN VIENNA ON OCT. 5: STATEMENT Between that 1mm cut and the SPR 1mm drain ending in three weeks, oil supply is about to drop big

Link to [url]https://www.zerohedge.com/commodities/opec-output-cut-looks-increasingly-likely-producers-narrow-down-options[/url] or https://www.zerohedge.com/commodities/opec-output-cut-looks-increasingly-likely-producers-narrow-down-options

OPEC+ meets on Wednesday, October 5, to discuss the market and fundamentals situation as oil prices have fallen below $90 per barrel, a level last seen just before the Russian invasion of Ukraine. It is "likely" that the group will agree on a cut, a source at OPEC told Reuters.

and; [url]https://www.zerohedge.com/commodities/us-hits-chinese-firms-new-sanctions-over-iran-oil-sanctions-busting[/url] or https://www.zerohedge.com/commodities/us-hits-chinese-firms-new-sanctions-over-iran-oil-sanctions-bustingThe US has slapped new sanctions on Chinese firms related to Iran’s petrochemical and petroleum trade, after years of reports of Chinese tankers engaged in sanctions-busting activity, and at a moment that a finalized restored JCPOA nuclear deal has all but collapsed.

-

And further according to the US Treasury readout, the actions target "Iranian brokers and several front companies in the UAE, Hong Kong, and India that have facilitated financial transfers and shipping of Iranian petroleum and petrochemical products."

DJ, of course India, China are also global pharma giants....For "the west" outlook is energy prices, medication-prices, inflation will go up...[url]https://en.wikipedia.org/wiki/Failed_state[/url] or https://en.wikipedia.org/wiki/Failed_state ;

failed state is a political body that has disintegrated to a point where basic conditions and responsibilities of a sovereign government no longer function properly (see also fragile state and state collapse). A state can also fail if the government loses its legitimacy even if it is performing its functions properly. For a stable state, it is necessary for the government to enjoy both effectiveness and legitimacy. Likewise, when a nation weakens and its standard of living declines, it introduces the possibility of total governmental collapse. The Fund for Peace characterizes a failed state as having the following characteristics:

Common characteristics of a failing state include a central government so weak or ineffective that it has an inability to raise taxes or other support and has little practical control over much of its territory and hence there is a non-provision of public services. When this happens, widespread corruption and criminality, the intervention of state and non-state actors, the appearance of refugees and the involuntary movement of populations, sharp economic decline, and military intervention from both within and without the state in question can occur.[1]

Metrics have been developed to describe the level of governance of states. The precise level of government control required to avoid being considered a failed state varies considerably amongst authorities.[2] Furthermore, the declaration that a state has "failed" is generally controversial and, when made authoritatively, may carry significant geopolitical consequences.[2]

DJ...with inflation getting out of control, massive distrust in politics/government (not doing their job), pandemics out of control with not enough health care capacity...some western states may have to face this perspective...








NYT daily totals indicate 13.7K U.S. COVID deaths for the month of September. That is nearly equal to the high estimate — 14K — of flu deaths for the 2021-2022 season (October-May).

DJ..."Flu-Rona" is very likely to get worse this year...co-infections of (the many-all still named) "Omicron" variants and "flu" will push excess deaths to record high levels...[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory did countries simply stop reporting on MPX ????

Stephen Reicher

@ReicherStephen
·
As Covid hospitalisation rise by 37% in a week, the President of the Royal College of Emergency Medicine says: "Covid just makes everything that much harder and it's entirely valid to link this with critical incidents being called across the country..." https://theguardian.com/world/2022/oct/01/latest-covid-surge-a-heavy-straw-on-camels-back-for-every-hospital-in-uk?CMP=share_btn_tw

DJ...I did start "scenario's" at the start of this pandemic early 2020...The present scenario's are "beyond the worst ones" I could think of....

To allow myself some optimism; What if somehow global conflicts decreased NOW ? A basic problem-making dealing with the pandemics much harder-still would be "printed money" created out of thin air...Due to climate collapse countries claim to go for "green energy" so banks are less willing to invest-long term-into fossil fuels...

Some claims are about 3 billion (out of the almost 8 billion) people did get infected with CoViD...even if only 1% would develop long/chronic CoViD it would be 30 million...A more realistic number may go to 1-in-8 ? Long/Chronic CoViD is the most widespread "form" of CoViD....Healthcare, education may have been hit very hard...

So even if we would be able to end major conflicts from a "pandemic perspective" we are in a much worse position then a year ago....

End of part 2...

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: October 01 2022 at 11:17pm

DJ, part 1,

Latest NL inflation year-to-year [url]https://nltimes.nl/2022/09/30/ministers-call-171-inflation-rate-terrible-extreme[/url] or https://nltimes.nl/2022/09/30/ministers-call-171-inflation-rate-terrible-extreme was 17,1%...Most of it related to increase of energy costs...DJ-And I do not expect those energy costs (increasing energy imports have to be paid in US$) to go down...

To limit inflation interest rates are also going up...this does not only affect companies, households...but also the healthcare sector...

Hospitals have "limited budgets" now face both high inflation and interest rates...at least part of medication, medical gear is imported-also outside the Euro-zone...so those costs also may go up...European Healthcare may see inflation costs for this sector close to 20% this year...

-At the same time we did see a CoViD-winterwave starting, flu-numbers (H3N2) increasing, MPX numbers (ignored in reporting) going up...I do not like cynicism-but a lot of the high-risk population could have died allready from heatwaves, earlier CoViD waves...delayed care...Only long/chronic CoViD may result in a new large group of high risk patients...

HCW-ers are exhausted..for now may get better pay working in other sectors...So increasing demand for healthcare is now facing a major decrease in healthcare capacity...We already were in a healthcare crisis...it is now getting much worse...[url]https://www.coronaheadsup.com/europe/europe-another-record-breaking-winter-wave-predicted/[/url] or https://www.coronaheadsup.com/europe/europe-another-record-breaking-winter-wave-predicted/ 

-[url]https://www.thailandmedical.news/news/latest-singapore-in-a-new-covid-19-wave-driven-by-various-new-omicron-variants-including-ba-2-75-with-an-average-of-about-4,000-new-cases-per-day[/url] or https://www.thailandmedical.news/news/latest-singapore-in-a-new-covid-19-wave-driven-by-various-new-omicron-variants-including-ba-2-75-with-an-average-of-about-4,000-new-cases-per-day Austria [url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table has 8,529 new cases-last 7 days-per million of population (=0,85% of its population testing positive in the last seven days...) Taiwan 12,279-per million...Singapore 3,680 per million..

-[url]https://www.thailandmedical.news/news/warning-newer-sars-cov-2-variants-have-evolved-to-overcome-the-robust-innate-immune-system-of-children-infants-and-children-are-more-vulnerable-now[/url] or https://www.thailandmedical.news/news/warning-newer-sars-cov-2-variants-have-evolved-to-overcome-the-robust-innate-immune-system-of-children-infants-and-children-are-more-vulnerable-now lots of links in the article. Innate immunity is the immunity defense you are born with...findings indicate new variants now are better in getting around those defenses-making CoViD a major risk for babies, young children...(the idea of getting infected to boost immunity for CoViD-19 was wrong from the start-high risk! Not only for severe disease, long/chronic CoViD but also for MIS-C, Multi Inflamatory Syndrome, an overreaction of the immune system both seen in C children, A adults and N new borns...) 

-[url]https://www.thailandmedical.news/news/breaking-u-s-nih-study-finds-that-sars-cov-2-spike-proteins-and-mrnas-can-translocate-into-the-nucleus-of-host-cells-unlike-any-other-coronaviruses[/url] or https://www.thailandmedical.news/news/breaking-u-s-nih-study-finds-that-sars-cov-2-spike-proteins-and-mrnas-can-translocate-into-the-nucleus-of-host-cells-unlike-any-other-coronaviruses link to [url]https://www.biorxiv.org/content/10.1101/2022.09.27.509633v1[/url] or https://www.biorxiv.org/content/10.1101/2022.09.27.509633v1 ;

AAbstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe pathophysiology in vulnerable older populations and appears to be highly pathogenic and more transmissible than SARS-CoV or MERS-CoV [1, 2]. The spike (S) protein appears to be a major pathogenic factor that contributes to the unique pathogenesis of SARS-CoV-2. Although the S protein is a surface transmembrane type 1 glycoprotein, it has been predicted to be translocated into the nucleus due to the novel nuclear localization signal (NLS) “PRRARSV”, which is absent from the S protein of other coronaviruses. Indeed, S proteins translocate into the nucleus in SARS-CoV-2-infected cells. To our surprise, S mRNAs also translocate into the nucleus. S mRNA colocalizes with S protein, aiding the nuclear translocation of S mRNA. While nuclear translocation of nucleoprotein (N) has been shown in many coronaviruses, the nuclear translocation of both S mRNA and S protein reveals a novel pathogenic feature of SARS-CoV-2.

Author summary One of the novel sequence insertions resides at the S1/S2 boundary of Spike (S) protein and constitutes a functional nuclear localization signal (NLS) motif “PRRARSV”, which may supersede the importance of previously proposed polybasic furin cleavage site “RRAR”. Indeed, S protein’s NLS-driven nuclear translocation and its possible role in S mRNA’s nuclear translocation reveal a novel pathogenic feature of SARS-CoV-2.

DJ-The TMN article mentions more severe disease (even worse then SARS-1/MERS) specialy in the elderly...Also links to chronic/long CoViD...

End of part 1,

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: October 01 2022 at 2:56am

twitter....








Isn't this appalling? These are amongst the people we owe the most to in our society - the key workers. They shouldn't be having to skip meals to feed their kids.

link;[url]https://www.theguardian.com/society/2022/sep/30/nhs-nurses-not-eating-at-work-in-order-to-feed-their-children-survey-finds?CMP=Share_iOSApp_Other[/url] or https://www.theguardian.com/society/2022/sep/30/nhs-nurses-not-eating-at-work-in-order-to-feed-their-children-survey-finds?CMP=Share_iOSApp_Other ;

Some nurses are so hard up that they are having to not eat at work in order to feed and clothe their children, research among hospital bosses has found.

Lack of money is also prompting some NHS staff to call in sick in the days before they get paid because they can no longer afford the travel costs for their shift. Others are taking a second job outside the NHS in an effort to make ends meet.


The impact of the cost of living crisis on health service workers in England has emerged in a survey of chief executives, chairs and other senior figures in health trusts undertaken by NHS Providers, which represents trusts.

Miriam Deakin, the director of policy and strategy at NHS Providers, said: “There are heart-rending stories of nurses choosing between eating during the day and being able to buy a school uniform for their children at home.

“Increasing numbers of nurses and other staff, particularly in the lower pay bands, are finding they are unable to afford to work in the NHS.”

More than a quarter (27%) of trusts already operate food banks for staff, and another 19% plan to open one, to help relieve the acute financial difficulties faced by staff.

The survey also found that some staff:

  • Are stopping contributing to their NHS pension in order to free up cash.

  • Cannot fill up their cars because of petrol price rises.

  • Have mental health issues due to the stress of paying their bills.

The situation is so serious that some low-paid health staff, such as healthcare assistants, are quitting their jobs in the NHS and taking better-paid roles in pubs and shops instead, NHS chiefs said.

DJ-German (government run) [url]https://www.dw.com/en/german-russian-relations-through-history/g-61178567[/url] or https://www.dw.com/en/german-russian-relations-through-history/g-61178567 trying to ignore the economic-pandemic stories...[url]https://www.dw.com/en/coronavirus/s-32798[/url] or https://www.dw.com/en/coronavirus/s-32798 

[url]https://www.france24.com/en/europe/20220929-macron-faces-first-major-strike-since-re-election-as-unions-oppose-pension-reform[/url] or https://www.france24.com/en/europe/20220929-macron-faces-first-major-strike-since-re-election-as-unions-oppose-pension-reform in France ;

Fresh elections?

With deficits spiralling and public debt at historic highs, Macron views pushing back the pension age as one of the only ways the state can raise revenues without increasing taxes.

But his centrist party lost its majority in parliament in June, severely undermining his ability to make changes that are broadly unpopular.

Labour Minister Olivier Dussopt said that the 44-year-old head of state would not hesitate to call fresh elections if opposition parties voted down the government over the reform.

"If all of the opposition comes together to adopt a vote of no-confidence and brings down the government, he (Macron) will let French people decide and say what sort of a majority they want," Dussopt told the LCI channel. 

No opposition party has pledged to support the centrist minority government so far, but the conservative Republicans might still be persuaded, observers say.

DJ...another source;

[url]https://flutrackers.com/forum/forum/local-regional-communities-and-organizations/cidrap/959806-cidrap-covid-19-continues-upward-trend-in-europe[/url] or https://flutrackers.com/forum/forum/local-regional-communities-and-organizations/cidrap/959806-cidrap-covid-19-continues-upward-trend-in-europe ;

Sep 30, 2022

Europe's COVID cases showed more signs of rising last week, marking the first regionwide spike since the most recent BA.5 wave, the European Centre for Disease Prevention and Control (ECDC) said today in a weekly update.

In the past, increasing cases in Europe have come ahead of similar rises in other regions, so trends in Europe are a closely watched global indicator.

Seniors hit hardest in Europe


Cases in people ages 65 and older rose 9% compared to the previous week, which the ECDC said was led by recent increases in 14 of 26 countries in the European Union that reported data. Deaths continued a decreasing trend.

Generally, hospitalization and intensive care unit (ICU) markers were stable in the region, but of 27 reporting countries, 14 noted an increasing trend. The ECDC said the overall picture is that increasing transmission in the majority of countries is mainly affecting seniors, which is in turn impacting hospitals.

"Changes in population mixing following the summer break are likely to be the main driver of these increases, with no indication of changes in the distribution of circulating variants," the ECDC said.

In the United Kingdom, most COVID indicators rose last week compared to the previous week, the Health Security Agency (HSA) said yesterday, pointing out that hospitalizations are highest in those ages 85 and older and that officials have seen a large spike in hospitalizations in those older than 80.

Officials said the North East region had the highest hospital admission level and over the whole region, deaths remained stable.

Mary Ramsay, MBBS, who directs the HSA's public health programs, said, "It is clear now that we are seeing an increase which could signal the start of the anticipated winter wave of COVID-19." She added that the time to get a booster shot if eligible is now. "Cases have started to climb, and hospitalizations are increasing in the oldest age groups," Ramsay said.

Most US markers decline amid subvariant shifts


In the United States, COVID metrics continue to fall, as variant proportions continue to shift. In a weekly update, the Centers for Disease Control and Prevention (CDC) said the 7-day average for new daily cases decreased 13.1% compared to the week before, with the 7-day average for new COVID deaths down 6.7%.

The 7-day average for new daily COVID hospitalizations dropped 7.4% compared to the week before. Hospitalizations have decreased by 25% over the past month, with rates highest in adults ages 85 and older.

One measure that rose was the 7-day average for PCR test positivity, which increased slightly from 9.6% to 9.8%. Wastewater surveillance suggests that 53% of monitoring sites reported a decrease in SARS-CoV-2 levels, while 41% reported an increase.

Regarding variant proportions, BA.5 is still dominant, but continues to decline slowly as newer Omicron subvariants continue to rise slowly, the CDC said today in its latest proportion updates. BA.5 declined from 83.2% to 81.3% over the past week, while BA.2.75 rose from 1.2% to 1.4% and BF.7 rose from 2.4% to 3.4%. Also, the level of BA.4.6, seen at highest levels in the southern Midwest states, rose from 11.8% to 12.8%.

7.5 million have received updated booster


In other updates today, the CDC said more than 7.5 million people have gotten their updated booster doses, up from 4.4 million last week. However, it also noted that 49.9% of the eligible population has yet to receive any booster dose.

A new survey from the Kaiser Family Foundation (KFF) said half of the public has heard little or nothing about the new booster shots and many don't know if the CDC recommends them. The findings also suggest that one third of adults and nearly half of seniors say they've either gotten the new booster or intend to get it as soon as possible.

The survey found a bit of improvement in COVID vaccination for children, which suggests a 7% rise from July. However, half said they will "definitely not" get their child vaccinated against COVID.

On flu [url]https://flutrackers.com/forum/forum/united-states/seasonal-flu-2009-2014-including-h1n1-pandemic-2009-aj/925260-us-fluview-weekly-surveillance-flu-report-2021-2022-season-for-trend-analysis?view=stream[/url] or https://flutrackers.com/forum/forum/united-states/seasonal-flu-2009-2014-including-h1n1-pandemic-2009-aj/925260-us-fluview-weekly-surveillance-flu-report-2021-2022-season-for-trend-analysis?view=stream latest; H3N2 flu dominating over H1N1-flu cases increasing in the US...

DJ...[url]https://www.rivm.nl/griep-griepprik/feiten-en-cijfers[/url] or https://www.rivm.nl/griep-griepprik/feiten-en-cijfers flu-like symptoms are increasing in NL-however H3N2 detections are going down...(it is still early)...I miss NL numbers on MPX...they stopped reporting them ????

In general; the west is moving into a crisis unseen in recent history....Not because of disasters-but because of crazy politics....This pandemic was avoidable...the NATO expansion/sanctions war are a total disaster....Climate collapse is NOT stopped...[url]http://arctic-news.blogspot.com/2022/09/crossing-3c.html[/url] or http://arctic-news.blogspot.com/2022/09/crossing-3c.html "profits first" politics for sale have become a global disaster...

Music; [url]https://www.youtube.com/watch?v=bcLazPauA1c[/url] or https://www.youtube.com/watch?v=bcLazPauA1c There 's got to be a morning after....Maureen Mc Govern 1973...

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: October 01 2022 at 2:21am

let me go for a part 3...trying to look at how hyperinflation, refugees, energy problems are affecting Europe (including the UK) ability to deal with the pandemic...








Today is my last day at University College London, and I want to finally get out of my chest the nightmare I have lived in there for the past 4 years Please read my open letter about the situation and share it carefully with potential students that could take a post at UCL Astro

see [url]https://twitter.com/cosmonist/status/1575890925477580803/photo/1[/url] or https://twitter.com/cosmonist/status/1575890925477580803/photo/1 "anti science-science" going for PR...








Latest ONS infection data shows a modest increase in England, up 11% from last week's reported figure but this understates the true weekly increase, as only a further 3 days have been added. Looking at the daily estimates, the weekly increase is actually 26% to 17th Sept.

-


Please stop. We've all had enough of this shitshow.


Image



-








🚨 NEW: Devon’s health and social care system "under extreme pressure" with long waits in A&E:

DJ link [url]https://www.torbayandsouthdevon.nhs.uk/about-us/news-and-publications/news/2022/09/help-us-help-you-24247/[/url] or https://www.torbayandsouthdevon.nhs.uk/about-us/news-and-publications/news/2022/09/help-us-help-you-24247/ ;

Published: 30 September 2022

Devon’s health and social care system is under extreme pressure today and expected to be throughout this weekend, meaning people are facing longer than usual waits in our Emergency Departments. Rising COVID-19 numbers, high demand for services and delays to discharging people from hospital are all contributing to pressure on the system.

People are being urged to do their bit to help support services by choosing the best service for their needs if they are ill or injured, staying at home if they have the symptoms of an infectious illness such as norovirus (known as the winter vomiting bug), flu or COVID-19 and by picking up any family or friends promptly when they are ready to be discharged from hospital.

NHS Devon’s Chief Nurse, Darryn Allcorn said: “If you do attend an emergency department and it isn’t a life-threatening emergency you may be directed to a more appropriate service. We ask you to be understanding that this is because there are other people who are in much more urgent need of our care.

“We are also urging family and friends of people in hospital to pick up their loved ones as soon as possible when they are ready to be discharged and the hospital has contacted them.”

Another source;








Truss, Kwarteng, and Clarke doubling down on their ‘small state’ ideology and rolling the pitch for spending cuts is totally detached from reality on at least three fronts:

-

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 30 2022 at 11:28pm

DJ, part 2,

Some US tweets;

And here's the divergence confirmed in new #COVID hospital admissions per regions. Compare Northeast Regions 1-3 with total US. HHS Region 1 is the only (first?) one up.

see also [url]https://twitter.com/x2IndSpeculator/status/1575999743117123584/photo/1[/url] or https://twitter.com/x2IndSpeculator/status/1575999743117123584/photo/1 (side arrow to photo 4) 

Replying to 
This graph is great at showing how we've been oddly flat, but clearly elevated, all summer. Just like the wastewater data shows. I honestly don't know what to make of this pattern - is this what "endemic" looks like? Is that our new baseline level between waves?

-

Replying to 
Similar happened in England. Endemic without NPIs or PIs means constant (re)infections; so permanently higher baseline level & waves muted. Then, authorities compare this level with the tops of the highest early waves (which btw have been followed by deep lows) & declare victory.

DJ... the US, UK, NL are run by political criminals...putting short term profits ("economy") above long term public health...If one looks at the bla-bla on climate collapse these "leaders" produce...NOT even limiting air travel, empty words...Again-the pandemic is the outcome of criminal politics...We can NOT get out of this worsening pandemic with the present "political clique"...not representing the people but an elite...

Some more on US-UK pandemic patterns;

Replying to 
England had a very different pattern from us - they had 3 distinct waves (BA1, BA2, and BA5), at fairly consistent intervals (3 months). With no periods of flatness - they kept going either up or down. It's the level of flatness we had here, going neither up nor down, that's odd.

-

Replying to 
That's true, they had more distinct waves, although those waves are more frequent but smaller in amplitude than in 2020/21. But, I meant more how the baseline is higher than at the previous lows in 2020 & 2021, and it's now considered normal. That high baseline is endemicity.

