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PANDEMIC ALERT LEVEL
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Now tracking the new emerging South Africa Omicron Variant

pandemic breakfast

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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 21 2022 at 11:59pm

(part 1 still looks complete...)

DJ [url]https://www.thailandmedical.news/news/breaking-sars-cov-2-ba-2-75-variant-spawns-an-even-more-worrisome-subvariant-ba-2-75-2-that-carries-spike-mutations-r346t,-f486s-and-d1199n[/url] or https://www.thailandmedical.news/news/breaking-sars-cov-2-ba-2-75-variant-spawns-an-even-more-worrisome-subvariant-ba-2-75-2-that-carries-spike-mutations-r346t,-f486s-and-d1199n TMN with link to [url]https://github.com/cov-lineages/pango-designation/issues/963[/url] or https://github.com/cov-lineages/pango-designation/issues/963 

So BA.2.75.2 (old/first BA.2.75 will be 2.75.1 from now I expect). 

Proposal for a sublineage of BA.2.75
Earliest sequence: 04.07.2022 (India)
Countries detected: India, Chile, England, Singapore, Spain, Germany

Defining mutation:
S:R346T
S:F486S
S:D1199N

This variant is defined by S:R346T, S:F486S, S:D1199N and was first detected in India. Now it is present in 6 countries across 3 continents (expansion into Germany with todays GISAID upload). 11 seq on Usher as of 18.08.22. Sequences carrying S:D1199N where mentioned by @RajLABN in #918. However the proposed sublineage is apparently distinct from those mentioned in #961 (i.e. #918, #957, #944). Sequence quality is fine but the sublineage currently clusters with a bunch of lower quality sequences with a lot of dropouts (see below).

-

I independently noticed this lineage when reviewing new uploads of BA.2.75

It is an independent lineage not obviously related to any other of the big circulating branches - so I think this is ready for designation - especially considering the Spike profile and rapid growth internationally.

Nucleotide mutations on top of BA.2.75:
C5192T, G22599C, T23019C, G25157A

-

Added new lineage BA.2.75.2 from #963 with 10 new designations #966

DJ TMN expects a new variant to show up in october-possibly a recombination; even better in avoiding defenses/immunity and with more airborne-long distance-spread. 

Even if no wildcard variant arises, it's quite hard to predict which variant is going to be dominant in ~2 months from now. The most likely candidates look like - BA.5 + S:346T (e.g. BF.7) - BA.2.75 Interesting about BA.2.75 is that it already has lots of interesting lineages 1/

DJ, two months is "a long time" in this pandemic; lots of new variants could show up, may get dominant in some regions...

Some of the many complications;

-very limited testing...so limited sequencing..

-variants with-for now-mild/no symptoms (maybe vaccines limiting disease ?) could be missed and "get ugly" later on

-Earlier spread of one variant may offer better protection/immunity then spread of another 9sub)variant. So pandemic history may matter !

-Spread in animals may become a problem

-Co-infections with other diseases (flu-season !)

-New recombinations may even be missed in testing...people may have more then one CoViD-variant

-Vaccines/anti-virals (etc) may result in variant selection...(stopping some (milder ?) variants resulting in more room for worse variants...)

DJ-But I am NOT an expert...just making my mind up...

Exponential growth is one of my other "basics"...What would now be able to stop the virus ? If immunity, temperature, distance decrease as factors ? There are "tens of billions of hosts" to infect, and re-infect over and over ! 

Answer; what would stop this virus is running out of hosts...So some people may be able to go into long term isolation...[url]https://en.wikipedia.org/wiki/Noah%27s_Ark[/url] or https://en.wikipedia.org/wiki/Noah%27s_Ark (also by the way mentions 40 days of rain...quarantine=40 days...so pretty old idea...).

A bit more optimistic [url]https://www.thailandmedical.news/news/university-of-minnesota-led-phase-three-randomized-clinical-trial-shows-that-metformin-reduces-risk-of-covid-19-disease-severity-and-mortality-[/url] or https://www.thailandmedical.news/news/university-of-minnesota-led-phase-three-randomized-clinical-trial-shows-that-metformin-reduces-risk-of-covid-19-disease-severity-and-mortality- maybe we are able to find better protection/medication, link;[url]https://clinicaltrials.gov/ct2/show/NCT04510194[/url] or https://clinicaltrials.gov/ct2/show/NCT04510194 ;

Detailed Description:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly spreading viral infection causing COVID-19 disease. There currently is no definitive preventive or early outpatient treatment therapy for Covid-19. Study study assess 3 existing generic medications: metformin, fluvoxamine, and ivermectin.

Metformin: in-silico, in-vitro, ex-vivo tissue assays suggest that metformin inhibits viral replication of SARS-CoV-2 virus (Castle et al; Gordon et al; and Schaller et al). Several retrospective cohort analyses have suggested an association between taking metformin prior to SARS-CoV-2 infection and less severe outcomes. Kow, J Med Virol conducted a meta analysis, with an overall odds ratio for mortality of 0.62 (0.43-0.89). Gordon et al found decreased SARS-CoV-2 and increased cell viability with metformin in vitro. (Gordon et al, Nature). While anti-viral activity may be contributing to the observational associations of reduced severity of Covid-19, metformin has a proven history of beneficial immune-modulatory effects, including on CRP, IL-6 and TNF-alpha, neutrophil extracellular traps, and improved T cell immunity. Outpatient metformin use has now been associated with lower IL-6, CRP, and neutrophil-lymphocyte ratio in persons with Covid-19 (Lou et al, Diabetes Care 2020).

Fluvoxamine: appears to have anti-inflammatory effects in SARS-CoV-2 infection. There is evidence that SARS-CoV-2 infection causes ER stress and activates pathways of unfolded protein response. Sigma-1 receptor (S1R) is an ER chaperone protein that regulates cytokine production through interaction with IRE1. Fluvoxamine is a selective serotonin reuptake inhibitor that is a powerful S1R agonist. Fluvoxamine has previously been shown to protect mice from septic shock and reduce the inflammatory response. There is potential for fluvoxamine as an immunomodulatory treatment for SARS-Cov-2. Fluvoxamine in CACO2 cells infected with SARS-Cov-2 had a reduction in production of a subset of cytokines including IL-6, IL-8, CXCL1, and CXCL10.53 A randomized controlled clinical trial of 152 patients showed that patients who received fluvoxamine were less likely to experience clinical deterioration, or serious adverse events due to SARS-Cov-2 when compared to placebo (0% vs. 8%). A follow-up real-world observational cohort had similar findings of 0% (0/65) hospitalization with fluvoxamine vs. 12% (6/48) with observation.

Ivermectin has also shown anti-inflammatory effects that would reduce the harmful cytokine cascade noted in severe Covid-19 disease. A recent trial assessing a multi-therapy including 12mg one-time dose of ivermectin found a 75% reduction in hospitalizations. Another small double-blinded RCT showed significant increased chance of viral clearance after a 5-day course of ivermectin. Another March 2021 RCT reported no effect on diminishing symptoms, but was under-powered for assessing reductions in hospitalization. An RCT with ivermectin must be done in the US, as endemic strongyloidiasis in other countries may confound results.

Statistical Considerations:

An independent data safety monitoring board will assess safety approximately twice per month; and will assess futility and efficacy at least twice throughout the study. If one of the arms reaches pre-specified boundaries for futility or efficacy, the DSMB will recommend closing of that arm(s). The detailed statistical analysis plan will be developed by the blinded statistician and co-investigators and per the protocol will be submitted to the DSMB.

DJ..We may need (a mix of ?) all medication available if we will see new record waves of CoViD(+) with very limited hospital capacity remaining...








Updated fit of global SARS-CoV2 lineage frequencies based on all  +  data, now with BF.7 / BA.5.2.1.7 represented separately. BA.2.75 still predicted to overtake in many places, but BA.5.2.1.7 has similar advantage over plain BA.5, so different outcomes

DJ, my non-expert opinion; increase testing (also more animals !) and sequencing to at least get a better view of what is coming...

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory Monkeypox MPX could develop the same way as CoViD did....with some bad luck may even become the major problem...

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 22 2022 at 10:56pm

DJ,

Co-infections....[url]https://www.coronaheadsup.com/science/co-infection/italy-monkeypox-sars-cov-2-and-hiv-co-infection/[/url] or https://www.coronaheadsup.com/science/co-infection/italy-monkeypox-sars-cov-2-and-hiv-co-infection/ ;

“In this study we present the clinical features and diagnostic procedure of the first documented case of co-infection with monkeypox virus, SARS-CoV-2 and HIV-1”.

Our patient, an Italian 36-year-old male spent 5 days in Spain from 16 to 20 June 2022. Nine days after, he developed fever (up to 39°C), accompanied by sore throat, fatigue, headache and right inguinal lymphadenomegaly. On 2 July he resulted positive for SARS-CoV-2. On the afternoon of the same day a rash started to develop on his left arm. The following day small, painful vesicles surrounded by an erythematous halo appeared on the torso, lower limbs, face and glutes.

Full report at the Journal of Infection

and [url]https://www.coronaheadsup.com/africa/ethiopia-man-survives-triple-coinfection-of-covid-19-hiv-and-tuberculosis/[/url] or https://www.coronaheadsup.com/africa/ethiopia-man-survives-triple-coinfection-of-covid-19-hiv-and-tuberculosis/ september 2021;

A 55-year-old male arrived at the hospital with HIV, Covid-19 and tuberculosis. On June 6, 2021, the patient recovered and was discharged after 10 days in hospital

This case report suggests, after 10 days of admission with triple infections, there is a good clinical prognosis and survival from COVID-19. On admission, further diagnosis and investigations of TB coinfection should be performed for all patients admitted with COVID-19 due to their similar and non-specific clinical manifestations.

Dovepress.com case report

DJ, My non-expert idea of co-infection was it would/could result both in more severe disease AND possibly even new diseases/virusses....

[url]https://www.journalofinfection.com/article/S0163-4453(22)00479-0/fulltext#seccesectitle0008[/url] or https://www.journalofinfection.com/article/S0163-4453(22)00479-0/fulltext#seccesectitle0008 ;

On admission, the patient reported being treated for syphilis in 2019. In September 2021, he performed an HIV test with a negative result. He suffered from bipolar disorder, for which he regularly took carbamazepine 200 mg daily. He was vaccinated for SARS-CoV-2 with two doses of Pfizer's BNT162b2 mRNA vaccine (the last in December 2021) and had already contracted COVID-19 in January 2022. He also reported of having condomless intercourse with men during his stay in Spain.

-

This case highlights how monkeypox and COVID-19 symptoms may overlap, and corroborates how in case of co-infection, anamnestic collection and sexual habits are crucial to perform the correct diagnosis. 
SARS-CoV-2 BA.4 and BA.5 subvariants are currently responsible for more than 1 million COVID-19 cases per day worldwide. Hence, clinicians should be aware of the possibility of SARS-CoV-2 and monkeypox virus co-infection, particularly in subjects with a recent history of travel to monkeypox-outbreak areas. If monkeypox is suspected, an oropharyngeal swab should be performed even in the absence of cutaneous manifestations as the skin may be spared, but the oral or rectal mucosa may be involved [].
Our case emphasises that sexual intercourse could be the predominant way of transmission. Therefore, complete STI screening is recommended after a diagnosis of monkeypox. 
In fact, our patient tested positive for HIV-1 and, given his preserved CD4 count, we could assume that the infection was relatively recent. To note, the monkeypox oropharyngeal swab was still positive after 20 days, suggesting that these individuals may still be contagious for several days after clinical remission. Consequently, physicians should encourage appropriate precautions. 
As this is the only reported case of monkeypox virus, SARS-CoV-2 and HIV co-infection, there is still not enough evidence supporting that this combination may aggravate patient's condition. Given the current SARS-CoV-2 pandemic and the daily increase of monkeypox cases, healthcare systems must be aware of this eventuality, promoting appropriate diagnostic tests in high-risk subjects, which are essential to containment as there is no widely available treatment or prophylaxis.

DJ....The other side of freedom is responsability....IF people "did it to themselves" (smoking-lung cancer, STD's due to "living wild") and we face a healthcare crisis then there may be some "logic" in putting some groups at the end of the line...

In this story the patient involved also had mental problems. So -in a pandemic- it always is more complex...

[url]https://www.thailandmedical.news/news/study-shows-that-diets-rich-in-ultra-processed-foods-increases-risk-of-covid-19[/url] or https://www.thailandmedical.news/news/study-shows-that-diets-rich-in-ultra-processed-foods-increases-risk-of-covid-19 There are clear links between poverty, eating the wrong food, lack of education...

DJ-Governments have a role to play in education. If you only have good education for "the rich" all of the country ends up being more vulnerable...

[url]https://www.thailandmedical.news/news/breaking-study-finds-that-upregulated-interleukin-6-drives-development-of-rare-liver-cancers-covid-19-infections-causes-elevated-il-6-levels-in-many[/url] or https://www.thailandmedical.news/news/breaking-study-finds-that-upregulated-interleukin-6-drives-development-of-rare-liver-cancers-covid-19-infections-causes-elevated-il-6-levels-in-many alcohol abuse also a main reason for liver problems...

DJ-I think we may have a "government-crisis" in the way that on the one hand "public" want a "strong government" offering solutions to complex problems...On the other hand the same "public" does not want to give up any "freedoms"....

