Tracking the next pandemic: Avian Flu Talk |
New research finds 49 new strains of COVID19 |
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AI
Adviser Group Joined: January 21 2020 Status: Offline Points: 8850 |
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Posted: March 16 2020 at 11:34am |
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BREAKING! New Research Indicates SARS-CoV-2 Coronavirus Is Indeed Mutating Into Various Strains That Have Specific Preference Of Attacking Human Host Cells Source: Coronavirus Research Mar 16, 2020 8 hours ago Coronavirus research: A new non-peer reviewed study published in the open platform MedRvix indicates that the SARS-Cov-2 coronavirus could be evolving or mutating into various strains with each a different mode of attacking or binding to human host cells and with different infected patients varying symptoms and effects.
(https://www.medrxiv.org/content/10.1101/2020.03.10.20033944v1.full.pdf+html) In this new study alone, 49 new strains were identified and one strain in particularly that was identified as the ZJ01 Strain was completed different from the earlier strains that were first identified in Wuhan. The earlier strain basically attacked human host cells using the ACE-2 receptors whereas the new strain had a preference for binding via the Furin cleavage site. (https://www.thailandmedical.news/news/breaking-latestcoronavirus-research-reveals-that-the-virus-has-mutated-gene-similar-to-hiv-and-is-1,000-times-more-potent-) Thailand Medical News had already earlier already covered other studies showing that the SARS-CoV-2 coronavirus has to date four discovered modes of attacking or binding to human host cells.( https://www.thailandmedical.news/news/breaking-preprint-research-shows-that-sars-cov-2-has-third-binding-mode,-making-it-a-truly-potent-coronavirus-that-is-in-a-league-of-its-own) and (https://www.thailandmedical.news/news/breaking-new-coronavirus-research-shows-that-the-sars-cov-2-coronavirus-has-a-fourth-route-of-attacking-human-host-cells-making-it-a-real-super-virus The Phylogenetic analysis suggested that SARS-CoV-2 exhibited remarkable evolutionary divergence, with potential evolutionary branches within SARS-CoV-2. During the initial Wuhan epidemic, there were 2 main strains the, WIV02 (2019-12-31)/WH19008 (2019-12-30) and MT0270641 (2020-1-29)/ZJ01(2020-1-23) and these were the basis for the potential of forming evolutionary branches during dissemination. Later just in China alone, 8 strains were identified. The relative synonymous codon usage (RSCU) analysis showed that there were various differences among 8 strains (MN938384, CNA0007334, WIV06, ZJ01, NMDC60013002-05, CNA0007332, MN988668, WIV07) and other members of SARS-CoV-2 family (Fig 1B), where MN938384, CNA0007334, WIV06 and ZJ0. Among aforementioned 8 strains which were collected in Wuhan, Guangdong and Hangzhou, six were collected at the early stage of COVID-19 (2019-12-26 to 2020 -1-2). The collection time of MN938384 was no later than 2020-1-14 (virus submission time), while ZJ01 was collected on 2020-1-23. ZJ01, including 7 deletions, 4 insertions and 24 substitutions. For the rest 3 mutation sites, NO.20 was caused by a sequencing error while NO.14 and No. 38 widely existed in SARS-CoV-2 family. Among ZJ01 unique mutations, 10 (NO.22-31) were located on the S protein, including 3 samesense mutation, 2 deletion mutation and 5 missense mutation, which led to amino acid changes of Ser596, Gln613, Glu702, Ala771, Ala1015, Pro1053 and Thr1066. Further similarity analysis indicated that the main difference among various coronaviruses located in the Receptor Binding Domain (RBD) region of S1. Intriguingly, the differences between ZJ01 and other members of SARS-CoV-2 mainly resided in in the S1/S2 and S2 (please refer to detailed diagrams in the study.) The new evolved ZJ01 strain has a better affinity of binding to the furin-cleavage sites and it produced milder symptoms in the infected patients and less damage to the lungs and kidneys. However researchers warned although the patients from these strains recovered faster, the midterm and long term effects of the residual viral loads or dormant loads in the patients could be more harmful in the future but studies are needed to carefully observe and conclude that. Also these new discoveries and studies about the various new mutations could have repercussions of drug and vaccine development. We at Thailand Medical News are very confused as to why the WHO or any research entities or medical entities are not mentioning about this mutations and various strains being formed at such a rapid phase and why we too have been warned by certain authorities to stop making research data available to the general public. There are currently many other studies, some peer reviewed that has confirmed that the virus is actually mutating at a rapid stage and contrary to the initial information we were fed and also there are more than 49 strains at the moment, some with distinct characteristics. |
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AI
Adviser Group Joined: January 21 2020 Status: Offline Points: 8850 |
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Early on the Chinese stated this virus was mutating extremely fast. Looks like they were not lying. |
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AI
Adviser Group Joined: January 21 2020 Status: Offline Points: 8850 |
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The question is, is it possible to become infected or reinfected with these additional strains? Put it this way, it is possible to catch multiple stains of the flu in a year and or to have two different strains of the flu at the same time. Is there any reason to think this virus will be any different? |
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Technophobe
Assistant Admin Joined: January 16 2014 Location: Scotland Status: Offline Points: 88450 |
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Thank you AI. This could explain TurboGuy's puzzling test results and puts the British Government's experiment into very shaky territory. |
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How do you tell if a politician is lying?
