Click to Translate to English Click to Translate to French  Click to Translate to Spanish  Click to Translate to German  Click to Translate to Italian  Click to Translate to Japanese  Click to Translate to Chinese Simplified  Click to Translate to Korean  Click to Translate to Arabic  Click to Translate to Russian  Click to Translate to Portuguese  Click to Translate to Myanmar (Burmese)

PANDEMIC ALERT LEVEL
123456
Forum Home Forum Home > Main Forums > Latest News
  New Posts New Posts RSS Feed - Pfizer 47% at 5 months
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Now tracking the new emerging South Africa Omicron Variant

Pfizer 47% at 5 months

 Post Reply Post Reply
Author
Message
Pixie View Drop Down
Admin Group
Admin Group
Avatar

Joined: June 05 2006
Location: United States
Status: Offline
Points: 19668
Post Options Post Options   Thanks (0) Thanks(0)   Quote Pixie Quote  Post ReplyReply Direct Link To This Post Topic: Pfizer 47% at 5 months
    Posted: October 04 2021 at 7:52pm

https://www.latimes.com/science/story/2021-10-04/pfizer-covid-vaccine-waning-not-deltas-fault


Research conducted in Southern California has confirmed the dramatic erosion of the Pfizer-BioNTech COVID-19 vaccine’s protection against “breakthrough” coronavirus infections.

The new study, one of the largest and longest to track the effectiveness of a vaccine in Americans, found that the vaccine’s ability to protect against infection stood at 88% in its first month, then fell to 47% after just five months.

But even as the Delta variant became the predominant strain across the Southland, the vaccine’s effectiveness at preventing COVID-19 hospitalizations held steady at close to 90% for as long as six months. What’s more, it maintained that power across vaccine recipients of all age groups.

The study, funded by Pfizer and published Monday in the journal Lancet, also provides strong new evidence that the waning immunity against infection probably would have been seen with or without the arrival of the Delta variant.


The researchers, led by infectious disease epidemiologist Sara Tartof of Kaiser Permanente Southern California, drew on several findings to conclude the Delta variant was not the driving factor in the vaccine’s waning efficacy against infection. Instead, the passage of time appeared to be the key to a vaccinated person’s resurgent vulnerability.


For starters, Tartof and her colleagues found that a fresh inoculation with the Pfizer-BioNTech vaccine protected just as well against an infection with the Delta variant as it did against infection with other versions of the coronavirus.

Second, the vaccine’s ability to keep vaccinated people out of the hospital remained high across a span of time when the Delta variant gained ground in Southern California.


And third, breakthrough infections were more closely linked to the amount of time that had lapsed since vaccination than they were to the particular viral variant involved.


By showing that waning immunity, not the Delta variant, was the likely reason for the rise in breakthrough infections, the study suggests it may not be necessary to reformulate a Pfizer-BioNTech booster that specifically targets Delta. For now, at least, a third shot identical to the first two would probably extend the vaccine’s early record of protection against all strains, including Delta, Tartof said.

The Southern California research scoured the medical records of 3,436,957 patients ages 12 and older who were enrolled in Kaiser Permanente Southern California’s healthcare system between mid-December and early August. Close to 2.3 million of them remained unvaccinated during that period, while just over 1 million received two doses of the Pfizer-BioNTech vaccine, now known as Comirnaty.

The rates of SARS-CoV-2 infection, as well as of hospitalization for COVID-19, were tallied for both groups of patients and compared for as long as six months.

The protection provided by Comirnaty beyond six months has been an open question, hinted at only by Israeli studies that suggest COVID-19 hospitalization rates rise in those above 60 years of age.

In another recent study, researchers from Emory University and Stanford found that six months after being inoculated with Comirnaty, roughly half of 56 young and middle-aged adults had no detectable neutralizing antibodies against the SARS-CoV-2 virus. The reduced immunity was particularly dramatic against the coronavirus variants Delta, Beta and Mu.