You may end up with governments telling people to limit time in the shower-saving energy-but also lots of airtravel, increase of car-use (public transport "high risk") wasting a lot of energy...

The downward spiral is government "out of contact" with the general public...making solutions for all kinds of problems even harder. Also more room for those still making profit from cigarettes to flying, coal, oil, cars, weapons...

I think this pandemic is "political". Making profit seems to be more important then public health...Now more then during 2003 SARS-1...

Because we "never" will get out of problems that we the way we "think/govern" will change...Question however is will it be in time to at least be able to limit some of the major damage allready unfolding...

[url]http://arctic-news.blogspot.com/2022/08/dangerously-large-arctic-sea-ice-extent.html[/url] or http://arctic-news.blogspot.com/2022/08/dangerously-large-arctic-sea-ice-extent.html ;

At first glance, one might think that this relatively large extent was a sign of healthy sea ice. After all, the larger the sea ice, the more sunlight gets reflected back into space. At the same time, however, the situation is very dangerous, as there is a growing risk that large eruptions of methane will occur from the seafloor of the Arctic Ocean.


Why is the situation so dangerous? There are many contributors to the danger, three of them are:

1. Sea ice acts as a seal

Sea ice acts as a seal that impedes transfer of ocean heat from the Arctic Ocean to the atmosphere. 

2. Lid on North Atlantic

Ocean stratification is increasing globally, as ocean warming is stronger for upper layers versus the deep ocean. Stratification increased from 1960 to 2018 by 5.3% for the upper 2000m and by as much as 18% for the upper 150m, while salinity changes also play an important role locally, a 2020 study finds.

This lid on the North Atlantic reduces transfer of ocean heat to the atmosphere and enables large amounts of salty, warm water to enter the Arctic Ocean, diving under the sea ice. 

(DJ-Some claim the Arctic Ocean is becoming more and more a part of the Atlantic Ocean...)

3. Latent heat buffer loss 

Sea ice acts as a buffer that absorbs heat, while keeping the temperature at zero degrees Celsius. As long as there is sea ice in the water, this sea ice will keep absorbing heat, so the temperature doesn't rise at the sea surface. The amount of energy absorbed by melting ice is as much as it takes to heat an equivalent mass of water from zero to 80°C.


This ice has meanwhile all but disappeared, so without this latent heat buffer further incoming heat must go elsewhere, i.e. the heat will further raise the temperature of the water of the Arctic Ocean.


Compound impact

The danger is that, as more salty, warm water keeps arriving in the Arctic Ocean while the latent heat buffer has largely disappeared and while sea ice extent is relatively large, this will raise the temperatures and salinity levels at the bottom of the Arctic Ocean enough to destabilize hydrates in sediment at the seafloor of the Arctic Ocean, resulting in methane eruptions both from these hydrates and from free gas underneath these hydrates.

Conclusion 

In conclusion, there is a growing risk that methane will erupt from the seafloor of the Arctic Ocean and cause a dramatic rise in temperature.

Even without such eruption of methane from the seafloor of the Arctic Ocean, temperatures look set to rise strongly soon, as we move into an El Niño and face a peak in sunspots. 

Either way, the resulting temperature rise could drive humans extinct as early as in 2025 with temperatures continuing to skyrocket in 2026.

This makes it in many respects rather futile to speculate about what will happen beyond 2026. At the same time, the right thing to do now is to help avoid the worst things from happening, through comprehensive and effective action as described in the Climate Plan.

DJ-Recognizing the problem is a first step in solving the problem...

In the present "wider" pandemic (Monkeypox/MPX as a secondary effect of the CoViD pandemic) ;

-Immunity defense of "hosts" is getting weaker

-Diseases develop in ways to work around immunity, spread longer distance, higher R0

-Spread longer distance, higher R0 (measles has a higher R0 then most types of the Flu)

So in the "disease triangle" 1-Disease, 2-Host able to get infected, 3-Spread

all 3 factors work towards exponential growth...(resulting in longer, higher pandemic waves more often...with an increase of diseases)

The idea could be to find a vaccine stopping a host getting infected...so far there-however-is not such a (nasal ?) vaccine available...Lockdowns/NPI are meant to decrease speed of spread...but when mutations/other diseases then increase the R0 Non Pharma Interventions have their limits...There are very serious warnings for SARS-2 (or possibly SARS-3) developing a "new recombination" able to spread much faster and infect over and over...Such a new variant would fit in the exponential model...

Understanding the process (pandemics, climate change) should enable us to act...But then "we" need to re-find the balance between "freedom" and "responsability"!

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 22 2022 at 11:16pm

Part 2,








England’s COVID hospital admissions in the first 60 days of summer: 

2022: 78,029 
2021: 34,740 
2020: 6,566 

The failure of herd immunity.

and;








This is how COVID is becoming “milder”: 

🏴󠁧󠁢󠁥󠁮󠁧󠁿 ENGLAND’s deaths in 
July: 2022: 5,575 
2021: 1,642 
2020: 1,203 

🇮🇹 ITALY’s deaths in 
July: 2022: 3,733 
2021: 497 
2020: 374 


🇪🇸 SPAIN’s deaths in 
July: 2022: 3,188 
2021: 768 
2020: 117 

Do NOT trust politicians and their experts.

DJ, Denial is NOT solving any problem, climate change, pandemics, fiat currency-problems only get worse...Maybe trust the right politicians and experts...you need them !

Updated fit of global SARS-CoV2 lineage frequencies based on all  +  data, now with BF.7 / BA.5.2.1.7 represented separately. BA.2.75 still predicted to overtake in many places, but BA.5.2.1.7 has similar advantage over plain BA.5, so different outcomes

and








Even if no wildcard variant arises, it's quite hard to predict which variant is going to be dominant in ~2 months from now. The most likely candidates look like - BA.5 + S:346T (e.g. BF.7) - BA.2.75 Interesting about BA.2.75 is that it already has lots of interesting lineages

DJ, One risk could be overlooking risk of co-infections, mild/asymptomatic variants hardly detected becoming high risk via a few mutations...

Another article saying CDC is failing its mission to control and prevent disease—pretending it shouldn't need to do anything and not following science—instead of stepping up to do what it should. This one in fortune magazine

DJ, link [url]https://fortune.com/2022/08/21/is-the-pandemic-over-when-will-covid-end-us-covid-epidemic-soft-landing-cdc-pandemic-omicron-masks-vaccination-prevention-endemic/[/url] or https://fortune.com/2022/08/21/is-the-pandemic-over-when-will-covid-end-us-covid-epidemic-soft-landing-cdc-pandemic-omicron-masks-vaccination-prevention-endemic/ ;

The rules belie the state of things. COVID levels in at least some parts of the U.S. were recently at or around highs seen during the Omicron surge late last year into early this year. 

We’re talking all-time highs. 

With testing at record lows, the only reason we know is because some communities look for the virus in wastewater. What does it say that the best indicator of disease spread in this country is now the filthy water that fills sewers?

DJ, Maybe it is saying "we do not want to know" ? We need a way out...not a concrete wall...Good experts give a way out...

In the absence of clear closure, or any closure, sometimes we’re guilty of creating our own—the way we might mentally craft a satisfying end to a movie that ends abruptly.

We are all human..."leaders" provide "guidance" ...but only if we are willing to accept it...

[url]https://en.wikipedia.org/wiki/Labyrinth#Etymology[/url] or https://en.wikipedia.org/wiki/Labyrinth#Etymology ;

Labyrinth is a word of pre-Greek origin whose derivation and meaning are uncertain. Maximillian Mayer suggested as early as 1892[9] that labyrinthos might derive from labrys, a Lydian word for "double-bladed axe".[10] Arthur Evans, who excavated the palace of Knossos in Crete early in the 20th century, suggested that the palace was the original labyrinth, and since the double axe motif appears in the palace ruins, he asserted that labyrinth could be understood to mean "the house of the double axe".[11] The same symbol, however, was discovered in other palaces in Crete.[12] Nilsson observed that in Crete the double axe is not a weapon and always accompanies goddesses or women and not a male god.[13]

The association with "labrys" lost some traction when Linear B was deciphered in the 1950s, and an apparent Mycenaean Greek rendering of "labyrinth" appeared as da-pu-ri-to (𐀅𐀢𐀪𐀵).[11][14][15][16] This may be related to the Minoan word du-bu-re or du-pu2-re, which appears in Linear A on libation tablets and in connection with Mts Dikte and Ida, both of which are associated with caverns.[17][18] Caverns near Gortyna, the Cretan capital in the 1st century AD, were called labyrinthos.[16]

Pliny's Natural History gives four examples of ancient labyrinths: the Cretan labyrinth, an Egyptian labyrinth, a Lemnian labyrinth, and an Italian labyrinth. These are all complex underground structures,[19] and this appears to have been the standard Classical understanding of the word.

Beekes also finds the relation with labrys speculative, and suggests instead a relation with Greek λαύρα ('narrow street').[20]

DJ, the present crisis is confronting us with a "labyrinth" a myriad [url]https://en.wikipedia.org/wiki/Myriad[/url] or https://en.wikipedia.org/wiki/Myriad (

A myriad (from Ancient Greek μυριάς, myrias) is technically the number 10,000 (ten thousand); in that sense, the term is used in English almost exclusively for literal translations from Greek, Latin or Sinospheric languages (Chinese, Japanese, Korean), or when talking about ancient Greek numerals.

More generally, a myriad may be used in colloquial vernaculars to imply an indefinitely large number.[1])

of questions on how to go on...

DJ, Labyrinth, myriad or very old words...we may be facing a mix of crises unseen in modern history...However history itself is proof we did find a way out !

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 23 2022 at 10:30pm

DJ, 

People have some basic ideas. Politicians often go for "political science" fitting their idea's...The basic western idea half a year ago was Russia would not invade Ukraine...sanctions would stop it...that idea was very wrong...MI6/CIA "claims" of Putin=weak, would not survive western sanctions were wrong as well...

DJ-Let me put it more direct; Russia-China trade, Russia self-supporting economy, both were very strong indicators that sanctions-not new-would have limited effect...Those sanctions now backfire...

In pandemics a widespread political "idea" was infectious diseases pose limited risks; we can deal with it...This may be part of the reason why SARS-1 in 2003 was stopped, SARS-2 in 2019 could start spreading...DJ-The "easy story" is "it started in Wuhan-China"...the more complex one may be very limited cases may have started in Africa (Angola ?) at least months earlier...still does not exclude Chinese (oil) links with Angola...

So now  TMN; [url]https://www.thailandmedical.news/news/latest-who-warns-of-several-breakthrough-monkeypox-cases-and-now-states-that-current-monkeypox-vaccines-are-not-100-percent-effective[/url] or https://www.thailandmedical.news/news/latest-who-warns-of-several-breakthrough-monkeypox-cases-and-now-states-that-current-monkeypox-vaccines-are-not-100-percent-effective DJ...the CoViD-story of mistakes is repeated with MPX-Monkeypox...

I do not like the sarcasm of TMN..but some basic points may be correct;

-MPX did start spreading in a gay community with men often having sex with lots of partners...

-At least some of them have other sexual transmitted diseases (STD) including HIV

-"We"governments did not stop the spread in a very early stage; a.o. by very clear warnings on the risks

-Vaccines found to only offer 85% protection against older MPX are now being used..

-But lots of cases in vaccinated people show up (some only vaccinated after infection-idea was it would stop getting sick)

-MPX-virus is mutating...

-MPX may have the potential of developing into a much more serious disease

-Aerosol/surface contact spread..

So will MPX get "bigger then CoViD"? It is to early to tell-but it may be easier to catch...

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory including suspected cases MPX now over 52,000 with 116 deaths (only 9 of them in countries were MPX is "new"). Real numbers may be 10x reported numbers...

Getting the basic risk wrong, resulting in yet another healthcrisis...

Of course background; [url]https://halturnerradioshow.com/index.php/en/news-page/world/russia-announces-us-practiced-nuclear-bombing-run-against-russia[/url] or https://halturnerradioshow.com/index.php/en/news-page/world/russia-announces-us-practiced-nuclear-bombing-run-against-russia , DJ-I think China, Iran also may be preparing for war-mainly with the US.

Europe is dealing with extreme drought, lots of other parts on the globe facing the same climate disaster...

Most of the west in a semi-permanent political crisis as well...(DJ, trump is a symptom...you do not solve the problem by going after one man...). 

-CoViD is NOT over (UK);

The Continuous Mortality Investigation (CMI) has published its weekly Mortality Monitor covering deaths to 12 August. There were 9% more deaths this week than if death rates were the same as 2019. Another significant excess.  1/3

-

CMI calculates 132,500 excess deaths in the UK since the start of the pandemic. The total has increased by 12,100 in 2022. Cumulative mortality rates YTD are 1.8% of a full year’s mortality worse than 2019.  2/3

-

Calculated excess deaths (870) were significantly higher than the number of deaths mentioning COVID on the death certificate (592). That extends the recent run of non-COVID excess on top of deaths with COVID.  3/3 Full report publicly available here: https://actuaries.org.uk/system/files/field/document/Mortality%20summary%20pandemic%20monitor%20Week%2032%202022%20v01%202022-08-23.pdf

[url]https://www.euromomo.eu/graphs-and-maps[/url] or https://www.euromomo.eu/graphs-and-maps  giving some indications on excess deaths in Europe...some countries are "slow" in reporting/including excess deaths...Statistics becoming a way to lie....

