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PANDEMIC ALERT LEVEL
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Online Discussion: Tracking new emerging diseases and the next pandemic; Coronavirus Pandemic Discussion Forum.

My 5 year old grandson in serious condition COV - Event Date: March 02 2020 - April 03 2020

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Usk View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Calendar Event: My 5 year old grandson in serious condition COV
    Posted: March 20 2020 at 4:33am

For those millions in this war who still think this isn’t a danger to the young and healthy get your head out of your****

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((((((((((______)))))))))))) ___________  usk


(above is a virtual coronavirus hug, ie keeping a distance)

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 5:20am

We are worrying with you, Usk.

Chin up pal!

Absence of proof is not proof of absence. & Never underestimate the power of human stupidity.
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Post Options Post Options   Thanks (1) Thanks(1)   Quote BabyCat Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 5:21am

Wow. It's affecting so many, closer and closer to all of us. Prayers for your family. 

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Post Options Post Options   Thanks (1) Thanks(1)   Quote FluMom Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 5:22am

So sorry, Prayers.  

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 5:43am

Thank you. We can’t go see him. His dad is in ICU with him. Just as support. They’re starting him  my grandson on cloniquine  the anti malary drug and steroids. He just got symptoms two days ago and they said his immune system went into hyperdrive

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 5:44am

Please keep us updated.

Absence of proof is not proof of absence. & Never underestimate the power of human stupidity.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote ME163 Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 5:47am

Usk, my heart goes out to you.  I am praying for you..  Keep in touch.   

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Post Options Post Options   Thanks (1) Thanks(1)   Quote hoosiermom22 Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 5:53am

Praying 🙏🏻 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Tabitha111 Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 6:25am

To my fellow Virginian....hugs to you and so very sorry.  

I thought steroids were contraindicated in Covid19...but perhaps they are good for the little ones? Thank goodness they are starting him on Cloroquinine!

'When you feel as though you can't do something, the simple antidote is action: Begin doing it. Start the process, even if it's just a simple step, and don't stop at the beginning.'
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 6:30am

Steroids depress the immune system.  It sounds as if an overactive immune system is the problem this time.  

Absence of proof is not proof of absence. & Never underestimate the power of human stupidity.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Tabitha111 Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 7:10am

I think I just read a news story on your grandson on facebook! Oh my....


'When you feel as though you can't do something, the simple antidote is action: Begin doing it. Start the process, even if it's just a simple step, and don't stop at the beginning.'
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Sheep Lady Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 7:16am

Prayers that his little body responds to treatment.  Praying for you all  Usk.

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Post Options Post Options   Thanks (1) Thanks(1)   Quote JellyMama Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 7:19am

Please God, take care of this little boy and make him well.

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Post Options Post Options   Thanks (1) Thanks(1)   Quote ViQueen24 Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 9:32am

Prayers for you all Usk.  Keep us updated.

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Post Options Post Options   Thanks (1) Thanks(1)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 9:37am

Read this resesrch pn Primates  and SARs. Hope it works

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Martin J Vincent, Eric Bergeron, [...], and Stuart T Nichol

Additional article information

Abstract

Background

Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.

Results

We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

Conclusion

Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

Keywords: severe acute respiratory syndrome coronavirus, chloroquine, inhibition, therapy

Background

Severe acute respiratory syndrome (SARS) is an emerging disease that was first reported in Guangdong Province, China, in late 2002. The disease rapidly spread to at least 30 countries within months of its first appearance, and concerted worldwide efforts led to the identification of the etiological agent as SARS coronavirus (SARS-CoV), a novel member of the family Coronaviridae [1]. Complete genome sequencing of SARS-CoV [2,3] confirmed that this pathogen is not closely related to any of the previously established coronavirus groups. Budding of the SARS-CoV occurs in the Golgi apparatus [4] and results in the incorporation of the envelope spike glycoprotein into the virion. The spike glycoprotein is a type I membrane protein that facilitates viral attachment to the cellular receptor and initiation of infection, and angiotensin-converting enzyme-2 (ACE2) has been identified as a functional cellular receptor of SARS-CoV [5]. We have recently shown that the processing of the spike protein was effected by furin-like convertases and that inhibition of this cleavage by a specific inhibitor abrogated cytopathicity and significantly reduced the virus titer of SARS-CoV [6].