DJ...in climate change some "politicians" proberbly would love to put the year 2000 as a "base line" and claim "climate collapse is not that bad"...In this pandemic one could use 2021 as a baseline and claim 2022 "is not that bad" simply ignoring pre-pandemic statistics...

"Politics" should not be in creative lies...blame games, pushing for more wars...The present "leaders" did "lead" us to "unseen horizons" ...there may be some time left to make a U-turn...








1) Those calling for abstinence for infection control were flippant and neglectful authorities, dismissing the concerns of the marginalized with an impractical suggestion 2) The people calling for continued mask use are not the authorities, but rather the marginalized themselves

-








Replying to 
What seems to be the only lesson from the pandemic, is that governments have weighed the cost on economy of prevention measures versus letting people die. As the population accepts+++ massive mortality, no need for Public Health anymore.

DJ..so what will be "western leaders" next step ? In climate change they defunded "unwelcome science"...[url]https://en.wikipedia.org/wiki/Karen_Silkwood[/url] or https://en.wikipedia.org/wiki/Karen_Silkwood

Karen Gay Silkwood (February 19, 1946 – November 13, 1974) was an American chemical technician and labor union activist known for raising concerns about corporate practices related to health and safety in a nuclear facility.

She worked at the Kerr-McGee Cimarron Fuel Fabrication Site in Oklahoma, making plutonium pellets, and became the first woman on the union's negotiating team. After testifying to the Atomic Energy Commission about her concerns, she was found to have plutonium contamination on her person and in her home. While driving to meet with a New York Times journalist and an official of her union's national office, she died in a car crash under unclear circumstances.

Her family sued Kerr-McGee for the plutonium contamination of Silkwood. The company settled out of court for US $1.38 million, while not admitting liability. Her story was chronicled in Mike Nichols's 1983 Academy Award nominated film Silkwood in which she was portrayed by Meryl Streep.

of course also in the west unwelcome voices have "accidents" (we did have some "bizarre cases" here in NL [url]https://nl.wikipedia.org/wiki/Maarten_van_Traa#Overlijden[/url] or https://nl.wikipedia.org/wiki/Maarten_van_Traa#Overlijden , [url]https://en.wikipedia.org/wiki/Assassination_of_Pim_Fortuyn[/url] or https://en.wikipedia.org/wiki/Assassination_of_Pim_Fortuyn ...other ways of silencing scientists are "promotions" to other fields of science, putting child porn on their computer, claims of tax fraud...). 

DJ-We are in unknown territory..."leaders" did "lead" us here...

Music; [url]https://www.youtube.com/watch?v=wJVpihgwE18[/url] or https://www.youtube.com/watch?v=wJVpihgwE18 "We've got to get out of this place" (Vietnam-war clip...)...

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 30 2022 at 10:54pm

DJ, part 1 (yesterday part 3 did proof the twitter problem...) 

October 1...

"This is exactly what the Security Council was made to do. Defend sovereignty, protect territorial integrity, promote peace and security," said US ambassador to the United Nations, Linda Thomas-Greenfield, adding "The United Nations was built on an idea that never again would one country be allowed to take another's territory by force."

Memory loss, amnesia, may be linked to long CoViD...

[url]https://nltimes.nl/2022/09/30/ministers-call-171-inflation-rate-terrible-extreme[/url] or https://nltimes.nl/2022/09/30/ministers-call-171-inflation-rate-terrible-extreme ;

Statistics Netherlands’ announcement that inflation was 17.1 percent in September, according to the European harmonized method, hit the Cabinet hard. Various Ministers commented, calling the inflation rate terrible and pointing out that the government is working on softening the blow.

“It is terrible,” said Finance Minister Sigrid Kaag, NOS reports. “It’s really extremely high, also in the countries around us.” She pointed out that the Cabinet already announced a 17 billion euros package to boost purchasing power next year and is working on the energy price cap for consumers.

DJ...creating, "printing" more money only worsens inflation...

[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table as indication only; global cases at -3%, Europe cases +14%, Africa +0,5%...(Oceania cases depend on Australia reporting them...-19% is a "false statistic"...Australia reporting cases once, twice a week...?) 

Some statistics per country/cases, Tunesia +87%, Austria +66%, Germany +60%, Italy +57%, NL +56%, Ghana +46%, Algeria +39%, Papua New Guinea +36%, Singapore, Denmark both +35%, Chile +34%, France, China (!) +33%, South Africa, Saudi Arabia, Libya all +25%, Bangladesh +16%, Brazil +9%, Israel , Croatia, Ethiopia, Iceland all +8%, Spain +5%, Taiwan +3%..

There are 76 countries reporting an increase of cases...Three countries reporting over 10,000 new cases per million of the population...Montserrat, Dominaca are small...Taiwan ( with 12,082 cases per million in the last 7 days) is a larger country...good healthcare, testing, reporting...39 more countries reported over 1,000 new cases per million...

In other words, three countries did report 1%+ of their population testing positive last week, 39 countries did find 0,1%+ of their population tested positive...[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time UK cases going up..."incorrect statistics" in worldometers has UK cases -4%...

US cases in worldometers -26%...other (twitter) sources may signal the US has a variant escaping testing ?????

Of course with "politics" going for more war, hyperinflation, any basis for limiting this pandemic is missing...

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory a few countries had a last update september 22...a lot of them simply stopped reporting in august...

And this; [url]https://www.aconlabs.com/public-notice-of-counterfeitflowflex-covid-19-antigen-home-test-kits/[/url] or https://www.aconlabs.com/public-notice-of-counterfeitflowflex-covid-19-antigen-home-test-kits/ ;

ACON Laboratories, Inc., has become aware that counterfeit versions of its FDA-authorized Flowflex® COVID-19 Antigen Home Tests in the 1 Test/ kit box configuration marked as Lot# COV2010030 and COV2030016 are being illegally distributed in the United States through unauthorized distributors. These counterfeit tests have not been authorized, cleared, or approved by the FDA for distribution or use in the United States, but their packaging and components may very closely resemble authentic FDA-authorized Flowflex tests. 

Consumers should take precautions to avoid purchasing Flowflex in the 1 Test/ kit box configuration marked as Lot# COV2010030 and COV2030016, that was not distributed through an authorized distributor. ACON is currently not aware of any counterfeit tests in the 2 Test/ kit box and 5 Test/ kit box configurations. The performance of these counterfeit tests has not been adequately established and there is concern about the risk of inaccurate results when people use these unauthorized tests.

Flowflex tests from Lot# COV2010030 and COV2030016 purchased from ACON’s authorized distributors or retail partners listed on FlowflexCOVID.com are authentic and safe to use.

DJ...I have some of the test-kits here at home...In NL the print on the side is a bit different from the US...If fake-test are the problem-in some countries-at least there would not be variants escaping testing....








2 Brazilian HCWs contract #monkeypox, seemingly during a home care visit to a person later confirmed to have MPX. The report, in , underscores the importance of good infection control practices & the role fomites can play in transmission. https://wwwnc.cdc.gov/eid/article/28/12/22-1343_article

DJ...some indication MPX did increase spread after schools/workplaces reopened...simply not being reported...

How NOT to fight a pandemic !

End of part 1

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 30 2022 at 12:15am

part 3...twitter...posting from twitter is problematic...

My, oh, my, what's this? #SARS2 spiking in Massachusetts wastewater again. Hopefully next week Biobot will release all regions data, not only for the Northeast.

-

Now, this divergence is just bizarre. Is there some new variant in the Northeast that hasn't reach other parts of the US? Is it BarbeQue.1.1 time already?

-








Replying to 
This is the gentle increase that corresponded to the starting of schools (I don't know why other regions didn't have that). The new spike is what's unusual. I hear that lots of people/kids are sick with stuff that test negative on rapid tests. No idea what that's about ðŸ¤·ðŸ»â€â™€ï¸

DJ...US cases -27% deaths -25%...reporting/testing may be one problem...there will be regional differences...Floriada, South Carolina may be dealing with "Ian"/stormdamage...

Is there also a variant spreading (a.o.) in the US that is escaping from testing ????

[url]https://public.tableau.com/app/profile/raj.rajnarayanan/viz/USAVariantDB/VariantDashboard[/url] or https://public.tableau.com/app/profile/raj.rajnarayanan/viz/USAVariantDB/VariantDashboard ; a mega-mix of sub-variants...

#COVID19 #VariantDashboard - #UnitedStates  TOP lineages (15-DAY TRENDS): 21.90%  BA.5.2.1 12.89%  BA.5.2 11.13%  BA.5.1 10.84%  BA.4.6 3.36%   BF.10 3.25%   BA.5.6 3.04%   BA.5.5 3.01%   BA.5 2.11%   BA.5.2.9

for the US-last 15 days...but again-if people test-do not get a + even with symptoms...sequencing may miss variants...








- We’re now seeing multi-system inflammatory syndrome in newly born INFANTS. SARS2 never attenuated. It never became mild. It still has a Sag, MHCI downreg, immune evasion/disruption/destruction, & viral persistence. It is not compatible with human physiology. Wear NIOSH PPE.

-

Around 16 million working-age Americans have long Covid today. 2 to 4 million are out of work due to long Covid. Annual cost of those lost wages alone is $170 billion a year (up to $230 billion).

link [url]https://www.brookings.edu/research/new-data-shows-long-covid-is-keeping-as-many-as-4-million-people-out-of-work/[/url] or https://www.brookings.edu/research/new-data-shows-long-covid-is-keeping-as-many-as-4-million-people-out-of-work/ DJ-of course also a lot of human suffering...depression, PTSD, etc on top of other health issues...

[url]https://www.medscape.com/viewarticle/981583[/url] or https://www.medscape.com/viewarticle/981583 ;DJ, For the US long/chronic CoViD costs could run into trillions...worldwide simply  unimaginable...Outcome of "saving the economy" ...it is destroying the economy !!!








Man who says he will die if covid protections are lifted dies of covid after covid protections are lifted What’s wrong with us?

Link;[url]https://www.cbc.ca/news/canada/thunder-bay/immunocompromised-death-covid-19-1.6597716[/url] or https://www.cbc.ca/news/canada/thunder-bay/immunocompromised-death-covid-19-1.6597716 ;

An immunocompromised man in Thunder Bay, Ont., who feared the consequences of relaxed public health measures died last month after testing positive for COVID-19.

Joe Lunn, a heart transplant recipient, told CBC News in March that he was worried about the Ontario government's decision to do away with vaccine certificates in public places.

He had also expressed concerns about its plans to end mask mandates, saying he felt safer in public when others were also taking precautions against spreading the virus. 

"I have fought too hard to stay alive to give up because you feel inconvenienced by a four-by-four inch cloth," he said at the time.

DJ...is this murder ? Is not stopping CoViD, climate collapse genocide ? If not-why not ? 








Covid hospitalisations on the up again, not just in England, but in several Western European countries...


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DJ,

part 2-a look at [url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table "post pandemic" statistics....with poor reporting, at best as indication...however lots of extra info will give a more realistic view...

Global cases now at -4%...Europe cases +10%...winterwave did start here...Oceania cases +65%, deaths +2% (at the moment...). There are 66 countries reporting an increase of cases...Germany, Italy 50%+  Chile, Guatamala, Ghana all +46% ....[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time UK self reporting numbers going up -over 2.1 million reporting symptoms....

There are lots of statistics-the Our World In Data-jungle....but what is needed is good testing and good reporting...sequencing may tell us more on what variants are spreading...however the picture I get is people may be infected by more then one variant...

[url]https://www.thailandmedical.news/news/breaking-university-of-queensland-study-discovers-that-sars-cov-2-actually-attacks-the-dna-of-heart-cells[/url] or https://www.thailandmedical.news/news/breaking-university-of-queensland-study-discovers-that-sars-cov-2-actually-attacks-the-dna-of-heart-cells link to [url]https://onlinelibrary.wiley.com/doi/10.1111/imm.13577[/url] or https://onlinelibrary.wiley.com/doi/10.1111/imm.13577 ;

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ complications. In comparison with the 2009 pandemic (pH1N1), SARS-CoV-2 infection is likely to lead to more severe disease, with multi-organ effects, including cardiovascular disease. 

SARS-CoV-2 has been associated with acute and long-term cardiovascular disease, but the molecular changes that govern this remain unknown. In this study, we investigated the host transcriptome landscape of cardiac tissues collected at rapid autopsy from seven SARS-CoV-2, two pH1N1, and six control patients using targeted spatial transcriptomics approaches. 


Although SARS-CoV-2 was not detected in cardiac tissue, host transcriptomics showed upregulation of genes associated with DNA damage and repair, heat shock, and M1-like macrophage infiltration in the cardiac tissues of COVID-19 patients. 


The DNA damage present in the SARS-CoV-2 patient samples, were further confirmed by γ-H2Ax immunohistochemistry. In comparison, pH1N1 showed upregulation of interferon-stimulated genes, in particular interferon and complement pathways, when compared with COVID-19 patients. 


These data demonstrate the emergence of distinct transcriptomic profiles in cardiac tissues of SARS-CoV-2 and pH1N1 influenza infection supporting the need for a greater understanding of the effects on extra-pulmonary organs, including the cardiovascular system of COVID-19 patients, to delineate the immunopathobiology of SARS-CoV-2 infection, and long term impact on health.

DJ...in short; it looks like CoViD is damaging hearth(muscle) DNA....

There is an increase of excess deaths-[url]https://www.euromomo.eu/graphs-and-maps/[/url] or https://www.euromomo.eu/graphs-and-maps/ above "normal" for all ages...But also depending on deaths being reported...What is defined as "a CoViD-death" -often as far as I know-the criteria is testing positive for CoViD and death-(from CoViD symptoms) within 4 weeks...Car accidents, wars, killing people that tested + for CoViD are not supposed to be included...however CoViD does do a lot of damage all over the body-long term...So what is a good definition for "death from CoViD" ? 

Does it matter ? I think the main point is -even with a strict definition- CoViD killing more people then -for example-the flu...It is-in that way-a serious risk. On top of that lots of long term health issues...[url]https://www.dutchnews.nl/news/2022/09/ministers-plan-e15000-payout-to-health-workers-with-long-covid/[/url] or https://www.dutchnews.nl/news/2022/09/ministers-plan-e15000-payout-to-health-workers-with-long-covid/ ;

Ministers want to give a ‘no strings’ €15,000 pay out to healthcare workers who developed coronavirus during the early stages of the pandemic and are now dealing with the impact of Long Covid. The pay out is not meant to be seen as damages, or some form of invalidity benefit, but is a ‘recognition of the suffering’ nurses and other healthcare staff have experienced, care minister Conny Helder told MPs on Thursday.
-

The two largest Dutch trade unions have threatened to take legal action against the government unless it offers compensation to healthcare workers suffering from long covid. They have welcomed news of the payout, but say it may be too little too late. The FNV and CNV say the government has failed to address the needs of some 5,500 frontline healthcare workers who are still suffering the effects of coronavirus infections in the early waves of the pandemic. According to the unemployment agency UWV, some 600 healthcare workers have been declared unfit for work due to long covid symptoms. A further 1,000 have been on sick leave for two years, and now risk losing their jobs. The unions say that government guidelines for protective equipment and quarantine violated World Health Organisation standards, allowing hundreds of healthcare workers to become infected

DJ...the pandemic is NOT over...CoViD is still a very serious health risk...with more then 3 million new cases being reported...Global CoViD deaths being rported (worldometers) number dropped from +10,000 last week to +8,000 last 7 days...That pattern indicates the effect of the last wave of CoViD on deaths may be decreasing...but again CoViD death is not well defined...reporting/testing is "poor"...numbers only may give some indication at best...

Thailand Medical News on its site -top bar- warning; Daily CoViD-19 infections, Hospitalizations and deaths rising in UK and elsewhere in Europe...Worldometers on deaths in some European countries ;

Denmark +42% ( last week 31, last 7 days 44 on a population of 5,8 million, 8 per million of the population)

Poland +32% ( last week 96, these last 7 days 127...population 37,7 million 3 per million of the population)

Germany +11%, France +7%...UK simply not reporting in these numbers...

-Another issue [url]https://www.thailandmedical.news/news/breaking-researchers-warn-that-sars-cov-2-could-also-infect-aquatic-mammals-such-as-dolphins-and-whales-creating-new-viral-reservoirs[/url] or https://www.thailandmedical.news/news/breaking-researchers-warn-that-sars-cov-2-could-also-infect-aquatic-mammals-such-as-dolphins-and-whales-creating-new-viral-reservoirs link [url]https://www.mdpi.com/2076-0817/11/10/1096[/url] or https://www.mdpi.com/2076-0817/11/10/1096 ;

Abstract

Due to marine mammals’ demonstrated susceptibility to SARS-CoV-2, based upon the homology level of their angiotensin-converting enzyme 2 (ACE2) viral receptor with the human one, alongside the global SARS-CoV-2 occurrence and fecal contamination of the river and marine ecosystems, SARS-CoV-2 infection may be plausibly expected to occur also in cetaceans, with special emphasis on inshore species like bottlenose dolphins (Tursiops truncatus). 

Moreover, based on immune and inflammatory responses to SARS-CoV-2 infection in humans, macrophages could also play an important role in antiviral defense mechanisms. In order to provide a more in-depth insight into SARS-CoV-2 susceptibility in marine mammals, we evaluated the presence of SARS-CoV-2 and the expression of ACE2 and the pan-macrophage marker CD68. Aliquots of tissue samples, belonging to cetaceans stranded along the Italian coastline during 2020-2021, were collected for SARS-CoV-2 analysis by real-time PCR (RT-PCRT) (N = 43) and Immunohistochemistry (IHC) (N = 59); thirty-two aliquots of pulmonary tissue sample (N = 17 Tursiops truncatus, N = 15 Stenella coeruleoalba) available at the Mediterranean Marine Mammal Tissue Bank (MMMTB) of the University of Padua (Legnaro, Padua, Italy) were analyzed to investigate ACE2 expression by IHC. 

In addition, ACE2 and CD68 were also investigated by Double-Labeling Immunofluorescence (IF) Confocal Laser Microscopy. 

No SARS-CoV-2 positivity was found in samples analyzed for the survey while ACE2 protein was detected in the lower respiratory tract albeit heterogeneously for age, gender/sex, and species, suggesting that ACE2 expression can vary between different lung regions and among individuals. Finally, double IF analysis showed elevated colocalization of ACE2 and CD68 in macrophages only when an evident inflammatory reaction was present, such as in human SARS-CoV-2 infection.

DJ...basic story; sea mammals have ACE-2 receptors able to get infected with CoViD-19 -however so far no CoViD-19 infection was detected in this study...

There are more "receptors" then ACE-2 able to get infected by CoViD-virus...Most people do not have much contacts with other species beside pets...Cats may be more vulnerable then dogs for catching CoViD...but even cats seem not be good in spreading CoViD....Minks may be the most-known-problematic animal for CoViD; easy catching AND spreading it...rats, mice (etc) may be more an unknown risk...

DJ-One possible bad scenario is that we may find no major problems in mice, rats etc...untill there is a new variant able to infect & spread high speed...via urine/dropping also possibly infecting other species, pets...[url]https://www.wormsandgermsblog.com/[/url] or https://www.wormsandgermsblog.com/ and lots of other institutions trying to do the best they can to monitor CoViD-risks in non-human hosts...

-Exponential growth..."explosion" of disease may show in increase of CoViD cases...Is also seen in decrease of immune protection after CoViD infection...resulting in an increase of all kinds of other (infectious) diseases. But it may also show in the number of (sub) variants of CoViD...Omicron now over 1,000 subvariants ? 

Another "exponential" aspect is spread outside the almost 8 billion humans...there are trillions of other animals on this planet...

So-if we would like to see an end to the pandemic-the last thing one wants is massive spread of CoViD in non-human hosts...Even if spread-for now-would be limited-it is a further risk....

[url]https://outbreak.info/situation-reports[/url] or https://outbreak.info/situation-reports showing 625 known/reported Omicron subvariants...

DJ-the picture I more and more get on this ongoing pandemic is "depressing"...."out of control"...a potential very major healthproblem able to kill millions of people in the coming years..

There are ways to stop/limit this; from (better) vaccines, masks to limiting travel (since virusses travel-for-free !) we are not doing enough to get out of this crisis...

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 29 2022 at 10:06pm

DJ, more then enough news...

Of course hurricanes -destroying homes and hospitals- most likely will worsen a pandemic. Extreme weather is increasing worldwide...in many ways it can be linked to increasing pandemic risks...Wars, climate change do result in lots of refugees-often in not such good health...however most of global travel is NOT related (yet) to refugees...but vacation, trade...Airtravel has been a main factor in spreading CoViD, worsening climate "change"-in fact climate collapse...

If we seriously wanted to deal with pandemics, climate collapse airtravel would be 5-10% of what it was in 2019....in most places air travel is at pre-pandemic level "saving the economy/profits..."

Some did make claims the "pandemic is over"; 

A pandemic is an epidemic occurring on a scale that crosses international boundaries, usually affecting people on a worldwide scale.[13] A disease or condition is not a pandemic merely because it is widespread or kills many people; it must also be infectious. For instance, cancer is responsible for many deaths but is not considered a pandemic because the disease is not contagious—i.e. easily transmittable—and not even simply infectious.[14]

In 2009, the World Health Organization (WHO) dropped the words "with enormous numbers of deaths and illness" from their definition.[15] In 2008, it also dropped the requirement of an "influenza pandemic" to be a new sub-type with a simple reassortant virus, meaning that many seasonal flu viruses now could be classified as pandemic influenza.[16]

[url]https://en.wikipedia.org/wiki/Pandemic#Stages[/url] or https://en.wikipedia.org/wiki/Pandemic#Stages ; Stage 6-pandemic in progress, sustained (spread) in more then one WHO region. There is also a "post peak" phase...but "post peak" does not mean you are out of the pandemic...there could be another peak...higher even then the previous one...