Maybe another example of wrong basic ideas;








Step 0 (H1 2022): The housing market only goes up, bro. What weakness are you talking about? Step 1 (Today): S**t, selling houses is becoming very hard. Step 2 (Soon on your screens): Let's lower house prices and turn this paper gain into real P&L as long as we still can.

DJ, Lots of people may be in lots of debt when housing prices go down/collapse...some claim housing prices were indicators of hyperinflation...

History has a lot of warnings on "balancing risks"...politics ignored history so now history is catching up with politics...

-Limiting travel

-Limit mass events

-increase testing/sequencing

-Masks as a rule in public spaces long term...

-Good information (not wishfull thinking) !

Would not only limit disease spread but may also help dealing with the climate disaster...

-DJ-my non expert opinion;

Even if we only would have a few more months, years, to live it is our "duty" to at least try to limit the total mess we made...A situation may be very bad but that is NOT an excuse to make it even worse...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
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part 2, twitter;








Questions about #LongCovid? Hear from clinicians treating Long Covid patients, Drs. Rae Duncan and Claire Taylor, answer your questions during our #TwitterSpaces event on Aug. 25th at 10 AM ET. Set a reminder with the link! #COVID19 #NotRecovered https://twitter.com/i/spaces/1mnGedgdYELKX

DJ, chronic/long CoViD may now be the most widespread form of CoViD...with some people maybe getting reinfected...

Yaneer Bar Yam also mentions [url]https://en.wikipedia.org/wiki/Encephalitis_lethargica[/url] or https://en.wikipedia.org/wiki/Encephalitis_lethargica ;

Encephalitis lethargica is an atypical form of encephalitis. Also known as "sleeping sickness" or "sleepy sickness" (distinct from tsetse fly-transmitted sleeping sickness), it was first described in 1917 by the neurologist Constantin von Economo[2][3] and the pathologist Jean-René Cruchet.[4] The disease attacks the brain, leaving some victims in a statue-like condition, speechless and motionless.[5] Between 1915 and 1926,[6] an epidemic of encephalitis lethargica spread around the world. The exact number of people infected is unknown, but it is estimated that more than one million people contracted the disease during the epidemic, which directly caused more than 500,000 deaths.[7][8][9] Most of those who survived never returned to their pre-morbid vigour.

In the words of the famed neurologist and writer Oliver Sacks:

They would be conscious and aware – yet not fully awake; they would sit motionless and speechless all day in their chairs, totally lacking energy, impetus, initiative, motive, appetite, affect or desire; they registered what went on about them without active attention, and with profound indifference. They neither conveyed nor felt the feeling of life; they were as insubstantial as ghosts, and as passive as zombies.[10]

No recurrence of the epidemic has since been reported, though isolated cases continue to occur.

-

The causes of encephalitis lethargica are uncertain.[15] Some studies have explored its origins in an autoimmune response,[5] and, separately or in relation to an immune response, links to pathologies of infectious disease—viral and bacterial,[5] such as in the case of influenza, where a link with encephalitis is clear.[16] Postencephalitic Parkinsonism was clearly documented to have followed an outbreak of encephalitis lethargica following the 1918 influenza pandemic; evidence for viral causation of the Parkinson's symptoms is circumstantial 

History is full of disease we still not understand...

GET THE NEW UPDATED BOOSTERS—US plans to offer the next generation of #BA5 & #BA4 variant-adapted booster shots to 12 and older soon after Labor Day! UK only has BA1 boosters meanwhile. US has ordered 170 million doses of the new #BA5/4 boosters. #covid19

-








I would definitely recommend taking the new #BA5 booster in 2-3 weeks. Definitely get the updated shot instead of the old Wuhan 1.0 shot if you can. UK and European approval unclear for BA5 booster. US will definitely be the first for BA5 shot.

DJ; My non-expert impression; Vaccines did save lives...but a lot of people never were able to get vaccinated. The vaccine did NOT stop the infection, only limited disease...So the strategy has to be MORE then "just vaccines" ...otherwise you may end up in a "race" against the virus we will have no chance of winning...What happened with nasal vaccines by the way ???

I would love to believe vaccines outweigh their potential risks but so far the present strategy did only sink us deeper into a global healthcrisis...STOP THE SPREAD !


Let’s remind people—the Centers for Disease Control and Prevention  is supposed to **prevent** outbreaks of diseases — or, failing that, **control** #COVID19 or #monkeypox➡️Let’s hold the  to that—not to favor airlines or corporations. https://rollingstone.com/culture/culture-commentary/cdc-response-covid-19-monkeypox-polio-screwed-1234578485/

DJ; "economy first" may destroy that economy...








We've released an updated SARS-CoV-2 dataset for Nextclade. Newly added Pango lineages are shown in the image. Especially the BA.2.75 sublineages (including BL.1) should be helpful. You can check out the current  tree of Pango lineages here: https://nextstrain.org/nextclade/sars-cov-2?label=clade:21L%20%28Omicron%29

photolink [url]https://twitter.com/CorneliusRoemer/status/1562087877986734080/photo/1[/url] or https://twitter.com/CorneliusRoemer/status/1562087877986734080/photo/1 

DJ-Lots of potential "new" variants of CoViD around....(for me impossible to follow...GISAID/Pangolin noemt deze nog steeds BA.5.2.1, maar het zijn waarschijnlijk BF.7 (BA.5.2.1.7).

so BF.7 =BA.5.2.1.7=recombination ???)









BA.4.6 has a growth advantage of 17% over BA.5* in the USA (over last 3 months)   BA.4.6 will fail against BA.2.75 (Cov-spectrum predicts a growth advantage of ~27% for BA.2.75 vs BA.4.6 in USA (over last 3 months)👇 https://cov-spectrum.org/explore/United%20States/AllSamples/Past3M/variants?aaMutations=S%3AL452R%2CS%3AF486V%2CN%3AP151S%2CS%3AR346T&aaMutations1=ORF1a%3AS1221L%2CORF1a%3AN4060S&analysisMode=CompareToBaseline&

DJ; One of my goals on this (once a) forum is making my mind up, what are the risks, what should I do...I will take yet another CoViD-vaccine next month...but knowing that -at best- it may only limit my risks...It is NOT the way out of a growing healthcrisis...in itself part of a man-made climate collapse...

"You can not fix stupid"...but are humans that selfdestructive ? 

I can't believe this needs to be said. But I think it does. We're living in an era where a lot of public health experts seem more and more disconnected from the reality of people who don't enjoy the same privileges they do- even though public health is about protecting everyone.

-

And this means a careful consideration of differential impact, including the social, economic environments people live in, access to support, healthcare, employment benefits. Somehow these considerations seem to have been lost - when they're at the core of public health.

DJ-I am on "hopium", there are maybe still "ways out" of these crises...but a lot of people simply deny "the house is on fire"...

End of part 2, stay safe, sane & happy !

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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DJ, 

-Maybe in short; war. NATO keeps escalating its war against RIC, Russia-Iran-China. NATO attacking/behind ataacks inside Russia. US bombing in Syria. 

Further escalation only is bringing us closer to global war. Insanity-in the west-rules....nobody is winning a nuclear war...

-[url]https://www.coronaheadsup.com/health/long-covid/usa-up-to-4-million-people-out-of-work-due-to-long-covid/[/url] or https://www.coronaheadsup.com/health/long-covid/usa-up-to-4-million-people-out-of-work-due-to-long-covid/

Around 16 million working-age Americans (those aged 18 to 65) have long Covid today. Of those, 2 to 4 million are out of work due to long Covid.

The annual cost of those lost wages alone is around $170 billion a year (and potentially as high as $230 billion).

DJ Same insanity in both climate and pandemics...

The Census Bureau’s June to July 2022 HPS survey found that 16.3 million people (around 8%) of working-age Americans currently have long Covid. This report uses HPS data rather than Current Population Survey (CPS) data—which is generally more robust—because the HPS asks questions specific to long Covid, and the CPS does not. The CPS asks about six specific manifestations of disability, which will likely identify some cases of long Covid, but almost certainly not all.

A recent Federal Reserve Bank of Minneapolis study corroborates the HPS figure. Using a longitudinal survey, it found that 24.1% of people who have contracted COVID-19 experienced symptoms for three months or more, which the author defined as long Covid.[3] And according to the Centers for Disease Control and Prevention, about 70% of Americans have contracted COVID-19. If 24.1% of them have had long Covid, 34 million working-age Americans have, at some point, had long Covid.

The Minneapolis Fed study found that 50% of respondents had recovered from long Covid. If we exclude that 50%, we are left with around 17 million people who may currently have long Covid—very near the HPS estimate of 16.3 million.

Brookings Institution: New data shows long Covid is keeping as many as 4 million people out of work

DJ I rather go for "chronic CoViD" ...8% of US workforce dealing with it, 2% of US workforce unable to work...It may give some indications on other western countries...








Amazing spontaneous collab among scientists of different disciplines on tracking sarscov2 variants Thx above all to  effort People doing research how it should be done. Open source. Relentless effort when governments appear not to give a damn anymore

-






Cornelius Roemer

@CorneliusRoemer
 · 
The new Pango lineages as called by Nextclade are already on @GenSpectrum! Here's a really useful overview, showing number, growth advantage, defining mutations etc Great curation work by a team of volunteer citizen scientists. https://cov-spectrum.org/collections/24 https://twitter.com/siamosolocani/status/1562348033014104064?t=ApJ5u0xSHOIlpyDlYJqP3g&s=19

DJ...in the present-much to close to global- war military may show wisdom politics lack...In this pandemic a lot of "good people" keep working till they drop...even with governments trying to silence them-like governments did silence science in the climate collapse...

Makes me wonder what kind of "democratic dysfunction" we now have to deal with...Politicians for sale ? I do not believe all politicians are corrupt...Just stupid ? Maybe tunnelvision...unable to "get a wider perspective" ? "Trying to get the kids to sit still in the backseat, missing the truck in front of them high speed..."

DJ-I often ask myself; Am I still "balanced" taking climate, pandemics, wars this serious (without sinking into depression-while it is depressive) ? Yet in history-maybe smoking is a good example-the majority simply is wrong...."group (lack of) thinking" is very dangerous...








It's because the US government has decided that the only valid data are those that companies are willing to provide. We have anointed pharma CEOs as the sole arbiters of policy

DJ, One argument against this is ill people bring even more profits then mass vaccinations...Well I guess there soon will be enough ill people, animals, for maximum profits...A sort of "capitalist illusion"...what is good for companies/shareholders is good for a country...Wars for profit...replacing fossil energy with "green energy"...with only limited reduction of energy consumption...lying to yourself that e-cars "save the planet" like "vaccines get us out of the pandemic"...

If we only further escalate wars "we" will win...Maximum profits for shareholders at the cost of humanity...a sick system !








Clear spike in heart attack cases after Covid-19 outbreak

[url]https://www.business-standard.com/article/current-affairs/hospitals-report-10-20-spike-in-heart-attacks-in-post-covid-19-era-122082401144_1.html[/url] or https://www.business-standard.com/article/current-affairs/hospitals-report-10-20-spike-in-heart-attacks-in-post-covid-19-era-122082401144_1.html 

DJ, CoViD-infection (and maybe limited vaccination ???) showing damage that went undetected weeks, months, after infection(vaccination). 

I think CoViD-vaccines did save a lot of lives...BUT Non-Pharma Interventions (masks, limiting contacts etc) did save even more lives...I do not have the knowledge or wisdom to claim "vaccines are to unsafe" I only notice the ongoing discussions...

(I put DJ in front to show it is my opinion-not a summary of a link...). 








CDC estimated US excess deaths Aug 2, 2020 - July 31, 2021:  443,419 Aug 1, 2021 - July 30, 2022:  514,033 Data source: https://data.cdc.gov/NCHS/Excess-Deaths-Associated-with-COVID-19/xkkf-xrst

DJ..updating recent numbers often complicating realistic statistics. [url]https://www.worldometers.info/coronavirus/#main_table[/url] or https://www.worldometers.info/coronavirus/#main_table has NL 22,590 deaths...other more realistic numbers are around 40,000 CoViD deaths...a lot of people in care centers "died from old age" when they died from CoViD...)

Enough for part 1...a grim part 1 again...

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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Part 2

[url]https://nltimes.nl/2022/08/23/dutch-covid-hospital-total-back-600-new-infections-hit-80-day-low[/url] or https://nltimes.nl/2022/08/23/dutch-covid-hospital-total-back-600-new-infections-hit-80-day-low We are getting out of a major summerwave...schools soon will reopen...no doubt both CoViD and MPX numbers will go up again in september...

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory now (at the time I look) 45,929 MPX confirmed cases...16,512 of them from the US...NL has 1,087 cases...about 1/20th of US population...so NL numberx20 would see over 20,000 NL cases...Germany 3,350 cases x4 =13,400 cases at US population levels...Numbers may say more on testing, reporting...what people can get tested for Monkeypox/MPX...most of the spread still will be in gay men...But if you only test gay men you may miss a lot of cases by now...

[url]https://www.thailandmedical.news/news/latest-who-warns-of-several-breakthrough-monkeypox-cases-and-now-states-that-current-monkeypox-vaccines-are-not-100-percent-effective[/url] or https://www.thailandmedical.news/news/latest-who-warns-of-several-breakthrough-monkeypox-cases-and-now-states-that-current-monkeypox-vaccines-are-not-100-percent-effective 

DJ-Vaccines may "limit damage" but not that much more...so governments have to do more to STOP THE SPREAD ! Honest information would help...but even that may be missing...

