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Now tracking the new emerging South Africa Omicron Variant

On vaccines...

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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Topic: On vaccines...
    Posted: July 20 2022 at 10:10pm

DJ, 

There is -and should be- a lot of discussion on vaccines. 

In this CoViD pandemic vaccines may play a role, Discussion on what role, how, who pays what could/should maybe bring better stategies...

I know not much of vaccines...just some basic info...Contact with weak or dead virus particles could start an immune response in a host...Those virus particles can be replaced by messanger RNA (m-RNA) to create a likewise reaction...as a basic idea as far as I understand it....

-Strategies;

Of course history is full of diseases and pandemics....people did all kind of things "to try and limit risks"...

Scapegoats, blaming some groups in the population, another country, is still very popular today but not very effective (and not science...).

So in most of history there was a sort of selection;

blame games started often by leaders that wanted to stay in position...

non-pharma interventions by other "leaders"...

-Non Pharma Interventions;

Most of history people did not live with a pharma-industry producing vaccines, medication...limiting (close) contacts, all kind of protection-masks, incense, ginger etc had to offer protection...I think some of those steps became the basis of early medical, pharma science...thousends of years ago...

Some diseases were caused by poison food, water...other diseases by infection...So a cure may work in some cases, not in others...

Till this day Non pharma Interventions keep making sense; low budget, easy to do....problem is more how long to do it...

[url]https://en.wikipedia.org/wiki/Quarantine[/url] or https://en.wikipedia.org/wiki/Quarantine ;

The word quarantine comes from quarantena or quarantaine, meaning "forty days", used in the Venetian language in the 14th and 15th centuries and also in France. The word is designated in the period during which all ships were required to be isolated before passengers and crew could go ashore during the Black Death plague. The quarantena followed the trentino, or "thirty-day isolation" period, first imposed in 1347 in the Republic of RagusaDalmatia (modern Dubrovnik in Croatia).[1][2][3][4]

Merriam-Webster gives various meanings to the noun form, including "a period of 40 days", several relating to ships, "a state of enforced isolation", and as "a restriction on the movement of people and goods which is intended to prevent the spread of disease or pests". The word is also used as a verb.[5]

Quarantine is distinct from medical isolation, in which those confirmed to be infected with a communicable disease are isolated from the healthy population.[6]

Quarantine may be used interchangeably with cordon sanitaire, and although the terms are related, cordon sanitaire refers to the restriction of movement of people into or out of a defined geographic area, such as a community, in order to prevent an infection from spreading.[7]

An early mention of isolation occurs in the Biblical book of Leviticus, written in the 7th century BC or perhaps earlier, which describes the procedure for separating out people infected with the skin disease Tzaraath. The medical nature of this isolation is, however, disputed. As traditional exegesis (dated 700 CE) sees it as a punishment for trespassing one of several negative commandment, most notably Evil Speech.[8] A more recent hypothesis postulates that the infected are required to isolate themselves in order to prevent spread of disease[citation needed] (although the Bible does not imply contagiousness of Tzaraath):

Anyone with such a defiling disease must wear torn clothes, let their hair be unkempt, cover the lower part of their face and cry out, "Unclean! Unclean!" As long as they have the disease they remain unclean. They must live alone; they must live outside the camp

DJ, In my view Non pharma Intervention is very effective still...In todays world with internet I think NPI should do the main job...

It would need active governments, medical world defining ways of producing and logistics at the lowest possible pandemic risk. Asian countries may go for this strategy...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: July 20 2022 at 10:43pm

[url]https://virologyj.biomedcentral.com/articles/10.1186/s12985-022-01831-0[/url] or https://virologyj.biomedcentral.com/articles/10.1186/s12985-022-01831-0 part 2...vaccines;

Adverse effects of COVID-19 vaccines and measures to prevent them

Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. 

The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals. 

According to European Medicines Agency recommendations, frequent COVID-19 booster shots could adversely affect the immune response and may not be feasible. 

The decrease in immunity can be caused by several factors such as N1-methylpseudouridine, the spike protein, lipid nanoparticles, antibody-dependent enhancement, and the original antigenic stimulus. 

These clinical alterations may explain the association reported between COVID-19 vaccination and shingles. 

As a safety measure, further booster vaccinations should be discontinued. 

In addition, the date of vaccination should be recorded in the medical record of patients. 

Several practical measures to prevent a decrease in immunity have been reported. 

These include limiting the use of non-steroidal anti-inflammatory drugs, including acetaminophen to maintain deep body temperature, appropriate use of antibiotics, smoking cessation, stress control, and limiting the use of lipid emulsions, including propofol, which may cause perioperative immunosuppression. 

In conclusion, COVID-19 vaccination is a major risk factor for infections in critically ill patients.

DJ; Vaccines are NOT the "holy grail" ..do have (lots of) risks...

In my view Non pharma Intervention should be the main-if not only-tool....

There are countries (Haïti, North Korea a.o.) claiming Non Pharma is effective...not because they did not want to go for vaccines, simply because most of the world did not get any vaccines....

-How vaccines are used;

Big Pharma main goal is profit in most (western) countries....Even when a lot of work is funded by tax payers profit is #1....

Big Pharma has a very bad reputation on creating public health risks out of greed, testing on the poor in "countries we keep poor"...

