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Tracking the next pandemic: Avian Flu Talk

Biomolecule May Neutralize Coronavirus

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ViQueen24 View Drop Down
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    Posted: September 14 2020 at 8:13pm

https://pittsburgh.cbslocal.com/2020/09/14/pitt-scientists-discover-biomolecule-that-may-neutralize-coronavirus/


University Of Pittsburgh Scientists Discover Biomolecule That May Neutralize Coronavirus

The researchers reported that Ab8 is "highly effective" in preventing and treating SARS-CoV-2 infection in mice and hamsters.

By: KDKA-TV News Staff

PITTSBURGH (KDKA) — University of Pittsburgh scientists have isolated a biomolecule that “completely and specifically” neutralizes the virus that causes coronavirus.



University of Pittsburgh School of Medicine researchers isolated the smallest biological molecule to date that neutralizes the SARS-CoV-2 virus, according to a report published Monday in the journal Cell. The antibody component is 10 times smaller than a full-sized antibody and has been used to create a drug known as Ab8 for use as a therapeutic and preventative against SARS-CoV-2, the report says.

The researchers reported that Ab8 is “highly effective” in preventing and treating SARS-CoV-2 infection in mice and hamsters.

“Ab8 not only has potential as therapy for COVID-19, but it also could be used to keep people from getting SARS-CoV-2 infections,” said co-author John Mellors, M.D., chief of the Division of Infectious Diseases at UPMC and Pitt, said in a release from UPMC. “Antibodies of larger size have worked against other infectious diseases and have been well tolerated, giving us hope that it could be an effective treatment for patients with COVID-19 and for protection of those who have never had the infection and are not immune.”

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: September 15 2020 at 6:41am

How do you tell if a politician is lying?
His lips or pen are moving.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote WitchMisspelled Quote  Post ReplyReply Direct Link To This Post Posted: September 15 2020 at 7:24am

Which one?  There are four produced in the body.  Which might also make sense if younger bodies produce more of the particular biomocule than older bodies.  

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Post Options Post Options   Thanks (1) Thanks(1)   Quote ViQueen24 Quote  Post ReplyReply Direct Link To This Post Posted: September 15 2020 at 7:42am

It's a much smaller molecule than the antibodies that I think you're thinking of, Witchy.

Here's an article that may break it down a little more:

https://www.cbs19.tv/article/news/health/coronavirus/researchers-hopeful-promising-covid-19-therapeutic/507-e83c6c89-568e-423d-bbe2-e52eb4e7f55a

Scientists say they've discovered promising potential therapeutic that neutralizes coronavirus

Researchers published the findings saying an isolated tiny antibody component could potentially be a therapeutic drug and COVID-19 prophylactic.
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WASHINGTON D.C., DC — Researchers at the University of Pittsburgh School of Medicine say they have isolated "the smallest biological molecule to date," which according to scientists "completely and specifically neutralizes" the coronavirus, or SARS-CoV-2, the virus that causes COVID-19 disease. 

The findings have been published in the journal Cell and according to the study, the molecule that has been discovered is 10 times smaller than a full-sized antibody. 

The biological molecule has been used to make a new drug, currently known as Ab8, which researchers hope could potentially be a viable and effective therapeutic, and even a prophylactic to treat and protect against SARS-CoV-2.

University of Pittsburgh researchers worked with other scientists at the University of North Carolina at Chapel Hill, the University of British Columbia, University of Saskatchewan and the University of Texas Medical Branch at Galveston to evaluate Ab8 and its efficacy. 

Study co-author John Mellors at UPMC said “Ab8 not only has potential as therapy for COVID-19, but it also could be used to keep people from getting SARS-CoV-2 infections.” Mellors says that the scientists have hope that this could be an effective treatment because larger sized antibodies have worked against other infectious diseases and have been "well tolerated," he says

According to Mellors, the biological molecule they've discovered and have used to make Ab8 could also give protection to "those who have never had the infection and are not immune."

The researcher's finding, which were reported Monday, are based on applications in infected mice and hamsters. The hope is that the tiny size of the biological molecule will increase the potential that it can infuse into tissue with better results, therefore better neutralizing the coronavirus. 

A senior author of the journal Cell publication, Dimiter Dimitrov, Director of the University of Pittsburgh Center for Antibody Therapeutics, was also one of the first to discover that antibodies had the potential to neutralize the original SARS coronavirus back in 2003. 

As the U.S. grapples to mitigate the spread of COVID-19, a vaccine, therapeutics and testing have been front and center in the national dialogue regarding the pandemic.

Recently, tests touted by President Donald Trump and his top officials to help reopen the economy have been widely available, but predictions for their usefulness haven't panned out. 

The tests check the blood for antibodies that help fight off infections, but as the Associated Press reported, scientists still haven't determined whether those antibodies shield someone from getting infected again. Medical experts have also warned that the tests cannot be safely used to return workers to the office. Despite such warnings, some big labs continue to market the tests to employers. And dozens of tests with unverified accuracy continue to be sold. 


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