Israel has 215 MPX cases confirmed...x 33,5 would get you at 7,000 cases "compared to US statistics/population"...To be honest I think lots of countries may choose to miss a lot of cases...

[url]https://www.timesofisrael.com/israel-using-vaccination-nation-chops-to-fight-monkeypox-doctor-says/[/url] or https://www.timesofisrael.com/israel-using-vaccination-nation-chops-to-fight-monkeypox-doctor-says/ ;

Just over 2,000 people have received monkeypox vaccines, since their rollout in early August, which medical professionals say reflects a far bigger achievement than the number suggests.

That is because, unlike the attempt to vaccinate everyone for COVID, the strategy for monkeypox is to immunize only those considered at significant risk. And so, each time someone receives a vaccine, it is a success in pinpointed preventative health.

DJ...who is at risk for MPX ? Is vaccination the only/best way of protection ? Good statistics need good testing ! Hotel workers getting infected by cleaning the beds, children sharing a house with a person infected with MPX...If you do not have good numbers-deal with MPX incubation of up to 3 weeks-again-no doubt-you run behind the facts. 

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Transmission_patterns[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Transmission_patterns ;

The reproduction number during the initial phase of the 2022 global outbreak of monkeypox was estimated to be 1.29.[127]

As the MPX outbreak developed, nosocomial and other forms of human-to-human spread became apparent, with a notable example being a doctor in an Israeli hospital becoming infected probably while removing protective clothing after examining monkeypox patients.[128] Contaminated surfaces within hospitals and households may be infectious,[129] with widespread contamination of surface and air samples taken from monkeypox isolation rooms in UK hospitals being documented.[130]

In August, the first known case of probable human-to-dog transmission was reported with the canine exhibiting very similar signs and symptoms of monkeypox infection to that of humans.[131]

DJ, I expect MPX cases increase will go up with schools/workplaces reopening. [url]https://www.cidrap.umn.edu/news-perspective/2022/08/who-unveils-new-monkeypox-variant-names[/url] or https://www.cidrap.umn.edu/news-perspective/2022/08/who-unveils-new-monkeypox-variant-names 

DJ-What is complicating MPX-variants (must be several) also is that an above average group of cases have other (STD) diseases...Some models expect over 1 million MPX cases by november...I think realistic-good-testing may produce such a number allready next month...a further "denial strategy" could even see "claims" by "experts-for-sale" and "politicians-for-sale" PMX is "over"...Insane denial of problems/crises is dominant in many countries political elite...

Wars, climate collapse, pandemics are-by now-the outcome of governments going for profit in stead of public interests...We have been here before in history...revolutions usual the outcome...








Update: http://covidmeetups.com, a network to find others who take COVID precautions, has now grown to more than 4,000+ members across 50 countries! Our local and online business directory is also live. Please retweet to help us grow even further, thank you!

Self-help-groups can help people in dealing with (in most cases by now chronic) CoViD...also may increase pressure on politics to do their jobs !








I’m wondering if people would send their kids to school with a mask if another child in the class was recovering from chemo. Or would you tell the other child’s parents to have their kid one-way mask?

DJ, Maybe learning/working from home has to be the new normal ? If the idea-at least is-to get a grip on the exponential growing healthcrises...








For public and scientists getting lost in new Omicrons we have now released a very easy collection on   (thx  ) to track the fastest designated lineages. This is possible just thx to nextclade team and   https://cov-spectrum.org/collections/24 vs BA.5*

DJ...[url]https://outbreak.info/situation-reports[/url] or https://outbreak.info/situation-reports now has;

B.1.1.529 "Omicron" with 309 subvariants

BA.2/BA.2.X also "Omicron" with 136 subvariants

BA.5/BA.5.X still "Omicron" with 58 variants...

and BA.2.75/BA.2.75.X with 5 "Omicron" subvariants (including BL.1)

So at least 508 sub-variants of "Omicron"...(some people/hosts may have older/other (sub)variants hidden in their body/not detected...)

[url]https://github.com/cov-lineages/pango-designation/issues[/url] or https://github.com/cov-lineages/pango-designation/issues with 52 discussions "open"....

DJ-You have to be "very optimistic" to "claim" this pandemic is " under control"...it is NOT ! Very likely [url]https://www.coronaheadsup.com/coronavirus/covid-19-when-do-the-winter-waves-start/[/url] or https://www.coronaheadsup.com/coronavirus/covid-19-when-do-the-winter-waves-start/ the coming years only will bring even worse waves...

We have to find a much better strategy if we want to survive...








"Around 16 million working-age Americans have long Covid today.. Of those, 2 to 4 million are out of work.. 22% of people with long Covid were unable to work.. another 45% had to reduce hours worked.." It's a thought-provoking article.

DJ 22% of chronic CoViD cases translating to 2% of US workers...? [url]https://www.brookings.edu/research/new-data-shows-long-covid-is-keeping-as-many-as-4-million-people-out-of-work/[/url] or https://www.brookings.edu/research/new-data-shows-long-covid-is-keeping-as-many-as-4-million-people-out-of-work/ 


#COVID19 #VariantDashboard - #UnitedStates  TOP lineages (15-DAY TRENDS): 23.87% BA.5.2.1   13.33% BA.5.2 11.39% BA.5.1 7.24% BA.5 6.84% BA.5.5 6.51% BA.4.6 5.60% BA.5.6 2.85% BA.4.1 2.27% BF.10 2.03% BA.5.1.1 Tracker: http://tinyurl.com/mryj4uu7 #OmicronUpdates 08/24/22 

DJ BF.10 is recombination-variant ????

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
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DJ, 

In a refugee-center in the north of NL-sewage samples-polio was detected. Refugees have to sleep outside since the NL government is better in wars then in dealing with the consequences of wars...Very likely lots of other diseases, in lots of places, in refugees fleeing western (escalation of) wars...[url]https://southfront.org/holding-defender-europe-2023-exercises-in-kosovo-aimed-against-serbia-and-russia/[/url] or https://southfront.org/holding-defender-europe-2023-exercises-in-kosovo-aimed-against-serbia-and-russia/ NATO pushing for a new "Yugoslavia-war" ? 

[url]https://nltimes.nl/2022/08/25/netherlands-5th-worst-europe-monkeypox-infections-dutch-total-1136[/url] or https://nltimes.nl/2022/08/25/netherlands-5th-worst-europe-monkeypox-infections-dutch-total-1136 ;

The Netherlands has one of the highest total number of confirmed monkeypox cases in all of Europe. The country ranked fifth according to a report on the situation released on Wednesday by the European Centre for Disease Prevention and Control (ECDC) and the WHO Regional Office for Europe.

Spain by far has the most diagnosed cases of the infection, with 6,283, compared to any other country on the continent. That was followed by the United Kingdom (3,340), Germany (3,329), and France (2,889).


When the report was released, the Dutch total stood at 1,090. That figure rose on Thursday to 1,136 in data released by the RIVM, the country’s public health institute. That reflected a 4 percent increase in a week. The number of infections was 818 one month ago.

The RIVM said the number of infections diagnosed last week was a sign that the spread of monkeypox may be levelling off. The increase of 46 total infections was the lowest reported in a week since mid-June, shortly before numbers climbed towards a peak a month later. Thus far, the most cases in the Netherlands have been found in the combined region of Noord-Holland and Flevoland, where 671 people have tested positive for monkeypox. That was followed by 186 in Regio West, which includes a large part of the Randstad south of Schiphol Airport.


The Netherlands is vaccinating high-risk people against monkeypox using two doses of the Imvanex smallpox vaccine. For the week ending on 17 August, 2,840 people received a jab, and 3,465 others were vaccinated the week before that. Almost 2,000 people got their first shot in the first few days after they became available. The most vaccinations have been given in the Amsterdam region, which accounts for a third of all jabs.

DJ, Monkeypox/MPX cases going down in some regions in part-most likely-due to gay men limiting partners...However MPX does spread also via surfacecontact/aerosols...[url]https://www.coronaheadsup.com/health/monkeypox/cdc-advice-for-schools-on-monkeypox/[/url] or https://www.coronaheadsup.com/health/monkeypox/cdc-advice-for-schools-on-monkeypox/ ;

Some links; [url]https://www.cdc.gov/poxvirus/monkeypox/schools/faq.html[/url] or https://www.cdc.gov/poxvirus/monkeypox/schools/faq.html 

also twitter-link; 

(1/n) WHO: Monkeypox epicenter moves from Europe to Americas: Tedros said "That has now reversed, with less than 40% of reported cases in Europe and 60% in the Americas."

-

"In all three cases of occupational exposure, health workers were wearing recommended personal protective equipment but were exposed to body fluid while collecting samples," the WHO and ECDC said.

DJ, limited spread at (US-other ?) universities..."children" under 18...younger children often link to household contact. 

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory DJ-Over 47,000 confirmed cases-most likely real number much higher...but if the very likely still main way of spread-gay sex-is under control somewhat maybe MPX can be stopped...

"Social ???" media censoring correct info on diseases -while sometimes giving room for non-sense (for profit) still can do a lot of damage...

DJ-Monkeypox still can become a very major global public health risk. Co-infections with other diseases most likely will worsen outcomes (??? very limited reports on that however...[url]https://www.coronaheadsup.com/science/co-infection/italy-monkeypox-sars-cov-2-and-hiv-co-infection/[/url] or https://www.coronaheadsup.com/science/co-infection/italy-monkeypox-sars-cov-2-and-hiv-co-infection/  and [url]https://www.journalofinfection.com/article/S0163-4453(22)00479-0/fulltext#seccesectitle0008[/url] or https://www.journalofinfection.com/article/S0163-4453(22)00479-0/fulltext#seccesectitle0008 ;On day 5 (July 9, 2022), almost all constitutional symptoms were resolved and previously altered laboratory test values normalized. On day 6 (July 11, 2022), nasopharyngeal swabs for SARS-CoV-2 and monkeypox virus were still positive, despite the absence of new skin lesions. Since symptoms had resolved, the patient was discharged to home isolation. On 19 July 2022 he returned to our institute to underwent a new oropharyngeal swab for monkeypox virus, which was still positive. The crusts had healed almost completely, leaving a small scar (Figure 2, Panels E to H). A triple combination of dolutegravir, abacavir and lamivudine was initiated for HIV treatment. )

DJ...[url]https://www.coronaheadsup.com/coronavirus/research-paxlovid-of-no-benefit-to-the-under-65s/[/url] or https://www.coronaheadsup.com/coronavirus/research-paxlovid-of-no-benefit-to-the-under-65s/ ;“Among patients 65 years of age or older, the rates of hospitalization and death due to Covid-19 were significantly lower among those who received nirmatrelvir than among those who did not. No evidence of benefit was found in younger adults.”

So under 65 are "younger adults" , article [url]https://www.nejm.org/doi/full/10.1056/NEJMoa2204919?query=featured_home[/url] or https://www.nejm.org/doi/full/10.1056/NEJMoa2204919?query=featured_home 

[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time UK self reported CoViD cases are getting to 1,6 million...may get below lowest 2022 numbers for the UK so far (June had 1,6 million cases). 

[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table global tested/reported CoViD cases -5% last 7 days compared to week before...still over 5 million+ new cases were reported last week, Reported CoViD deaths number down from 16,512 to 13,964...still close to 2,000 CoViD deaths per day...

Russia cases +30%, Japan +23%, Vietnam +21%, Portugal +13%, Taiwan +10%, Italy +6%...statistics may give only very limited indications...it may be a/pre-symptomatic spread is increasing but simply not tested...

WesElyMD

@WesElyMD
 · 
16/👇Frere showed glial cells are activated by COVID & sustain inflammation, which in turn, sadly sets into motion a pathway toward overall brain atrophy (shrinking), long-term cognitive disability & mental health disorders seen in your friends w LC. https://bit.ly/3zB7gLk
Show this thread

DJ, "Long"/chronic CoViD can take its time to do a lot of damage....

End of part 1

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 26 2022 at 12:03am

DJ, 

Can "statistics" be of much use in a pandemic ? I think the problem is getting/value data may be the problem...What is the definition of "a case"? Just a positive test ? Or do people have to have symptoms as well ? Do you see "re-infections" as new cases, or consider them "old cases" not to be included. If people die later then 4 weeks after a positive test, or already had other illness, is that a "CoViD death"? 

MPX has an incubation time of (around) three weeks with also some indications for a-symptomatic (still pre-symptomatic...symptoms taking more time to show up ?) spread...A lot of testing is focussed on gay men...household members with symptoms may get tested...but at least a-likely small-percentage is missed. 

Problem with those missed cases (for instance in hotel workers catching MPX cleaning hotelrooms) is they may spread (mutate-develop) a sub-variant of MPX that is much better in aerosol/surface spread...But those cases are NOT getting tested often...

Schools and workplaces soon will be reopening, creating a mega-mix of virusses...CoViD-testing  now a DIY-at home test...MPX only often limited to high risk groups...so 

The greatest expert of all expected the #COVID pandemic to be behind us after 2021. This is what we are up against: dogmatic textbook ordinary respiratory virus/pandemic downplayers of SARS2 unique special features united with minimizers left & right, backed up by deniers.

on Fauci...statistics can be a "great way to lie"....simply stop public testing, so "no reported cases" and the "pandemic is over"! 