(High risk studies on "gain of functions" of virusses were transferred to countries with less strict rules. The Wuhan-lab some claim "leaked CoViD" did a study on corona virusses paid for by the US but outsourced to China for risk reasons...then starting some a "blame game"..."CCP-virus"...). 

The main goal in many (western) countries of medication, vaccines etc is profit...

-Medical use;

"Non Sterilizing" vaccines limit disease after infection...Sterilizing vaccines stop also the spread of disease...

One of the main problems in CoViD is vaccinated people still getting infected. So you need a wider strategy also including Non Pharma Intervention....STOP THE SPREAD !!!!

Because by now CoViD did see a selection process of mutations that did get better in evading immunity (both after earlier infection and vaccination). Over time vaccines are getting less and less effective in doing their job; limit disease....(they did not stop the infection from the start). 

Strategies on "vaccination only" with non-sterilizing vaccines during a pandemic are the best way to worsen a pandemic....

Vaccines at the start did offer good protection...but NOT stopping the spread made vaccines a danger not a help, a way out....Vaccination strategy was and is the main problem in my non-expert view...

New (nasal) vaccines may offer help-a way out-ONLY !!! in combination with Non Pharma rules (masks, limits of contacts). 

DJ, The discussion on vaccines, pandemics, many other issues, did get "out of control"...In the US "everything became political" and that is not helping...

Social science is needed to get effective communication started...Vaccines, medical world, has to serve public health not shareholders...other then we all being "shareholders" in a way public health is in the interests of us all...

End of part 2 (of me trying to formulate my critical view on vaccines...Yes I did get 2x Pfizers, 2x Moderna...I do think vaccines have a good use...But I do disagree on making profits out of public healthcare...I think it is a governments job to have good public services and in return for offering those public services (not only healthcare but also housing, FREE !!! education, maybe even FREE-tax funded public transport...) ask for tax from that public...

"Taxation without representation" is the outcome of neo-liberalism in wich governments offer hardly any public services (themselves) and tax money ends up at the 1%...further increasing socio-economic imbalance...This pandemic is political....

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiwiMum Quote  Post ReplyReply Direct Link To This Post Posted: July 21 2022 at 12:04am

The real problem, in my opinion, is that the vast majority are completely over Covid. Most of us have had it and most of us recovered just fine. People just want to get on with their lives and put it behind them. 

Speaking for myself only I'll say that I don't want to wear a mask or have spaced seating. I've had Covid and my first reaction to a positive test was a split second of fear. The governments have done a good job in spreading the fear, but then I got a grip of myself and whilst I had it I logged my symptoms and those of my family and my conclusion was  that yes we were ill, too ill to go to work and too ill to do anything much at all, but only for about 4 or 5 days, then we started to feel better. My children were quicker, and only ill for 3 days. I'm pretty sure we've just had the BA4 or 5 variant and it was like a nasty flu but quite short lived. 

I now consider us to be immune. I know that some people are catching it a second time but the only people I know who are doing that are fully vaccinated. We're strong and healthy. Been there, done that. And everyone my age feels the same. I know some older people who are frightened of it, but I have friends who are actively trying to catch it right now. 

So talk of non pharmaceutical interventions (NPI) is just irritating. It's a vote loser. Covid is rampant here but we're getting closer to the election and the government is losing popularity because it's interfering in our lives too much and affecting our businesses and right now, if it went to the vote, Labour would be out. I'm a grown up and I don't need mothering by Jacinda or anyone else. The governments of the world are turning their countries into nanny states and no one wants that. 

Personally I think they should abolish all restrictions and just let the individual take whatever precautions they feel are right for them. 

Covid is just like the flu, in fact, to me who has had both flu and Covid, I'd say they are indistinguishable, and both Covid and the flu can be fatal to the elderly, the weak and the immunocompromised and that's why that group of people get a flu shot every Autumn, but what we don't do is force everyone else to get a flu shot too. I'd rather have the flu and allow my immune system to flex it's muscles than have a flu shot. So yes Covid is killing some people, but so is the flu. As callous as this sounds, that's life I'm afraid.

We need to move forward.

Those who got it wrong, for whatever reason, may feel defensive and retrench into a position that doesn’t accord with the facts.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: July 21 2022 at 1:48am

KiwiMum, thanks for your reaction; 

Some points; 

-New Zealand did see at least 1,803 confirmed CoVid deaths so far...Global deaths at least [url]https://www.worldometers.info/coronavirus/[/url] or https://www.worldometers.info/coronavirus/ at 6,4 million...real number may be several times that number....

However I think different countries can choose different roads...Countries could learn from each other. 

-How many people did get infected. Worldometers has 572 million "positive tests"....also real number will be much higher...Is it 2 billion out of the almost 8 billion people on this planet ? Maybe even 4 billion ? Or "only" 1 billion "humans" ? As far as I know over 100 non-human species may have tested positive... This CoViD pandemic is multi-species...making it even harder to control...

-What role should governments play ? Good info could mean less government restrictions....I rather see good info-leaving people to make up their minds themselves....Freedom has responsability as the other side of that coin....

Like in the climate discussion however "freedom" should not mean destruction....Fossil fuel consumption has gone much to far much to long....A government can limit air travel to 5-10% of prepandemic...That at least would have some impact on both pandemics and climate change...