So -do we see a stop of CoViD spread in ANY WHO region ???? On what bases "a responsible person" could make a claim the pandemic is over ? "Endemic";

In epidemiology, an infection is said to be endemic (from the Greek á¼νen, "in, within" and δῆμοςdemos, "people") in a population when that infection is constantly maintained at a baseline level in a geographic area without external inputs.[1] For example, chickenpox is endemic (steady state) in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus Anopheles). While it might be common to say that AIDS is "endemic" in some countries, meaning found in an area, this is a use of the word in its etymological, rather than epidemiological or ecological, form.

For an infection that relies on person-to-person transmission, to be endemic, each person who becomes infected with the disease must pass it on to one other person on average. Assuming a completely susceptible population, that means that the basic reproduction number (R0) of the infection must equal one. In a population with some immune individuals, the basic reproduction number multiplied by the proportion of susceptible individuals in the population (S) must be one. This takes account of the probability of each individual to whom the disease may be transmitted being susceptible to it, effectively discounting the immune sector of the population. So, for a disease to be in an endemic steady state it is:

{\displaystyle R_{0}\times S=1}{\displaystyle R_{0}\times S=1}

In this way, the infection neither dies out nor does the number of infected people increase exponentially but the infection is said to be in an endemic steady state. An infection that starts as an epidemic will eventually either die out (with the possibility of it resurging in a theoretically predictable cyclical manner) or reach the endemic steady state, depending on a number of factors, including the virulence of the disease and its mode of transmission.

If a disease is in an endemic steady state in a population, the relation above allows us to estimate the R0 (an important parameter) of a particular infection. This in turn can be fed into a mathematical model for the epidemic. Based on the reproduction number, we can define the epidemic waves, such as the first wave, second wave, etc. for COVID-19 in different regions and countries.[2]

[url]https://en.wikipedia.org/wiki/Endemic_phase_of_COVID-19#Medical_view[/url] or https://en.wikipedia.org/wiki/Endemic_phase_of_COVID-19#Medical_view ;

On 14 April 2022, the World Health Organization said that COVID-19 is far from becoming an endemic disease and could still trigger large outbreaks around the globe.[1]

In June 2022, an article in Human Genomics said that the pandemic was "still raging" but "now is the time to explore the transition from the pandemic to the endemic phase. The latter will require worldwide vigilance and cooperation, especially in emerging countries", and suggested that developed countries should assist in boosting vaccination rates worldwide.[2]

and [url]https://en.wikipedia.org/wiki/Endemic_phase_of_COVID-19#Analysis[/url] or https://en.wikipedia.org/wiki/Endemic_phase_of_COVID-19#Analysis ;

A 2021 article in The Lancet called restrictions being lifted in the United Kingdom "dangerous and immature" and expressed concern that mass infection could lead to vaccine resistance and would impact young people, children and health services.[75] In The BMJ in February 2022, several health policy and public health experts criticised the British government's "living with COVID" plan, suggesting the end of free COVID-19 testing could exacerbate health inequality, and suggesting the plan did not account for required resources for localised contact tracing and hospital capacity.[76]

Elizabeth Stokoe and colleagues wrote that the phrase "living with COVID-19" is a cliché that has two opposed, disputed meanings. On the one hand it can mean simply returning to pre-pandemic living; on the other it can mean that life now must incorporate public health mitigation measures to reduce the impact of the disease. In the United Kingdom, the phrase had enjoyed wide currency among politicians and the popular media, particular in the later, post-2021, phases of the pandemic.[77]

DJ...Like the IPCC (International Panel on Climate Change) the WHO is a political organization...while both groups should put science-not profits-first..."living with the virus" made this pandemic almost impossible to control by now....[url]https://en.wikipedia.org/wiki/Variant_of_concern#Criteria[/url] or https://en.wikipedia.org/wiki/Variant_of_concern#Criteria ...the refusal to give new names to several variants-now all called "Omicron" is anti-science....

Governments denying major risks for the human species are endangering human live...They are not "just" failing...but when you know the risks, know how to limit those risks but rather go for profit governments may be pushing for genocide by pandemics, climate collapse...

False claims "the pandemic is over" by people in a high position is criminal...it is like claiming the house is safe when it is burning out of control...Telling a blind person it is safe to cross the street when it is not...Governments, health agencies have a job making as best as possible risk assesments...inform the public...

Hurricane warnings save lives...knowing the risks and not warning is killing people...millions of them...and that is totally unacceptable !

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 29 2022 at 12:05am

part 2, 

[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table European cases-bad statistics cases +8%...since lots of countries do not provide daily updates "statistics erode over non-reporting days"...[url]https://www.rivm.nl/coronavirus-covid-19/weekcijfers[/url] or https://www.rivm.nl/coronavirus-covid-19/weekcijfers september 27 had NL test result cases +39%...but they only report on tuesday and friday...so worldometer has NL cases now "only" at +16%...

Status of the latest #COVID19 Wave in #NorthEast #USA (MD, PA, DE, NY, MA, VT, CT, NJ, ME, NH, RI) Top circulating variants - BA.5.2.1, BA.4.6 (~14%), BA.5.2 Other: BF.7 (2.6%) BQ.1 (1.2%) BE.1.1 (1.7%) Closely watching hospitalizations.. Don't let your guard down! 15/n

DJ, In worldometers US cases -31% [url]https://public.tableau.com/app/profile/raj.rajnarayanan/viz/HospitalCapacity-USA/HospitalCapacity[/url] or https://public.tableau.com/app/profile/raj.rajnarayanan/viz/HospitalCapacity-USA/HospitalCapacity with several US states hospital capacity in use allready over 90%...(Roode Eylant/ (old Dutch name..) Rhode Island ) and 12 states 80% or more...

[url]https://www.coronaheadsup.com/health/treatment/remdesivir/preprint-mutated-sars-cov-2-variant-resistant-to-remdesivir/[/url] or https://www.coronaheadsup.com/health/treatment/remdesivir/preprint-mutated-sars-cov-2-variant-resistant-to-remdesivir/ ;

A new preprint study shows that two kidney transplant patients treated with immunosuppressive drugs, and who later had a lengthy COVID-19 infection, developed a version of the virus with a genetic change that made it resistant to the antiviral therapy remdesivir.

Our work emphasizes the potential risk of immune escape in immunocompromised hosts, a scenario in which novel spike mutations evade a suboptimal immune response and contribute to recrudescence of symptomatic infection. Equally concerning are recent reports in immunocompromised hosts highlighting the proclivity of SARS-CoV-2 to develop spike mutations conferring resistance to immunotherapeutics after treatment with monoclonal antibodies.

As remdesivir use has become widespread, and we show that mutations associated with remdesivir resistance arise in vivo, our work emphasizes the importance of augmented surveillance efforts to detect clinically significant mutations in immunocompromised patients. Potentially foreshadowing an “endgame” scenario for the COVID-19 pandemic, complex cases like the ones described in this report may presage the eventual need for more advanced molecular diagnostics at the onset of illness to guide therapeutic decisions. It is reasonable to assess for new mutations in patients with prolonged illness who experience persistent infection despite initial therapy.

Preprint: Remdesivir resistance in transplant recipients with persistent COVID-19

DJ [url]https://www.thailandmedical.news/news/with-the-debut-of-over-200-new-immune-evasive-omicron-variants-and-sub-lineages-expect-a-winter-of-dangerous-reinfections-and-coinfections[/url] or https://www.thailandmedical.news/news/with-the-debut-of-over-200-new-immune-evasive-omicron-variants-and-sub-lineages-expect-a-winter-of-dangerous-reinfections-and-coinfections  (TMN) a.o. a link [url]https://cov-spectrum.org/collections/24[/url] or https://cov-spectrum.org/collections/24 to 203 Omicron subvariants with evasive mutations...TMN again warning some new variants have "qualities" seen in SARS 1...[url]https://en.wikipedia.org/wiki/SARS-CoV-1#SARS[/url] or https://en.wikipedia.org/wiki/SARS-CoV-1#SARS

In the SARS outbreak of 2003, about 9% of patients with confirmed SARS-CoV-1 infection died.[14] The mortality rate was much higher for those over 60 years old, with mortality rates approaching 50% for this subset of patients.[14]

Of course the 2003-SARS-1-outbreak was limited...hospitals could provide a lot of HQ care....this winter hospitals may be without enough staff, energy, finance, medication...

The most important tool in any crisis is information...

However if governments, some "experts-for-sale" simply deny the problems (climate collapse, pandemics, risks of war) and only go for short term profits-based on greed and stupidity fighting for dominance...well then the only real answer has to be get other leaders in place....

TMN mentions shorter intervals in reinfections, likely lots more co-infections...DJ-Those co-infections may be outside CoViD...a CoViD-H5N1 flu coinfection could become a disaster...Of course global H5N1 is "out of control" in birds...but also detected infoxes...very likely in other mammals eating dead infected birds...Vaccines-even the newest-could become "less effective" soon...Still might offer some protection against severe disease...

But a "vaccination strategy" in wich vaccines do NOT stop spread of infection-only limits disease-needed a major Non Pharma Intervention strategy that has been totally missing "saving the economy"...A bit like sand bags in front of the front door during a hurricane bringing over 3 meter (12 feet !!!) waves...it is simply not enough !!!!

Somehow "experts" are unwilling to accept science not fitting their "world view"...Exponentials in climate change, pandemics can result in very major changes in a short time...

Maybe first steps are small; 1%, 2%, 4%...we can handle it...8%, 16% "economy first"...32%, 64%...collapse...in a society as complex as modern western ones small changes may allready cause major disruptions... "Just in time delivery" may see a proces getting destroyed when some aspects are "not in time"...

I think you have to put a pandemic against a background. The Spanish Flu did kill that many because of World War One...The coming CoViD winter wave-in combination with CoViD fatigue, bad info, governments unable to understand the crisis...it is a mega mix that can result in the worst human crisis since the middle ages plague in Europe (or the "discovery of the America's by Europeans killing up to 90% of the original American population..Massive slave trade-killing tens of millions of slaves either during transport (as cargo) or in the fields...Brazilian slaves were seen as short term investments..if they worked a few years the investment was "worthwile"...old slaves did cost money...I will not even start on breeding slaves...). 

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 28 2022 at 11:23pm

DJ, 

Let me start with a non-pandemic item, music related;[url]https://www.gelderlander.nl/arnhem/amerikaanse-zangeres-moet-arnhems-hotel-verlaten-om-discussie-over-steak-je-zet-toch-geen-75-jarige-op-straat-br~a9cbdb50/[/url] or https://www.gelderlander.nl/arnhem/amerikaanse-zangeres-moet-arnhems-hotel-verlaten-om-discussie-over-steak-je-zet-toch-geen-75-jarige-op-straat-br~a9cbdb50/ one of my favorite old time singers Melanie (now 75) and her son were kicked out of the Arnhem Centre "Bastion Hotel" in a fight over a steak....insanity rules...

[url]https://www.youtube.com/watch?v=PoyyZEaDUyU[/url] or https://www.youtube.com/watch?v=PoyyZEaDUyU "Beautifull People"...1971 somehow [url]https://en.wikipedia.org/wiki/Melanie_(singer)[/url] or https://en.wikipedia.org/wiki/Melanie_(singer) somehow was in my town Arnhem several times...never expected to end up kicked out of a local hotel...[url]https://twitter.com/melaniesafka[/url] or https://twitter.com/melaniesafka and [url]https://www.facebook.com/melanie.safka.5[/url] or https://www.facebook.com/melanie.safka.5 ...crazy !

-There is some talk of a Polar Vortex [url]https://www.severe-weather.eu/global-weather/polar-vortex-cooling-forecast-winter-2022-2023-influence-united-states-europe-fa/[/url] or https://www.severe-weather.eu/global-weather/polar-vortex-cooling-forecast-winter-2022-2023-influence-united-states-europe-fa/ wich could bring cold weather to the US, Europe "later on"...in the middle of an energy crisis (for wich a growing number of people point to biden...) in "the west"...It will increase social unrest...Mass protests, riots and pandemics are NOT a good combination...More on-what looks like US attacks on European-Russia pipelines in non pandemic latest news...insanity rules...

[url]https://www.coronaheadsup.com/europe/europe-another-record-breaking-winter-wave-predicted/[/url] or https://www.coronaheadsup.com/europe/europe-another-record-breaking-winter-wave-predicted/ ;(Ourworldindata)

These European Covid-19 infection charts do NOT look good – almost every country in Europe has a higher Covid case level now than before the huge Omicron winter wave of 2021.

We compared Covid  cases numbers for 27th September 2021 and 27th September 2022 across a few European countries to see how they were faring before the new winter wave sets in.

In almost every European country we looked at, Covid case numbers are far above those on the same date the year last year, and that is despite a dramatic reduction in testing across the continent.

 

Germany currently has nearly SEVEN times as many Covid cases as on the equivalent day last year,

Italy has nearly seven times as many Covid cases as on the equivalent day last year,

France has about seven times as many Covid cases as on the equivalent day last year,

The entire European Union has around three times as many Covid cases as on the equivalent day last year,

Rising Covid case numbers are already feeding through to increased hospitalizations in France and Germany. Hospitalizations in both countries are already running at about twice the level of 27th September 2021.

Our prediction for the European winter wave of 2022: 
Due to a lack of simple, cheap and effective Covid mitigations being implemented across Europe, we predict another record-breaking year for the pandemic on the continent.

If you are travelling over the winter holidays, please take every precaution you can to prevent infection or reinfection.

DJ, [url]https://nltimes.nl/2022/09/28/rivm-new-covid-restrictions-despite-rising-cases-nl-unprepared-sharp-increase[/url] or https://nltimes.nl/2022/09/28/rivm-new-covid-restrictions-despite-rising-cases-nl-unprepared-sharp-increase ;

It is not yet necessary to take extra measures against the spread of the coronavirus, Jaap van Dissel of the public health institute RIVM said in a briefing to parliament on Wednesday. The basic measures like regular hand washing and going into isolation if you test positive should suffice, he said. At the same time, the Cabinet's advisory group, the Social Impact Team (MIT), cautioned that the Netherlands is not ready to handle a severe increase in infections and Covid-19 hospitalizations.

According to Van Dissel, the government's thermometer to monitor the pandemic's status is currently at its lowest level. That means the pressure on healthcare and society is limited and likely to remain so for the time being.


Van Dissel stressed that the Netherlands is not yet in a stable “endemic phase” of this pandemic. There is still a lot of uncertainty about the emergence of new variants, how much immunity has been built against the coronavirus, and how long that will last.

On Tuesday, the RIVM reported that the expected autumn wave of coronavirus infections may have started in the Netherlands. Although there were fewer than 400 patients with Covid-19 in Dutch hospitals on September 9, that figure rose significantly in subsequent days. Just in the past week, the number of patients jumped by more than a third to 631. The percentage of those patients needing intensive care remained low at 35, though that figure also rose by ten in a week. Hospitals admitted 34% more patients with Covid-19 on average over the last seven days compared to the week before. That includes 117 new hospital admissions on Tuesday, the most in nearly two months.


The surging hospital data coincides with a rise in coronavirus particulate matter found in sewer water, the rising basic reproduction (R) value that models the spread of the coronavirus, and the number of infections diagnosed by a healthcare facility. The latter jumped towards a seven-week high, rising by 39 percent, far outpacing the 27 percent increase in testing at the GGD.

The country is not ready for another rapid coronavirus outbreak

Jolande Sap, the chair of the MIT, warned that the Netherlands has not adequately prepared for the continuation of a sharp increase in infections over the next six months. At the same briefing Van Dissel attended, Sap said that it "cannot be ruled out that those scenarios will happen."

Sap said that the government should continue to keep coronavirus access passes as a legal option to impose on the public if the situation spirals out of control. In the past, the access passes were distributed based on vaccination status, prior infections, and test status. The passes were used to enter a variety of locations, like bars, restaurants, museums, and events, depending on the state of the coronavirus pandemic in the Netherlands.

She also said that the government was not placing enough consideration on people who may be impacted by a tightening of measures, such as young people, and people who have had difficulty becoming a part of the workforce. She also said that politicians need to better debate the ethics of the Cabinet's decision-making, "such as the trade-off between saving lives immediately, and protecting long-term quality of life."

Unenthusiastic vaccination turnout; Face masks should return, experts say

Figures from the RIVM show that people who got their Covid-19 vaccinations and a booster shot are 47 percent less likely to require hospitalization than people who skipped the booster shot and just got the repeat shot. After the repeat shot, people are 22 percent less likely to end up in the hospital with a coronavirus infection. The chance of needing intensive care is also smaller.

Given the increase in infections, especially among people over the age of 70, it is a “good time to start vaccinating again,” Van Dissel said. The Netherlands started the latest round of coronavirus vaccinations, using updated Pfizer and Moderna vaccines that offer better protection against the Omnicron variant, last week.

Turnout for the new vaccination round has been low, with fewer than 16 percent of people over 80 receiving a jab, though some may not be able to get a new vaccination because of a recent infection. “You see that people are less interested in a repeat jab when the extra shot is sensible,” said virologist Bert Niesters to the Telegraaf. “It is especially so if you have an underlying condition or you are older.”

He said it is clear that the coronavirus is not gone, particularly since the current Cabinet has not recommended any further measures to slow the new wave of infections. “With the current increasing figures, I would think it would be wise if there were a new emphasis on wearing face masks in busy places, such as in supermarkets, public transport, and in line at Schiphol,” Niesters told the newspaper.

“This is already normal in other countries such as Germany. Together with good hand hygiene, this helps to limit the spread.”

Radboudumc internist and infections expert Chantal Bleeker-Rover agreed. "Wearing a mask over the mouth and nose is much more effective than measures, such as extra cleaning, placement of splash screens, and creating walking routes," she told Omroep Gelderland. "If people want to protect themselves, such a mask is much more effective than those other things.

On Dutch twitter;








I'm not sure what goes into these calculations here, but the BQ.1(.1) growth advantage is visible globally. And unless these outbreaks were preferentially sequenced because they are BQ.1(.1) - they should only increase parameter noisiness, not bias the growth advantage estimate.

DJ [url]https://twitter.com/BertMulderCWZ[/url] or https://twitter.com/BertMulderCWZ (in Dutch) a.o. there is shock and anger on the total stupidity of a non-functioning strategy...From ventilation (who will pay) to sticking to old vaccines (still in storage...) NL government is failing again...Political bla-bla with potential loss of lives this coming winter due to diseases that should have been stopped -for NL alone-maybe in the tens-of-thousends....

End of part 1....

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 28 2022 at 3:03am

part 2, 

Lots of non-pandemic (directly) news...trying to just follow that...

[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table with simply very limited numbers/reporting the statistics are at best giving some indication; 

Global cases would be -14%...Japan a.o. had very high numbers...So Japan -27% on cases, South Korea -42% makes some sense...from very high numbers...US cases -43% however does NOT make sense...did they stop reporting US cases ? 

Europe cases +6%, with Germany cases +42%...NL +39%...France still +27% while they already were in high numbers...Oceania +8%, Australia +11% for cases...

[url]https://www.thailandmedical.news/news/spike-346-mutations-emerging-in-many-new-omicron-variants-and-sub-lineages-is-helping-sars-cov-2-to-escape-neutralization-by-all-known-antibodies[/url] or https://www.thailandmedical.news/news/spike-346-mutations-emerging-in-many-new-omicron-variants-and-sub-lineages-is-helping-sars-cov-2-to-escape-neutralization-by-all-known-antibodies again development in the WRONG direction !

-[url]https://forum.arctic-sea-ice.net/index.php/topic,3863.0.html[/url] or https://forum.arctic-sea-ice.net/index.php/topic,3863.0.html a discussion on if the Arctic melting season is over or not...Like pandemics you may need lots of data to reach a conclusion...[url]https://www.wormsandgermsblog.com/2022/09/articles/animals/cats/monkeypox-guidance-for-vets/[/url] or https://www.wormsandgermsblog.com/2022/09/articles/animals/cats/monkeypox-guidance-for-vets/ we may simply not have enough info...

[url]https://www.wormsandgermsblog.com/2022/09/articles/animals/birds/avian-influenza-response-approaches-does-one-size-really-fit-all/[/url] or https://www.wormsandgermsblog.com/2022/09/articles/animals/birds/avian-influenza-response-approaches-does-one-size-really-fit-all/ what are the risks of Avian Flu...

Another major concern I have with any strict policy is driving things underground. If bird owners know a positive test means all their birds will be killed, they’re more likely to try to ride out a problem and not get testing done. That means we lose valuable information, don’t get a chance to respond to help contain the issue, and we can miss the ability to manage disease properly if it’s something other than flu. I can absolutely see non-commercial bird owners avoiding testing if stories of mandatory depopulation of birds like theirs increase. We need to know the extent of the spread of this virus so we can take other steps to control it, and driving things underground doesn’t help.