"Politics solved the problem"-great ! Just another lie...









If the man leading the fight vs. #SARS2 thought it will just blow over after two years why would the world's politicians invest in long-term preparedness? That's a bad prediction coming from the top which politicians happily embraced & that's why we are unprepared for the future.

and








Doctors, scientists and advocates attempting to warn the public about the dangers of COVID have been having their factual tweets flagged as misinformation and accounts suspended. Twitter acknowledged the issue and is reviewing their team’s protocol

DJ...so "shoot the messenger" ..."politics surprised by CoViD/MPX resurfacing" ...no doubt MSM "breaking news-non sense"....

Roland Baker 2.0

@RolandBakerIII
 · 
Monkeypox cases at 10 universities so far: Texas State University, Penn State, University of Maryland, Georgetown University, Berkeley, University of Texas at Austin, West Chester, George Washington, Bucknell and University of Delaware twitter.com/emily3lytle/st…

and 

World Health Network

@TheWHN
 · 
Questions about #LongCovid? Hear from clinicians treating Long Covid patients, Drs. Rae Duncan and Claire Taylor, answer your questions during our #TwitterSpaces event on Aug. 25th at 10 AM ET. Set a reminder with the link! #COVID19 #NotRecovered https://twitter.com/i/spaces/1mnGedgdYELKX

so "politics" is dumping yet another job, people help themselves...by the way-there is no clear definition for "long/chronic CoViD"...some go for still symptoms 4 weeks after a positive test the other "extreme" may define it 6 - 12 months after a positive test...The number of people dealing with "L.C." (Long CoViD) is also depending on the definition used...Very likely over 10% of people catching CoViD may have (some) healthissues one year later-after first positive test...But it may also depend on what variant of CoViD people did catch, viral load, age/health history etc. Some indication more men die from CoViD while women more often develop "L.C."...

Statistics only focussing on positive tests and CoViD-deaths (within 28 days of +test) may be usefull for indication of how the pandemic is developing...The "real story" (also on vaccines) is much more complex...with lots of good experts discussing on what is important and why...

-On politics;

💡If we can forgive pandemic PPP loans, cancel corporate debt in bankruptcy, or allow corporations to dump all employee pension liabilities in bankruptcy “reorganizing” (cough )—then damnit, we can help forgive $10k of student loans in a predatory student loan world.

-

2) To be clear, many airlines have dumped employee pensions during bankruptcies, including also 

 airlines and 

 Airlines. https://pbgc.gov/wr/large/united/united-airlines-plan-restoration

-

3) Many pilots fought for years for their pension payouts after legacy US Airways (which merged with AA) dumped their pensions off to PBGC, a US govt entity that insures pensions after parent company dumps pensions. https://thestreet.com/.amp/investing/stocks/us-airways-pilots-still-fight-for-pension-payouts-11-years-after-bankruptcy-case-12703297

DJ, billions of fiat currency-tax payer-money is going to share holders via Big Pharma, "defense/war industry" and "banksters"...Maybe the real disease is we live in a "greed based world" by now...the "only measure of succes" is the billions on your bank account...Every created crisis another profit-oppertunity...everything is for sale...








"Routine Covid tests in English hospitals are to be scrapped next week despite a near doubling in UK deaths from the virus this summer compared with the same period last year."

DJ, "privatize everything" ...the NHS in the UK was the outcome of healthdisasters going on early last century...Good public health did improve quality of longer lives...somehow "we" now vote for criminals like bojo...followed by an even worse truss...Pandemics ARE political ! 

If we do not "change the top" the public healthcrisis only will worsen...

End of part 2

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 26 2022 at 11:33pm

DJ, 

[url]https://www.coronaheadsup.com/science/variants/recombinants/xay/xay-delta-omicon-recombinant-under-observation/[/url] or https://www.coronaheadsup.com/science/variants/recombinants/xay/xay-delta-omicon-recombinant-under-observation/

A new SARS-CoV-2 recombinant lineage from South Africa has been highlighted by Tulio de Oliveira, Director of the Centre for Epidemic Response & Innovation in South Africa today.

The Delta/Omicron recombinant was first identified on the 28 June 2022 and designated as XAY on the 25th August 2022

-

Delta/Omicron (‘Deltacron’) recombinants haven’t been particularly successful in competing with Omicron sublineages so far, but XAY seems to have gained a toehold in Limpopo and Gauteng, South Africa.

DJ-May be nothing, but-worst case-could become one of the drivers for a "new" CoViD-pandemic. (Also in new variants/latest news). A recombination variant could be (much) better in evading immunity...so vaccinated/earlier infected hosts would only have limited/no protection...

South Africa now is on its way to spring/summer...so we "may be lucky" this time...

[url]https://www.thailandmedical.news/news/study-shows-that-sars-cov-2-coronavirus-is-evolving-to-make-humans-sick-faster-as-incubation-periods-are-getting-shorter-with-newer-variants[/url] or https://www.thailandmedical.news/news/study-shows-that-sars-cov-2-coronavirus-is-evolving-to-make-humans-sick-faster-as-incubation-periods-are-getting-shorter-with-newer-variants ;

DJ; link to [url]https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2795489[/url] or https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2795489 ;

Conclusions

Although variants such as Alpha, Beta, and Gamma are currently only prevalent in a few countries in Southeast Asia, South America, and Africa, the Delta and Omicron variants have become the dominant strains in many countries around the world. Identifying the incubation period of different variants is a key factor in determining the isolation period. The pooled incubation period of COVID-19 in this study was 6.57 days. The incubation period for COVID-19 caused by the Alpha and Beta variants was approximately 5 days. The incubation period of COVID-19 caused by the Delta and Omicron variants was significantly shorter than that of the other variants.

Lots of indications that some newer variants go into lower respitory system/lungs..resulting in more severe disease. Stories on the 1918-"Spanish Flu" pandemic mention people getting ill in the morning, dead in the evening...From a "virus perspective"; the virus goal is to create as much new virusses via a host as possible...it will keep looking-via mutations-to increase virus-production. Higher viral load may increase spread...some claims also long distance spread...Season-effects in the early stages (2020) could mean in summer -10% cases, winter +10% cases...but season effect this year-2022-was "very limited"...Again I am not an expert-just trying to "get a view on events"!

[url]https://www.coronaheadsup.com/australasia/australia/australia-12-of-the-workforce-off-sick-with-long-covid/[/url] or https://www.coronaheadsup.com/australasia/australia/australia-12-of-the-workforce-off-sick-with-long-covid/ ;

An estimated 31,000 Australian workers are calling in sick every day because of the debilitating symptoms of long COVID.

Treasury data given to News Corp papers shows 12 per cent of the labour force is staying home sick because of the long-term after effects of the virus.

Meanwhile, NSW Premier Dominic Perrottet is pushing to shrink the required seven-day isolation period to five days for people who test positive for COVID.

Sydney Morning Herald report

 

Let’s recall that, until July 2021, Australia had had almost ZERO cases of Covid-19. By August 2022, that figure had climbed to nearly TEN MILLION CASES.

-

Opening Australia’s borders to the coronavirus has turned out to be a massive act of self harm.
For 18 months, Australia had Covid under control. Then it threw it away.

DJ, Insane politicians/"experts" are the main cause SARS-2 did become a global disaster while 2003-SARS-1 was limited..."Saving the economy/profits" is destroying the economy...killing millions, causing long term healthproblems for hundreds of millions..."Politics" starting/escalating more wars only proof of the need for other politicians...

[url]https://southfront.org/uk-foreign-secretary-ready-to-use-nuclear-weapons-if-need-be/[/url] or https://southfront.org/uk-foreign-secretary-ready-to-use-nuclear-weapons-if-need-be/ ; The main frontrunner of the British Conservative Party, Lis Truss, made it clear that she would not hesitate to use nuclear weapons if she deemed it necessary. Her words threaten world stability, considering that she may be the next prime minister of the UK, precisely in the midst of a global context of tensions and security crisis. If the nuclear powers are unwilling to guarantee peace, the future of international relations could be devastating.

DJ, bojo did think of himself as "winston churchill", liz truss confuses herself with margeret tatcher (friend of pinochet and other fascist dictators). There is something going very wrong in "the west"...how can it be crazy persons end up in high positions...who is paying for that ? 

Climate change denial is followed by pandemic denial and wars...

-Monkeypox;

[url]https://www.coronaheadsup.com/health/monkeypox/brazil-first-case-of-monkeypox-in-a-dog/[/url] or https://www.coronaheadsup.com/health/monkeypox/brazil-first-case-of-monkeypox-in-a-dog/

The Brazilian Ministry of Health has been notified of the first confirmed case of monkeypox in a domestic animal.

It is a 5-month-old puppy that lived in the same environment and had contact with a confirmed human case of the disease. The animal started to show symptoms on August 13, it started with pruritus (itching), with lesions and crusts located on the back and neck.

The Minas Gerais State Health Department instructed the Juiz de Fora Municipal Health Department to isolate the animal and disinfect the site with bleach. It was also instructed that, whenever the owner needed to come into contact with the animal (for food and hygiene of the place), to use gloves, mask, long-sleeved shirt and pants (skin protection).

In Brazil, until now, there was no documented evidence of transmission of the disease from humans to animals. However, given the latest notifications, this type of transmission is being studied. There are two reports in the world about the infection being acquired through human transmission: in the United States and in France.

Brazilian Ministry of Health report

DJ, The main driver-still-for MPX is gay sex. But the main worry has to be spread via surfaces, aerosols and the mutations in MPX variants...

In some regions new cases of MPX seem to slow down, however high risk groups (addicted , "sex-slaves", isolated ) still could spread disease-often they already may have other STD/diseases possibly increasing the risks...Reopenin schools/workplaces could result in an increase of cases also in younger age groups. 

End of part 1


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part 2, twitter








THREAD: The WHO put out an exhaustive breakdown on monkeypox demographics globally. I’m going to highlight key findings. Buckle up: we’re going to get into all of it—age, gender, SEX—without flinching, including how 98.2% cases are male, 1.8% female https://worldhealthorg.shinyapps.io/mpx_global/

-

GENDER: Of 22,000 or so suspected cases globally, 98.2% are male, 1.8 % are females. (The CDC has started looking at trans/NB/GNC gender, but I couldn’t find it here from the WHO). There are only 397 suspected female cases in the whole world.

-

SEX (more as an action, not an identity) among males: “Among cases w known sexual orientation, 95.6% (10309/10785) identified as men who have sex with men. Of those …111 / 10309 (1.1%) were identified as bisexual men.” 96.7% are MSM at least sometimes—almost all  the of males.

DJ...in further tweets 39 MPX cases in children under 4 y/o and NO reported spread on schools yet...However "schools" may be schools for age to 12 y/o...several US universities report MPX (limited) spread...










Now SEX in 397 FEMALE cases. Again, fascinating: —96% heterosexual identified   — 61 % of cases likely sexually transmitted —34% (1/3!) suspected in a sex party setting

Some other remarks;

-These WHO numbers reflect early spread, over 22,000 cases. We are now over 50,000 confirmed cases. 

-Spanish studies showed % of gay men decreasing quite fast..from household to hotel/hospital spread increasing

-Variants seem also to increase. We never had such a major MPX outbreak before..

-Asymptomatic spread (incubation time put at around 3 weeks...maybe in some cases it takes longer ???) has been reported

-Very likely the real number of MPX cases must be in the hundreds of thousends...people may not seek medical care, hope they will recover within weeks

DJ-MPX is a major risk for all of us...MPX does spread in mice and rats...we may only see the top of the mountain...

Nationwide wastewater sampling for monkeypox: https://storage.googleapis.com/wastewater-export/mpox.html

and








California Wastewater testing for monkeypox is showing declining levels in most areas but it is pretty noisy: https://soe-wbe-pilot.wl.r.appspot.com/charts#page=overview_mpxv

may be of more use then retrospective statistics...Again! There are NO gay virusses !!!! Like HIV/AIDS in may start in limited groups (gay, prostitution) but it will spread further ! MPX is much more infectious then HIV/AIDS and has a potential to develop towards a new form of "pox"...It should be taken very serious ! And this is NOT happening now ! 

S T O P   T H E   S P R E A D   ! ! ! ! !








The US Department of Transportation is suspending 26 flights by Chinese airlines next month in a dispute over Beijing’s strict policies when travelers test positive for Covid

DJ....insane....








XAY (and its sister recombinant - the minor, currently unassigned 'constellation 2') have both been found in South Africa - they are unique in that they are clearly related but have a very complex pattern of recombination compared to previous recombinants

Again !!!! This CoViD pandemic is NOT over ! We should expect a winter-wave in the north, a summer wave in the south of the globe !!! [url]https://www.coronaheadsup.com/coronavirus/covid-19-when-do-the-winter-waves-start/[/url] or https://www.coronaheadsup.com/coronavirus/covid-19-when-do-the-winter-waves-start/ ;

DJ...recombination-variants may turn out-if they are able to spread-much higher risk then "Omicron" subvariants...








In the genomic surveillance we observe increases of certain BA.5 subvariants (ie. BF.7). It is increasingly difficult to track these variants using variant analysis due to limited changes in the spike protein. Sequencing remains crucial to supplement our variant analysis data.

DJ, Much to limited testing/reporting means much to little sampling/sequencing...we may miss to much info to see what is coming...