Political parties going for "freedom" without accepting "responsability" as the other side destabilize "nature" and we are facing the consequences of that now....

In a good functioning democracy governments have a limited-balanced-role....NOT a "nanny-state"....but governments -governing- means setting rules...From taxation (a.o. to have healthcare) to a (sort of) prison/correction system...I think that is what a governments job is....

To fight pandemics (and other major problems; climate change, crime etc.) governments need public support...


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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 16 2022 at 1:52am

Lots of questions on "new better-for profit (NOT public healthcare priority #1!!!) vaccines";

[url]https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4206070[/url] or https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4206070 

Abstract


Students at North American universities risk disenrollment due to third dose COVID-19 vaccine mandates. We present a risk-benefit assessment of boosters in this age group and provide five ethical arguments against mandates. 


We estimate that 22,000 - 30,000 previously uninfected adults aged 18-29 must be boosted with an mRNA vaccine to prevent one COVID-19 hospitalisation. 


Using CDC and sponsor-reported adverse event data, we find that booster mandates may cause a net expected harm: per COVID-19 hospitalisation prevented in previously uninfected young adults, we anticipate 18 to 98 serious adverse events, including 1.7 to 3.0 booster-associated myocarditis cases in males, and 1,373 to 3,234 cases of grade ≥3 reactogenicity which interferes with daily activities. 


Given the high prevalence of post-infection immunity, this risk-benefit profile is even less favourable. 


University booster mandates are unethical because: 

-1) no formal risk-benefit assessment exists for this age group; 

-2) vaccine mandates may result in a net expected harm to individual young people; 

-3) mandates are not proportionate: expected harms are not outweighed by public health benefits given the modest and transient effectiveness of vaccines against transmission; 

-4) US mandates violate the reciprocity principle because rare serious vaccine-related harms will not be reliably compensated due to gaps in current vaccine injury schemes; 

and 

-5) mandates create wider social harms. We consider counter-arguments such as a desire for socialisation and safety and show that such arguments lack scientific and/or ethical support. 


Finally, we discuss the relevance of our analysis for current 2-dose CCOVIDovid-19 vaccine mandates in North America.

DJ-This US/UK study is devastating.....are humans (or countries) used a testcases for vaccines ? Some claim Israel was used to test Pfizer vaccines...since it did not have a VAERS/adverse reaction administration... 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 22 2022 at 3:57am

[url]https://www.youtube.com/watch?v=WjG3VoX3Ldk[/url] or https://www.youtube.com/watch?v=WjG3VoX3Ldk Dr. John Campbell on excess deaths...

Questions on safety of vaccines did result in youtube warning/censorship...Totally unacceptable !

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 22 2022 at 10:31pm

Welcome good news;

[url]https://www.thailandmedical.news/news/breakthrough-mice-study-shows-that-prophylactic-intranasal-administration-of-sars-cov-2-specific-immunoglobulin-y-protects-against-covid-19[/url] or https://www.thailandmedical.news/news/breakthrough-mice-study-shows-that-prophylactic-intranasal-administration-of-sars-cov-2-specific-immunoglobulin-y-protects-against-covid-19  

link to; [url]https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010782[/url] or https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010782 ;

Abstract

Safe, passive immunization methods are required against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants. Immunization of chickens with antigen is known to induce specific IgY antibodies concentrated in the egg yolk and has a good safety profile, high yield of IgY per egg, can be topically applied, not requiring parenteral delivery.

 Our data provide the first evidence of the prophylactic efficacy of Immunoglobulin Y antibodies against SARS-CoV-2 in mice. Lohmann hens were injected with recombinant SARS-CoV-2 RBD protein; IgY-Abs were extracted from the eggs and characterized using SDS-PAGE. Antiviral activity was evaluated using plaque reduction neutralization tests.

 In additional experiments, IgY-RBD efficacy was examined in mice sensitized to SARS-CoV-2 infection by transduction with Ad5-hACE2 (mild disease) or by using mouse-adapted virus (severe disease). 

In both cases, prophylactic intranasal administration of IgY-Abs reduced SARS-CoV-2 replication, and reduced morbidity, inflammatory cell infiltration, hemorrhage, and edema in the lungs and increased survival compared to control groups that received non-specific IgY-Abs. These results indicate that further evaluation of IgY-RBD antibodies in humans is warranted.

Author summary

We report the generation, characterization and antiviral activity of egg yolk derived IgY-Abs against the SARS-CoV-2 Receptor Binding Domain. Using two different models of murine SARS-CoV-2 infection, we show that intranasal prophylactic administration of IgY-Abs reduced viral replication, and reduced inflammatory cell infiltration, hemorrhage, and edema in the lungs.

DJ, studies on nasal vaccines have been going on for two years...It may be able to get us out of this pandemic...(I hope !)

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 26 2022 at 9:54am

More "nasal vaccine news";

[url]https://www.coronaheadsup.com/health/treatment/research-nasal-saline-irrigation-reduces-severity-in-high-risk-covid-patients/[/url] or https://www.coronaheadsup.com/health/treatment/research-nasal-saline-irrigation-reduces-severity-in-high-risk-covid-patients/ ;

SARS-CoV-2 positive participants initiating nasal irrigation were over 8 times less likely to be hospitalized than the national rate.

