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PANDEMIC ALERT LEVEL
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" 4 Distinct Deadly 5HN1 Viruses " Dr. Niman

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    Posted: April 03 2006 at 10:15am


Human H5N1 Bird Flu in China Raise Pandemic Concerns

Recombinomics Commentary
April 3, 2006

"China has released three human H5N1 bird flu sequences. These sequences are similar to each other and most closely related to a duck isolate in Fujian Province. However, these isolates are quite distinct from other H5N1 sequences in China and elsewhere.

Consequently, the pandemic vaccine in clinical trails around the world and the new vaccine target from Indonesia that was recently selected by the United States will not offer significant protection against these newly released sequences from China. Moreover, the vaccines under development will also offer little protection against the Qinghai strain which is linked to recent human outbreaks in Turkey, Iraq, Egypt, and Azaerbaijan.

Thus, at this time there are four distinct H5N1's causing fatal human infections which will likely require custom pandemic vaccines. Thus, as H5N1 evolves, the distance between vaccines under development and new versions of H5N1 cause human infections is increasing. In 2004 human cases in Vietnam and Thailand were linked to a similar H5N1. Last year Indonesia and China reported human cases and the recent release of sequence data clearly shows that the H5N1 in humans in Indonesia is quite distinct from H5N1 infecting humans in China and all three versions are distinct from the Qinghai strain of H5N1 causing human infections in the Middle East and Africa.


The spread of human H5N1 cases has also been associated with changes in the receptor binding domain. The first reports were identified in 2003 isolates from a Hong Kong family that had visited Fujian province. The H5N1 isolated from the patients contained S227N. This change was subsequently found in human isolate(s) in Vietnam and most recently in the index case in Turkey.

One of the isolates from China has a change at the adjacent position, Q226R. Unlike the S227N change, Q226R has not been linked to increased affinity for human receptors, although Q226L is the change in human H3 HA that has been linked to increased affinity. Another change, G228S ahs been predicted for Europe due to recombination between Qinghai H5N1 and European swine H1N1.

In addition to these changes within the receptor binding domain, changes near the receptor binding domain, (P185S, N186S, R193K) have been recently reported in Iraq and China. These changes in and around the receptor binding domain are cause for concern because donor sequences are frequently found in flu from birds and the H5N1 host and geographical ranges are rapidly expanding.

The number of changes is also not know because many of the recent human isolates have been sequestered in a private WHO database. The human H5N1 sequences from Iraq, Indonesia, and China have been released in the past few weeks. However, human sequences from Turkey, Azerbaijan., Egypt and additional sequences from China and Indonesia have not been released, so additional polymorphisms linked to the receptor binding domain may have already entered the reservoir of human H5N1 infections.

H5N1 is clearly rapidly evolving via recombination, as efforts to address these genetic changes continue to lag."
   
http://www.recombinomics.com/News/04030603/H5N1_China_Pandemic.html


    
    
    
    
   
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Post Options Post Options   Thanks (0) Thanks(0)   Quote seesthelight Quote  Post ReplyReply Direct Link To This Post Posted: April 03 2006 at 10:44am
Rick , thanks for posting this article. .
 
The USA and the world really needs to step it up, IMHO.
 But I am not holding my breathe. It does appear to be the way the world works on even a good day.
 
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Guests Quote  Post ReplyReply Direct Link To This Post Posted: April 03 2006 at 10:46am
THIS IS NOT GOOD NEWS.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote CitizenBlue Quote  Post ReplyReply Direct Link To This Post Posted: April 03 2006 at 11:11am
Actually this was expected. This is why the gene sequencing of H1N1 was so important. It showed that rapid mutation probably occurred prior to the 1918 pandemic. While it is bad news, they thought this might be happening; it just was that China was not releasing their data (until recently) to confirm. It does not necessarily mean five different pandemics, just that the virus is possibly "trying" (hate to ascribe intel to virus) to mutate (or recombine) to infect new organisms or to be more efficient at transmission in birds. The kicker here is human infection rates, for every human infected the chances of efficient H2H transmission mutations increase. Think of the human body as an experiment for the virus, each human body it gets to know it can mutate to become more efficient. Amazing things viruses, not considered a life form, but survival instincts seems to be present, amazing.
    