End of part 2

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 27 2022 at 11:31pm

DJ, 

Two stories on skin-problems and CoViD(vaccines)...

[url]https://halturnerradioshow.com/index.php/en/news-page/world/triple-or-quadruple-covid-vax-recipients-now-developing-sores-not-monkeypox[/url] or https://halturnerradioshow.com/index.php/en/news-page/world/triple-or-quadruple-covid-vax-recipients-now-developing-sores-not-monkeypox DJ-Hal Turner has been spreading a lot of non-sense on vaccines, masks, CoViD (and for that matter climate, gayrights etc). still his story;

Doctors in the United Kingdom say they are "baffled" as numerous persons who admit receiving either three or four doses of the COVID-19 "vaccine" are starting to develop strange, painful, sores all over their bodies.   

These are **NOT** Gay or bi-sexual men.  They are **NOT** people who engage in an "orgy lifestyle."   And all of them test NEGATIVE for Monkeypox.   This . . .  is something new.

The ***ONLY***thing any of these people have in common is they are ***ALL*** either Triple or quadruple COVID vaxed.  No other commonality -- at all.

The sores are developing on hands, then spreading to the rest of their bodies.

The male in the image above was fine seven days ago.  Then this appeared, and is spreading all over his body.

The sores are said to be extremely painful.  They are, as seen above, disgusting to look at.

Tests of the contents of the sores DO NOT detect any Bacteria.  Nothing from inside one of these sores grows in a Petri Dish, even after five days.

Tests also cannot see any Viruses.

Additional tests for Fungus, Mold, etc., are pending.

So far, no explanation of what this is, or if it is contagious human-to-human.

DJ...what is missing is sources...Most likely some "anti-vax-activists group" making this claim...

I did get four vaccines-have a history of skin problems-so far "in my bubble" I do not see any of these problems...

[url]https://www.thailandmedical.news/news/breaking-sars-cov-2-infections-can-trigger-henoch-schonlein-purpura-hsp-disease-in-children-and-also-in-adults[/url] or https://www.thailandmedical.news/news/breaking-sars-cov-2-infections-can-trigger-henoch-schonlein-purpura-hsp-disease-in-children-and-also-in-adults 

DJ-TMN most of the times HAS links to science studies...I would not be surprised if CoViD also results in skin-problems...in fact the article itself has 15 links to studies...

[url]https://en.wikipedia.org/wiki/Henoch%E2%80%93Sch%C3%B6nlein_purpura[/url] or https://en.wikipedia.org/wiki/Henoch%E2%80%93Sch%C3%B6nlein_purpura ;

Henoch–Schönlein purpura (HSP), also known as IgA vasculitis, is a disease of the skinmucous membranes, and sometimes other organs that most commonly affects children. In the skin, the disease causes palpable purpura (small, raised areas of bleeding underneath the skin), often with joint pain and abdominal pain. With kidney involvement, there may be a loss of small amounts of blood and protein in the urine (hematuria and proteinuria), but this usually goes unnoticed; in a small proportion of cases, the kidney involvement proceeds to chronic kidney disease. HSP is often preceded by an infection, such as a throat infection.

HSP is a systemic vasculitis (inflammation of blood vessels) and is characterized by deposition of immune complexes containing the antibody immunoglobulin A (IgA); the exact cause for this phenomenon is unknown. In children, it usually resolves within several weeks and requires no treatment apart from symptom control but may relapse in a third of cases and cause irreversible kidney damage in about one in a hundred cases. In adults, the prognosis is different from in children. The average duration of cutaneous lesions is 27.9 months.[3] For many, it tends to be relapsing–remitting over a long period of time, rather than self-limiting and there tend to be more complications.[4]

DJ, some "media" may still go for CoViD  'as a lung-virus" (can't fix stupid !)  while reality is CoViD can/will do damage all over the body...

What I hate most in viral diseases like CoViD;

-The virus may hide/stay in the body for years/rest of your life..

-The virus itself can get active after months if not years...

-The virus may also start other diseases...even when you can get rid of the virus those diseases stay (like diabetes...). 

-Long/chronic CoViD is part of a list including chronic Q-fever, ME-CFS, possibly Lyme disease...lots of ???-no answers...

-DJ I have given up-more or less-on following (sub)variants...The "several forms" of Omicron-in fact different Variants Of Concern has now maybe over 1,000 sub-variants...[url]https://outbreak.info/situation-reports[/url] or https://outbreak.info/situation-reports 

[url]https://outbreak.info/situation-reports/ba.2.75*%20%5Bomicron%20(ba.2.75.x)%5D?loc&selected[/url] or https://outbreak.info/situation-reports/ba.2.75*%20%5Bomicron%20(ba.2.75.x)%5D?loc&selected BA.2.75 allready has at least 5 sub-variants...

So an article like [url]https://www.coronaheadsup.com/science/variants/omicron/ba-2-75/preprint-ba-2-75-centaurus-may-be-much-more-infective-than-pre-existing-variants/[/url] or https://www.coronaheadsup.com/science/variants/omicron/ba-2-75/preprint-ba-2-75-centaurus-may-be-much-more-infective-than-pre-existing-variants/ makes me wonder what kind(s) of subvariant(s) is being discussed...

“These results suggest that BA.2.75 can cause more severe respiratory disease than BA.5 and BA.2.”

Two more preprints out recently suggest that Omicron Centaurus BA.2.75 variant could present more of a problem to humanity than the BA.5 variant currently dominant in many countries worldwide.

In the first preprint, researchers tested the docking affinity of BA.2.75 with ACE2 receptors compared to BA.5, and found BA.2.75 had a higher docking affinity. BA.2.75 also had the longest evolutionary distance of the S gene.

Preprint 1: SARS-CoV-2 Omicron BA.2.75 variant may be much more infective than pre-existing variants

 

In the second preprint, researchers compared damage caused by BA.2.75, BA.5 and BA.2 to the lungs of hamsters. The results were pretty startling:

“In BA.2.75, the replicative ability of BA.2.75 in the lungs was higher than that of BA.2 and BA.5.”

“These results suggest that BA.2.75 can cause more severe respiratory disease than BA.5 and BA.2.”

Preprint 2: Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

DJ, BA.5/BA.4 recombinations also may have higher risks...

So it is only getting more complex...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 28 2022 at 11:04pm

DJ...no part 2 yesterday...limited time..

[url]https://www.aol.com/news/more-polio-virus-detected-upstate-185107969-193020161.html?soc_src=aolapp[/url] or https://www.aol.com/news/more-polio-virus-detected-upstate-185107969-193020161.html?soc_src=aolapp polio detected in another New York State county...So it may be spreading...NL did see polio in refugee-sewage...(Afghanistan-link ?).

[url]https://www.coronaheadsup.com/health/animals/fish/preprint-severe-organ-damage-in-zebrafish-infected-with-sars-cov-2/[/url] or https://www.coronaheadsup.com/health/animals/fish/preprint-severe-organ-damage-in-zebrafish-infected-with-sars-cov-2/

“Our studies revealed that zebrafish showed inflammatory reaction to SARS-CoV-2 rSpike protein which provoked damage to organs (liver, kidney, ovaries and brain) …and resulted in 78.6% of survival rate in female adults during the first seven days.”.

We demonstrated, for the first time, that zebrafish injected with fragment 16 to 165 (rSpike), which corresponds to the N-terminal portion of the protein, presented mortalities and adverse effects on liver, kidney, ovary and brain tissues.  Preprint: Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish

DJ [url]https://www.coronaheadsup.com/health/vaccine/preprint-intranasal-delivery-of-sars-cov-2-spike-protein-is-sufficient-to-cause-olfactory-damage/[/url] or https://www.coronaheadsup.com/health/vaccine/preprint-intranasal-delivery-of-sars-cov-2-spike-protein-is-sufficient-to-cause-olfactory-damage/  A march 23 study on SARS-2 in Zebrafish...so not proof of CoViD spreading in fish...more an indication for a potential of spread in fish ????

[url]https://www.thailandmedical.news/news/u-s-nih-s-and-u-s-army-s-neurocovid-study-shows-that-sars-cov-2-infections-causes-serious-damage-to-microvessels-in-the-brain[/url] or https://www.thailandmedical.news/news/u-s-nih-s-and-u-s-army-s-neurocovid-study-shows-that-sars-cov-2-infections-causes-serious-damage-to-microvessels-in-the-brain 

DJ-CoViD can do damage all over the body...(maybe some of the damage only showing later on...initial infection without (major) symptoms). 








Looks likely to be hand-foot-&-mouth disease caused by a common virus. But the real story is more why "Viruses have been doing strange things since the COVID pandemic started." Widespread immune-exhaustion/suppression a huge concern. https://theconversation.com/tomato-flu-outbreak-in-india-heres-what-it-really-is-189413?utm_source=twitter&utm_medium=bylinetwitterbutton via 

DJ [url]https://www.the-sun.com/health/6085346/fears-grow-tomato-flu-outbreak-health-officials-warning/[/url] or https://www.the-sun.com/health/6085346/fears-grow-tomato-flu-outbreak-health-officials-warning/ another skin problem...








Jessica Ellis

@baddestmamajama
 · 
Incidentally and anecdotally, my nurse at the hospital yesterday said “we are completely full with heart and vascular issues - young people, kids, people having strokes, I’ve never seen this.” When I asked her why she said “I think post-Covid.”

DJ...we may face more and more problem as the result of failing to deal with CoViD...[url]https://en.wikipedia.org/wiki/Exponential_growth[/url] or https://en.wikipedia.org/wiki/Exponential_growth ; The growth of a bacterial colony is often used to illustrate it. One bacterium splits itself into two, each of which splits itself resulting in four, then eight, 16, 32, and so on. The amount of increase keeps increasing because it is proportional to the ever-increasing number of bacteria. 

Growth like this is observed in real-life activity or phenomena, such as the spread of virus infection, the growth of debt due to compound interest, and the spread of viral videos. In real cases, initial exponential growth often does not last forever, instead slowing down eventually due to upper limits caused by external factors and turning into logistic growth.

DJ, Exponential Growth /EG in a pandemic -NOT under control !- may not only result in endless (sub)variants of a virus, a next step could be other diseases getting out of control...recombinations, new diseases. Other diseases using the oppertunity to increase spread...


HARD DECISIONS—US government is forced to end its giveaway of #COVID19 at-home tests this week because of insufficient congressional funding—only enough RATs in reserve in the event of a fall surge. Pandemic response needs funding urgently. #CovidIsNotOver

DJ...If you want to get a grip on a pandemic you need massive testing ! Also in people/hosts without symptoms !!! You need to know how well vaccines are doing...how immunity evasion is working out...Government/political inaction made CoViD a pandemic...It is "beyond crazy" we go for another rounds of vaccines but fail to provide massive testing...


Federico Gueli

@siamosolocani
 · 
New update from @GenSpectrum  of current growth advantages: BA.5.2 + Orf1b:1050N is now very close (with a lot more of sequences and a prevalence between 15-30% worlwide) to BA.2.75 It will be a war of sublineages , so really hard to make any statement. https://cov-spectrum.org/collections/24

It is as good as 100% certain we will see another CoViD pandemic wave within 3 months...Very likely this wave will be worse then previous (winter) waves...A reason to "stop at home testing" is the virus/variants may evade testing...So you need BETTER tests not NO tests !!!

[url]https://public.tableau.com/app/profile/raj.rajnarayanan/viz/USAVariantDB/VariantDashboard[/url] or https://public.tableau.com/app/profile/raj.rajnarayanan/viz/USAVariantDB/VariantDashboard 

In the US BA.2.75 now 0,47% of last 15 days US cases...but other subvariants may pose a bigger risk...

DJ-I keep it with this for today...stay safe &sane !



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DJ, In latest news, nuclear war I did write my perspective on the Ukraine offensive/NATO offensive in Ukraine. Iraq is also moving towards civil war. So-background for this pandemic-increase of refugees-is "not good"...

[url]https://www.coronaheadsup.com/europe/russia/russia-second-highest-ever-peak-of-covid-19-cases/[/url] or https://www.coronaheadsup.com/europe/russia/russia-second-highest-ever-peak-of-covid-19-cases/ ;

Russia has seen a steady increase in Covid-19 cases over the past three weeks, and the second-highest ever wave of the pandemic in Russia was reported on the 27th August 2022 by OurWorldinData. 

>> Over the past week, the incidence of COVID-19 in Russia increased by 21.2%, on August 29, according to the Russian state operational headquarters for combating the spread of coronavirus.

“The incidence rate of a new coronavirus infection over the past week per 100 thousand of the population was 200.8 and increased by 21.2% compared to the previous week,” the publication says.

The ministry also noted that the increase in incidence occurred in 82 regions of Russia, while in 28 regions the increase in incidence was higher than the national average.

The headquarters also reported an increase in the number of hospitalizations. The hospitalization rate for the past week per 100,000 population was 16.7, which is 21.1% higher than the previous week. An increase in hospitalizations was recorded in 70 subjects of the Russian Federation.

<< Rossaprimavera.ru report

 

Russia is seeing a noticeable uptick in Covid-19 cases, shown below. Covid-19 cases seem to be running at more than twice the rate observed on August 29th 2021, one year ago.

DJ, [url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table has Russia cases +21% compared to last week, deaths +24% in the last 7 days...Russian cases last 7 days close to 300,000 (as far as tested/reported), US did see over 450,000 cases in the same time-cases in US -30%. 