Seventy-nine high-risk participants were enrolled. Analyzed by intention-to-treat, by day 28, COVID-19 symptoms resulted in one ED visit and no hospitalizations in 42 irrigating with alkalinization, one hospitalization of 37 in the povidone-iodine group, (1.27%) and no deaths.

Eleven reported irrigation-related complaints and four discontinued use. Symptom resolution was more likely for those reporting twice daily irrigation

Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients

 

Starting twice daily flushing of the mucus-lined nasal cavity with a mild saline solution soon after testing positive for COVID-19 can significantly reduce hospitalization and death, investigators report.

They say the technique that can be used at home by mixing a half teaspoon each of salt and baking soda in a cup of boiled or distilled water then putting it into a sinus rinse bottle is a safe, effective and inexpensive way to reduce the risk of severe illness and death from coronavirus infection that could have a vital public health impact.

Eurekalert.org article

 


Amazon nasal Irrigation sinus rinse kit for adults and kids

DJ, Nasal vaccines may-by technique- do better then traditional vaccinations in a muscle.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: November 10 2022 at 2:27am

Some latest info on vaccines [url]https://www.independentsage.org/demystifying-and-debunking-mrna-vaccines/[/url] or https://www.independentsage.org/demystifying-and-debunking-mrna-vaccines/ 

DJ-Vaccines are just part of the story...If you want to see "CoViD as a flu" -and you also never go for flu-vaccines-I think you may be "double wrong"...but you have a right to choose...

In my opinion CoViD-risks are increasing;

-newer variants able to evade better immunity (from both earlier infection and/or vaccines)

-CoViD may have long term health effects

-new variants could cause infection in other/more parts of the body

There was an "idea" CoViD would "become milder" over time-more cold like (maybe also based on idea's on the Russian 1890-flu-possibly being CoViD) however given the ongoing spread, extreme high numbers CoViD managed to get worse...

So-even as vaccines never will be 100% perfect-balancing risks and gains may (again) move towards getting vaccinated...

DJ-Even China has NO mandatory vaccinations (however testing may be mandatory)...so vaccines should ALWAYS be a choice-based on the best available info !

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote badger2 Quote  Post ReplyReply Direct Link To This Post Posted: November 10 2022 at 9:33am

The Chinese military's SARS-like bat coronavirus, ZC45 spike protein, contains an RGD motif. SARS-CoV-2 spike protein RGD motif is at positions  403-405. HCov-229E coronavirus contains an RGD motif at positions 341-343.


The RGD motif links to integrin binding. Here we link integrin binding to the glomerular basement membrane:


Glomerular Basement Membrane-Derived Perlecan Inhibits Mesangial Cell Adhesion to Fibronectin

https://pubmed.ncbi.nlm.nih.gov/8832207

'....The resulting avidity level is too low for mediating cell binding but sufficient to induce integrin organization into focal contacts.'


4 Nov 2022  A Population-Based Analysis of Risk of Glomerular Kidney Disease Relapse After COVID-19 Vaccination

https://pubmed.ncbi.nlm.nih.gov/36332971

'....Glomerular kidney disease can worsen to complete kidney failure and dialysis, so the consequences are significant if there is a problem with mRNA, spike protein, and progression of disease.'


To have left out the RGD motif in Pfizer mRNA vaccine would have been a mistake for Pfizer, and this motif in the mRNA "vaccine" is likely implicated in glomerular kidney disease exacerbation.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Newbie1A Quote  Post ReplyReply Direct Link To This Post Posted: November 22 2022 at 8:18pm
If it's to be - it's up to me!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: November 23 2022 at 7:52am

Please don’t post trash

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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiwiMum Quote  Post ReplyReply Direct Link To This Post Posted: December 20 2022 at 10:30am

Originally posted by Maxxx17 Maxxx17 wrote:

Vaccinations are always a good thing, but it seems to me that not all of them are useful, but more often they are harmful to people. It's hard to say which vaccines are helpful and which are not.

Some vaccines are great. I've had most of them and so have my family, but the Covid "vaccines" aren't actually vaccines. They don't fit the description of a vaccine in almost all categories, but in particular, they do not stop the recipient catching the disease. It's a real shame that they used the word vaccine to describe this medical treatment as I feel it's pushed people's trust in vaccines backwards.

Those who got it wrong, for whatever reason, may feel defensive and retrench into a position that doesn’t accord with the facts.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: December 24 2022 at 11:59am

[url]https://www.coronaheadsup.com/health/vaccine/vaccine-injured/censored-by-youtube-anecdotals-movie-explores-covid-19-vaccine-injuries/[/url] or https://www.coronaheadsup.com/health/vaccine/vaccine-injured/censored-by-youtube-anecdotals-movie-explores-covid-19-vaccine-injuries/ ;A new video exploring the subject of Covid-19 vaccine injuries has been scrubbed by Youtube within hours of going live – watch the full video below.

Vaccine injury is not a topic that should be casually censored by big tech.

