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Langya virus in China

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KiwiMum View Drop Down
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    Posted: August 09 2022 at 1:46pm

This has appeared in the UK press about the Langya virus in China. 35 people ill with it. It comes from shrews, and is generally not fatal.

https://www.dailymail.co.uk/health/article-11095995/Langya-virus-Warning-brand-new-virus-detected-China.html

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A new type of animal-derived Henipavirus (also named Langya henipavirus, LayV) that can infect humans has been found in East China's Shandong Province and Central China's Henan Province, and has so far infected 35 people in the two provinces, according to an article published in the New England Journal of Medicine (NEJM) by scientists from China and Singapore.

The new type of Henipavirus was found in throat swab samples from febrile patients in eastern China with a history of contact with animals in recent times, according to media reports.

Scholars who participated in the study pointed out that this newly discovered Henipavirus, which may have come from animals, is associated with some febrile cases, and the infected people have symptoms including fever, fatigue, cough, anorexia, myalgia, and nausea.

Further investigation found that 26 out of 35 cases of Langya henipavirus infection in Shandong and Henan provinces have developed clinical symptoms such as fever, irritability, cough, anorexia, myalgia, nausea, headache and vomiting.

Henipavirus is one of the important emerging causes of zoonosis in the Asia-Pacific region, Shanghai-based media thepaper.cn reported, noting that both Hendra virus (HeV) and Nipah virus (NiV) from this genus are known to infect humans with fruit bats as the natural host of both viruses.

Henipavirus can cause severe disease in animals and humans and are classified as biosafety Level 4 viruses with case fatality rates between 40-75 percent, according to the data from World Health Organization (WHO), highlighting that this is much higher than the fatality rate of the coronavirus.

However, there is currently no vaccine or treatment for Henipavirus and the only treatment is supportive care to manage complications.

The cases of Langya henipavirus so far have not been fatal or very serious, so there is no need for panic, said Wang Linfa, a Professor in the Programme in Emerging Infectious Diseases at Duke-NUS Medical School who was involved in the study, adding that it is still a cause for alert as many viruses that exist in nature have unpredictable results when they infect humans.

https://www.globaltimes.cn/page/202208/1272556.shtml

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 09 2022 at 8:20pm

[url]https://www.coronaheadsup.com/health/henipavirus/china-35-infected-with-langya-henipavirus/[/url] or https://www.coronaheadsup.com/health/henipavirus/china-35-infected-with-langya-henipavirus/ ;

The Langya henipavirus, which can be transmitted from animals to humans, has been discovered in China, with 35 human infections reported so far.

A study titled “A Zoonotic Henipavirus in Febrile Patients in China” that was published in the New England Journal of Medicine on 4th August 2022 said that a new henipavirus associated with a fever-causing human illness had been identified in China.

The study said an investigation identified 35 patients with acute infection of the Langya henipavirus in China’s Shandong and Henan provinces, and that 26 of them were infected with the Langya virus only, with no other pathogens.

The 26 patients developed symptoms including fever (100 percent), fatigue (54 percent), a cough (50 percent), loss of appetite (50 percent), muscle pain (46 percent), nausea (38 percent), headache (35 percent) and vomiting (35 percent).

They also showed a decrease in white blood cells (54 percent), low platelet count (35 percent), liver failure (35 percent) and kidney failure (8 percent).

When asked for confirmation, CDC Deputy Director-General Chuang Jen-hsiang (莊人祥) on Sunday that said according to the study, human-to-human transmission of the virus has not been reported, and that a serological survey of domestic animals found 2 percent of the tested goats and 5 percent of the tested dogs were positive.

Taipeitimes.com report

Preprint: A Zoonotic Henipavirus in Febrile Patients in China

DJ More;

Langya henipavirus is a species of henipavirus first detected in the Chinese provinces of Shandong and Henan in December 2018. It was discovered in 35 total patients between December 2018 and August 2021. Langya henipavirus affects humans as well as other animals species, including shrews – its presumed original host.

Wikipedia: Langya Henipah virus

 

Clinical presentation

Incubation period is approximately 5–16 days (and rarely up to 2 months). Both Hendra and Nipah virus infections can cause a severe influenza-like illness with fever, myalgia, headache, and dizziness. This may progress to severe encephalitis with confusion, abnormal reflexes, seizures, and coma; respiratory symptoms may also be present. Relapsing or late-onset encephalitis can occur months or years after acute illness. The case-fatality ratio of Hendra virus is 57% (among 7 known human cases, 4 were fatal). Case-fatality ratios for Nipah virus infection are 40%–70% but have been 100% in some human outbreaks.

CDC: Henipaviruses

 

Henipavirus can cause severe disease in animals and humans and are classified as biosafety Level 4 viruses with case fatality rates between 40-75 percent, according to the data from World Health Organization (WHO), highlighting that this is much higher than the fatality rate of the coronavirus.

However, there is currently no vaccine or treatment for Henipavirus and the only treatment is supportive care to manage complications.

Global Times report

 

Just last week, on the 3rd August 2022, The Wuhan Institute of Virology was accused of experimenting with Nipah viruses in 2019 by a speaker at a US Senate Panel’s Hearing on Gain-of-Function Research:

“In December 2019, they were doing synthetic biology on a cloning vector of the Nipah virus, which is 60% lethal. We just experienced a 1% lethal virus,” Quay said. “My estimate is, that could set us back a millennium. The Black Plague was a 20% lethal event, and it was a 250-year event for civilization to return.”

Dailysignal.com report

So -my impression- limited numbers = limited statistics...An acute and chronic phase. On top of other diseases/co-infections outcome likely worse...

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