Is there room for a "balanced approach"? [url]https://thebulletin.org/2022/09/is-the-next-pandemic-brewing-on-the-netherlands-poultry-farms/[/url] or https://thebulletin.org/2022/09/is-the-next-pandemic-brewing-on-the-netherlands-poultry-farms/ (good article-hope to find time for more on it later on...) DJ-If you want to put public health on top-relate it to possible very major risks of High Pathogenic Avian Influenza (HPAI) often-not only-H5N1 (other H5/H7 types a.o. also risks) spreading into humans there may be NO room....

DJ-I am not an expert but if I had to make a decission we would STOP animal farms NOW ! High populated area's may be most at risk...NL-south part-is almost a 10 million+ city...NW Europe-depending on definition is 60-100 million people in lots of urban area's...From millions of minks, (most of them now killed)  chicken, pigs to cows this pandemic should learn us this is asking for disaster...

We may be just a few steps away from a much worse pandemic...STOP THE SPREAD ! STOP creating lots of other diseases in overcrowded farms ! There are a few other area's in the world combining millions of people with millions of animals...China is being blamed for many outbreaks...but it simply is NOT only China...In Africa one has mega cities housing millions-often poor...combining it with lots of animals, poor hygiene...

A next pandemic may already have started-we only will learn it in a few weeks, month...Sequencing, testing is out of capacity...

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 27 2022 at 10:28pm

DJ, 

-When you use a car to go somewhere nearby the means of transport may be 10x the weight of your body...using lots of fuel, space, causing enviromental damage...I personally take a bicycle...less then 1/10 of my weight...taking limited space, very low cost...in urban area's often faster (easy parking !)...

In this pandemic vaccines may stand for cars, masks for bikes...

YES-(New) vaccines may have done a great job in limiting disease - no they did not stop the pandemics. Masks may have (maybe) done more to "stop the spread"...

In traffic you have both cars and bikes...in a pandemic one may need both vaccines and Non Pharma Interventions...how to balance that should be part of a strategy...and I am missing a clear strategy here in NL, most of "the west". China has a clear "Zero CoViD" strategy-has a "strong government" able to enforce it...other countries are in between strategies and what they are able to do...

Maybe the biggest mistake in the present pandemic is NOT limiting air traffic to 5-10% from pre-pandemic level (would also fit climate plans). All kinds of virusses/variants are allowed to fly for free. We are importing variants/diseases from Brazil, Africa, China etc...are exporting our own diseases around the globe...

In Dutch "mopping the floor with the tap still open" (dweilen met de kraan open)...If vaccines would be sterilizing there could maybe some room for this "leaky strategy" but vaccines so far do NOT stop infection or spread-at best limit disease so far...however newer variants are a nightmare...

[url]https://en.wikipedia.org/wiki/Exponential_growth[/url] or https://en.wikipedia.org/wiki/Exponential_growth ; The growth of a bacterial colony is often used to illustrate it. One bacterium splits itself into two, each of which splits itself resulting in four, then eight, 16, 32, and so on. The amount of increase keeps increasing because it is proportional to the ever-increasing number of bacteria. Growth like this is observed in real-life activity or phenomena, such as the spread of virus infection, the growth of debt due to compound interest, and the spread of viral videos. In real cases, initial exponential growth often does not last forever, instead slowing down eventually due to upper limits caused by external factors and turning into logistic growth.

DJ..to put it (very) simple; exponential growth is doubling of something over time...(1-2-4-8-16-32-64-128 etc...). 

[url]https://en.wikipedia.org/wiki/Exponential_growth#Biology[/url] or https://en.wikipedia.org/wiki/Exponential_growth#Biology ;

  • The number of microorganisms in a culture will increase exponentially until an essential nutrient is exhausted, so there is no more of that nutrient for more organisms to grow. Typically the first organism splits into two daughter organisms, who then each split to form four, who split to form eight, and so on. Because exponential growth indicates constant growth rate, it is frequently assumed that exponentially growing cells are at a steady-state. However, cells can grow exponentially at a constant rate while remodeling their metabolism and gene expression.[3]
  • A virus (for example COVID-19, or smallpox) typically will spread exponentially at first, if no artificial immunization is available. Each infected person can infect multiple new people.

DJ..one basic -WRONG !!!- idea was once you did get CoViD (like the idea is for SARS-1/2003) you would have long term immunity...It is unclear how many billion (non)human CoViD infections there have allready been-but CoViD developed into evading immunity on a major scale...So previous infections may NOT stop the exponential growth trend either much or long term...

Vaccines may have done a great job (most vaccines worldwide were not m(essenger)RNA but "old(er) style" made in China, India, Russia often using an adeno-virus "bringing the CoViD message" resulting in (better) immunity/limiting damage after a CoViD infection...However new variants (now all named "Omicron" may be over a thousend by now !) are able to work around vaccine immunity...

Since the high number of CoViD-infections do damage immunity (a.o.) "humans-as a species" may have less immunity against all kind of other diseases...(exponentiol growth in width not in depth). 

Compared to the Spanish Flu (killing between 20 and a 100 million; 2-5% of the global population. I go for the wide timeline of 1917-1923.) were people developed immunity against reinfection SARS-2/CoViD-19 is a much larger problem...

A virus is "on the edge of live" because it needs a host for reproduction...There are close to 8 billion human hosts...CoViD has been detected in up to a hundred other species...so...what is stopping exponential growth for CoViD ? DJ-Vaccines, NPI may be buying time...but it is a very big problem...

-[url]https://www.thailandmedical.news/news/study-validates-previous-findings-that-sars-cov-2-reinfections-are-now-occurring-at-shorter-intervals--current-cdc-and-ecdc-reinfection-definitions-ar[/url] or https://www.thailandmedical.news/news/study-validates-previous-findings-that-sars-cov-2-reinfections-are-now-occurring-at-shorter-intervals--current-cdc-and-ecdc-reinfection-definitions-ar e obsolete !

Lots of links in the article...One major remark [url]https://www.thailandmedical.news/news/breaking-long-covid-is-a-misnomer-the-conditions-are-being-caused-by-viral-persistence-and-viral-peptides-similar-to-retrotransposons-and-introns[/url] or https://www.thailandmedical.news/news/breaking-long-covid-is-a-misnomer-the-conditions-are-being-caused-by-viral-persistence-and-viral-peptides-similar-to-retrotransposons-and-introns in many cases once the virus is in it may stay...So reinfection could mean another variant on top of variants allready in the host...

The virus -often hiding- may keep doing damage...may even renew a start in spread. Sometimes a "re-infection" may mean the "old" virus is "out of hiding"...

For that matter-in my non expert view ( I know something of history, limited of biology...NOT a medical person...) 

-Long CoViD may be related to damage done by a CoViD infection...with some luck however the virus is gone...

-Chronic CoViD may be long term infection WITH the virus (variants-could be more then one...) still in the body...

DJ-Non Pandemic in latest news...refugees spreading infection, water/flooding linked diseases DO have a link with the pandemic. Economies falling apart means less money/capacity for healthcare (here in NL in some sectors 10%+ on sick leave...) Avian Flu-H5N1 in my opinion is "a very major risk"...2022 is a very bad year for "bird flu" worldwide...

African Swine Fever (ASF)-pandemic in pigs (2018-20) was before CoViD...Bird Flu now getting this big...may have some links with CoViD (missed/masked in pigs, birds ???)...

"One Health" does not exclude humans but has a more holistic view...we are all part of nature...I am NOT a statistician...but ASF NOT being linked to CoViD how likely is that ? 

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 27 2022 at 10:02am

part 2,

I will put non-pandemic items in the latest news section with the same name (as long as not being sabotaged...). 

[url]https://www.coronaheadsup.com/coronavirus/germany-chancellor-olaf-scholz-and-interior-minister-nancy-faeser-test-positive-for-covid/[/url] or https://www.coronaheadsup.com/coronavirus/germany-chancellor-olaf-scholz-and-interior-minister-nancy-faeser-test-positive-for-covid/ ;

German Chancellor Olaf Scholz has tested positive for COVID-19. Scholz’s office said he had gone into isolation and cancelled his public appointments for the week.

Germany’s Interior Minister Nancy Faeser has also tested positive for the first time since the start of the pandemic.

“Now Corona got me too, for the first time. The virus remains insidious. Everyone take care of yourselves this fall!”


DW.com report

DJ...I did not see reports of more cases after the UK royal funeral...so may have been limited ? 

[url]https://nltimes.nl/2022/09/27/new-covid-wave-may-begun-patient-total-new-infections-set-new-40-day-highs[/url] or https://nltimes.nl/2022/09/27/new-covid-wave-may-begun-patient-total-new-infections-set-new-40-day-highs

Officially diagnosed coronavirus infections have been rising for four weeks in the Netherlands. A high number of people testing positive at the GGD over the past seven days is one piece of evidence suggesting the start of a new coronavirus wave, warned public health institute RIVM. The report published on Tuesday showed the most infections since August 13, with figures from the hospitals showing the highest number of Covid-19 patients in care since August 18.

“This may be the start of the expected COVID fall wave. Vaccination and testing are very important in this phase to prevent the numbers from rising sharply,” the RIVM said in a statement.

DJ, see also (more correct) [url]https://www.rivm.nl/en/news/autumn-wave-of-COVID-19-may-be-starting-vaccination-and-testing-are-key[/url] or https://www.rivm.nl/en/news/autumn-wave-of-COVID-19-may-be-starting-vaccination-and-testing-are-key 

Most of Europe may be getting into another wave [url]https://www.thailandmedical.news/news/latest-sars-cov-2-bq-1-1-and-ba-2-3-20-variants-driving-exponential-daily-new-infections-and-hospitalizations-across-europe-with-high-incidences-of-ar[/url] or https://www.thailandmedical.news/news/latest-sars-cov-2-bq-1-1-and-ba-2-3-20-variants-driving-exponential-daily-new-infections-and-hospitalizations-across-europe-with-high-incidences-of-ar 


7 BA.2-like have been sequenced fast. ðŸ‘ And with some interesting results! 1 BJ.1 (BA.2.10.1.1) 2 BL.1 (BA.2.75.1.1) 1 BA.2.75.5 1 BA.2.75.2 2 BA.2.75.2/BA.5.2.1 recombinants Likely breakpoint at the spike between 23019 (S:F486S) and G24620T (S:A1020S). They do not have D1199N

-


A total of 177 randomly selected SARS-CoV-2 positive samples, collected between September 14th&Sept 20th 2022 at  testing facilities, 0/177(0%) indicated a BA.1-like, 6/177(3%) a BA.2-like and 171/177(97%) a BA.4/5-like variant. Thanks to  and GGD lab.

see how things develop further...

end of part 2

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 27 2022 at 2:51am

DJ, 

Some points;

-[url]https://www.tropicaltidbits.com/[/url] or https://www.tropicaltidbits.com/ following "Ian" developing into a major hurricane on its way to hit Florida/US...May bring very serious damage/flooding...

-A.o. Alexander Mercouris on "Ukraine"; Today last day of referendum. The four regions will start the procedure to be included into Russia tomorrow. Russia could declare war september 30-hoping to end this war before december 31. DJ-I think France/Germany may be involved-via Saudi Arabia (and Türkiye ?) - in talks with Russia on Ukraine...(sort of Minsk-3 like ?) After Sweden and Italy elections bringing a win for extreme right parties at least part of the EU is shifting...US, UK, Poland may not be willing to move...Very likely the "west" may see a split...

The economic damage is getting that serious the "west" has to make a move...

Pandemic(s)

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory may be facing very major under reporting...









Heavy-tailed sexual contact networks and monkeypox epidemiology in the global outbreak, 2022: MSM with the highest number of partners are key to keeping R0<1  (H/T )

-









In other words a very small portion of people have an extreme number of partners and this has the largest affect on collective behavior i.e. an R0 which is much higher than one. And this hypothesis fits the data better than alternate hypotheses.

link; [url]https://www.science.org/doi/full/10.1126/science.add4507[/url] or https://www.science.org/doi/full/10.1126/science.add4507 DJ-A small group going for "super spread" may develop into massive spread via aerosol, contact of surface etc...Under diagnosing, under reporting may be a major problem...People may "sit it out" only go for help if they get very ill...Still could spread the virus via aerosols, blood/pus...I think schools/workplaces reopening-early this month-by now (incubation 3 weeks) would bring an increase of cases...but it may be hard to detect if people do not go for help...

[url]https://www.coronaheadsup.com/health/who/who-the-end-of-the-pandemic-is-still-a-long-way-off/[/url] or https://www.coronaheadsup.com/health/who/who-the-end-of-the-pandemic-is-still-a-long-way-off/ ;

Just two weeks ago, WHO Director Tedros Ghebreyesus told reporters that the world had “never been in a better position to end the pandemic”, and “the end is in sight.”.

Today, the message from Tedros has changed again. Here is the revised message:

We have spent two and a half years in a long, dark tunnel and we’re just beginning to glimpse the light at the end of that tunnel, but it is still a long way off and the tunnel is still dark with many obstacles that could trip us up if we don’t take care.

We all need hope that we can and we will get to the end of the tunnel and put the pandemic behind us but we’re not there yet. We’re still in the tunnel and we will only get to the end by focusing on the path ahead and by moving forward with purpose and care.purpose and care.

WHO: Monkeypox, COVID-19 & Other Global Health Issues Virtual Press Conference

 

This change of tone from the World Health Organisation comes just days after American President, Joe Biden, also walked back his comments that the pandemic was over.

 

Our question is this; why was the disastrous “the pandemic is over” message disseminated globally just days before the start of what could be the worst winter wave in pandemic history?
Mixed messages don’t save lives…

DJ...information/communication may be the #1 tool in any crisis...But sending stupid info does do a lot of damage...

[url]https://www.thailandmedical.news/news/latest-sars-cov-2-bq-1-1-and-ba-2-3-20-variants-driving-exponential-daily-new-infections-and-hospitalizations-across-europe-with-high-incidences-of-ar[/url] or https://www.thailandmedical.news/news/latest-sars-cov-2-bq-1-1-and-ba-2-3-20-variants-driving-exponential-daily-new-infections-and-hospitalizations-across-europe-with-high-incidences-of-ar ds. (TMN)

DJ A.o. link to [url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time self-reporting UK CoViD cases now above 2 million and going up...[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table Europe cases +3% (with very poor -often not daily- reporting resulting in "false" statistics...) Oceania cases +9% (they are now in spring...) 

TMN mentioning London UK hospitals reaching their limits...UK "gov" simply denying the crisis...the article is full of links...

DJ-It would fit in with the exponential model...NOT stopping the spread, vaccines only limiting disease-in that way at best buying time...There may be discussion on how many people did catch CoViD...some "experts" claim all of us must have had "contact" with CoViD by now...others go for "billions"...Vaccines-looking at statistics-did save lives...for CoViD deaths within 28 days after infection...however excess deaths may indicate there arte major problems...

Other diseases [url]https://www.thailandmedical.news/news/breaking-long-covid-is-a-misnomer-the-conditions-are-being-caused-by-viral-persistence-and-viral-peptides-similar-to-retrotransposons-and-introns[/url] or https://www.thailandmedical.news/news/breaking-long-covid-is-a-misnomer-the-conditions-are-being-caused-by-viral-persistence-and-viral-peptides-similar-to-retrotransposons-and-introns the CoViD-virus variants staying in the body doing damage -certainly in combination-could make this winter a major challenge... 

-There is some discussion on timing of vaccines [url]https://www.statnews.com/2022/09/09/doubling-up-on-covid-booster-flu-shot-may-have-downside/[/url] or https://www.statnews.com/2022/09/09/doubling-up-on-covid-booster-flu-shot-may-have-downside/ ...If you want to vaccinate a lot of people in a short time it could be usefull to combine a CoViD-vaccination with a flu-vaccination...However some people have serious healthissues after the CoVid vaccination...so they may have hesitations on getting both vaccines in one time...It may also be the first time-in many countries-that large scale co-vaccinations (flu/CoViD0 are getting organized...So there may be limited data on (more) side effects...

[url]https://flunewseurope.org/[/url] or https://flunewseurope.org/ indicates "limited flu activity" in Europe; 

  • Influenza activity has increased though remains at interseasonal levels.
  • Israel and Spain both have an influenza virus positivity in sentinel primary care specimens of at least 10%.
  • Estonia, Georgia, Germany, Greece, the Netherlands, UK (Northern Ireland) and Sweden reported sporadic geographic activity, Malta reported local activity, Scotland reported regional activity and Portugal reported widespread activity. 
  • Azerbaijan, Georgia, Luxembourg and Slovenia reported low influenza intensity.
  • Display of data will be updated on a monthly basis during the interseason period (weeks 21-39).

DJ..we are now in week 39 so very likely weekly updates become available...We had another major bird-flu outbreak in NL yesterday-meaning 200,000 birds will get killed...H5N1 may be a growing risk...

End of part 1...(maybe later part 2 ???) 

We cannot solve our problems with the same thinking we used when we created them.
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100% treatment of coronavirus and other infectious diseases with monoclonal antibodies. Treatment without contraindications and I will be able to transfer this ability to people.

Give me a chance to beat the coronavirus.

I have the strongest acquired t-cell immunity. Purposefully strengthen the immune system for more than 7 years. During all the time, lymphocytes were from 44 to 56%. Immunity is constantly stressed due to two rare internal diseases.

How did I achieve such immunity

My mother is a retired cook by profession. I eat 5 times a day only healthy food by healthy food I mean every morning I eat milk porridge, every day I eat at least 200 grams of vegetables and fruits, every evening I drink kefir, every day I drink metformin medicine. I do not work on disability. Due to illness, all kinds of sports are prohibited except for an exercise bike. I do sports on an exercise bike every day.

To prove that I have t-cell immunity. I can provide the test results of 5 immunograms. In 3 immunograms, lymphocytes and t-cells are significantly exceeded in abs.number / ml, I made an immunogram at the Almetyevsk AIDS Center.1 the immunogram was made at the end of August by the polyclinic of PJSC Tatneft after much persuasion. 2 I did an immunogram 20 days later at the request of a local immunologist . 3 I did an immunogram half a year later on the day after the illness. The 2nd and 3rd immunogram was paid for by the polyclinic where the analysis was done, they became interested that my lymphocytes and t-cells were exceeded . In the second and fifth immunogram, the immunologist wrote something.

As proof that acquired immunity. I did 7 blood tests made according to the leukoformula lymphocytes above normal neutrophils below normal, I did it in a private laboratory Invitro.

Monoclonal antibodies are the strongest weapon against the coronavirus.Monoclonal antibodies are produced from immune cells.

I have had coronavirus 2 times. 1 time in August for 4 days in super light form. On July 26, the deputy heads were healthy.the doctor of the polyclinic of PJSC Tatneft will prove. On August 1, I was at his reception again, I looked sick and he advised me to go home. I was ill at home with symptoms of coughing, sneezing, runny nose and fever On August 3, I did PCR at the Almetyevsk polyclinic of PJSC Tatneft, whether I am sick or not.On the 4th day, a nurse from the polyclinic came, first she communicated with me in a mask and then she made sure that I was healthy and continued to communicate without a mask. By the way, my mother also had a mild coronavirus in 10 days, but with the loss of sense of smell, I accidentally learned about 2 infections from doctors, antibodies to coronavirus spontaneously rose from 204 to 316. I've had the coronavirus 3 times in September 20, the symptoms were sore throat 1 day, a headache 2 days and a runny nose 4 days and I think a new mutation

If my immunity was able to protect me, then I can probably transfer this ability to people. My medicine cures in 3 days, the analogue of my medicine cured the former president of the United States. And as a vaccine, its effect is unlimited in time.

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part 2

[url]https://www.youtube.com/watch?v=_q0XvfIqRJY[/url] or https://www.youtube.com/watch?v=_q0XvfIqRJY Alexander Mercouris/AM; Russia Prepares Knock Out Blow, Ukraine Offensive Stalls; Rumours of Saudi Peace Deal Giving Donbass, Kherson to Russia

DJ, AM discussing a possible peace initiative from Saudi Arabia/GCC [url]https://en.wikipedia.org/wiki/Gulf_Cooperation_Council[/url] or https://en.wikipedia.org/wiki/Gulf_Cooperation_Council (and Türkiye). 

AM expects US/UK/Ukraine,Baltics, Poland (DJ-Finland) may be against any talks with Russia...DJ, However European elections in Sweden, Italy press (most) EU "leaders" for damage control. [url]https://www.zerohedge.com/political/nancy-pelosi-savagely-booed-nyc-festival-doesnt-bode-well-dems-ahead-mid-terms[/url] or https://www.zerohedge.com/political/nancy-pelosi-savagely-booed-nyc-festival-doesnt-bode-well-dems-ahead-mid-terms US mid term elections, UK breaking up may even change US, UK position....

The (West) European economy is close to collapse...high inflation, growing unrest...the Ukraine war is going on to long, becoming a major burden for most of the EU...

AM also mentioned the military perspective. Russia's next step could be major offensives to capture/annex even more of Ukraine...Odessa, Nikolayev, Charkov...Ukraine was better of with the agreements made in Türkiye...even better if they could have avoided this war. The longer the war goes on the more parts of Ukraine end up as parts of Russia...

-[url]https://www.tropicaltidbits.com/[/url] or https://www.tropicaltidbits.com/ and [url]https://www.nhc.noaa.gov/refresh/graphics_at4+shtml/042342.shtml?cone#contents[/url] or https://www.nhc.noaa.gov/refresh/graphics_at4+shtml/042342.shtml?cone#contents "Ian" is expected to bring major damage to the SE of the US...The Philippines did see a typhone killing several, lots of damage...

DJ-Climate collapse could bring an end to a clear (Ant)Arctic pattern of "melting/freezing-season"....storms could bring above melting temperatures/seawater into (Ant)Arctic zones in a way we did not see before....