The vaccine injured are “the most hated people in modern society”

A member of the vaccine injured group UKCVFamily speaks out about her experiences following vaccination with the Astrazeneca Covid-19 vaccine. Isn’t about time we stopped gaslighting these innocent victims?   … Continue reading

DJ, I did not see all of the video yet...but most of the people seem to be pro-vaccine, pro-science...Only their healthissues are being denied, ignored...eventough they very likely will be linked to vaccines safe for most...but not all !

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: December 24 2022 at 12:25pm

[url]https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00768-4/fulltext[/url] or https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00768-4/fulltext ;

CORRESPONDENCE| VOLUME 22, ISSUE 1P16, JANUARY 01, 2022

Transmissibility of SARS-CoV-2 among fully vaccinated individuals

Vaccine effectiveness studies have conclusively demonstrated the benefit of COVID-19 vaccines in reducing individual symptomatic and severe disease, resulting in reduced hospitalisations and intensive care unit admissions. However, the impact of vaccination on transmissibility of SARS-CoV-2 needs to be elucidated. 
A prospective cohort study in the UK by Anika Singanayagam and colleagues regarding community transmission of SARS-CoV-2 among unvaccinated and vaccinated individuals provides important information that needs to be considered in reassessing vaccination policies. 
This study showed that the impact of vaccination on community transmission of circulating variants of SARS-CoV-2 appeared to be not significantly different from the impact among unvaccinated people.  
The scientific rationale for mandatory vaccination in the USA relies on the premise that vaccination prevents transmission to others, resulting in a “pandemic of the unvaccinated”. Yet, the demonstration of COVID-19 breakthrough infections among fully vaccinated health-care workers (HCW) in Israel, who in turn may transmit this infection to their patients, requires a reassessment of compulsory vaccination policies leading to the job dismissal of unvaccinated HCW in the USA.
 Indeed, there is growing evidence that peak viral titres in the upper airways of the lungs and culturable virus are similar in vaccinated and unvaccinated individuals.2,3,5–7 
A recent investigation by the US Centers for Disease Control and Prevention of an outbreak of COVID-19 in a prison in Texas showed the equal presence of infectious virus in the nasopharynx of vaccinated and unvaccinated individuals. 
Similarly, researchers in California observed no major differences between vaccinated and unvaccinated individuals in terms of SARS-CoV-2 viral loads in the nasopharynx, even in those with proven asymptomatic infection. 
Thus, the current evidence suggests that current mandatory vaccination policies might need to be reconsidered, and that vaccination status should not replace mitigation practices such as mask wearing, physical distancing, and contact-tracing investigations, even within highly vaccinated populations.
I declare no competing interests.

-








I found the most extreme example yet a few days ago: a BA.2 with 137 private mutations—134 of them transitions, the type that molnupiravir is known to induce. There can be little doubt this is a molnupiravir creation. 

DJ, It may be to early to state vaccines, anti-virals may have worsened the pandemic. It may have resulted in creating more variants. In that way-on the short term vaccines may have saved millions of lives...to see that effect undone on the longer term...????

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: December 26 2022 at 11:59pm

Dr. John Campbell [url]https://www.youtube.com/watch?v=AYiwms-Yp5s[/url] or https://www.youtube.com/watch?v=AYiwms-Yp5s on the "Moderna-deal".....

Full video first posted 24th December 2022. 

Moderna Chief Executive Stephane Bancel https://www.cnbc.com/2022/06/22/moder... 

That capacity that we’re building in the UK, that they are committed to buying the product for the next ten years 

NOTES TO EDITORS: the details of the strategic partnership between the government and Moderna are commercially sensitive 

UK, Prime Minister, Moderna (2020) https://www.theguardian.com/politics/... Mr. Sunak refused to disclose whether he will profit from a surge in the share price of Moderna 

Theleme has a $500m investment in US-based Moderna 

Mr. Sunak was a founding partner of Theleme Partners and one of the executives managing its US office. 

He left the firm in 2013 Theleme is registered in the Cayman Islands (which does not make company records public) 

Moderna goes global https://globalnews.ca/news/9258211/gr... 

Canada New factory in Montreal area, Laval, Que Mr. Trudeau took part in a groundbreaking ceremony Completed in 2024 or 2025 mRNA vaccines, 100 million doses per year Covid, influenza, respiratory syncytial virus Innovation Minister François-Philippe Champagne Canada committed to purchase a certain number of vaccines Part of a seven-year agreement 200+ workforce No to leave out 

Australia https://www.monash.edu/news/articles/... Monash Technology Precinct, Victoria COVID-19, influenza and respiratory syncytial virus (RSV) 100 million doses per year mRNA vaccines Monash Vice-Chancellor, Professor Margaret Gardner bring together all of the elements of an mRNA innovation ecosystem that will deliver long-term health and economic benefits for the community

DJ, [url]https://en.wikipedia.org/wiki/Moderna[/url] or https://en.wikipedia.org/wiki/Moderna ;

Moderna, Inc. (/məˈdɜːrnə/ mə-DUR-nə)[4] is an American pharmaceutical and biotechnology company based in Cambridge, Massachusetts that focuses on RNA therapeutics, primarily mRNA vaccines. These vaccines use a copy of a molecule called messenger RNA (mRNA) to produce an immune response.[5][1]