Africa is the only region reporting an increase of cases +5%  with Nigeria +26%, Tunesia +20%...testing in Africa remains poor. An increase of cases sometimes may mean they did get testing kits...On a global scale Honduras cases +113% (from 1,435 to 3,050 these last 7 days), Bangla Desh +39% jump out...On Russia [url]https://tass.com/world/1499285[/url] or https://tass.com/world/1499285  not much details...(more or less like [url]https://rossaprimavera.ru/news/70a2d05c[/url] or https://rossaprimavera.ru/news/70a2d05c )

Only limited info at [url]https://outbreak.info/location-reports?loc=RUS&dark=true[/url] or https://outbreak.info/location-reports?loc=RUS&dark=true however BA.2.75 at 1% in Russia-last 60 days-reported august 4 could indicate a problem...BE.1.1 and BF.5 both at 2% ...recombinations ???


#COVID19 #VariantDashboard - #UnitedStates  TOP lineages (15-DAY TRENDS): 29.29% BA.5.2.1   13.83% BA.5.2 13.27% BA.5.1 7.70% BA.4.6 6.79% BA.5.5 5.89% BA.5 5.18% BA.5.6 2.79% BA.4.1 2.03% BE.1 1.76% BA.5.1.1

DJ, In the US BE.1 at 1,76% of all 15 day samples...











All eyes on #Tennessee and #Pennsylvania! Week-over-week trend in new conformed cases >50% Source: http://charts.medriva.com/us/

so some indications a winter-wave may already having an early start ?

[url]https://www.thailandmedical.news/news/breaking-new-sars-cov-2-variants-causing-blocked-airways-and-respiratory-distress-in-children-in-hong-kong[/url] or https://www.thailandmedical.news/news/breaking-new-sars-cov-2-variants-causing-blocked-airways-and-respiratory-distress-in-children-in-hong-kong 

DJ-Hong Kong cases +34%, deaths +41% (41 last week, 58 these last 7 days) [url]https://outbreak.info/location-reports?loc=HKG&dark=true[/url] or https://outbreak.info/location-reports?loc=HKG&dark=true also not very up-to-date BA.2.74 at 3% -last 60 days-per august 15? 

DJ-Disease may manifest/express themselves different in different age groups. HK now has a lot of serious disease in 0-8y/o ? 

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory MPX-cases still under 49,000? Proberbly countries stop reporting cases ? 








Gwinnett County elementary school confirms positive case of monkeypox. Officials with Gwinnett County Public Schools said that an individual at Dacula Elementary School located on the 2500 block of Fence Road has tested positive for the virus.

DJ, Schools are reopening if not already started...so both MPX (MonkeyPoX) and CoViD (Corona Viral Disease) will start further spreading...

Replying to  and 
I didn't write for AJ. She blocked me after the usual gang mocked me too. But, that's not the point. The most influential crowd decided to downplay the special constellation of features of SARS2 from the start, and now that the consequences are revealed they are changing history.

DJ, lots of "embedded experts-for-sale" claimed "live with the virus/pandemic=over" ...of course it is NOT over...








📍“she couldn’t work or drive, had lost 30 pounds, had spinal pain and lost complete vision in her left eye. She even thought about taking her own life. Smith was experiencing #longCovid.” But Black LC sufferers were especially being ignored by doctors. 😓

DJ, healthcare is not the same for everyone...so the consequences of this-ongoing-pandemic are not the same...An elite could claim "live with the virus" but that elite may be out of touch with reality for most people...

Statistics are "a great way to lie"; if you do not test you will not find cases, if there are cases in hospital you can choose to not report them so "no problem"...

Don’t be a COVID minimizer—As many kids died in the first 8 months of 2022 of #COVID19 in England🏴󠁧󠁢󠁥󠁮󠁧󠁿 as the first 8 months of 2020+2021 **combined**. 👀 Kids are not practically immune. Kids are vulnerable. Protect kids. Get them boosted. #CovidIsNotOver 

DJ, I think vaccinations did reduce CoViD-deaths-at least for some time...However to get out of this pandemic much more is needed !

-Non Pharma Interventions work !

-masks, social distancing !

-Ventilation in schools/workplaces (here in NL we end up in discussions on who will pay for that ...)

-A right to work/study from home (work from home did increase in the last years...often still not a legal right. Study from home is more difficult...maybe a switch to on-line learning...?)

-GOOD INFO !!! (Not the "post-pandemic non-sense embedded MSM comes up with !)

Here in NL only tuesday/friday CoViD updates from the NL-CDC....

DJ,

[url]https://forum.arctic-sea-ice.net/index.php/topic,3828.50.html[/url] or https://forum.arctic-sea-ice.net/index.php/topic,3828.50.html 

Most in a poll on Blue Ocean Event in the Arctic expect such an event in 2026-2030...(I am a bit more pessimistic...) Climate collapse did see politics going for lots of empty words...There is a "transfer to green energy" but most of it is for profit reasons..."e-cars" are not much better then some other cars...PR-talk...

This pandemic did see Big Pharma making billions of profit...but even a basic discussion on healthcare, infectious diseases, freedom versus responsibility is missing...

If we deal with crises as a for-profit-oppertunity we only will get more crises...

End for today...perspectives for war, climate, pandemics remain "very bad"...we need to re-think what we are doing !

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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DJ, 

-Looking at [url]https://www.ventusky.com/?p=36;-33;2&l=gust[/url] or https://www.ventusky.com/?p=36;-33;2&l=gust hurricane/cyclone season may get (re)started...Taiwan/East China may face [url]https://www.tropicaltidbits.com/storminfo/#12W[/url] or https://www.tropicaltidbits.com/storminfo/#12W "super typhoon Hinnamnor" later on moving towards Japan.In the Atlantic storms may not reach land most of the time. But september starts tomorrow-autumn for meteo/weather-science.

Pakistan did see severe flooding 1/3-1/4 of the country under water-+1,100 deaths...also a lot of cows did not survive-worsening the foodcrisis.

-The [url]https://liveuamap.com/[/url] or https://liveuamap.com/ "Ukraine offensive" DJ-in my opinion may be mostly PR...Killing lots of -most Ukraine- soldiers for no good reason. Still "the west" keeps pushing for escalation.."the rest" of the world may see this horror/insanity with growing disgust...[url]https://southfront.org/washington-recruiting-afghan-pilots-to-fight-in-ukraine/[/url] or https://southfront.org/washington-recruiting-afghan-pilots-to-fight-in-ukraine/ ; According to recent reports, the US is recruiting Afghan pilots to fight in Ukraine. The objective would be to restore Ukrainian Air Force troops after the numerous casualties caused by Russian forces during the special military operation. With that, it remains evident that the US wants to prolong the conflict at all costs, even if it is necessary to sacrifice more and more lives.

DJ, NATO restored a "sort of" Ukraine air force by collecting all kinds of Soviet-era planes and sending them into Ukraine...in fact to be shot down within 24 hrs if they are used...

If Ukraine "has to win the war" it only has a chance if NATO gets more involved-however that would start World War Three...

-[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory MPX now over 50,000 confirmed & reported cases. Limited CFR-deaths reported from the US and Brazil...both with other healthissues as well...So it may remain "hard" to get a realistic picture of MPX...Yes-there is a MPX pandemic, Yes-limited number of people die from it...The main problem however may be in the mix of CoViD, MPX and other diseases...both for more severe disease as for new illnesses...









Peru 🇵🇪 reports a 2nd death of a 35 year old patient who had monkeypox; The cause of death was septic shock caused by Bacterial pneumonia.

-CoViD cases [url]https://www.worldometers.info/coronavirus/#main_table[/url] or https://www.worldometers.info/coronavirus/#main_table reported august 30 new cases 546,424, CoViD deaths 1,673...A bad flu year may see 600,000 deaths...[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table last 7 days did see 12,503 CoViD deaths getting reported, the week before it was 16,091...with lots of CoViD deaths NOT getting in the statistics as death by (a.o. ) CoViD...52 weeks x 10,000 deaths would see 520,000 deaths...CoViD statistics-with major underreporting-still above "a bad flu year"...

[url]https://www.thailandmedical.news/news/breaking-california-study-finds-that-prior-viral-infections-including-that-by-h3n2-influenza-can-cause-covid-19-severity-due-to-antigenic-interference[/url] or https://www.thailandmedical.news/news/breaking-california-study-finds-that-prior-viral-infections-including-that-by-h3n2-influenza-can-cause-covid-19-severity-due-to-antigenic-interference ;

link to [url]https://pubmed.ncbi.nlm.nih.gov/33910993/[/url] or https://pubmed.ncbi.nlm.nih.gov/33910993/ an april 2021 study...Again a mix of diseases may see much more severe outcomes...Even the best science/computermodels may have a very hard time making sense of the "mega-mix" of (often local/regional) diseases...








Replying to 
This indicates I had a stroke at 45 years old, after COVID. Likely due to COVID. In my clinical experience with COVID & #longcovid Which is quite a bit of experience. I was just hoping to avoid the personal experience, but here we are!

DJ, also long term damage may still have to show...


An Asian beetle causes an uproar in Lucerne—the authorities react immediately "The Asian long-horned beetle can cause major tree damage within a short period of time. The authorities have taken immediate action. They don't have much time. Action!

DJ...all kinds of insects/diseases may worsen foodproduction...

If I want to be very "optimistic" I could maybe see some growing signs "we-as humans-face an existential crisis"...










Incoming—CDC vaccine advisers expected to vote Thursday on updated #BA5 variant boosters. New shots likely available within days. This is the booster I’m waiting for.

DJ, in my non-expert opinion vaccines need to be part of a larger strategy...and that strategy still is missing ! 

Limited time...so that will be it for today...

We cannot solve our problems with the same thinking we used when we created them.
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It is your fault that Ukraine prolongs the war by defending itself. Not ours for invading.
Quote Tweet







MFA Russia 🇷🇺

@mfa_russia
 · 
💬 #Zakharova: Giving more weapons to Ukrainian nationalists who are fighting their own people only prolongs the conflict and increases casualties.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote ksc Quote  Post ReplyReply Direct Link To This Post Posted: August 31 2022 at 3:16am

That's almost as funny as putin puppets claiming all UKR planes are shot down in 24 hours...

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Post Options Post Options   Thanks (0) Thanks(0)   Quote ksc Quote  Post ReplyReply Direct Link To This Post Posted: August 31 2022 at 3:21am

Russia has not launched aircraft into the air defense zone of Ukraine for more than three months

  • WAR
  •  
  • #Ukraine air force looks 2b more active & teddy's getting some spectacular views. Yesterday in south region where 🇺🇦 launched an offensive, they flew 16 missions, striking 🇷🇺 ammo depots, hardware etc. Note mirrors for rear/side views. Pics from Aug29 vid  https://facebook.com/kpszsu


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Post Options Post Options   Thanks (0) Thanks(0)   Quote ksc Quote  Post ReplyReply Direct Link To This Post Posted: August 31 2022 at 3:39am

has Russia destroyed the Ukrainian Air Force?



On August 29, 2022, Russian state news agency TASS published an article claiming that the Ukrainian Air Force was all but destroyed. 

"The entire qualified operating personnel of Ukraine’s former air force - of Mig-29, Su-27 and Su-25 aircraft - have been practically eliminated by the effective actions of the Russian Aerospace Forces and the air defense systems," an unnamed source within the military said, according to TASS. 

This is not the first time a claim like this has been made. Since the start of its full-scale invasion of Ukraine in February 2022, Russia has continued to repeat the claim that Ukrainian air assets had been almost entirely destroyed. 

In fact, on the very first day of the invasion, TASS published a statement issued by the Russian Defense Ministry, which said that Ukraine’s air defense facilities, military airfields and aviation had been destroyed with high-precision weapons. 

In March 2022 the ministry said once again that the “Ukrainian Air Force practically ceased to exist” and, later the same month, Russian Defense Minister Sergei Shoigu repeated the claim once more.  

Shoigu reiterated the claim again in June after the ministry said that it had destroyed an entire Ukrainian air base full of aircraft and personnel. 

Discrepancies 

However, the figures presented in these claims also tended to shift.  

According to Flight Global’s World Air Forces directory, at the end of 2021, the Ukrainian military (the Air Force, the Army and the Navy) had 196 active airplanes and 122 helicopters. 

The original February 24 announcement made by the Russian Defense Ministry claimed that Ukraine had 152 airplanes and 149 helicopters, which might have not included the ones used for training. By March it was announced that from this figure, 123 airplanes and 77 helicopters were destroyed. An announcement made in May stated that 180 aircraft and 127 helicopters had been destroyed. 

Later announcements did not refer to the number of destroyed aircraft, likely because the figure would greatly surpass the number of aircraft owned by Ukrainians in the first place. However, separate claims about Russian forces destroying Ukrainian aircraft continued to appear almost every day. 

Russia’s attempts to claim that it had destroyed more aircraft than had ever been owned and operated by Ukraine did not go unnoticed by the Russian public, and numerous attempts to explain this problem were published by the country’s media. Some experts claimed that the initial assessment was wrong and that the Ukrainian Air Force, in fact, had more than 600 active combat aircraft. Others alleged that the West is secretly providing Ukraine with large numbers of aircraft. Another explanation suggested that Ukraine had hastily reactivated large stocks of inactive ex-Soviet airframes in its numerous aircraft factories. 

