Is Tamiflu an Antibiotic? - Genericcures

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   More on Tamiflu;
[url]https://afludiary.blogspot.com/2024/03/the-lancet-correspondence-global.html[/url] or https://afludiary.blogspot.com/2024/03/the-lancet-correspondence-global.html ;
Twenty years ago Amantadine was the preferred influenza antiviral. It was cheap, plentiful, and worked reasonably well as both a treatment, and a preventative.  

It was so popular it was allegedly used by Chinese farmers to protect their flocks from avian flu, which is believed led to growing resistance (see Nature News China's chicken farmers under fire for antiviral abuse). 

By late 2005 Amantadine was beginning to lose its effectiveness against the H3N2 seasonal flu virus and some strains of the H5N1 bird flu. In January of 2006 the CDC issued a warningto doctors not to rely on Amantadine or Rimantadine to treat influenza.Tamiflu (Oseltamivir) - an NAI (neuraminidase inhibitor) - was approved for use in the U.S. in 1999. While far more expensive, it became the new treatment standard.  
While occasional instances of Oseltamivir resistance were recorded prior to 2007, in nearly every case, it developed after a person was placed on the drug (i.e. `spontaneous mutations’). 
Although of obvious concern to the patient receiving treatment, it occurred in only about 1% of treated cases, and studies suggested that these resistant strains were `less biologically fit’, and were therefore thought unlikely to spread from human-to-human.
Which of course, is exactly what they did do. Between 2007 and 2008, the incidence of resistant seasonal H1N1 viruses literally exploded around the globe. 
So much so, that by the end of 2008, nearly all of the H1N1 samples tested in the United States were resistant to oseltamivir and the CDC was forced to issue major new guidance for the use of antivirals (see CIDRAP article With H1N1 resistance, CDC changes advice on flu drugs).
DJ, "anti-virals work untill they stop working"....Virusses may develop/select mutations getting around antivirals/immunity...

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Dutch Josh Members Profile Send Private Message Find Members Posts Add to Buddy List Adviser Group Joined: May 01 2013 Location: Arnhem-Netherla Status: Online Points: 95817	Post Options Post Reply Quote Dutch Josh Report Post Thanks(0) Quote Reply Topic: Is Tamiflu an Antibiotic? - Genericcures Posted: March 21 2024 at 5:05am
	More on Tamiflu; [url]https://afludiary.blogspot.com/2024/03/the-lancet-correspondence-global.html[/url] or https://afludiary.blogspot.com/2024/03/the-lancet-correspondence-global.html ; Twenty years ago Amantadine was the preferred influenza antiviral. It was cheap, plentiful, and worked reasonably well as both a treatment, and a preventative. It was so popular it was allegedly used by Chinese farmers to protect their flocks from avian flu, which is believed led to growing resistance (see Nature News China's chicken farmers under fire for antiviral abuse). By late 2005 Amantadine was beginning to lose its effectiveness against the H3N2 seasonal flu virus and some strains of the H5N1 bird flu. In January of 2006 the CDC issued a warningto doctors not to rely on Amantadine or Rimantadine to treat influenza. Tamiflu (Oseltamivir) - an NAI (neuraminidase inhibitor) - was approved for use in the U.S. in 1999. While far more expensive, it became the new treatment standard. While occasional instances of Oseltamivir resistance were recorded prior to 2007, in nearly every case, it developed after a person was placed on the drug (i.e. `spontaneous mutations’). Although of obvious concern to the patient receiving treatment, it occurred in only about 1% of treated cases, and studies suggested that these resistant strains were `less biologically fit’, and were therefore thought unlikely to spread from human-to-human. Which of course, is exactly what they did do. Between 2007 and 2008, the incidence of resistant seasonal H1N1 viruses literally exploded around the globe. So much so, that by the end of 2008, nearly all of the H1N1 samples tested in the United States were resistant to oseltamivir and the CDC was forced to issue major new guidance for the use of antivirals (see CIDRAP article With H1N1 resistance, CDC changes advice on flu drugs). DJ, "anti-virals work untill they stop working"....Virusses may develop/select mutations getting around antivirals/immunity...
	We cannot solve our problems with the same thinking we used when we created them. ~Albert Einstein