The company's only commercial product is the Moderna COVID-19 vaccine, marketed as Spikevax. As of 2022, the company has 44 treatment and vaccine candidates, of which 21 have entered clinical trials. Targets for vaccine candidates include influenzaHIVrespiratory syncytial virusEpstein–Barr virus, the Nipah viruschikungunya, a combined single-shot COVID-19 booster and influenza vaccine, a cytomegalovirus vaccine, and two cancer vaccines. The company's pipeline also includes candidates for cancer immunotherapy using OX40 ligandinterleukin 23IL36G, and interleukin 12 as well as, in partnership with AstraZeneca, a regenerative medicine treatment that encodes vascular endothelial growth factor A to stimulate blood vessel growth for patients with myocardial ischemia.[1]

-

NIH vaccine patent dispute[edit]

Moderna is involved in a patent dispute with the NIH over its COVID-19 vaccine.[58] According to the NIH, three of its scientists played a major role in developing the vaccine over four years of collaboration.[59][60] After first refuting the shared patent application entirely, Moderna postponed the final payment for filing the application, thereby leaving the patent application unfiled as of December 2021.[60]

Pfizer and BioNTech patent lawsuits[edit]

On August 26, 2022, Moderna sued Pfizer and BioNTech in both Massachusetts and Germany, accusing the Pfizer–BioNTech COVID-19 vaccine of violating the patent on Moderna's mRNA vaccine technology.[61]

DJ, [url]https://en.wikipedia.org/wiki/Operation_Warp_Speed[/url] or https://en.wikipedia.org/wiki/Operation_Warp_Speed ;

Operation Warp Speed (OWS) was a public–private partnership initiated by the United States government to facilitate and accelerate the development, manufacturing, and distribution of COVID-19 vaccines, therapeutics, and diagnostics.[1][2] The first news report of Operation Warp Speed was on April 29, 2020,[3][4][5] and the program was officially announced on May 15, 2020.[1] It was headed by Moncef Slaoui from May 2020 to January 2021 and by David A. Kessler from January to February 2021.[6] At the end of February 2021, Operation Warp Speed was transferred into the responsibilities of the White House COVID-19 Response Team.[7]

The program promoted mass production of multiple vaccines, and different types of vaccine technologies, based on preliminary evidence, allowing for faster distribution if clinical trials confirm one of the vaccines is safe and effective.[citation needed] The plan anticipated that some of these vaccines will not prove safe or effective, making the program more costly than typical vaccine development, but potentially leading to the availability of a viable vaccine several months earlier than typical timelines.[8]

Operation Warp Speed, initially funded with about $10 billion from the CARES Act (Coronavirus Aid, Relief, and Economic Security) passed by the United States Congress on March 27, 2020,[1] was an interagency program that includes components of the Department of Health and Human Services, including the Centers for Disease Control and Prevention, Food and Drug Administration, the National Institutes of Health, and the Biomedical Advanced Research and Development Authority (BARDA); the Department of Defense; private firms; and other federal agencies, including the Department of Agriculture, the Department of Energy, and the Department of Veterans Affairs.[1]

DJ...so billions of US taxpayersmoney ended up in a for profit commercial new pharma producer signing exclusive contracts (excluding other vaccines-the number of Moderna vaccine leave no room for other vaccines...) with UK, Canada, Australia government. Billions go to "share holders" (including the UK PM ????)...

This is NOT the way to restore trust in either politics or vaccines....

DJ-Vaccines did save billions of lives since introduction. Vaccines against all kinds of diseases are needed at a certain level to keep those diseases under control. "Only for profit pharma" is destroying trust in ALL vaccines....

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: December 31 2022 at 2:34am

Dr. John Campbell trying to make up his mind on the safety of m-RNA vaccines; [url]https://www.youtube.com/watch?v=JYR1wz-Cf_M&t=608s[/url] or https://www.youtube.com/watch?v=JYR1wz-Cf_M&t=608s ; Rotavirus vaccine Rotashield, (1999),1 to 2 serious events per 10,000 vaccinees, Vaccine withdrawn 

Covid mRNA vaccines, 1 serious event per 800 vaccinees, 

Vaccine officially promoted 

Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults

DJ-links [url]https://pubmed.ncbi.nlm.nih.gov/36055877/[/url] or https://pubmed.ncbi.nlm.nih.gov/36055877/ and [url]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428332/[/url] or https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428332/ (full text);

Abstract

Introduction: In 2020, prior to COVID-19 vaccine rollout, the Brighton Collaboration created a priority list, endorsed by the World Health Organization, of potential adverse events relevant to COVID-19 vaccines. We adapted the Brighton Collaboration list to evaluate serious adverse events of special interest observed in mRNA COVID-19 vaccine trials.

Methods: Secondary analysis of serious adverse events reported in the placebo-controlled, phase III randomized clinical trials of Pfizer and Moderna mRNA COVID-19 vaccines in adults (NCT04368728 and NCT04470427), focusing analysis on Brighton Collaboration adverse events of special interest.