-








A few days later and we have some more data to support a growing suspicion that the US is actually entering a second wave of monkeypox cases. We'll be watching this closely and posting updates throughout next week. https://monkeypoxtracker.net/countries/US


DJ...is this second wave related to schools/workplaces reopening ? [url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Statistics[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Statistics may give some info...[url]https://www.paho.org/en/documents/paho-monkepox-sit-rep[/url] or https://www.paho.org/en/documents/paho-monkepox-sit-rep 

Post-COVID-19 syndrome: retinal microcirculation as a potential marker for chronic fatigue https://medrxiv.org/content/10.1101/2022.09.23.22280264v1

link;[url]https://www.medrxiv.org/content/10.1101/2022.09.23.22280264v1[/url] or https://www.medrxiv.org/content/10.1101/2022.09.23.22280264v1 ;

Abstract

Post-COVID-19 syndrome (PCS) summarizes persisting sequelae after infection with the severe-acute-respiratory-syndrome-Coronavirus-2 (SARS-CoV-2). PCS can affect patients of all covid-19 disease severities. As previous studies revealed impaired blood flow as a provoking factor for triggering PCS, it was the aim of the present study to investigate a potential association of self-reported chronic fatigue and retinal microcirculation in patients with PCS, potentially indicating an objective biomarker.

A prospective study was performed, including 201 subjects: 173 patients with PCS and 28 controls. Retinal microcirculation was visualized by OCT-Angiography (OCT-A) and quantified by the Erlangen-Angio-Tool as macula and peripapillary vessel density (VD). Chronic Fatigue (CF) was assessed with the variables ‘Bell score’, age and gender. The VD in the superficial vascular plexus (SVP), intermediate capillary plexus (ICP) and deep capillary plexus (DCP) were analyzed considering the repetitions (12 times). Taking in account of such repetitions a mixed model was performed to detect possible differences in the least square means between different groups of analysis.

An age effect on VD was observed between patients and controls (p<0.0001). Gender analysis yielded that women with PCS showed lower VD levels in SVP compared to male patients (p=0.0015). The PCS patients showed significantly lower VD of ICP as compared to the controls (p=0.0001, [CI: 0.32; 1]). Moreover, considering PCS patients, the mixed model reveals a significant difference between chronic fatigue (CF) and without CF in VD of SVP (p=0.0033, [CI: -4.5; -0.92]). The model included age, gender and the variable ‘Bell score’, representing a subjective marker for CF. Consequently, the retinal microcirculation might be an objective biomarker in subjective-reported chronic fatigue of patients with PCS.

DJ, If bloodflow to the eye can be measured as being different in post-CoViD patients how is blood flow to other organs effected ?

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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DJ, 

Last few sentences of my 2nd yesterday post went missing....twitter and this forum end up in a fight...

-I will try to "keep this forum alive" for another few months...Maybe not posting anything could start others posting ? Am I in the way for others ? There is a need for info on "pandemics" with a CoViD-winter wave on the rise, a possible bad flu, MPX and lots of other-possible-unwelcome surprises...

As always I hope to be wrong...healthproblems decrease etc...I just do not expect that and use this forum to make my mind up on why...

-In Ukraine Russia would not have organized the referenda in 4 regions if they did not expect to win them. Tomorrow it will be the last day of voting...Some indication that after sept.27 Russia will put an ultimatum to Ukraine to leave the four oblasts/regions - soon Russia will declare them-like Crimea-part of Russia. 

Why does it matter ?  

1. Those four regions-as part of Russia-will see the regular Russian Army moving in..

2. Any attack on those area's will be seen as an attack on Russia (may even bring a [url]https://en.wikipedia.org/wiki/Collective_Security_Treaty_Organization[/url] or https://en.wikipedia.org/wiki/Collective_Security_Treaty_Organization reaction.

3. Some countries (North Korea, Syria) may accept that step...it will tell Russia something of what support they have...

It will not end the war...

Pandemics;

Yesterday had some "horror news" [url]https://www.thailandmedical.news/news/sars-cov-2-presents-its-fall-and-winter-2022-variant-collections-featuring-ba2-75-2,-bq-1-1,-bw-1,-xbb,-bu-1,-br-2,-bm-1-1-1,-ca-1,-bj-1-and-bn-1[/url] or https://www.thailandmedical.news/news/sars-cov-2-presents-its-fall-and-winter-2022-variant-collections-featuring-ba2-75-2,-bq-1-1,-bw-1,-xbb,-bu-1,-br-2,-bm-1-1-1,-ca-1,-bj-1-and-bn-1 and [url]https://www.coronaheadsup.com/science/ade/preprint-reevaluation-of-antibody-dependent-enhancement-for-sars-cov-2-treatments/[/url] or https://www.coronaheadsup.com/science/ade/preprint-reevaluation-of-antibody-dependent-enhancement-for-sars-cov-2-treatments/ 

Today [url]https://www.coronaheadsup.com/science/variants/omicron/ba-2-75-2/ba-2-75-2-and-bq-1-1-approaching-sars-1-level-escaping-capability/[/url] or https://www.coronaheadsup.com/science/variants/omicron/ba-2-75-2/ba-2-75-2-and-bq-1-1-approaching-sars-1-level-escaping-capability/ comes on top of that...

A new Twitter thread out today from Yunlong Cao gives further details about the variants BA.2.75 and BQ.1.1.

“Updating information regarding convergent variants BA.2.3.20, BN.1, BA.2.10.4, BN.2.1, BA.4.6.1, BQ.1, BQ.1.1. In short, BA.2.75.2 and BQ.1.1 are the most antibody-evasive convergent variants tested, far exceeding BA.5 and approaching SARS-CoV-1 level. (1/4)”

 

“BA.2.75.2 is slightly more evasive than BQ.1.1 against plasma from BA.2/BA.5 breakthrough infections. Its due to the enriched NTD-NAbs elicited by BA.2/BA.5 infections, which BQ.1.1 can’t escape. Note that these variants are approaching SARS-CoV-1 level escaping capability. (2/4)

 

“As expected, BQ.1.1 escapes Evusheld and bebtelovimab, making all clinically available antibody drugs ineffective. BQ.1.1 and BA.2.75.2 both displayed sufficient hACE2 binding capability. (3/4)”

 

“We should be able to update information on BU.1, BR.2, BM.1.1.1, CA.1, and XBB within two weeks. I agree with @CorneliusRoemer that XBB will be the most immune-evasive convergent variant for now, since it should be able to escape the majority of both NTD/RBD NAbs. (4/4)”

 

Do we have any idea what protection bivalent [vaccines] will afford against these?

“I don’t think the current WT/BA.1 or WT/BA.5 bivalent vaccines would be very effective against those convergent variants, based on the released mouse vaccination data.”

 

Yunlong Cao has already featured in two other posts on Coronaheadsup.com about BA.2.75.2 and other variants of interest. You can find the posts here and here

 

Cornelius Roemer: “BQ.1.1 is showing quite some growth, especially in England where the first sample was submitted 9 days ago and now there are already 28 sequences. I hope there is some sort of biased sampling going on. Otherwise this doesn’t look good.”

DJ, Indications are simply very bad....

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
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part 2

But... What you really want to do is prevent becoming infected in the first place. Each time you get infected or reinfected there is a chance you can develop long-term consequences or possibly permanent damage to your body as COVID-19 is not a cold. 34/

-









While being vaccinated can reduce the chance of developing Long COVID, even 1 in 10 vaccinated people who got infected developed Long COVID. 35/

-

Infection puts people at increased risk of heart attack, stroke, cardiovascular issues, blot clots, brain damage, neurological and many more issues even months after infection. This happens in both adults and children, and even with mild infections. 36/

-

This means that we can't rely on vaccines alone, but need to invest in additional measures that are variant proof. Part 2 will discuss how the virus is transmitted and ways to help reduce the risk of becoming infected. 37/

-in other words; STOP THE SPREAD !!!!








BQ.1.1 now has been overtook in the lead by BA.2.3.20 ( spotted it very early from really 3-4 seqs), XBB is roaring behind these two. https://cov-spectrum.org/collections/24         

DJ...I try to follow and understand developments of this pandemics...Once new variants did get new names-by the WHO...Now the WHO sticks to naming all new variants "Omicron" resulting that "BA" types now see BQ, XBB,BM, BW etc subtypes-possibly also with a BA name...very likely also "Omicron" but for an "interested non expert" by now impossible to follow...








“Maybe it would be better to catch ’rona and get it over with, now that I’m fully vaccinated?” Chris remembers speculating. He did. Chris came down with a scratchy throat. 12 days he got hit by congestive heart failure.

DJ...I have been limiting contacts since march 2020...go for limiting risks without locking myself up...Why do governments, WHO, (E)CDC etc. fail public health ? "Saving the economy" in fact is destroying that economy...Here in NL it did increase internet sales...with that low pay jobs replacing better paid jobs...[url]https://nltimes.nl/2022/09/24/netherlands-give-bonuses-full-time-workers-fight-staff-shortages[/url] or https://nltimes.nl/2022/09/24/netherlands-give-bonuses-full-time-workers-fight-staff-shortagesThe Cabinet can take big steps towards solving the staff shortages that now affect all sectors of the Dutch labor market by making it worth it for people to work more,

and [url]https://nltimes.nl/2022/09/23/food-banks-hague-running-food-people-need-help[/url] or https://nltimes.nl/2022/09/23/food-banks-hague-running-food-people-need-help 

"Saving the economy" did result in sick leave 10%+ of staff in some sectors, increase of poverty (also as a result of increasing wars...)..Here in NL people may be forced to spent less on health insurance-while health risks increase. Health care is overstretched...in many countries the coming winter wave may bring a "black scenario" with not enough healthcare capacity for all...

This could result in triage;

-"light" cases may  get medication, basic info for self treatment

-"moderate cases" may see selection (a.o. by age, healthstatus, years of live saved...)  and be able to get care

-"severe cases" may be "helped to die without major suffering" 

We did see discussion on these worst case scenario's in the past winter waves...the coming winter-wave will bring us even closer...








This saga is horrible & sad.  has done an excellent, selfless job educating the public about indoor air & warning about risky technologies. She is being sued for defamation for $180 MILLION w/ $400,000 expected legal fees! Pls share & help.

DJ...does insanity has limits ? (twitter use on this forum has...)

We cannot solve our problems with the same thinking we used when we created them.
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DJ,

- In latest news/sept. 24 I did post a last comment. Mayby one major point, while the US is confronting Russia, China India has an economic growth of 7,5%...doing lots of trade-via-Iran-with Russia...The "multi-polar" world can not be stopped..US ($) dominance is over...

-[url]https://forum.arctic-sea-ice.net/index.php/topic,3721.750.html[/url] or https://forum.arctic-sea-ice.net/index.php/topic,3721.750.html trying to get a view on Arctic melting...it may be hard to define the end of melting, begin of Arctic re-freezing...Some Arctic area's may still face melt...others are already refreezing...Also the definition of "ice" matters [url]http://arctic-news.blogspot.com/2022/09/blue-ocean-event-2022.html[/url] or http://arctic-news.blogspot.com/2022/09/blue-ocean-event-2022.html 

[url]https://www.tropicaltidbits.com/[/url] or https://www.tropicaltidbits.com/ and [url]https://www.nhc.noaa.gov/[/url] or https://www.nhc.noaa.gov/ "Ian" may hit the US as a strong hurricane wednesday/thursday..."remnants of Florian" are doing a lot of damage in the east of Canada...Alaska, Greenland did see major storms...

India now facing extreme weather...Pakistan still in floods...Climate collapse very likely only getting worse...

-So now pandemics...[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory even Greenland reported 2 cases...confirmed/suspected cases now close to 72,000 with testing/reporting "poor"...DJ-I expected MPX to increase with schools reopening...even an incubation time of 3 weeks may not explain why numbers do not go up faster...Do children get less symptoms, misdiagnosed, or simply MPX in children not getting reported ? [url]https://twitter.com/RolandBakerIII[/url] or https://twitter.com/RolandBakerIII among many others has a lot of good info/links...








At  we've been sequencing #monkeypox virus since July 2022. In our latest preprint we analyze  the first 109 MPXV sequences we generated for #washingtonstate tl;dr . community spread, multiple introductions, and one case of co-infection by multiple #MPXV strains

On CoViD ;


Replying to 
And several more BQ.1, BQ.1.1 and BA.2.3.20, which seem to grow faster than BJ.1 worldwide!

DJ BA.4.6 becoming dominant ??? 

[url]https://www.coronaheadsup.com/coronavirus/switzerland-red-foxes-infected-with-sars-cov-2/[/url] or https://www.coronaheadsup.com/coronavirus/switzerland-red-foxes-infected-with-sars-cov-2/ ...the more spread and time the more also animals will catch (a form of) the virus..some may also spread it...(two foxes -march 2022)

[url]https://www.coronaheadsup.com/health/vaccine/pfizer-biontech/pfizer-ceo-fighting-second-covid-infection-in-5-weeks/[/url] or https://www.coronaheadsup.com/health/vaccine/pfizer-biontech/pfizer-ceo-fighting-second-covid-infection-in-5-weeks/ ;DJ testing positive twice...mid august and late september-had 5 vaccines...no doubt limiting severe disease NOT stopping virus spread or reinfection...

The ADE nightmare...

[url]https://www.coronaheadsup.com/science/ade/preprint-reevaluation-of-antibody-dependent-enhancement-for-sars-cov-2-treatments/[/url] or https://www.coronaheadsup.com/science/ade/preprint-reevaluation-of-antibody-dependent-enhancement-for-sars-cov-2-treatments/ ;

A new preprint looking at the evidence for antibody-dependent enhancement (ADE) is getting a LOT of attention online – we link to it below so that you can read it for yourself.

In the present study, we reevaluated whether the approved therapeutic Ab drugs (casirivimab, imdevimab, and sotrovimab26,27) have any potential to cause ADE even in FcR- and ACE2-positive cells. In addition, we investigated sera from mRNA (Moderna)-vaccinated individuals in terms of ADE-causing potential by using the same double-positive cells. Here, we show that the casirivimab and imdevimab mAbs have the ability to induce ADE, but sotrovimab does not. Furthermore, some sera from individuals vaccinated with the mRNA vaccine targeting the S-protein also exhibited ADE potential against infection with the original strain. All sera examined, including sera showing neutralizing activity against the original Wuhan strain of SARS-CoV-2, exhibited no neutralizing activity against Omicron. Rather, some ADE activity was observed in some sera.

Although sera collected from mRNA-vaccinated individuals exhibited neutralizing activity, some sera gradually exhibited dominance of ADE activity in a time-dependent manner. None of the sera examined exhibited neutralizing activity against infection with the Omicron strain. Rather, some ADE of Omicron infection was observed in some sera. These results suggest the possible emergence of adverse effects caused by these Abs in addition to the therapeutic or preventive effect.

 

Preprint: Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cells

DJ...CoViD-19/SARS-2 seems to develop from evasion of immunity to even using immunity to spread...I am NOT an expert...but on what I read a.o. on twitter the present (lack of) strategy to limit CoViD is resulting in much worse CoViD variants...A bit like fighting a 10 acre wildfire-resulting in a 50 acre wildfire...

[url]https://www.thailandmedical.news/news/post-covid-fatigue-associated-with-increased-expression-of-inflammatory-genes-in-monocytes,-serum-pro-inflammatory-cytokines-and-increased-cd8-t-cells[/url] or https://www.thailandmedical.news/news/post-covid-fatigue-associated-with-increased-expression-of-inflammatory-genes-in-monocytes,-serum-pro-inflammatory-cytokines-and-increased-cd8-t-cells DJ-Some "experts" now quite openly linking "long/chronic CoViD' with ME/CFS...[url]https://www.medrxiv.org/content/10.1101/2022.09.15.22279970v1[/url] or https://www.medrxiv.org/content/10.1101/2022.09.15.22279970v1 but again; long/chronic CoViD can manifest itself in lots of ways...

Chronic CoViD may have (several subvariants) long term infection..

Long CoViD may have gotten rid of the virus but still see lots of damage/auto-immune (over) reaction...

(In my non-exper view). "Mild CoViD' could still result in long term problems...

[url]https://www.thailandmedical.news/news/cohort-study-finds-that-fish-oil-supplements-reduces-the-risk-of-covid-19-severity[/url] or https://www.thailandmedical.news/news/cohort-study-finds-that-fish-oil-supplements-reduces-the-risk-of-covid-19-severity DJ the correct use of suplements may limit risks, gurgling/getting throat (and nose) clean-possible virus out also may limit risks...

Masks, avoiding crowds help...a lot of non pharma interventions may do a much better job then the present "vaccinate-but-spread" (insane) strategy...

Non pharma Interventions do not make a lot of profits...but may be able to limit disease spread much better then the present "pseudo-strategy". I think co-infection with (lots of) diseases may bring disaster...Vaccines are NOT the way to limit that ! You need a strategy to STOP THE SPREAD !!! 

We keep importing all kinds of diseases, virus-fly-for-free insanity !!!

So [url]https://www.thailandmedical.news/news/sars-cov-2-presents-its-fall-and-winter-2022-variant-collections-featuring-ba2-75-2,-bq-1-1,-bw-1,-xbb,-bu-1,-br-2,-bm-1-1-1,-ca-1,-bj-1-and-bn-1[/url] or https://www.thailandmedical.news/news/sars-cov-2-presents-its-fall-and-winter-2022-variant-collections-featuring-ba2-75-2,-bq-1-1,-bw-1,-xbb,-bu-1,-br-2,-bm-1-1-1,-ca-1,-bj-1-and-bn-1 prepare for an even worse pandemic winter bringing all kinds of diseases with less immunity protection...

We could have avoided this disaster but we did not...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
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DJ, 

Limited "new news" on CoViD...[url]https://www.coronaheadsup.com/asia/japan/japan-more-than-800-infected-with-covid-after-dance-festival-superspreader-event/[/url] or https://www.coronaheadsup.com/asia/japan/japan-more-than-800-infected-with-covid-after-dance-festival-superspreader-event/

819 people were found to have been infected with coronavirus after a summer dance festival turned into a Covid superspreader event.

The Awa Odori in Tokushima City is originally a Buddhist Bon dance, and one of Japan’s most famous summer festivals. The marching dance festival was carried out on the city streets from August 12 through 15. It took place on its full scale for the first time in three years, with skilled dance groups performing and many tourists from outside Tokushima Prefecture joining the dance processions.

At an organizing committee meeting on Thursday, the results of a COVID-related survey of 123 dance groups were reported. These groups had taken part in this year’s festival.

The survey shows that of the members of the 86 groups that responded, 819 people were confirmed to have been infected with the virus between August 11 through 25, which included the festival period.

NHK Japan report

reminds me of another recent London-UK funeral mass event...[url]https://www.coronaheadsup.com/science/superspreader-events/the-queen-of-denmark-tests-positive-for-covid-19-after-that-funeral/[/url] or https://www.coronaheadsup.com/science/superspreader-events/the-queen-of-denmark-tests-positive-for-covid-19-after-that-funeral/ ...

Another major story has to be [url]https://www.coronaheadsup.com/health/ebola/uganda-ebola-death-toll-rises-to-12/[/url] or https://www.coronaheadsup.com/health/ebola/uganda-ebola-death-toll-rises-to-12/

At least 12 people have died from the Ebola Sudan Virus in Uganda’s Mubende district, according to Ugandan health authorities, the Uganda Radio Network reported.

As of Tuesday morning, the death toll stood at eight people, but officials say that two more people died on Wednesday morning in the hospital while two others died in a village in Madudu Sub County, the same area where the first case was confirmed on Monday. The first seven people, including an enrolled nurse, died before the outbreak was confirmed.

Dr. Emmanuel Paul Batibwa, the director of the Mubende Regional Referral hospital, says that 10 other people are currently admitted with severe signs of Ebola. He added that four contacts of a victim who died in the Kyaka refugee settlement have also been sent to Mubende hospital for screening and that their samples have been sent to the Uganda Virus Research Institute.

Radiotamazuj.org report

 

CNN are reporting that one of the dead is a one-year-old child.

CNN report

DJ, regional spread in Africa very likely...DRC high risk...








BQ.1.1 now has been overtook in the lead by BA.2.3.20 ( spotted it very early from really 3-4 seqs), XBB is roaring behind these two. https://cov-spectrum.org/collections/24         

DJ, also other variants showing up/increase of spread...so YES-winterwave is starting, NO official statistics will NOT show that....[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time self reported symptoms app, [url]https://coronadashboard.government.nl/landelijk/rioolwater[/url] or https://coronadashboard.government.nl/landelijk/rioolwater can be better indicators...

-The international situation deserves major attention...I see a trend (also in Sweden, Italy elections) towards putting national interests first...A lot of countries are tired of endless US wars...[url]https://www.zerohedge.com/political/us-empire-accelerating-toward-global-conflict-two-fronts-johnstone[/url] or https://www.zerohedge.com/political/us-empire-accelerating-toward-global-conflict-two-fronts-johnstone

On paper it looks completely irrational for the US empire to be ramping up aggressions against two powerful military and economic forces simultaneously, but it’s undeniable at this point that that is what’s happening. Clearly our rulers have some kind of strategy for how they’re going to see this through, though it remains to be seen whether that strategy is the desperate Hail Mary pass of a dying empire or a potentially highly effective plan using tools that aren’t currently visible to the public.

Either way, it looks like it’s probably a good time to relish human life on this planet while it’s here to be relished.

