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Now tracking the new emerging South Africa Omicron Variant

Study suggests possible COVID19 immunity exists

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    Posted: May 24 2020 at 1:47pm

A new study from scientists in the United States suggests that a significant majority of the population may already have some level of immunity to the coronavirus, a possible explanation for why so many individuals seem to experience few to no symptoms from the disease. 

The study, written by researchers in California, New York and North Carolina and soon to be published in the journal Cell, discovered that certain types of cells in blood samples taken from donors in 2015-2018—well before COVID-19 arose—were reactive against the COVID-19 virus. In other words, those blood samples were at least partially immune from the coronavirus even though they had never been exposed to it. 

"CD4+ T cell responses were detected in 40-60% of unexposed individuals. This may be reflective of some degree of crossreactive, preexisting immunity to SARS- CoV-2 in some, but not all, individuals," the researchers state in the paper. 

The scientists are careful to qualify their conclusions. "Whether this immunity is relevant in influencing clinical outcomes is unknown—and cannot be known without T cell measurements before and after SARS- CoV-2 infection of individuals—but it is tempting to speculate that the crossreactive CD4+ T cells may be of value in protective immunity," they write.

The research could provide an important clue for public health officials hoping to figure out why significant numbers of COVID-19 infections are either asymptomatic or else largely mild. The disease affects elderly and less healthy individuals most severely, with younger and healthy individuals for the most part spared its worst effects. 

Though the term "coronavirus" has become ubiquitous in recent weeks as a way to describe the virus causing the current pandemic, coronaviruses are actually a variegated strain of infectious agents that cause illnesses ranging from the common cold to SARS. 

The researchers in their paper suggest that the immune response seen in the uninfected blood samples could have been generated by the coronaviruses that cause the common cold.

https://justthenews.com/politics-policy/coronavirus/study-suggests-majority-population-may-already-have-some-degree

https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2930610-3 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiwiMum Quote  Post ReplyReply Direct Link To This Post Posted: May 24 2020 at 2:17pm

I've been in discussion with a virologist in London about the CCR5-Delta 32 mutation gene because in our homeschooling last year we studied this gene and how it can confer immunity to both the black death from the middle ages and modern day HIV. She told me that geneticists are looking in to it at the moment. Since we have European ancestry and 10% of Europeans have one copy of this gene, I would like to get us tested. We'd love to know if we're some of the lucky ones.

Those who got it wrong, for whatever reason, may feel defensive and retrench into a position that doesn’t accord with the facts.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: May 24 2020 at 8:47pm





In the UK around the West Midlands,

The Pakistani,and Bangladeshi community has been hit hard....


Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

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Post Options Post Options   Thanks (0) Thanks(0)   Quote DeepThinker Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2020 at 6:55am

To me this has been obvious since the diamond princess.   I have never seen any hard evidence that any more than 20-30% of the population was susceptible to this virus.  "Experts" have suggested that the attack rate was around 60-80%.   Once again they are wrong.  

It is great to see actual data and a possible explanation.

The hardest hit areas have already hit herd immunity.   It is time to FULLY open up in the northern hemisphere.   It is in every bodies interest to work towards herd immunity during the summer when people are the healthiest.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Hazelpad Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2020 at 3:26pm

sorry posted  twice see next post

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Hazelpad Quote  Post ReplyReply Direct Link To This Post Posted: May 25 2020 at 4:20pm

Hello Kiwimum

Sorry bit confused and wonder if I can ask something.

So what Al's  posted paper is talking about is the existence of memory CD4+ T cells and B cells,  possibly to another coronavirus.  This immunological memory is able to cross react and neutralise out the new pandemic virus. This  can happen.  Cowpox gave immunity to smallpox virus etc. So good research in a good journal ( Cell).  This is hopeful.  Thank you Al for posting this.

KiwiMum what you are talking about is a completely different process of viral immunity.  You are not talking about immunity via antibody/memory response.  Instead you are mentioning about people having immunity due to the type of receptor they have on their cells specifically referencing the receptor CCR5.  ( for those who don't know CCR5 is a co-receptor on many immune cells).

You say you are talking to a virologist about this.  At this point I was not aware of any coronavirus that can gain access to the immune cells like HIV.   If you have heard otherwise please let me know as it  highly interesting.

The reason for this is that patients with severe disease tend to have very low CD4+ CD8+ cell counts also their NK cells are low. You would expect high numbers not low.   These cells don't all share CCR5, but there are other co-receptors shared.  Perhaps the virus can enter these immune cells directly and destroy them.   I presumed the strange low number was simply due to viral induced inhibition as a byproduct of infection, not that the virus could enter the immune cells and bump them off.

I worked on CCR5 CCR7 CCR9 etc so would be interested why your virologist feels a coronavirus can enter through CCR5.  Any info would be very much appreciated.

As for your project it is a fascinating subject.  The CCR5 delta32 genotype was selected for across Europe during the plague ( many other reasons also).  When HIV came along it used CCR5 as a coreceptor to enter T cells, and bump them off.   A lot of the European population though had a gene coding for a  delta32  variant of the CCR5 receptor that HIV couldn't use.  

HIV therefore had to go the long way around  in European hosts and infect the T cells through dendritic cells and macrophages  ( went in often via he gut immune system ).  HIV got there but by the longer route.     At the time compared to African populations the lag from infection to full blown AIDS was prolonged.  Everyone thought it was due to people in Europe having better access to health services, when a lot of it was genetics.  

Warning ...Kiwimum.  I wouldn't spend any money getting genotyped for  CCR5 delta32.  I wouldn't want to know if I had it as it is associated with all sorts of nasties including MS, severe form of asthma, other autoimmune conditions, and highly with diabetes type 2 ( conditions associated with severe Covid19).  You would just be buying yourself a bag of worries.

Hz x



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