Results: Pfizer and Moderna mRNA COVID-19 vaccines were associated with an excess risk of serious adverse events of special interest of 10.1 and 15.1 per 10,000 vaccinated over placebo baselines of 17.6 and 42.2 (95 % CI -0.4 to 20.6 and -3.6 to 33.8), respectively. Combined, the mRNA vaccines were associated with an excess risk of serious adverse events of special interest of 12.5 per 10,000 vaccinated (95 % CI 2.1 to 22.9); risk ratio 1.43 (95 % CI 1.07 to 1.92). The Pfizer trial exhibited a 36 % higher risk of serious adverse events in the vaccine group; risk difference 18.0 per 10,000 vaccinated (95 % CI 1.2 to 34.9); risk ratio 1.36 (95 % CI 1.02 to 1.83). The Moderna trial exhibited a 6 % higher risk of serious adverse events in the vaccine group: risk difference 7.1 per 10,000 (95 % CI -23.2 to 37.4); risk ratio 1.06 (95 % CI 0.84 to 1.33). Combined, there was a 16 % higher risk of serious adverse events in mRNA vaccine recipients: risk difference 13.2 (95 % CI -3.2 to 29.6); risk ratio 1.16 (95 % CI 0.97 to 1.39).

Discussion: The excess risk of serious adverse events found in our study points to the need for formal harm-benefit analyses, particularly those that are stratified according to risk of serious COVID-19 outcomes. These analyses will require public release of participant level datasets.

DJ, One has to balance risks of vaccines/interventions with the risk of "problems", solutions have to be proportionate. Also "do no harm" medical ethics....

I-and Dr.J.C.-am not an immunologist/expert...

The definition of a serious adverse event (SAE) was provided in each trial’s study protocol and included in the supplemental material of the trial’s publication. [2][3][4] Pfizer and Moderna used nearly identical definitions, consistent with regulatory expectations. An SAE was defined as an adverse event that results in any of the following conditions: death; life-threatening at the time of the event; inpatient hospitalization or prolongation of existing hospitalization; persistent or significant disability/incapacity; a congenital anomaly/birth defect; medically important event, based on medical judgment.

DJ..If 1 in 800 vaccines results in these "Serious Adverse Events" then repeating those vaccines-boosters increases risks. Does this mean 5 vaccinations results in (long term) risks of 1 in 160 ? 

The Pfizer and Moderna trials are expected to follow participants for two years. Within weeks of the emergency authorization, however, the sponsors began a process of unblinding all participants who elected to be unblinded. In addition, those who received placebo were offered the vaccine. These self-selection processes may have introduced nonrandom differences between vaccinated and unvaccinated participants, thus rendering the post-authorization data less reliable. Therefore, to preserve randomization, we used the interim datasets that were the basis for emergency authorization in December 2020, approximately 4 months after trials commenced.

DJ...So we may not be able to get a good view on long term risk of vaccines...Also CoViD-infections in vaccinated may make a realistic view "hard"...The bizarre contracts the US, UK, Canada, Australia signed with Moderna-making Moderna vaccines the ONLY !!! vaccines used against CoViD for the coming 7 to 10 years makes me wonder if it is a maximum profit operation...

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: January 14 2023 at 9:23pm

DJ, 

In the strategy to deal with pandemics communication-experts could have done a good job. What-in the communication-totally derailed was the (lack of) discussion on vaccines. 

Between black and white there are over 50 shades of grey...

Some good expert-epidemiologists make the claim that vaccines saved millions of lives. I am NOT an expert-just trying to make up my mind on if I had to go for a vaccine or booster...

Other medical experts make the claim (m-RNA) vaccines are much more a risk then the vaccine producers claim. Also m-RNA vaccines would be "gene-therapy" [url]https://en.wikipedia.org/wiki/Gene_therapy[/url] or https://en.wikipedia.org/wiki/Gene_therapy ...well maybe they are-but if they offer protection, "do good" ? 

Again-I do not know if the name "gene therapy" describes [url]https://en.wikipedia.org/wiki/MRNA_vaccine[/url] or https://en.wikipedia.org/wiki/MRNA_vaccine "job"....I follow "the experts"...

There have been claims on [url]https://en.wikipedia.org/wiki/Myocarditis#Vaccination[/url] or https://en.wikipedia.org/wiki/Myocarditis#Vaccination

  • The Covid-19 mRNA vaccines have been associated with myocarditis. The FDA and European Medicines Agency estimates the risk of myocarditis after the Covid-19 vaccine as 1 case per 100,000 of those who are vaccinated.[33][34] The risk of myocarditis after Covid-19 vaccination was observed to be highest in males between 16-29 years of age, and after receiving the second dose of the mRNA Covid-19 vaccine.[35][36] For this high-risk group, incidence of myocarditis has been reported to be more than 1 case per 10,000.[37]

DJ, some studies claim 1 in 800 vaccinations result in myocarditis...so vaccinating 8 million people would result in 10,000 cases of myocarditis/pericarditis-hearthissues...

However...

In 2013, about 1.5 million cases of acute myocarditis occurred.[6] While people of all ages are affected, the young are most often affected.[7] It is slightly more common in males than females.[1] Most cases are mild.[2] In 2015 cardiomyopathy, including myocarditis, resulted in 354,000 deaths up from 294,000 in 1990.[8][5] The initial descriptions of the condition are from the mid-1800s.[9]

so, a lot of the hearthissues may NOT be related to vaccines at all...

say-1% of the vaccine related myocarditis cases are "major" then out of the 8 million vaccinated-10,000 myocarditis cases you end up with 1% is 100 major myocarditis cases ? 