DJ...Russia, China do have a strategy...both on CoViD and on national interests...The "western friends" of the US would do much better if they started asking serious questions on US plans...(More in latest news)...

I keep at at this for now...weekend

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Part 2, 

From a history point of view one has to relate pandemics with other events; Again the Spanish Flu did get that big because of World War One, mass troop movements, populations in food crises...

The present pandemics, CoViD, MPX, others now see a western "pseudo democratic elite" pushing for regime change wars in Russia, Iran, China...to "bring democrazy to Russian oil and gas"....Healthcare-all around the globe-is overstretched and exhausted...so yet more NATO agression is the last thing the world needs...

[url]https://www.thailandmedical.news/news/breakthrough-mice-study-shows-that-prophylactic-intranasal-administration-of-sars-cov-2-specific-immunoglobulin-y-protects-against-covid-19[/url] or https://www.thailandmedical.news/news/breakthrough-mice-study-shows-that-prophylactic-intranasal-administration-of-sars-cov-2-specific-immunoglobulin-y-protects-against-covid-19 in other words; nasal vaccines...in discussion for almost two years...link [url]https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010782[/url] or https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010782 ;

Abstract

Safe, passive immunization methods are required against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants. Immunization of chickens with antigen is known to induce specific IgY antibodies concentrated in the egg yolk and has a good safety profile, high yield of IgY per egg, can be topically applied, not requiring parenteral delivery. 

Our data provide the first evidence of the prophylactic efficacy of Immunoglobulin Y antibodies against SARS-CoV-2 in mice. Lohmann hens were injected with recombinant SARS-CoV-2 RBD protein; IgY-Abs were extracted from the eggs and characterized using SDS-PAGE. Antiviral activity was evaluated using plaque reduction neutralization tests. 

In additional experiments, IgY-RBD efficacy was examined in mice sensitized to SARS-CoV-2 infection by transduction with Ad5-hACE2 (mild disease) or by using mouse-adapted virus (severe disease).

 In both cases, prophylactic intranasal administration of IgY-Abs reduced SARS-CoV-2 replication, and reduced morbidity, inflammatory cell infiltration, hemorrhage, and edema in the lungs and increased survival compared to control groups that received non-specific IgY-Abs. 

These results indicate that further evaluation of IgY-RBD antibodies in humans is warranted.

Author summary

We report the generation, characterization and antiviral activity of egg yolk derived IgY-Abs against the SARS-CoV-2 Receptor Binding Domain. Using two different models of murine SARS-CoV-2 infection, we show that intranasal prophylactic administration of IgY-Abs reduced viral replication, and reduced inflammatory cell infiltration, hemorrhage, and edema in the lungs.

DJ...Even with "politics" going for who can make profits out of nasal vaccines -in most "western" countries it is good to see nasal vaccines may offer a way out...No doubt countries like India, China, Russia can provide most of the world with effective nasal vaccines-with some further development. Without going for profits for shareholders...

For that matter South Africa, Cuba-Iran cooperation offers hope for the world...

[url]https://www.coronaheadsup.com/coronavirus/research-all-covid-19-infections-include-a-wide-mix-of-sars-cov-2-virus-variants/[/url] or https://www.coronaheadsup.com/coronavirus/research-all-covid-19-infections-include-a-wide-mix-of-sars-cov-2-virus-variants/ ;

A fascinating peer reviewed research study that concludes that ALL Covid infections include multiple variants of the virus!

The researchers also note that “genetic variants observed in low frequency in SARS-CoV-2 infections can be early indicators of new strains responsible for later transmission surges”.

Researchers at Case Western Reserve University found wide genetic variation in SARS-CoV-2 viruses among 360 patients whose viral infections were genetically sequenced, showing that all individual infections include multiple variants of the virus.

The researchers noted that reporting about the virus usually highlights a single dominant strain, which leads to under-reporting virus genetic variation and can have serious consequences in public-health planning and response.

“Our work brings attention to the complexity of infectious diseases that is often over-simplified when considering only the most abundant virus in an infection, and we demonstrate the importance of examining the variations that are historically considered noise. We see that genetic variants observed in low frequency in SARS-CoV-2 infections can be early indicators of new strains responsible for later transmission surges.”

Press release: Researchers at Case Western Reserve University show that all COVID-19 infections include a wide mix of SARS-CoV-2 virus variants 

Research: COVID-19 infection and transmission includes complex sequence diversity

DJ, based on this knowledge..could we have missed CoViD spread in pigs infected with African Swine Fever (ASF) during the global ASF "pigdemic" 2018-2020 ? Did pigs not only get ASF, but also a pre-CoViD-19 virus mutating towards spread in humans ? [url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory MPX has to be seen against a CoViD pandemic background...

CoViD is resulting in less immunity protection...since at least 1/4 of the global human population may have had CoViD it will result in "more room"for other diseases to spread...

[url]https://www.coronaheadsup.com/health/long-covid/long-covid-impaired-lung-function-for-months-after-infection/[/url] or https://www.coronaheadsup.com/health/long-covid/long-covid-impaired-lung-function-for-months-after-infection/ ; Two different research articles out recently give graphic details of the lung damage that can be caused in both adults and children after a Covid infection. Up to half of all patients who had contracted Covid suffered from persistent pulmonary dysfunction.

and [url]https://www.thailandmedical.news/news/canadian-study-shows-even-after-a-year-up-to-41-percent-of-post-covid-individuals-still-have-autoantibodies-that-causes-autoimmune-issues[/url] or https://www.thailandmedical.news/news/canadian-study-shows-even-after-a-year-up-to-41-percent-of-post-covid-individuals-still-have-autoantibodies-that-causes-autoimmune-issues

it is quite easy to catch the virus...but once the virus is "in" it can do a lot of-long lasting-damage, with a perspective of the virus(variants) hiding in the body...for years. 

AGAIN STOP THE SPREAD !!!!! So far vaccines did not stop infection, spread, may have done a good job in limiting disease (while also causing vaccine related problems). So-is there a way out of this pandemic ? YES-but it has to include "zero CoViD" ...yet "west wants to save the economy-profits"....even if this means pandemics destroying the economy...








Here we go.... Again... ðŸ‘‰Weekly #COVID19 hospital admissions in EnglandðŸ´ó §ó ¢ó ¥ó ®ó §ó ¿ âš ï¸4,003 vs 3,418 âš ï¸+17% in just a week â€¼ï¸

And yes the CoViD winterwave has started, BA.2.75 subvariants increasing...Politics has to reduce testing if they want to hide reality...

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
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DJ, 

September 24, what will it bring ? (well we learn that tomorrow !)

In vaccines-general discussion yesterday I put a link to Dr. John Campbell [url]https://www.youtube.com/watch?v=WjG3VoX3Ldk[/url] or https://www.youtube.com/watch?v=WjG3VoX3Ldk ;

European Union, Excess mortality hits +16%, highest 2022 value so far UK latest excess death data, updated 16th September https://www.ons.gov.uk/peoplepopulati... https://www.ons.gov.uk/peoplepopulati... WE 2nd September

Dr.J.C. is now facing censorship "outsourced to a private company" youtube;

I said it several months ago. If this doctor gets censored it is a clear indication that something is seriously wrong with free speech. 
He has always used data and facts. We deserve the truth. Those judging misinformation have been giving inaccurate info and making huge mistakes. We deserve to hear the medical opinions of a diverse group and not just one.

Dr.J.C. has the courage to ask questions...on Ivermectin, vaccines...Like I do he is trying to "get a view" on this pandemic. He has much better knowledge in many fields then I do...

[url]https://www.coronaheadsup.com/health/vaccine/pfizer-biontech/dr-john-campbell-on-pfizer-deaths-its-a-scandal-on-par-with-watergate/[/url] or https://www.coronaheadsup.com/health/vaccine/pfizer-biontech/dr-john-campbell-on-pfizer-deaths-its-a-scandal-on-par-with-watergate/ ;

Dr John Campbell on the recent release of Pfizer documents showing that there were 1,223 deaths and 42,086 adverse events associated with the vaccine in the first three months of use.

DJ...so "politics" accept censorship, is outsourcing censorship, to "social media"....

[url]https://southfront.org/its-as-if-voters-want-to-remain-deceived/[/url] or https://southfront.org/its-as-if-voters-want-to-remain-deceived/ ;

Americans today don’t mind invading and occupying a country on the basis of sheer lies. But then Americans become exercised with hatred against Russia when it invaded Ukraine after NATO insisted that Ukraine would become a member (and so there was the real prospect of U.S. nuclear missiles becoming positioned just a five-minute flight to annihilating Moscow) after Obama had couped and grabbed Ukraine in 2014 in what some have called “the most blatant coup in history.” Controlling the media is controlling the mass-mind, in a ‘democracy’. But such a country can’t be any democracy, because its public are mere mental slaves to whatever liars appeal to the biggest percentage of the public’s prejudices. In America, it comes down to Democratic Party lies, versus Republican Party lies. Just like with science itself, democracy can be based only on the truth, the whole truth, and nothing but the truth.

Investigative historian Eric Zuesse’s new book, AMERICA’S EMPIRE OF EVIL: Hitler’s Posthumous Victory, and Why the Social Sciences Need to Change, is about how America took over the world after World War II in order to enslave it to U.S.-and-allied billionaires. Their cartels extract the world’s wealth by control of not only their ‘news’ media but the social ‘sciences’ — duping the public.

DJ, here pandemic, climate change denial meets US/NATO agression in the interest of a small elite with a "pseudo democratic cover"....

I try to understand WHY we are NOT STOPPING THE SPREAD....profits, greed, even getting close to genocide by pandemic on "groups we keep poor"....

"The pandemics are almost over" "because we stop testing and reporting""so case numbers are going down"....with such "leaders" again the pandemic is NOT our main problem !

End of part 1

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 21 2022 at 11:31pm

DJ,

Let me start with statistics (I used to start scenario's with it...the numbers reflected more reality back then...) [url]https://www.worldometers.info/coronavirus/#main_table[/url] or https://www.worldometers.info/coronavirus/#main_table total reported cases-with lots of countries no longer reporting, or not reporting on a daily basis, 434,092 for wednesday september 21...In total 1,324 CoViD deaths were reported...Based on these numbers...pandemic over ? NO!

Trends Europe-poor testing/reporting cases +6%, Oceania both cases/deaths +17%...other regions often claiming cases -20% or more...These statistics give an indication...France cases +38%, Germany cases +14%, NL cases -10% however based on reporting only twice a week...[url]https://coronadashboard.government.nl/[/url] or https://coronadashboard.government.nl/ (sort of NL-CDC) positive tests +6%, number of people going for a test +8%. Wastewater virusparts +21,2 % BA.2.75 (sub)variants increasing...

[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time for UK also indicating an upward trend (based on self reporting of symptoms). Twitter has some regions reporting increases (in sewage) others not..yet...

So "news" ;

[url]https://www.coronaheadsup.com/science/superspreader-events/the-queen-of-denmark-tests-positive-for-covid-19-after-that-funeral/[/url] or https://www.coronaheadsup.com/science/superspreader-events/the-queen-of-denmark-tests-positive-for-covid-19-after-that-funeral/ ;

Queen Margrethe of Denmark has tested positive for Covid-19 for the second time in one year after attending the biggest Covid superspreader event in pandemic history – the funeral of Queen Elizabeth II in Great Britain.

The Queen of Denmark, who was photographed just days ago comforting the new King of England, Charles III, has cancelled all of her appointments for the week following the test.

The 82-year-old monarch was one of 2,000 guests who attended Queen Elizabeth II’s state funeral on Monday.

She is Europe’s longest-serving head of state following the British monarch’s death.

She and Queen Elizabeth were third cousins, both being descended from Queen Victoria.

Queen Margrethe has been vaccinated against Covid and last tested positive in February this year when she presented mild symptoms.

BBC.co.uk report

DJ Of course princesses, kings etc. belong to history...A state funeral in the UK as mass spread event ? UK cases -85% based on denial by the UK "government"...

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory MPX did get updated...

-[url]https://www.coronaheadsup.com/coronavirus/joe-biden-the-pandemic-is-basically-is-not-where-it-was/[/url] or https://www.coronaheadsup.com/coronavirus/joe-biden-the-pandemic-is-basically-is-not-where-it-was/ ;

“There’s a lot of people — there’s not — the pandemic is, quote, “over,” as I got criticized for saying. But it basically is not where it was.”.

We’re also in a situation where — you know, we have a circumstance where, you know, when we passed the Recovery Act, we ended up being able — there were 2 million people in America had gotten a vaccination. We have over 230 million people are vaccinated. (Applause.)

But, by the way, if you haven’t gotten the booster, get it. There’s a lot of people — there’s not — the pandemic is, quote, “over,” as I got criticized for saying. But it basically is not where it was.

But guess what? The — over 65 to 80 percent of the people who died of the 5,000 dy- — dying never got their shot, never got their booster shot. And it can be — save lives.

The Whitehouse: Remarks by President Biden at a Reception for the Democratic National Committee 

DJ, Indicating the main global problem may be a "political one"....

On medical interventions; 

bad news;

[url]https://www.coronaheadsup.com/health/treatment/remdesivir/remdesivir-induced-emergence-of-sars-cov2-variants-in-patients-with-prolonged-infection/[/url] or https://www.coronaheadsup.com/health/treatment/remdesivir/remdesivir-induced-emergence-of-sars-cov2-variants-in-patients-with-prolonged-infection/ ;

“Remdesivir treatment can increase intra-host genomic diversity and result in the emergence of novel major variant species harboring fixed mutations,”.

We here investigate the impact of antiviral treatments such as remdesivir on intra-host genomic diversity and emergence of SARS-CoV2 variants in patients with a prolonged course of infection.

Sequencing and variant analysis performed in 112 longitudinal respiratory samples from 14 SARS-CoV2-infected patients with severe disease progression show that major frequency variants do not generally arise during prolonged infection. However, remdesivir treatment can increase intra-host genomic diversity and result in the emergence of novel major variant species harboring fixed mutations. This is particularly evident in a patient with B cell depletion who rapidly developed mutations in the RNA-dependent RNA polymerase gene following remdesivir treatment.

Article: Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection

DJ, An "incomplete" vaccination"strategy" also pushed for more new variants better in evading immunity...[url]https://www.coronaheadsup.com/coronavirus/lancet-covid-response-a-massive-global-failure-at-multiple-levels/[/url] or https://www.coronaheadsup.com/coronavirus/lancet-covid-response-a-massive-global-failure-at-multiple-levels/The Lancet Commission looking into the global SARS-CoV-2 pandemic response has levelled some withering criticism at the failure of governments and agencies to tackle the pandemic and uncover its origins.

they keep it polite, governments totally failed in dealing with this pandemic-like they fail in dealing with climate collapse...It reminds me of the (false) story of a monkey getting better results in investments then "investment experts"...

Good news; 

[url]https://www.coronaheadsup.com/health/treatment/research-nasal-saline-irrigation-reduces-severity-in-high-risk-covid-patients/[/url] or https://www.coronaheadsup.com/health/treatment/research-nasal-saline-irrigation-reduces-severity-in-high-risk-covid-patients/ ;

SARS-CoV-2 positive participants initiating nasal irrigation were over 8 times less likely to be hospitalized than the national rate.

Seventy-nine high-risk participants were enrolled. Analyzed by intention-to-treat, by day 28, COVID-19 symptoms resulted in one ED visit and no hospitalizations in 42 irrigating with alkalinization, one hospitalization of 37 in the povidone-iodine group, (1.27%) and no deaths.

Eleven reported irrigation-related complaints and four discontinued use. Symptom resolution was more likely for those reporting twice daily irrigation

Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients

DJ preventing the virus can get into via nose/mouth by "washing it out" (and masks preventing getting the virus in...) is simple, basic, effective !

Maybe later on a part 2...running out of time, not out of info...

We cannot solve our problems with the same thinking we used when we created them.
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part 2, NL situation; 

[url]https://nltimes.nl/2022/09/19/half-netherlands-wont-get-repeat-covid-vaccination[/url] or https://nltimes.nl/2022/09/19/half-netherlands-wont-get-repeat-covid-vaccination ;

About half of adult Netherlands residents see no need to get another jab against the coronavirus, NOS reports based on a survey by I&O Research. The new round of coronavirus vaccinations, using the renewed vaccines by Pfizer and Moderna to better protect against the Omicron variant, starts in the Netherlands today.

The researchers expect that the adults who didn’t get the booster shot (36.1 percent of the adult Dutch population) will also not get the repeat shot. Of those who did get the booster, 17 percent said they wouldn’t or probably wouldn’t get the repeat shot. 67 percent of people who got the booster will also get the repeat shot.


Age plays a clear role in the willingness to participate in this round of vaccinations. Young people between the ages of 18 to 34 are most reluctant, with 32 percent saying they won’t or probably won’t get the repeat shot. In the age group just above that, up to 49 years, 22 percent won’t go for the jab.

According to Marjolein van Egmond, professor of immunology at Amsterdam UMC, people often show up less for a second or third injection. “You often hear people say: I think I’ve had enough. But it doesn’t work that way in biology. The virus is still there, the immune system is decreasing, and a repeat shot is to refresh that defense,” she said to NOS. “In the elderly and those in poor health, it could be the difference between going to the hospital or not.”


Van Egmond called it “very likely” that there will be a revival of the coronavirus this autumn. “In the autumn, when it gets colder, people move closer together, and the virus spreads more easily

DJ...there is a government (tax funded) vaccination program. So people in NL do not have to pay for CoViD vaccines...Groups at increased risk/60+ also can get a (tax funded) flu vaccine next month...For young children there are also vaccinations free-of-charge, other specific groups at risk most often can get vaccinated without payment...

[url]https://nltimes.nl/2022/09/20/nl-residents-can-expect-big-increase-health-insurance-premiums-menzis-director[/url] or https://nltimes.nl/2022/09/20/nl-residents-can-expect-big-increase-health-insurance-premiums-menzis-director ;

Netherlands residents must prepare themselves for a significant increase in health insurance premiums, Menzis CEO and former PvdA leader Wouter Bos said on NPO Radio 1 program Geld of je Leven.

Sources leaked that the Cabinet will announce a 10 to 12 euros per month increase in health insurance premiums on Budget Day today. “People should indeed prepare for that amount,” Bos said. “Insurers can still choose whether they go above or below that. But it is obvious that the premium will go up.”


He called the premium increase inevitable, even in this time of bills piling up. “Ninety percent of this increase can be explained by the fact that people in healthcare want to earn more. I think that’s justifiable - they should also be able to cope with the higher prices. But if wages and prices rise sharply, this immediately translates into what we have to pay for healthcare.”

Health insurers can’t automatically use their own equity to reduce the premium because regulator DNB requires them to maintain a buffer for bad times, Bos explained. “We believe the buffer should be a little lower, but it is not up to us.”


He stressed that Menzis is very aware of the purchasing power crisis. “We believe that as a health insurance company, we have a broad responsibility. Preventing stress and debt problems is part of that. We work with municipalities and organizations that focus on debt problems. The biggest problem is if you find out too late that people have difficulties. We think we have that in order now.

DJ, Here in NL everybody is expected to take basic healthinsurance...There are people without legal status-sometimes living in NL for years-however unable to get basic healthinsurance...There is very limited, very basic medical care for that group (may be thousends...often in larger cities/poor area's). In a "bizarre market strategy" insurers try to sell health insurance...with lots of money ending up in advertising/sponsoring...

NL has a lot of oil and gas (a.o. North Sea) but the same "market dogma" means explorers selling the oil/gas to European/other buyers that then sell it to energy companies...Also supposed to be "market based" but in fact often companies (like [url]https://en.wikipedia.org/wiki/Vattenfall[/url] or https://en.wikipedia.org/wiki/Vattenfall ) that are still owned (100% of the shares) by some government...

There is a lot of criticism on "European market strategy"; consumers end up paying extra for profits, managers, advertising etc..."Competition" did not bring lower prices...Energy, healthcare, water all once-in many countries-was done by (local) government(s)...Privatization often made matters more complex and NOT cheaper...

[url]https://nltimes.nl/2022/09/21/consumer-confidence-new-low[/url] or https://nltimes.nl/2022/09/21/consumer-confidence-new-low ;

The mood among consumers deteriorated further in September. Consumer confidence dropped from -54 in August to -59 this month, breaking the record low for the fifth time this year. “Consumers have never been so negative about the economy and their financial situation,” Statistics Netherlands (CBS) said on Wednesday.

At -59, consumer confidence in September was a massive 50 points below the -9 average for the past two decades.


Consumers were even more pessimistic about the economy, with the economic climate sub-indicator falling from -74 in August to -79 in September. “Never before since the start of the measurement in 1986 were consumers so pessimistic about the economy.” Their willingness to buy was also historically low, dropping from -41 to -46.

Netherlands residents were more pessimistic than ever about their financial situation in both the past year and the coming 12 months. This month, 46 percent called it unlikely to very unlikely that they would be able to set aside money in the next year. And 85 percent of respondents felt that prices rose sharply in the past year, also a new record

DJ...in healthinsurance most people only now may go for a very basic insurance...could even exclude dental care...At the end this "market model" (based on neo-liberal phantasies) will further increase costs for healthcare...There is a -growing- shortage of all kinds of HCW-ers/staff...low pay-high risk...(reminds me of US soldiers told to use food stamps...bizarre !)...

[url]https://nltimes.nl/2022/09/21/first-frost-measured-late-last-night-netherlands[/url] or https://nltimes.nl/2022/09/21/first-frost-measured-late-last-night-netherlands ;

The first recorded instance of ground frost this autumn was measured in the Netherlands late Tuesday night. The temperature on the ground dropped to -1.8 degrees Celsius during the overnight period into Wednesday morning at the weather station in Eelde, Drenthe, according to Weeronline.

