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PANDEMIC ALERT LEVEL
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Tracking the next pandemic: Avian Flu Talk

H5N1 Clinical Presentations ~ Probable H2H
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Jhetta View Drop Down
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    Posted: April 04 2006 at 11:08am
Human Influenza A/H5N1  Clinical Features & Spectrum
http://ceid.med.cuhk.edu.hk/docs/Day2(DHui).pdf
 
Covers the following regarding H5N1
  • Probable Person to Person Transmission (page 23)
  • Clinical Presentations and Outcomes (page 24 - 31)
  • Disease Progression & Complications (page 6)
  • Reactive Haemophagocytosis (page 13)
  • Cytokin storms, ARDS, Renal Failure, MODS, Encephalitis (Page 27 - 28)
 Helpful Terms:
Multiple Organ Dysfunction Syndrome (MODS)
 
Acute Respiratory Distress Syndrome (ARDS)
 
Cytokine storm is a common designation for the technical term hypercytokinemia (sometimes spelled hypercytokinaemia).
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Points: 206 		Post Options Post Options   Thanks (0) Thanks(0)   Quote araywood Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 11:19am
Wow!!!!   HK dropped the big one!!!!!!!
NO NEWS IS WHO NEWS
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Guests Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 11:20am
    

Good information, thanks for the post!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Guests Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 11:35am
Thank you for the information...but this is horrible.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Guests Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 11:45am
Can someone open it?? I can't open pdf files !!
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Jhetta View Drop Down
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You can download Adobe Reader which opens pdf files here.
 
 
Originally posted by worrywart worrywart wrote:

Can someone open it?? I can't open pdf files !!
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endman View Drop Down
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Points: 1232 		Post Options Post Options   Thanks (0) Thanks(0)   Quote endman Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 11:48am
Did you all noticed that that the study calls the BF virus as type A influenza  or H5N1 pneumonia. So you can call BF as Type A influenza with (H5N1) subtype or just pneumonia
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Guests Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 11:51am
I thought we already knew about these H2H cases.  It was a small cluster that did not spread beyond the first transmission from the index patient to the aunt and mother.  I believe these are some of the "rare" cases of H2H referenced on the CDC website.
 
I don't think there is anything new here.
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Points: 206 		Post Options Post Options   Thanks (0) Thanks(0)   Quote araywood Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 12:05pm

I think we all have heard of these cases but it is the first time I have seen it in the same sentence as influenza A.
NO NEWS IS WHO NEWS
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Jhetta View Drop Down
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H5N1 Is An Influenza A... Virus Subtype
 
 
"H5N1 is an Influenza A virus subtype. The H5N1 flu is what is commonly meant when speaking of "bird flu" or "avian influenza". It is a viral disease that causes illness in many species including humans and is a pandemic threat. Experts believe it might mutate into a form that transmits easily from person to person. If such a mutation occurs, it might remain an H5N1 subtype or could shift subtypes as did H2N2 when it evolved into the Hong Kong Flu strain of H3N2."
 
 
Evolutionary characterization of the six internal genes of H5N1 human influenza A virus
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Points: 316 		Post Options Post Options   Thanks (0) Thanks(0)   Quote tonseck Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 2:18pm
Nothing new, just new packaging.  Maybe it will get wider distribution now.
Don't be afraid to be afraid; it keeps you on your toes.
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Points: 1272 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Jhetta Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 2:34pm
I don't know about you but I have read literally 100s of scientific papers on H5N1 and there is quite a bit of info in that doc that you will not find in just one paper.
 
I have not read many paper's that brings the symptoms together in such an organized manner while including lab results and chest x/rays.  
 
I bulleted the high points... the information could be helpful for healthcare workers or to those who may become infected.
 
Maybe a little technical for some!
   
Originally posted by carpenter carpenter wrote:

Nothing new, just new packaging.  Maybe it will get wider distribution now.
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Points: 1232 		Post Options Post Options   Thanks (0) Thanks(0)   Quote endman Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 2:46pm
Why they are talking about six H5N1 viruses I thought BF had only have two variants not six,  and why they calling human H5N1, is there a HUMAN H5N1 virus too ???
that is going around if yes where and how many cases.
Can anybody explained to me what they did in this study ???
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I have co-workers going to Russia and China and Vietnam this week they be back at the end of April let see what they will tell about the situation on the ground.
I have a feeling they will know less that we are
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Originally posted by endman endman wrote:

Why they are talking about six H5N1 viruses I thought BF had only have two variants not six,  and why they calling human H5N1, is there a HUMAN H5N1 virus too ???
that is going around if yes where and how many cases.
Can anybody explained to me what they did in this study ???
 
I know the second article is quite technical and difficult to understand.
 
They were talking about six internal genes of H5N1 not six different strains... They were expaining that the H5N1 viruses have continued to reassort, acquiring different internal genes from other influenza viruses of avian origin. The conclusions was the following: "Through a series of evolutionary analyses, the six internal genes of human H5N1 viruses were found to have diverged generally into two distinguishable evolutionary groups."

Check out http://www.recombinomics.com/whats_new.html for better info on how H5N1 changes via viral recombination. 
 
When they refer to Human H5N1 they mean a sample taken from a human that contracted H5N1. There have been cases of people contracting H5N1 from other people... however that is still quite rare.
 
It is possible that it may develop into more than two different groups via viral recombination... so that the two speratre vaccines under development now... would no longer be sufficent.

H5N1 Pandemic Vaccine Progress Well Shy of Half Empty
http://www.recombinomics.com/News/03310601/H5N1_Vaccine_Half_Empty.html
"When the trial began, only Vietnam and Thailand were reporting human H5N1 cases..  The sequences from these isolates were similar, so one vaccine could protect against both H5N1 versions. 
 
However, last summer it was clear that H5N1 was evolving away from the 2004 H5N1 target sequence from Vietnam. 
 
H5N1 was being transmitted and transported by wild birds and it was just a matter of time before these sequences also caused human cases.  In 2005 human cases in Indonesia and China were reported, and sequences from these areas suggested that the cross reactivity between H5N1 from Vietnam/Thailand and Indonesia/China would be poor and the Qinghai sequences were distinct from all of the above.  Now the Qinghai strain has cause human fatalities in Turkey, Iraq, Egypt, and Azerbaijan highlighting the need for multiple vaccines.
 
Sequence analysis indicates these H5N1’s are evolving via recombination and therefore new versions of H5N1 can be predicted. 

However, these predictions are dependent on the sequences of the circulating strains of H5N1 and much of the most recent data is sequestered in a private WHO database.  WHO announcements that H5N1 is evolving via “random mutations” indicates their advice is fatally maskwed and the sequestered sequences are not being properly analyzed." 
 
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Points: 30 		Post Options Post Options   Thanks (0) Thanks(0)   Quote serenity Quote  Post ReplyReply Direct Link To This Post Posted: April 04 2006 at 9:05pm
Wow, thanks!
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