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 9:43am

Further in vivo evaluation of this drug against 2019-nCoV infection is recommended. Notably, two compounds remdesivir (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87) and chloroquine (EC50 = 1.13 μM; CC50 > 100 μM, SI > 88.50) potently blocked virus infection at low-micromolar concentration and showed high SI (Fig. 1a, b). Cite this article Wang, M., Cao, R., Zhang, L. et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 30, 269–271 (2020). https://doi.org/10.1038/s41422-020-0282-0

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 9:45am

Sorry when I get upset I do research to help calm myself

It looks like these docs know what to try first

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 9:46am

There is no known cure just things to try

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 10:01am

Thank you, Usk.  We are still with you.

Absence of proof is not proof of absence. & Never underestimate the power of human stupidity.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 10:06am

Thank you all for your support it is so very much appreciated 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 10:13am

I  (and I know I'm not alone in this)  only wish I could do more, Usk.

Absence of proof is not proof of absence. & Never underestimate the power of human stupidity.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Newbie1A Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 10:13am

Usk, my heart hurts for you, prayers for fast recovery for your grandson & strength for you and all who love him.  Long distance hugs to you and yours - please keep us all updated as best you can.

If it's to be - it's up to me!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote kaye kaye Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 1:16pm

Praying for a fast recovery  for the little guy.

keep the joy
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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiwiMum Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 1:58pm

 I'm so sorry to hear about your grandson, what terrible news. He's in my prayers for a full and speedy recovery.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote WitchMisspelled Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 2:05pm

Usk, he's in my prayers for a full and speedy recovery.  Sending cyber hugs your way.  

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Post Options Post Options   Thanks (0) Thanks(0)   Quote pheasant Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 4:28pm

My family's praying as well for you all.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 5:33pm

I’m so sorry. Please let us know how he’s doing. We’re all thinking of him.



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Post Options Post Options   Thanks (0) Thanks(0)   Quote roni3470 Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 6:58pm

I am so sorry to hear.  Praying for you and your family!

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Post Options Post Options   Thanks (0) Thanks(0)   Quote BeachMama Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 7:11pm

Usk, I know I can say nothing to make you truly feel better — but I am SO sorry. My family and I will be praying for your grandson every single day. 

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Prayers for a speedy recovery. 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Turboguy Quote  Post ReplyReply Direct Link To This Post Posted: March 20 2020 at 7:40pm

Originally posted by Usk Usk wrote:

For those millions in this war who still think this isn’t a danger to the young and healthy get your head out of your****


He should be able to make it through. Little kids are extraordinarily resilient. Good that he is in the hospital and fairly early on in this. When he makes it through he might have missed the worst of this.

Wish him and his parents luck.

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Post Options Post Options   Thanks (2) Thanks(2)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: March 21 2020 at 6:26am

All your prayers and thoughts of support and  

HYDROXYCHLOROQUINE

Worked. He turned the corner last night breaking the 104 fever and his lungs except for right lower lobe is clear !!!  He should come home today to his house. Dad is still symptom free and so his is mom and older brother

Thank you again. They also used short z pac which I think is zythromycin and prednisone short 5 day course. Big sigh of relief!!

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: March 21 2020 at 6:32am

Just saw it was you Turboguy. How are you?  We were worried you had not posted. So glad you are back!

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Great news, Usk!! 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: March 21 2020 at 7:32am

So glad!   Glad for my friend (you Usk) glad for the little boy and glad for everyone as the treatment works for everyone it appears.

Good new at last!

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I am so happy for you and your family Usk!  This is great news!

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Happy News.  

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Post Options Post Options   Thanks (1) Thanks(1)   Quote LCfromFL Quote  Post ReplyReply Direct Link To This Post Posted: March 21 2020 at 8:10am

Originally posted by Usk Usk wrote:

All your prayers and thoughts of support and  

HYDROXYCHLOROQUINE

Worked. He turned the corner last night breaking the 104 fever and his lungs except for right lower lobe is clear !!!  He should come home today to his house. Dad is still symptom free and so his is mom and older brother

Thank you again. They also used short z pac which I think is zythromycin and prednisone short 5 day course. Big sigh of relief!!


This is FABULOUS news, Usk!!! Praying for continued recovery for him and protection for the rest of your family. 

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Praise God! Still praying for you all!

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Praise The Lord, he is better!

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That is good news glad he is improving

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Prayers, for you little one.  


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So glad he is getting beter!

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