It's always the lowest common denominator.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Corn Quote  Post ReplyReply Direct Link To This Post Posted: April 03 2006 at 12:46pm
get your very last preps done with in your abilities.
 
keep the gas tanks and cans full.
 
start practicing all forms of preventive hygene in public NOW. handeling money, mail,  Start minimizing public exposure as you can.
 
the roof is fixing to blow.
 
Take heed for what its worth. This alert is a personal observation.
Naysayers and  libriarians need not comply or reply.
 
Just close your eyes for a moment in some quiet place and let your mind mentally add up  the data.  Do what you feel in your heart.
 
We are as close as you could possibly ever know.
 
There will be no golden advanced warning.
 
*** This fear mongering, alarmist alert, brought to you by...CLOROX and the good folks at 3-M  resporator mask.Smile
 
Get with it or get caught.
 
Speculation is the only tool we have with a threat that can circle the globe in 30 days. Test results&news is slow.Factor in human conditions,politics, money&bingo!The truth!Facts come after the fact.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote pugmom Quote  Post ReplyReply Direct Link To This Post Posted: April 03 2006 at 2:13pm
WHO--if you are reading or listening or sneaking a peak at this forum--PLEASE PLEASE PLEASE RELEASE ALL YOUR H5N1 ISOLATES NOW FOR ANALYSIS!
jpc
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Rick Quote  Post ReplyReply Direct Link To This Post Posted: April 03 2006 at 2:44pm
Originally posted by CitizenBlue CitizenBlue wrote:

Actually this was expected. This is why the gene sequencing of H1N1 was so important. It showed that rapid mutation probably occurred prior to the 1918 pandemic. It does not necessarily mean five different pandemics, just that the virus is possibly "trying" (hate to ascribe intel to virus) to mutate (or recombine) to infect new organisms or to be more efficient at transmission in birds.     



My recollection was, that the newest H5N1 "clave" from Turkey, that was officially acknowledged, would require a seperate vaccine.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Guests Quote  Post ReplyReply Direct Link To This Post Posted: April 03 2006 at 3:06pm

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Posted: Today at 5:12pm

“So I am trying to put the pieces together- maybe someone can help me. Could all 4 strains that are dangerous to humans all wind up in North America at the same time? If not, which so far is the most likely one to end up here? Is one strain more lethal than the other strains?”


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DR. Niman
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Posted: Today at 6:02pm

“The Qingahi strain would be most mobile via wild birds.  The other three could walk off a plane.”



    
    
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Post Options Post Options   Thanks (0) Thanks(0)   Quote tazman Quote  Post ReplyReply Direct Link To This Post Posted: April 03 2006 at 3:07pm
[QUOTE=Corn]
 

Just close your eyes for a moment in some quiet place and let your mind mentally add up  the data.  Do what you feel in your heart.


I agree with you corn. Let the super-conscious mind guide you and listen to you intuition.

I consider this world situation to be similar to the buying a particular stock in a company. Most people jump in to buy a particular stock only after it has become famous for its good returns.

But you don't money that way. Only the people who buy before the euphoria make the real money.

A similar situation is brewing with H5N1. Most govt are quite to political reasons and when it hits, public panic will derail the economy.

I have been prepping for the past two weeks vigorously but I am still not self sufficient for the future.

This is significant challenge to people. Trying to learn how to store beans, rice, oil, honey, etc etc (endless list) for two years? Trying to assimilate knowledge and also trying to do something is trying all my senses.
Email me your favorite links:My Email
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Post Options Post Options   Thanks (0) Thanks(0)   Quote muhammad wasay Quote  Post ReplyReply Direct Link To This Post Posted: August 29 2013 at 6:13am
4*5
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Post Options Post Options   Thanks (0) Thanks(0)   Quote muhammad wasay Quote  Post ReplyReply Direct Link To This Post Posted: August 29 2013 at 6:15am
7X-13/16-6
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