There was also frost on the ground at the measuring point near Enschede. There, the temperature dipped to-1.0 degrees at a height of 10 centimeters above the ground.


Broad clearings in the cloud cover enabled the temperatures to drop, according to Weeronline. Officially, the first frost after the summer will be recorded as taking place on 20 September because of the time when the mercury first dipped below freezing at the station in Eelde.

The 28th of September is the average date when frost first occurs after the summer. Last year it happened on 21 September.


The earliest date for post-summer frost is 22 August, a record set in 1973. In 2014, the first frost did not happen until 5 November, the record for the latest first occurrence

DJ...In the last ten years we did often get winters without any (major) snow-or even much frost...However we did see -20C, lots of snow as an exception of the general picture...With people in NL now spending less on heating, good food, healthcare a cold winter can do a lot of healthcare damage...

[url]https://www.dutchnews.nl/news/2022/09/gas-price-cap-will-also-boost-energy-efficiency-experts-say/[/url] or https://www.dutchnews.nl/news/2022/09/gas-price-cap-will-also-boost-energy-efficiency-experts-say/ ; Experts say the government’s decision to introduce a price cap on energy bills will not only help households who are struggling financially but may also encourage people to take more steps to save energy. Details of the deal agreed between the finance ministry and energy companies still have to be finalised, but the plan is expected to save households around €2,000 a year. 

The government will set a maximum unit price for gas and electricity that will cover the first 1,200 m3 of gas and 2,400 kWh of electricity – the annual fuel consumption for an average household. 

Any energy used above that level will be charged at an uncapped rate based on market prices. The government says average household will pay around €290 a month for gas and electricity next year under the proposed price cap. 

The exact rates have not been finalised, but are expected to be around 70 cents for a unit of electricity and €1.50 per cubic metre of gas. This, experts say, makes it financially attractive for people to make sure their energy use stays below the ceiling. Ruut Schalij from energy specialist company eRisk Group told news website Nu.nl he expects to see the ‘biggest savings on energy spending ever’. 

‘Entire families will be able to join in,’ he said. ‘How can we keep our gas use under the 1,200 m3 limit. It will be a great competition, because it can be done.’ The government estimates that around half the country’s eight million households use less energy than the price ceiling covers – but that figure is strongly influenced by the number of people living alone. 

Families Broadcaster RTL says that single person households are likely to remain below the price ceiling and will pay around €205 for gas and electricity in the coming year. Couples living in terraced housing may use slightly more than the government’s estimate, and face bills of around €308 a month. However, families living in bigger houses, who use far more energy than the ceiling limit, will face much higher bills of around €680 a month, RTL said. RTL has a tool to help people estimate how much they will spend on gas and electricity next year.

DJ..16% of social housing has rooms with-still-single glass windows...I would like to see a programm creating more energy efficient houses...Poor urban area's-with allready major health issues-may not get enough help-sink to possibly even third world level...They often do not vote...are NOT represented, already have lots of issues with both government and language...

We may see a major social crisis/protest in those area's...often vaccination level (against all kinds of disease) is low...There was a study in Amsterdam. The richest area's had a survival at birth that was close to the best in the world...while poor area's in Amsterdam did see babies not surviving a first year at third world level...

BA.2.75 is on the rise in NL...at first in the larger cities...later on in other urban area's...Like in other countries it are the poor that pay for pandemics, climate disasters etc much more then the rich. It are the rich-with lots of (long distance) travel, cars etc. that do a lot of the damage...


We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 21 2022 at 12:09am

DJ, 

In latest news-nuclear war on how referenda in 4 Ukraine regions on joining Russia may end the "Special Military Operation" (in support of Donetsk, Luhansk) and change into war if there is further Ukraine action against what Russia then will see as (former Ukraine) part of Russia...

What is wrong with diplomacy !

-Pandemic(s)

[url]https://www.coronaheadsup.com/science/variants/omicron/ba-2-75/ecdc-designates-ba-2-75-as-a-variant-of-concern/[/url] or https://www.coronaheadsup.com/science/variants/omicron/ba-2-75/ecdc-designates-ba-2-75-as-a-variant-of-concern/ ;

Marco Cavaleri, Head of Health Threats and Vaccines Strategy at the European Medicines Agency has revealed today that the Omicron variant BA.2.75 is now being monitored as a Variant of Concern (VOC) by the ECDC.

The ECDC webpage dedicated to tracking SARS-CoV-2 variants hasn’t yet been updated – BA.2.75 is still listed as a Variant of Interest (VOI) there, but designating BA.2.75 as a VOC is a big step up in the threat profile for this particular variant.

DJ [url]https://outbreak.info/situation-reports?pango=BA.2.75[/url] or https://outbreak.info/situation-reports?pango=BA.2.75 provides info on last 60 days...on that basis BA.2.75 is under 0,5% of detected sequences...So far 47 countries reported BA.2.75 cases...most in India-region...Austria is at #4...[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table Austria cases +26% (however New Zealand is at #5...cases there -30%...but it may be poor testing/reporting...). 

[url]https://www.coronaheadsup.com/coronavirus/ba-2-75-2-exhibits-more-extreme-antibody-escape-than-any-variant-weve-seen-so-far/[/url] or https://www.coronaheadsup.com/coronavirus/ba-2-75-2-exhibits-more-extreme-antibody-escape-than-any-variant-weve-seen-so-far/ and other info on (a.o.) BA.2.75 variants is alarming...A main reason we do not yet see an explosion of global number of cases is lack of testing/reporting...[url]https://www.thailandmedical.news/news/great-news-the-official-arrival-of-fall-in-the-northern-hemisphere-is-being-commemorated-by-the-sars-cov-2-virus-with-a-rise-of-cases-in-various-count[/url] or https://www.thailandmedical.news/news/great-news-the-official-arrival-of-fall-in-the-northern-hemisphere-is-being-commemorated-by-the-sars-cov-2-virus-with-a-rise-of-cases-in-various-count 

-[url]https://www.coronaheadsup.com/asia/north-korea/north-korea-masks-mandated-for-the-winter-to-prevent-covid-19/[/url] or https://www.coronaheadsup.com/asia/north-korea/north-korea-masks-mandated-for-the-winter-to-prevent-covid-19/ ;

North Korea has announced a facemask mandate for the entire nation to begin in October and to last all winter. 

North Korea suffered a severe wave of Covid-19 in May 2022. Due to a lack of testing facilities at that time, the disease was often referred to as ‘malignant fever’.

The North Korean press release that we have translated and republished below is the first time we have seen Covid-19 referred to in an official North Korean document.

In the autumn season, the temperature is dropping in most areas of our country, including the northern alpine region, and the temperature difference between day and night is getting bigger.

The World Health Organization and health professional organizations in various countries have already expressed serious concerns about the consequences of complications caused by viruses due to the simultaneous flow of “COVID-19” and the common cold in the fall and winter of this year.

Our quarantine and health experts also emphasized the dangers of the common cold spreading in neighboring countries and regions in recent times, and recommending that all residents wear masks to protect their health from October when the weather starts to get cold.

While closely monitoring the nationwide quarantine situation, the National Emergency Response Command is continuously raising the overall social quarantine atmosphere by promptly delivering instructions detailing treatment and prevention measures related to the flu and materials following the change in the global quarantine situation.

In line with the demands of the heightened normal quarantine system, we are maintaining a general awareness and awareness of quarantine, while anticipatingly establishing epidemic prevention measures in response to seasonal changes.

We are strengthening our propaganda project so that everyone is familiar with health management methods and common sense that can prevent respiratory diseases and consciously observes hygiene and quarantine regulations.

A project that scientifically and technologically refines the examination systems and methods that can detect various diseases accompanied by fever at the relevant medical research institutes in a timely manner, and continuously explores and introduces reasonable methods to promote winter health management in accordance with realistic conditions. are also promoting

Quarantine units and health institutions at each level maintain a high degree of responsibility in the quarantine situation management and treatment prevention projects of their own areas and units, and in order to cleanly eradicate various pathogenic microorganisms, including Dolimb virus, in business spaces, work spaces, and living spaces. The disinfection of the spaces is being carried out more thoroughly.

KCNA.kp press release (in Korean)

DJ...Mask are a cheap and easy way to limit (aerosol) spread of infectious diseases...No doubt NK has been hit hard with CoViD...but very likely other infectious disease-on top of that-are very unwelcome. As far as I ubderstand Russia (in exchange for weapons ?), China (in exchange for coal) may have provided limited vaccines..(party members first ?)...So Non Pharma Intervention may be the main NK strategy...

-[url]https://www.coronaheadsup.com/health/ebola/uganda-ebola-outbreak-confirmed-8-suspected-cases/[/url] or https://www.coronaheadsup.com/health/ebola/uganda-ebola-outbreak-confirmed-8-suspected-cases/ ;

The World Health Organisation has confirmed an outbreak of Ebola in Uganda, the first time the disease has been recorded in the country for ten years.  The outbreak comes just weeks after the Democratic Republic of the Congo also declared an Ebola outbreak.

The health authorities in Uganda today declared an outbreak of Ebola after a case of the Sudan ebolavirus was confirmed in Mubende district in the central part of the country.

The Uganda Virus Research Institute confirmed the case after testing a sample taken from a 24-year-old male. This follows an investigation by the National Rapid Response team of six suspicious deaths that have occurred in the district this month. There are currently eight suspected cases who are receiving care in a health facility.

-

There have been seven previous outbreaks of the Sudan ebolavirus, with four occurring in Uganda and three in Sudan. Uganda last reported an outbreak of Sudan ebolavirus in 2012. In 2019, the country experienced an outbreak of Zaire ebolavirus. The virus was imported from neighbouring Democratic Republic of the Congo which was battling a large epidemic in its north-eastern region.

DJ...Is Ebola increasing ? Is there a CoViD-relation ? Very likely limited data...More healthcare surveilance may result in finding more infectious diseases..(may also work that way for Polio, measles etc...) so if you "look better you may see more"...

Uganda, DRC etc. may not be able to provide much info of the health background of Ebola cases...Did they have had CoViD, resulting in less immunity ? Is the Ebola-virus behaving differently-could we see a "Monkeypox/MPX scenario" for Ebola ???? After Ebola infection people may have long term-years- health issues...

-The "Big Picture" in my opinion is massive-billions of cases-spread of CoViD may endanger human defenses against lots of diseases...from cancers to flu...Excess deaths numbers around the globe may give some indications for that...

Again "STOP THE SPREAD" in my idea is urgently needed to stop pandemics becoming a major risk for human survival...but "who cares"? 

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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part 3, 

What NL info is there on [url]https://coronadashboard.government.nl/[/url] or https://coronadashboard.government.nl/

Positive tests went up +6%...waste water/sewage +4,4%, increase of BA.2.75 variants in NL...

[url]https://coronadashboard.government.nl/landelijk/reproductiegetal[/url] or https://coronadashboard.government.nl/landelijk/reproductiegetal NL R0 now at 1,07...an increase of 0,03...(per august 30-the R0 is calculated on data from 2 weeks ago). 

[url]https://coronadashboard.government.nl/landelijk/varianten[/url] or https://coronadashboard.government.nl/landelijk/varianten has more on the variants in NL; 

last 30 days NL variants were (22-28 august) 

93,1% BA.5

5,9% BA.4

0,5% BA.2.75

DJ-All three variants have loads of subvariants...moving a little further;29 august till september 4

92,9% BA.5

5,6% BA.4

0,7% BA.2.75

0,4% BA.2

15-21 august only had 0,3% BA.2.75..so it more the doubled while BA.5/BA.4 sequences went down...Also the R0 going up fits in with studies indicating BA.2.75 is more infectious...

[url]https://coronadashboard.government.nl/landelijk/ziekenhuis-opnames[/url] or https://coronadashboard.government.nl/landelijk/ziekenhuis-opnames 

NL has 42 people getting into hospital for CoViD each day at the moment, with 403 total (-3 since week before) CoViD cases in hospital...

[url]https://coronadashboard.government.nl/landelijk/geldende-adviezen[/url] or https://coronadashboard.government.nl/landelijk/geldende-adviezen advice; wash your hands...DJ-Not a bad advice in itself...but most of the spread is NOT via contact but aerosol...we do not even have masks in public transport...

[url]https://coronadashboard.government.nl/landelijk/verdenkingen-huisartsen[/url] or https://coronadashboard.government.nl/landelijk/verdenkingen-huisartsen GP data...

Other NL info-not new in fact; [url]https://nltimes.nl/2022/09/19/psychiatric-patients-may-extra-vulnerable-covid-19-study[/url] or https://nltimes.nl/2022/09/19/psychiatric-patients-may-extra-vulnerable-covid-19-study ;

The coronavirus-related mortality rate is much higher among psychiatric patients than among the general population, researchers from Nijmegen and Utrecht found after analyzing a special register.

The register contains information about 143 psychiatric patients who got Covid-19. Eighteen of them died, Trouw reports. That amounts to a mortality rate of 12 percent, while the RIVM estimated the average percentage of Covid-19 patients who died in 2020 at 1 to 6 percent.


“We expected the death rate to be higher than average, but not twice as high,” researcher Daphne Everaerd, a psychiatrist affiliated with Radboudumc in Nijmegen, said to the newspaper.

Most psychiatric patients live at home and not in care institutions, where the Covid-19 mortality rate is also higher. The researchers could not say whether vaccination coverage played a role in the higher mortality rate.


The researchers analyzed a Case Register opened by the Dutch Psychiatric Association (NVvP) in April 2020 due to early concerns that psychiatric patients were more likely to become seriously ill or die from the coronavirus. It was already known that psychiatric patients are more susceptible to infections because of poor physical conditions. The register is not a complete picture of all coronavirus infections among psychiatric patients. Patients with severe illnesses, like psychotic disorders, are overrepresented in the Case Register, while patients with addictions and intellectual disabilities are underrepresented.

The researchers found that psychiatric patients who had neuropsychiatric symptoms during the coronavirus infection, such as delirium and anxiety, often had a more severe course of the disease. The risk of death also seems to be higher in that group. Coronavirus patients with no previous psychiatric complaints who got neuropsychiatric symptoms during Covid-19 also became sicker, but their death rate was significantly lower.

According to Violet van Dee, a researcher at UMC Utrecht, these symptoms can serve as an “early signal for a more severe course” of Covid-19. “The problem with people with a psychiatric illness is that the new symptoms are more difficult to recognize. Perhaps they are suppressed by medicines like antipsychotics. It is important to be aware of this,” she said to Trouw.

The researchers stressed that their findings are not hard conclusions but indications that are in line with international studies. The results of their analysis were published in the Tijdschrift voor Psychiatrie on Monday.

DJ, Also in NL lower income groups, ehtnic groups are over represented...

A look at [url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table has NL cases -30%, deaths -25% however since NL now only twice a week reports it latest numbers these statistics simply give the wrong info...

[url]https://www.worldometers.info/coronavirus/#main_table[/url] or https://www.worldometers.info/coronavirus/#main_table NL population 17,2 million...number of confirmed tested CoViD cases in NL 8,4 million...The over 22,000 CoViD deaths is excluding the deaths in NL carecenters...they ended up in statistics as deaths from old age...other statistics put NL CoViD deaths over 40,000...Looking at cases per million-translation is 48,8% of the NL population tested positive...The NL 1,315 deaths per million is ignoring the care center deaths...(A more realistic number around 2,000 deaths per million? ). 

Comparing NL numbers with Germany there 39% of the population tested positive...1,777 deaths per million.

Belgium 38,7% of the population tested positive, 2,796 deaths per million...Belgium did include all their CoViD deaths (maybe even those dying after 4 weeks/test+)

Comparing countries is "complicated" when definitions differ...Belgium is much more active in testing then Germany...NL even less active then Germany looking at tests per million...

NL may be doing "reasonably high" in vaccinations...that number is not in these statistics...[url]https://coronadashboard.government.nl/landelijk/vaccinaties[/url] or https://coronadashboard.government.nl/landelijk/vaccinaties 82,8% of the NL population at least did get two vaccines...63,9% also a booster-vaccine...

[url]https://coronadashboard.government.nl/gemeente/GM0363/positief-geteste-mensen[/url] or https://coronadashboard.government.nl/gemeente/GM0363/positief-geteste-mensen Amsterdam did see 6,4 positive tests per 100,000 of the population in the last 7 days...Arnhem 5,5...Leiden-lots of students-had 8 per 100,000...there are regional differences...

Proberbly lots more info...[url]https://twitter.com/josetteschoenma[/url] or https://twitter.com/josetteschoenma a.o. also following NL situation...just as an example...

Most countries have similar government info-sites...it can give a lot of info on trends...One may compare it with other sites-you do not need a university degree to compare basic numbers !

End of part 3


We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 19 2022 at 11:56pm

Part two, 

[url]https://www.thailandmedical.news/p/about-us[/url] or https://www.thailandmedical.news/p/about-us ;DJ, I can not copy from this site...once promoting Thailand medical industry, now trying also to inform/educate...DJ-My impression is there may be one person behind a lot of the articles...I do not always agree with the words being used (more immunity evasion as "more fun") but most of the times it has links...makes sense for me-forming my opinion...

[url]https://www.thailandmedical.news/news/researcher-conducting-wastewater-surveillance-of-sars-cov-2-variants-predicts-that-the-next-concerning-variants-will-be-the-bu-and-bq-variants[/url] or https://www.thailandmedical.news/news/researcher-conducting-wastewater-surveillance-of-sars-cov-2-variants-predicts-that-the-next-concerning-variants-will-be-the-bu-and-bq-variants 

DJ TMN has a very outspoken opinion on this pandemic NOT being over. The present lack of strategies will result in newer variants doing even worse...a link [url]https://twitter.com/SolidEvidence/status/1571579049738117122[/url] or https://twitter.com/SolidEvidence/status/1571579049738117122 ;


There you have it.  BQ and BU.  I don't know if they will cause a spike in total cases, but barring something completely new appearing, I predict that they will be the dominant VOCs in the coming months.


and from that twitterlink;

Addendum.  It seems a few other lineages have hit very similar 'jackpot' combinations very recently. In addition to BU and BQ: BW.1 (BA.5.6 derivative) BS.1 (BA.2.3 derivative)   BR.2 (BA.2.75 derivative) other undesignated They all have N460K, L452R + other changes.

DJ Also a [url]https://github.com/cov-lineages/pango-designation/issues/1065[/url] or https://github.com/cov-lineages/pango-designation/issues/1065 link...discussing what the detected mutations mean...A lot of good info will show up later in "main stream media" as far as they are not claiming "pandemic=over"again and again...

The article is full of science-links...I have given up on "new variants" [url]https://outbreak.info/situation-reports[/url] or https://outbreak.info/situation-reports has lots of them...(Omicron itself close to 600 subvariants...critics claim naming them all "Omicron" is simply hiding the fact they are different "VoC"s Variants of Concern...). 

Maybe basic point is several variants have mutations that will bring more spread...

DJ-To keep it workable for me I use two basic ideas;

-1 Disease triangle; Disease-Transport-Host

-2 Exponential growth

If a disease does not spread (genetic origen) the R0-reproduction number is 0...simple...An infectious disease needs to spread, at least at the start have an R0 of 1+ ..if the R0 is lower then 1 the spread is decreasing...In other words 100 people would infect less then a 100 other people...If the R0 is 10 one would see 100 people infecting a 1,000 other people...

As far as I understand the R0 early 2020 in China for the variant(s) spreading there at that time may have been close to 6...Here in NL the highest R0 may have been around 2...

However the fear is new variants could have a R0 much higher then we do see so far...[url]https://en.wikipedia.org/wiki/Measles[/url] or https://en.wikipedia.org/wiki/Measles ;

Measles is an airborne disease which spreads easily from one person to the next through the coughs and sneezes of infected people.[7] It may also be spread through direct contact with mouth or nasal secretions.[14] It is extremely contagious: nine out of ten people who are not immune and share living space with an infected person will be infected.[5] Furthermore, measles's reproductive number estimates vary beyond the frequently cited range of 12 to 18.[15] The NIH quote this 2017 paper saying: "[a] review in 2017 identified feasible measles R0 values of 3.7–203.3".[16] People are infectious to others from four days before to four days after the start of the rash.[5] While often regarded as a childhood illness, it can affect people of any age.[17] Most people do not get the disease more than once.[7] Testing for the measles virus in suspected cases is important for public health efforts.[5] Measles is not known to occur in other animals.[14]

DJ..Comparing CoViD (Corona Viral Disease) with measles; lots of animals may be able to catch CoViD however spreading it further may be limited often...so far... (Minks, US deer a.o. are exceptions..). Another aspect of CoViD may be weakening general immunity...It is likely there are billions of CoViD cases...both in humans and at least non-human infections run in the tens-of-millions (with millions of minks getting killed in DK, NL etc. to limit the risk). 

[url]https://www.thailandmedical.news/news/american-study-discovers-that-sars-cov-2-infections-impairs-antiviral-innate-immune-gene-expression-in-the-placenta[/url] or https://www.thailandmedical.news/news/american-study-discovers-that-sars-cov-2-infections-impairs-antiviral-innate-immune-gene-expression-in-the-placenta link to [url]https://www.ajog.org/article/S0002-9378(22)00747-5/fulltext[/url] or https://www.ajog.org/article/S0002-9378(22)00747-5/fulltext ;

Conclusion

A maternal SARS-CoV-2 infection was associated with an impaired placental innate immune response in chorionic villous tissues and chorioamniotic membranes that was not correlated with gestational age at COVID-19 diagnosis, timer interval from COVID-19 diagnosis to delivery, maternal obesity, disease severity or placental pathology.