That study was posted last week on BioRXiv, a site where researchers share preliminary work before it has been peer-reviewed. But its findings of “a substantial waning of antibody responses” — as well as a drop in the immunity provided by T cells — suggest that a third booster immunization “might be warranted,” its authors wrote.

The Lancet study reflects a very large and diverse population of Californians who are still being tracked. As such, it is poised to offer U.S. policymakers some insight into who needs boosters most, and when.

“We really do need to track closely to make sure we catch it quickly if it does happen,” Tartof said in an interview.

She said the Kaiser Permanente team, in collaboration with Pfizer, continues to analyze its data weekly. The team is poised to alert public health officials if hospitalizations begin to creep up in any slice of the population, she added.

Back to Top
carbon20 View Drop Down
Moderator
Moderator
Avatar

Joined: April 08 2006
Location: West Australia
Status: Offline
Points: 65816
Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: October 04 2021 at 10:09pm

All vaccines wane over time,

It's the bodies "T"cells ability to recognise the threat of an already know pathogen entering the body,and to  kill off invader/cell once the body recognises what it's enemy is it can defeat it .

I mean why bother wasting energy if the threat has past, the pattern for the killer  "T"cells is stored in the bodies "data base"

For future reference.....

Take care all 😷😉💉

Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
Back to Top
carbon20 View Drop Down
Moderator
Moderator
Avatar

Joined: April 08 2006
Location: West Australia
Status: Offline
Points: 65816
Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: October 05 2021 at 4:37am
Two studies in this issue of Cell collectively suggest that, although SARS-CoV-2 infection may blunt long-lived antibody responses, immune memory might still be achieved through virus-specific memory T cells.4 Sept 2020
Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
Back to Top
carbon20 View Drop Down
Moderator
Moderator
Avatar

Joined: April 08 2006
Location: West Australia
Status: Offline
Points: 65816
Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: October 05 2021 at 4:46am
How do killer T cells work?


In cellular immunity, a killer T cell recognizes and kills a virus-infected cell because of the viral antigen on its surface, thus aborting the infection because a virus will not grow within a dead cell.
https://www.britannica.com › science
Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
Back to Top
EdwinSm, View Drop Down
Moderator
Moderator


Joined: April 03 2013
Status: Offline
Points: 24065
Post Options Post Options   Thanks (0) Thanks(0)   Quote EdwinSm, Quote  Post ReplyReply Direct Link To This Post Posted: October 05 2021 at 10:45pm

Thanks, Carbon, for the reminder that there is more than one line of defense that the body has.   

Too often the media seems to want a very simple 'one size fits all' picture.

Back to Top
carbon20 View Drop Down
Moderator
Moderator
Avatar

Joined: April 08 2006
Location: West Australia
Status: Offline
Points: 65816
Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: October 06 2021 at 4:20pm

All good , people are very ignorant of the benefits of having a vaccine and what they are  actually capable of......

not withstanding what a remarkable bit of Kit  the human body is.....

Take care all 😷😉💉

Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
Back to Top
carbon20 View Drop Down
Moderator
Moderator
Avatar

Joined: April 08 2006
Location: West Australia
Status: Offline
Points: 65816
Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: October 07 2021 at 6:01pm

The Conversation AU: No, COVID vaccines don't stay in your body for years.

https://theconversation.com/no-covid-vaccines-dont-stay-in-your-body-for-years-169247

Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
Back to Top
carbon20 View Drop Down
Moderator
Moderator
Avatar

Joined: April 08 2006
Location: West Australia
Status: Offline
Points: 65816
Post Options Post Options   Thanks (0) Thanks(0)   Quote carbon20 Quote  Post ReplyReply Direct Link To This Post Posted: October 10 2021 at 3:48am

CNN: Is my immunity waning? Doctors advise Pfizer vaccine recipients not to worry.

https://www.cnn.com/2021/10/09/health/pfizer-covid-vaccine-waning-questions-wellness/index.html

Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖

Marcus Aurelius
Back to Top
 Post Reply Post Reply
  Share Topic   

Forum Jump Forum Permissions View Drop Down