His lips or pen are moving. |
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Sheep Lady
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Terrifying! |
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Sheep Lady
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AI
Adviser Group Joined: January 21 2020 Status: Offline Points: 8850 |
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Well it may well change the entire game plan on every level. I know I'm rethinking my game plan. |
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carbon20
Moderator Joined: April 08 2006 Location: West Australia Status: Offline Points: 65816 |
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I have always had the belief that all viruses mutate whenever they infect a new host/person. That is why they are so hard to make a vaccine for them....... |
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Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖
Marcus Aurelius |
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AI
Adviser Group Joined: January 21 2020 Status: Offline Points: 8850 |
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Well all viruses do is mutate but this one is mutating at a rather high rate. And yeah I'm betting no vaccine, after all where is the SARS vaccine? |
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carbon20
Moderator Joined: April 08 2006 Location: West Australia Status: Offline Points: 65816 |
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Talk of a vaccine is to placate the masses... . i.e. which strain do you make a vaccine for.... SARS died out before a vaccine got off the drawing board..... |
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Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖
Marcus Aurelius |
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Usk
V.I.P. Member Joined: January 26 2020 Location: Virginia Status: Online Points: 7325 |
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So I wonder what our forum expert thinks about this news. He self proclaimed he is in the know. So is this fake news ? |
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Technophobe
Assistant Admin Joined: January 16 2014 Location: Scotland Status: Offline Points: 88450 |
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I can't speak for Chuck, but I will believe it when I see it. |
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How do you tell if a politician is lying?
His lips or pen are moving. |
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carbon20
Moderator Joined: April 08 2006 Location: West Australia Status: Offline Points: 65816 |
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I don't think.Dr Chuck is self proclaimed, I think he has had his bona fides vetted by them thats in charge..... Well one would hope so ...... |
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Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖
Marcus Aurelius |
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Thorne!
Adviser Group Joined: February 07 2020 Status: Offline Points: 2695 |
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What he said! And beyond that, with the data available now anyone can verify the numbers in less than 10 minutes, including the number of hospital and ICU beds. |
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AI
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Well I would welcome his opinion on my questions posed earlier in this thread relating to this topic. |
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AI
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carbon20
Moderator Joined: April 08 2006 Location: West Australia Status: Offline Points: 65816 |
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You only have to look at why we have seasonal flu jabs to answer your, question, When I was in high school 50 years ago I learnt that the reason we all get a cold every year is, a cold Is a coronavirus it changes all the time so a vaccine, and immunity from one year to the next is Not possible, So as far as i'm concerned this Wu is here to stay, in one form Or another, all we can hope for at this stage is, as it gets more transmissable(if that's possible)i,t loses it's killing ability In reality I somehow don't think that's going to happen, Is going to be a long year.....or 2 or 3...... Plan for worse ,hope for best.... Thats all we can do Make a will if you old, tell your loved ones YOU LOVE THEM.... |
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Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth.🖖
Marcus Aurelius |
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Beach Girl
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There wouldn't be a possibilty of cross-immunity? |
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Technophobe
Assistant Admin Joined: January 16 2014 Location: Scotland Status: Offline Points: 88450 |
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Maybe some, but I'm not counting on it. Generally, viruses evolve over time to be both more contagious and less lethal. This is how the virus achieves becoming endemic. Some strains which are more lethal emerge, but the host dies and they can't spread. Some go the other way, and everyone gets it. |
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How do you tell if a politician is lying?
His lips or pen are moving. |
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Pixie
Admin Group Joined: June 05 2006 Location: United States Status: Offline Points: 19668 |
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