DJ-Is this "bad"? YES This is terrible ! [url]https://en.wikipedia.org/wiki/Innate_immune_system[/url] or https://en.wikipedia.org/wiki/Innate_immune_system You are born with a basic immune system...If CoViD infection of the mother does damage that basic immunity system in the baby the baby may have immunity problems...Also pregnant women could be at more risk...

More studies are needed...

HOWEVER !!! IF !!!! CoViD-19 does massive damage to immunity are we heading towards billions of cases of [url]https://en.wikipedia.org/wiki/HIV[/url] or https://en.wikipedia.org/wiki/HIV ????

-Another point is how bad is CoViD [url]https://www.thailandmedical.news/news/breaking-report-claims-that-during-covid-19-pandemic-in-singapore,-up-to-60-percent-of-excess-deaths-was-due-to-sars-cov-2[/url] or https://www.thailandmedical.news/news/breaking-report-claims-that-during-covid-19-pandemic-in-singapore,-up-to-60-percent-of-excess-deaths-was-due-to-sars-cov-2 ...DJ by limiting the definition to "dying from CoViD within 28 days after a positive test" (I do not know if that is the international norm...) lots of excess deaths are not labelled as CoViD deaths...

[url]https://www.worldometers.info/coronavirus/#main_table[/url] or https://www.worldometers.info/coronavirus/#main_table has a global of almost 618 million tested/reported CoViD cases with 6,532,065 "reported" CoViD deaths...Some claim this means a "case fatality ratio" of just over 1%...

However the real number of CoViD cases in humans may be over 2 billion...a realistic number of people dying as a result from a CoViD infection would at least be double the official number-so over 13 million...(If one would go for 2 billion cases then 20 million deaths would be a "CFR" of 1%...). A bad flu may kill up to 0,6% of cases 

[url]https://en.wikipedia.org/wiki/Influenza[/url] or https://en.wikipedia.org/wiki/Influenza ; In a typical year, 5–15% of the population contracts influenza. There are 3–5 million severe cases annually, with up to 650,000 respiratory-related deaths globally each year. Deaths most commonly occur in high-risk groups, including young children, the elderly, and people with chronic health conditions. In temperate regions of the world, the number of influenza cases peaks during winter, whereas in the tropics influenza can occur year-round. Since the late 1800s, large outbreaks of novel influenza strains that spread globally, called pandemics, have occurred every 10–50 years. Five flu pandemics have occurred since 1900: the Spanish flu in 1918–1920, which was the most severe flu pandemic, the Asian flu in 1957, the Hong Kong flu in 1968, the Russian flu in 1977, and the swine flu pandemic in 2009.

DJ...So 5-15% of what population ? The almost 8 billion global population ? Say 10% to make it easy...800 million flu cases...then 1% would mean 8 million deaths...I believe the "norm" for flu-deaths per year is between 400,000 and 600,000...

Point is even if you go for 650,000 flu deaths per year CoViD killed 10x that number in reported, confirmed cases in less then 3 years...On top of that there are "pandemic deaths" not dying from CoViD but because the pandemic did result in not getting treatment in time for other illnesses..[url]https://www.euromomo.eu/graphs-and-maps#excess-mortality[/url] or https://www.euromomo.eu/graphs-and-maps#excess-mortality is one of the statistics on excess mortality (in Europe/Israel). 

DJ-So indications are new variants may have mutations resulting in more spread (R0 going up). Also CoViD results in weaker immunity. 

One of the major background stories is "bird flu" at record-all year round-level in many places...with lots of them [url]https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H5N1[/url] or https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H5N1 ...if (human) immunity is getting weaker we may see an increase of (lots of) other infectious diseases...More agressive types of flu could be one of them...but also [url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory (no longer updated...) very likely may have a CoViD link...

DJ-Again I am NOT an expert ! Trying to make up my mind on what to do...

-So far i did take four vaccinations (2x moderna (booster)/2x pfizer) and I can get another booster soon...

-I limit contacts/mass events...

-I try to get the best info available (and that does NOT come from the government/CDC-like experts...allthough [url]https://coronadashboard.government.nl/[/url] or https://coronadashboard.government.nl/ has lots of good info)

End of part 2...maybe I find time for a part 3...

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 19 2022 at 10:52pm

DJ, part 1,

-In general discussion I opened a topic on "this forum"...at best this is a forum on science. It has to provide room for different point of views, not for insults...I would welcome more-active-members. One of the reasons lots of people are not/no longer active may be due to the "climate" on this (and lots of other) forum(s)...

In general there seems to be less room for debate, exchange of views...I think that makes democracy weaker...Everybody is welcome to have their own opinion, nobody is "right" by definition...It is a view, an opinion...This is-again-not a scientific forum !

-I think one has to look at the background of pandemics. The Spanish Flu can be best understood by linking it to World War One...I do have a history background, not a medical one, and "history has room for lots of different views"...it is not an exact science.. So in latest news I plan to start something else...I have to think of a title; "Pandemic background" or something like that ? With discussion/info on economy, weather, wars...lots of things...

On the pandemic;

[url]https://www.coronaheadsup.com/health/ebola/research-long-ebola-symptoms-7-years-after-infection/[/url] or https://www.coronaheadsup.com/health/ebola/research-long-ebola-symptoms-7-years-after-infection/ ;

Even 5 years after acute Ebola infection, a majority of former patients continue to have symptoms and, for many, these continue to greatly impact their lives.

Symptoms of headache, fatigue, joint pain, muscle pain, hearing loss, visual loss, numbness of hands or feet were longitudinally assessed among participants in the Liberian Ebola Survivors Cohort study.

From June 2015 to June 2016, 326 survivors were enrolled a median of 389 days (range 51-614) from acute EVD. At baseline 75.2% reported at least one symptom; 85.8% were highly interfering with life. Over a median follow-up of 5.9 years, reporting of any symptom declined (odds ratio for each 90 days of follow-up = 0.96, 95% CI: 0.95,0.97; p < 0.0001) with all symptoms declining except for numbness of hands or feet. Rating of any symptom as highly interfering decreased over time. Among 311 with 5 years of follow-up, 52% (n = 161) reported a symptom and 29% (n = 47) of these as highly interfering with their lives.

Research: Post-Ebola Symptoms 7 Years after Infection: The natural history of Long Ebola

DJ [url]https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome#Viral_and_other_infections[/url] or https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome#Viral_and_other_infections ;

Post-viral fatigue syndrome (PVFS) or post-viral syndrome describes a type of chronic fatigue syndrome that occurs following a viral infection.[31] A recent review found Epstein-Barr virus (EBV) antibody activity to be higher in patients with CFS, and that a subset of patients with CFS were likely to have increased EBV activity compared to controls.[54] Viral infection is a significant risk factor for CFS, with one study finding 22% of people with EBV experience fatigue six months later, and 9% having strictly defined CFS.[55] A systematic review found that fatigue severity was the main predictor of prognosis in CFS, and did not identify psychological factors linked to prognosis.[56]

Another review found that risk factors for developing CFS after mononucleosis, dengue fever, or Q-fever included longer bed-rest during the illness, poorer pre-illness physical fitness, attributing symptoms to physical illness, belief that a long recovery time is needed, as well as pre-infection distress and fatigue.[57] The same review found biological factors such as CD4 and CD8 activation and liver inflammation are predictors of sub-acute fatigue but not CFS.[57] However, these findings are not generally accepted due to the use of the Oxford criteria in selecting patients. The CDC does not recognize attribution of symptoms as a risk factor.[6]

A study comparing diagnostic labels found that people labelled with ME had the worst prognosis, while those with PVFS had the best. Whether this is due to those with more severe or longer-lasting symptoms results in a label with the description of ME, or if being labelled with ME adversely causes a more severe or prolonged illness is unclear.[58]

So one may make a difference between "long CoViD" and "chronic CoViD" from that perspective. In (my view on) chronic cases the virus may still be hiding/active in the body..."L.C./Long CoViD" could be more related to damage the virus did do...In that view there may also be some "long chronic CoViD cases" ; with organ damage and still virus doing more damage...indications are a new CoViD infection may be worse...

-[url]https://www.coronaheadsup.com/health/hybrid-immunity/lancet-natural-immunity-associated-with-a-95-lower-risk-of-sars-cov-2-infection/[/url] or https://www.coronaheadsup.com/health/hybrid-immunity/lancet-natural-immunity-associated-with-a-95-lower-risk-of-sars-cov-2-infection/ ;

After the first 3 months, natural immunity was associated with a 95% lower risk of SARS-CoV-2 infection and an 87% lower risk of COVID-19 hospitalisation for up to 20 months.

The risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals who have survived and recovered from a previous infection remained low for up to 20 months. Vaccination seemed to further decrease the risk of both outcomes for up to 9 months, although the differences in absolute numbers, especially in hospitalisations, were small.

Lancet article: Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden

DJ, however as far as I understand the newest variants now showing up/detected may be much better in evading immunity...The article no doubt describing a situation from at least several months back...[url]https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00143-8/fulltext[/url] or https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00143-8/fulltext DJ Study is from march 31, 2022...

Methods

In this retrospective cohort study, we formed three cohorts using Swedish nationwide registers managed by the Public Health Agency of Sweden, the National Board of Health and Welfare, and Statistics Sweden. Cohort 1 included unvaccinated individuals with natural immunity matched pairwise on birth year and sex to unvaccinated individuals without natural immunity at baseline. Cohort 2 and cohort 3 included individuals vaccinated with one dose (one-dose hybrid immunity) or two doses (two-dose hybrid immunity) of a COVID-19 vaccine, respectively, after a previous infection, matched pairwise on birth year and sex to individuals with natural immunity at baseline. Outcomes of this study were documented SARS-CoV-2 infection from March 20, 2020, until Oct 4, 2021, and inpatient hospitalisation with COVID-19 as main diagnosis from March 30, 2020, until Sept 5, 2021.

So the info may be a bit "old"...maybe usefull to define a "baseline" however NOT usefull for the present (sub)variants...[url]https://www.coronaheadsup.com/coronavirus/ba-2-75-2-exhibits-more-extreme-antibody-escape-than-any-variant-weve-seen-so-far/[/url] or https://www.coronaheadsup.com/coronavirus/ba-2-75-2-exhibits-more-extreme-antibody-escape-than-any-variant-weve-seen-so-far/ and [url]https://www.coronaheadsup.com/science/variants/omicron/ba-2-75-2/ba-2-75-2-the-most-immune-evasive-strain-we-have-tested-so-far/[/url] or https://www.coronaheadsup.com/science/variants/omicron/ba-2-75-2/ba-2-75-2-the-most-immune-evasive-strain-we-have-tested-so-far/  in my opinion makes "protection after infection"claims unworkable, unrealistic...

-[url]https://www.coronaheadsup.com/science/origins/professor-jeffrey-sachs-is-pretty-convinced-covid-19-came-out-of-us-lab-biotechnology/[/url] or https://www.coronaheadsup.com/science/origins/professor-jeffrey-sachs-is-pretty-convinced-covid-19-came-out-of-us-lab-biotechnology/ ;

The chair of the Lancet Covid Commission, Professor Jeffrey Sachs, whose recent report into the global mismanagement of the SARS-CoV-2 pandemic we covered in this post, has used an online interview to explain his views on the origins of the SARS-CoV-2 coronavirus.

Professor Sachs says:

He is “pretty convinced [COVID-19] came out of US lab biotechnology”

That risky US-supported research may have led to millions of deaths

Thinks it is very possible that SARS-CoV-2 originated through dangerous virus research gone awry

There were several kinds of experiments of manipulation of the genes of dangerous viruses

He came to the conclusion that powerful actors were preventing a real investigation from taking place

There is extremely dangerous research taking place with little accountability

“It’s a blunder in my view of biotech, not an accident of a natural spillover”

He warns that there is dangerous virus research taking place without public oversight

He has come to the conclusion that there is extremely dangerous biotechnology research being kept from public view

He believes that there is clear proof that the NIH and many members of the scientific community have been impeding a serious investigation of the origins of COVID-19

“We don’t have definitive evidence of either hypothesis. But what we do have is definitive evidence that officialdom has tried to keep our eyes away from the lab creation hypothesis.”

Article: Why the Chair of the Lancet’s COVID-19 Commission Thinks The US Government Is Preventing a Real Investigation Into the Pandemic

DJ...As a "non-expert" I still think "it is natural"; bats have over 30 different corona virusses, SARS_1, MERS may have been early warnings...Is there a link to the African Swine Fever outbreak going global 2018-2020 ? Did pigs play a role in how "SARS-2" started ? 

There is a history of pandemics, climate change/collapse would further increase pandemic risks...so-in my opinion-"very limited room" for any lab-leak claims...(Peak Prosperity once claimed it had to be a lab-leak because of some basic changes very unlikely to be natural...again I am not a scientist/expert...). 

-Maybe on sources [url]https://www.coronaheadsup.com/[/url] or https://www.coronaheadsup.com/ does not provide info on who they are...Most of the time they do provide links for their stories/claims...DJ-Since a lot of their info makes sense to me (much more then "official" embedded media reuters, bbc, other military-industrial-complex owned media...). I could put (another) post on who owns the news...[url]https://en.wikipedia.org/wiki/Thomson_Reuters[/url] or https://en.wikipedia.org/wiki/Thomson_Reuters

Thomson Reuters Corporation (/ˈrɔɪtərz/ (listen) ROY-tərz) is a Canadian multinational media conglomerate.[4] The company was founded in Toronto, Ontario, Canada, where it is headquartered at the Bay Adelaide Centre.[5][6]

Thomson Reuters was created by the Thomson Corporation's purchase of the British company Reuters Group in April 2008[7] and is majority owned by The Woodbridge Company, a holding company for the Thomson family.[8]

DJ For if you had any illusions on western press...it is about profits, NOT about information...

End of part one..


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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 18 2022 at 11:05pm

part 2-twitter

John Ross ðŸ’‰ðŸ’‰ðŸ’‰

@JohnRossMD
 · 
Astonishing graphic looking at race, socioeconomic status, and gender as predictors of US death rates from COVID in 2020. Blue-collar workers in "never remote" jobs had vastly disproportionate mortality. Paper by @bethpathek et al ðŸ‘‰https://ncbi.nlm.nih.gov/pmc/articles/PMC9102098/
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DJ [url]https://twitter.com/JohnRossMD/status/1545774040748625922/photo/1[/url] or https://twitter.com/JohnRossMD/status/1545774040748625922/photo/1 we are NOT all in the same boat !








Income, along with race and gender, is a shockingly robust predictor of COVID mortality in the US

more or less the same in lots of countries...Indonesia had a vaccine strategy trying to vaccinate those with high risk of spreading CoViD first (cab/bus drivers, healthcare, teachers...) maybe the strategy may make the difference ? 








Replying to 
Also BW.1 very similar (BA.5.6.2.1) with 444T and 460K designated tonite.

DJ...a bit cryptic, most likely yet another 9sub) variant even better in evading immunity...

One of the questions I have is what can/should I do ? I can get another booster-vaccine...I proberbly will take it...in the hope it offers some protection for me, may contribute to at least limiting the pandemic...In a recent NL poll 50% of adults that can get a new booster are willing to take one...Those that already did get booster(s) 67% is willing to take another one...

DJ, vaccines and vaccine-strategy are two different things in my opinion. Vaccines-I think-can statisticly be related with less (direct) CoViD deaths (within 28 days after a positive test). However excess deaths now in many places even higher then in 2020, 2021 may indicate "vaccines are far from perfect"...

Vaccine strategy has vaccines as part of a bigger plan...Vaccines may go to some groups first but on top of that there is also Non pharma Intervention; (legal right to) work/study from home, no mass events if possible, travel restrictions...STOP THE SPREAD !








Replying to 
Note that neither BQ nor BU are BA.2.75 descendants. BQ is a BA.5.3.1 descendant. BU is a BA.5.2 descendant. And BQ.1.1 is at least for now showing more growth advantage than BA.2.75.2 at https://cov-spectrum.org/collections/24 [as always sort by “CI (low)”]. Multiple lineages to watch.

DJ, claims that this pandemic is "almost"(???) over in my opinion border to insanity...








What we think is happening is that cryptic lineages are very long-term infections in people (often >1 year).  Perhaps GI infections.   The hosts are obviously mounting an immune response, but are not able to clear the infection.

DJ, long term infections may bring lots of mutations...oral/nasal tests in these people may be negative...missing the virus hidden in the body...In some cases more then one variant...








We see this in real data. For polyclonal serum to early #SARSCoV2, dominant epitope contained site E484 & subdominant epitope contained K417. Mutating E484 alone causes escape, mutating K417 alone causes no escape, & mutating both (as eventually virus did) causes lots of escape.

Winterwave is coming...

DJ-Again-exponential growth will not only result in lots of subvariants of CoViD but also less immunity against other diseases...

Three developments -mixing- may END humanity;

-1 Wars...what is wrong with diplomacy ?

-2 Pandemics...STOP THE SPREAD

-3 Climate collapse ...Puerto Rico did not recover from "Maria" 5 years ago...now they had "Fiona"...Pakistan is flooded-bringing lots of diseases and worsening the global foodcrises...

DJ-I live here and now...try to make the best of it...there are lots of things to enjoy ! I do worry about "the future", the next generations...Informing people may be a start !

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
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DJ, 

-In latest news/nuclear war my "view" on the present situation...Russia IS using Iran drones in Ukraine...claims of Chinese Army convoys entering Ukraine in support of Russia I think are very likely...need more confirmation. Russia-Iran-China RIC may have decided to go in the offensive on many frontlines...

It did not have to be this way...

Global war of course only worsening the pandemics. Wounded Ukraine military ending up in European -already overstretched-hospitals. Refugees with all kinds of diseases (here in NL polio in sewage linked to refugees) are a major concern...most refugees worldwide are linked to climate collapse (1/3 of Pakistan is flooded...).

-Pandemic news;

These two articles are linked; 

1 [url]https://www.coronaheadsup.com/health/long-covid/survey-reinfection-worsens-long-covid/[/url] or https://www.coronaheadsup.com/health/long-covid/survey-reinfection-worsens-long-covid/ ;

Reinfection worsens symptoms of Long COVID or triggers a recurrence of symptoms in people who have recovered.

Survey results were similar across adults and young people. As many as 89% of respondents first got Long COVID after their first infection, compared with 10% after the second infection, and just 1% after the third infection. Overwhelmingly, reinfection worsened the symptoms of Long COVID in most people who were still symptomatic.

In those who still had Long COVID at the time of reinfection, 80% saw their symptoms worsen vs. 10% who saw their Long COVID symptoms improve. Around 85% saw old symptoms return or new additional symptoms vs. 10% who had a resolution or improvement of symptoms.

In 60% of people who were in recovery or remission with Long COVID, reinfection caused a recurrence of Long COVID.

Survey: Effect of Covid Reinfection on People Living With Long Covid

and 2 [url]https://www.coronaheadsup.com/coronavirus/ba-2-75-2-exhibits-more-extreme-antibody-escape-than-any-variant-weve-seen-so-far/[/url] or https://www.coronaheadsup.com/coronavirus/ba-2-75-2-exhibits-more-extreme-antibody-escape-than-any-variant-weve-seen-so-far/ ;

Two preprints have been published over the last few days that give more details about the Omicron BA.2.75.2 sublineage. Both preprints show that BA.2.75.2 could represent a very serious threat to human health in the immediate future.

Ben Murrell, a researcher from the Karolinska Institute in Sweden, has published a long thread on Twitter that we are republishing below. The details are from the first preprint, titled “Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies”

-

In the second preprint, Yunlong Cao has given further details of his work that we first covered in this post. These details are from the second preprint, entitled “Imprinted SARS-CoV-2 humoral immunity induces converging Omicron RBD evolution”.

DJ [url]https://www.biorxiv.org/content/10.1101/2022.09.15.507787v1[/url] or https://www.biorxiv.org/content/10.1101/2022.09.15.507787v1 

In short - the two stories- newer variants are better in evading immunity, reinfection while reinfection does cause more long term damage....I discussed the-very serious !- article yesterday in my part 2. 

[url]https://www.thailandmedical.news/news/breaking-taiwan-experiencing-anomalous-covid-19-surge-people-are-getting-re-infected-with-same-variants-ie-ba-2-3-and-ba-5-2-1-16-bf-16[/url] or https://www.thailandmedical.news/news/breaking-taiwan-experiencing-anomalous-covid-19-surge-people-are-getting-re-infected-with-same-variants-ie-ba-2-3-and-ba-5-2-1-16-bf-16 fits in that "big picture"...and it is BAD !!!!

So, given the very bad outlook-very likely massive spread of CoViD resulting in less human immunity defenses-giving room for all kinds of other diseases (like MPX) to spread one would expect governments to protect public health...

[url]https://www.thailandmedical.news/news/biden-announces-that-the-covid-19-pandemic-is-over-study-shows-covid-19-increases-the-risk-of-alzheimer-in-older-adults-by-between-50-to-80-percent[/url] or https://www.thailandmedical.news/news/biden-announces-that-the-covid-19-pandemic-is-over-study-shows-covid-19-increases-the-risk-of-alzheimer-in-older-adults-by-between-50-to-80-percent DJ-Again this pandemic is the outcome of a total political faillure ! 

Both politics and (MIC owned) "media" continue to worsen the pandemic...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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