Every 80,000 given vaccines is 1 major myocarditis case-just as an example-I do not know the "most correct" numbers...Such a number may be higher then expected based on the info the vaccine producers came up with...There may also be allergic reactions to the vaccine;[url]https://en.wikipedia.org/wiki/MRNA_vaccine#Side_effects[/url] or https://en.wikipedia.org/wiki/MRNA_vaccine#Side_effects 

My view;

-Vaccination is medical intervention and never 100% risk-free

-Communication on the risks has to be open and transparant...this is NOT the case now

-In a major healthcrisis there should NOT be any profits being made out of that crisis...m-RNA vaccine producers make billions in profit while the research was tax-funded...

-As far as I am aware only the US did see discussion on mandatory vaccinations...North Korea did not have (much) vaccines...so even there people were NOT forced to take vaccinations...(In Europe there was discussion on mandatory vaccines for HCW-ers, police/army etc. limited groups-and the discussion ended by trade unions making the point of self determination of people..Also most employers wanted to avoid-get out-of that discussion-encourage people to take the vaccine..). 

-Mass vaccinations with non-sterilizing vaccines; you could still catch the virus-vaccine limits disease-did need a wider (then vaccine-only) strategy. That wider strategy was and is still missing...

-The outcome is on the short term maybe vaccines saved millions of lives but also on the longer term -more immune evasion due to vaccines-the vaccine (lack of) strategy may result in new variants that claim much more lives...we did only end up buying time...

-New vaccines (oral, nasal) may do a better job-however the "variant soup" could result in "the virus" better able to get around it...

So-it is an ongoing story...claims more vaccinated people run MORE risk of catching CoViD could point to [url]https://en.wikipedia.org/wiki/Antibody-dependent_enhancement[/url] or https://en.wikipedia.org/wiki/Antibody-dependent_enhancement the virus using immunity reactions to spread...

DJ-I did take five times a m-RNA vaccine and for now it may have kept me-and those around me- safe. Waning/decrease of vaccine immunity means vaccine protection last 4 to 6 months...

So...when I get offered another booster I have to make up my mind...Communication-TRUSTED, HONEST !!! communication !!! would be more then welcome...Most people on this globe never did get vaccinated...the m-RNA vaccine is mostly a western countries discussion-for now...

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: January 22 2023 at 3:24am

DJ, 

There are lots of questions on vaccine-safety....

dr.john campbell [url]https://www.youtube.com/watch?v=OD0na_NZaLM[/url] or https://www.youtube.com/watch?v=OD0na_NZaLM on excess deaths;

There is a striking difference in how mortality rates in 2022 compare to 2019 at different ages 2.5% higher for ages 75-84 7.8% higher for ages 20-44 In the UK, there have been around 155,300 more deaths from all causes than expected from the start of the pandemic to 6 January 2023

DJ...he then links this story with;

The UK government has granted pharmaceutical giant Pfizer a legal indemnity protecting it from being sued, enabling its coronavirus vaccine to be rolled out across the country as early as next week. 16th December 2020

DJ...7,8% more deaths in the age group 20-44 in 2022 compared to 2019-UK may NOT be linked to vaccines...most of that age group in the UK did not get vaccinated-as far as I have info...so that higher number of deaths most likely may be linked to CoViD...not the vaccine...

Vaccines-for-profit during a global healthcrisis is "sick"...certainly when vaccine producers-with tax money developing and producing those vaccines-do not have to take responsibility for their product....

But that are two different stories....

[url]https://www.coronaheadsup.com/coronavirus/israeli-head-of-biological-research-i-was-wrong-three-times-when-i-was-vaccinated/[/url] or https://www.coronaheadsup.com/coronavirus/israeli-head-of-biological-research-i-was-wrong-three-times-when-i-was-vaccinated/

Prof Shmuel C. Shapira MD MPH, head of the Israel Institute for Biological Research for 8 years, on being vaccinated for Covid three times.

“I was wrong 3 times: * Taking the first mRNA shot * Taking the second mRNA shot * And again taking the third mRNA shot. Unfortunately, irreversible mistakes.”

DJ...without further info this is a "non-story"...

Again-[url]https://www.thailandmedical.news/news/covid-19-news-are-all-these-antibodies-elicited-by-various-jabs-and-boosters-and-frequent-sars-cov-2-infections-really-safe-for-the-human-body[/url] or https://www.thailandmedical.news/news/covid-19-news-are-all-these-antibodies-elicited-by-various-jabs-and-boosters-and-frequent-sars-cov-2-infections-really-safe-for-the-human-body ...my very limited non-expert view...

YES-there are risks in using non-sterilizing vaccines. They will result in more immune evasion by mutation-selection...

YES-there may be limits to what protection vaccines can offer to new variants better in evading immunity

the question is how safe/unsafe the (mRNA) vaccines were/are...? Did Pfizer, Moderna provide all needed info ? (My impression=no...)

Are there some groups at higher risk for vaccine complications (young men-hearth issues ?) ...looks like it...

DJ-I do NOT have the knowledge to make judgements...I did get vaccinated 5 times...hope it was "wise"...can not undo it...But IF there are risks better stay informed on it...

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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