But none of these claims aligned with official information. Russia did not correct its initial claim that Ukraine had 152 airplanes and 149 helicopters, continuing to repeat these figures in later statements. The country also made multiple claims that it had incapacitated all Ukrainian airbases and military factories several times over. 

Additionally, Russian leaders continued to threaten to further escalate the war if Western powers were to supply combat aircraft to the Ukrainian Air Force. At the time, Western countries were openly hesitant to provide new aircraft to Ukraine. Ukraine was only supplied with transport and attack helicopters, and in rather low numbers. The country was also supplied with aircraft parts that may have helped it to reactivate some old or damaged jets.  

Evidence 

Oryx blog, which documents visually confirmed loss of equipment in the Russian-Ukrainian war, lists 41 Ukrainian airplanes and 13 helicopters as confirmed losses as of late August 2022. The list is by no means complete, as visual confirmation is difficult to obtain in a war zone. However, this assessment is the only hard data we have regarding the Ukrainian losses, with Russian reports lacking any kind of visual confirmation. 

Photographic and video evidence of Ukrainian military aircraft and helicopters continuing to operate and conduct combat sorties has been plentiful throughout the entire conflict. Sukhoi Su-27s were filmed bombing Snake Island in May, and as late as mid-August the type has been spotted over Donbas. 

August also saw widespread use of AGM-88 HARM anti-radiation missiles against Russian anti-aircraft installations. Photos showing parts and fragments of these missiles were published on Russian social media channels and, while initial speculations suggested Ukraine might have adapted them to be fired from ground-based vehicles, the claim that the missiles are being fired by Ukrainian aircraft seem far more realistic. 

On August 30, the Ukrainian Air Force published a video showing MiG-29 fighter jets firing HARMs, confirming that not only is the type still active, but it has been adapted to perform an unusual role. A number of other videos depicting MiG-29s operating and launching missiles were also published during the summer of 2022

There have also been numerous allegations that aircraft supported Ukraine’s initial push around Kherson on August 29. Several unconfirmed videos of Su-25 ground attack aircraft have been posted on social media, although the time and location they show cannot be assessed. Meanwhile, Russia’s Defense Ministry claimed that its forces shot down two Su-25s over Zaporizhzhia, east of Kherson, on that day.  

Finally, in a video, which originated on Russian Telegram channels and was widely circulated following the attack, a Russian soldier can be heard stating that their positions were attacked by Ukrainian “tanks, aviation, artillery”. The footage can be said to provide at least some circumstantial evidence that Ukrainian aircraft have been involved in fighting during recent days – despite Russia’s insistence that Ukrainian aircraft have been completely destroyed. 

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... and from today's nazi briefing more lies to prove they lie every single day. But puppets are easily fooled...

"

In its daily briefing, the Russian defence ministry said Ukraine’s forces had suffered heavy losses in equipment and men.

It also said its forces had shot down three Ukrainian helicopters and that Ukraine had lost four fighter jets during two days of fighting around the Mykolaiv-Kriviy Rih frontline and in other areas of southern Ukraine.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote ksc Quote  Post ReplyReply Direct Link To This Post Posted: August 31 2022 at 4:11am

#Ukraine the counter-offensive in #Kherson it is reported that the Ukrainian Military Aviation shot down all the Russian air defence systems in the area with the new anti radar missiles provided by the USA




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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 31 2022 at 11:11pm

DJ, 

Sad to see how "someone claiming to defend freedom and democracy" in fact is (defending) silencing those with other opinions...Not a sign of strength but a sign of weakness...

For "Nuclear War" etc. see latest news...

[url]https://www.worldometers.info/coronavirus/#main_table[/url] or https://www.worldometers.info/coronavirus/#main_table ;

Yesterday, last day of august, global reported new cases 653,940 with reported CoViD deaths 1,979...In this list Russia reported (only) 46,321 new cases, 92 deaths...Trends for cases +19%, deaths +28%...it looks like Ukraine stopped reporting cases/deaths...(I think war related...wars make pandemics worse...).  In "central/eastern Europe only Slovenia reporting an increase of cases +0,8%...UK has cases now +11% on a weekly basis in worldometers, UK deaths -35%...

[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time does not show the UK-increase yet...

Global cases -17%, deaths -16%...Bangladesh cases +38%, Brazil +34%, Hong Kong +32%, Russia and Taiwan both +19%...

[url]https://www.coronaheadsup.com/europe/italy/italy-mandatory-self-isolation-for-covid-19/[/url] or https://www.coronaheadsup.com/europe/italy/italy-mandatory-self-isolation-for-covid-19/ ;

Italy is ramping up its Covid-19 winter wave preparations by announcing the return of mandatory self-isolation for those who test positive for the virus.

On the subject of the Covid positive quarantine, the Italian health minister said “there is an opinion from the Superior Health Council (CSS) that is coming and as soon as it is formalized we will make the appropriate assessments. What is certain is that if a person is positive he must stay at home, this is the very clear and clear indication. On the number of days the evaluation in these hours is made by the CSS. According to the indications of the CSS-he stated-if a person is positive he is, symptoms or no symptoms, and if it is, he must remain in isolation to avoid the spread of the infection”.

Italy is also about to approve the use of updated Covid-19 vaccines targeting the Omicron variant, despite their limited use in preventing infection:

“Our expectation is that tomorrow the European Medicines Agency Ema will be able to give the green light to vaccines adapted against the Omicron variant and then the pronouncement of the Italian Medicines Agency Aifa will follow. We count on having updated vaccines available by mid-September,” said the health minister.

Ansa.it report (in Italian)

 

Italy has had a pretty awful pandemic so far, with both infection and death rates from Covid regularly exceeding European averages. Their elderly population has borne the brunt of the unrelenting attacks by the virus since early 2020. 

Unlike the UK and the USA, however, the Italian response to Covid hasn’t been blighted by poor planning, bad leadership, a recalcitrant population or a reluctance to take common-sense measures to prevent infection. Italy’s bad luck in tackling the virus appears to be largely down to demographics and their famously open and gregarious society.

DJ..Italy cases -13%, deaths _26%...This month-september-schools/workplaces will reopen and see spread of all kinds of diseases...So far the pandemic strategy only made matters worse...

[url]https://www.thailandmedical.news/news/breaking-italian-and-american-scientist-provide-evidence-that-sars-cov-2-was-already-circulating-in-europe-as-early-as-september-2019[/url] or https://www.thailandmedical.news/news/breaking-italian-and-american-scientist-provide-evidence-that-sars-cov-2-was-already-circulating-in-europe-as-early-as-september-2019 ...TMN..

[url]https://www.sciencedirect.com/science/article/pii/S0013935122013068[/url] or https://www.sciencedirect.com/science/article/pii/S0013935122013068 ;

Abstract

As a reference laboratory for measles and rubella surveillance in Lombardy, we evaluated the association between SARS-CoV-2 infection and measles-like syndromes, providing preliminary evidence for undetected early circulation of SARS-CoV-2. Overall, 435 samples from 156 cases were investigated. RNA from oropharyngeal swabs (N = 148) and urine (N = 141) was screened with four hemi-nested PCRs and molecular evidence for SARS-CoV-2 infection was found in 13 subjects. Two of the positive patients were from the pandemic period (2/12, 16.7%, March 2020–March 2021) and 11 were from the pre-pandemic period (11/44, 25%, August 2019–February 2020).

-

The earliest sample with evidence of SARS-CoV-2 RNA was from September 12, 2019, and the positive patient was also positive for anti-SARS-CoV-2 antibodies (IgG and IgM). Mutations typical of B.1 strains previously reported to have emerged in January 2020 (C3037T, C14408T, and A23403G), were identified in samples collected as early as October 2019 in Lombardy. One of these mutations (C14408T) was also identified among sequences downloaded from public databases that were obtained by others from samples collected in Brazil in November 2019. We conclude that a SARS-CoV-2 progenitor capable of producing a measles-like syndrome may have emerged in late June-late July 2019 and that viruses with mutations characterizing B.1 strain may have been spreading globally before the first Wuhan outbreak. Our findings should be complemented by high-throughput sequencing to obtain additional sequence information. We highlight the importance of retrospective surveillance studies in understanding the early dynamics of COVID-19 spread and we encourage other groups to perform retrospective investigations to seek confirmatory proofs of early SARS-CoV-2 circulation.


DJ [url]https://www.coronaheadsup.com/science/origins/research-evidence-of-sars-cov-2-before-wuhan-outbreak-in-2019/[/url] or https://www.coronaheadsup.com/science/origins/research-evidence-of-sars-cov-2-before-wuhan-outbreak-in-2019/ 

China claimed CoViD-19 was imported...I think it is both important and impossible to dive deeper..."politics" want this pandemic to have a China-link...The TMN article has some further links to early CoViD findings...[url]https://www.coronaheadsup.com/antarctica/sars-cov-2-variant-found-in-antarctic-soil-samples-from-2018-2019/[/url] or https://www.coronaheadsup.com/antarctica/sars-cov-2-variant-found-in-antarctic-soil-samples-from-2018-2019/  (on unclear findings)

[url]https://www.coronaheadsup.com/coronavirus/bmj-first-uk-compensation-payment-for-covid-19-vaccine-death/[/url] or https://www.coronaheadsup.com/coronavirus/bmj-first-uk-compensation-payment-for-covid-19-vaccine-death/ ;

Vikki Spit from Cumbria is believed to be the first person to receive vaccine injury compensation after her 48 year old partner, Zion, died in May 2021 following vaccination with the Astrazeneca vaccine.

DJ...vaccinations are medical interventions and may give strong reactions. 

End of part 1, more/twitter in part 2

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: August 31 2022 at 11:25pm

Part 2, 

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory Confirmed MPX cases now almost 51,000-with suspected cases close to 60,000. 

There are 120 MPX deaths reported, 13 of them in countries with no history of MPX. However co-infections, lack of testing may miss MPX deaths (as a co-factor). 








A severely immunocompromised TX man infected w/ #monkeypox died Sunday, but authorities R waiting to adjudicate the role of MPX in his demise ...       

and


olireiv

@olireiv
 · 
Argentina:  "The Ministry of Public Health of Tucumán has warned that an outbreak of bilateral pneumonia has been detected in the province, where six cases of unknown origin and aetiology have already been reported. Two people have died 1/2 https://pagina12.com.ar/477856-tucuman-investigan-un-brote-de-neumonia-bilateral-que-ya-cau

-








Replying to 
Yes, I saw this one yday in spanish-spoken media. It looks VERY intriguing because 6 of the cases are health workers. 25 different bacteria , 1 hantavirus and 1 coronavirus were considered as the main cause, but ALL the results came Negative.

DJ; link [url]https://www.perfil.com/noticias/reperfilar/tucuman-alerta-maxima-en-torno-a-un-agente-patogeno-no-identificado-que-causa-neumonia.phtml[/url] or https://www.perfil.com/noticias/reperfilar/tucuman-alerta-maxima-en-torno-a-un-agente-patogeno-no-identificado-que-causa-neumonia.phtml  (Spanish)


-


context: Japan also experienced a drop in life expectancy in 2021 (but not in 2020), for the first time since 2011 (the yr of Tohoku earthquake). Female: 87.57 (-0.14) Male: 81.47 (-0.07)

DJ...like in excess deaths numbers there are many factors; heatwaves, several diseases...but the global record number of refugees also is "not helping"...








Long 🧵the NIH preprint out today showing prior COVID-19 infection can actually dampen response to boosters - so infection + boosting (hybrid immunity) doesn't always mean a better response. It can mean a dampened response because B-cells post-infection haven't recovered fully.

and [url]https://www.thailandmedical.news/news/breaking-california-study-finds-that-prior-viral-infections-including-that-by-h3n2-influenza-can-cause-covid-19-severity-due-to-antigenic-interference[/url] or https://www.thailandmedical.news/news/breaking-california-study-finds-that-prior-viral-infections-including-that-by-h3n2-influenza-can-cause-covid-19-severity-due-to-antigenic-interference 

DJ-I always believed "what does not kill you makes you stronger" was "overoptimistic"....The "wider" discussion is how CoViD-infection-on this massive-billions of cases-scale effects immunity  of "us all" against all kinds of other diseases...MPX acting in this new way has to have a CoViD-immunity problem link...


Eric Feigl-Ding

@DrEricDing
 · 
NEW—3 children have tested positive for #monkeypox in Dallas County. Just ignore this you think it’s a total coincidence that schools have started to reopen. https://cbsnews.com/dfw/news/three-children-in-dallas-county-test-positive-for-monkeypox/

DJ, since MPX is "another animal" it may not follow CoViD in the same way...however it has the (pox) risks of becoming even worse then CoViD ! 

STOP THE SPREAD !!! Do not wait till case-fatality-ratio CFR is going up...it may be to late by then !









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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 01 2022 at 11:58pm

DJ....

-Welcome news [url]https://www.zerohedge.com/geopolitical/iran-delivers-ukraine-peace-initiative-europe-moscow[/url] or https://www.zerohedge.com/geopolitical/iran-delivers-ukraine-peace-initiative-europe-moscow Iran willing to put a French proposal on peace in Ukraine-at least start of it-in Moscow and Kiev. 

We need de-escalation if we want to avoid world war three/nuclear war !

-Argentina new CoViD recombination ???? [url]https://www.thailandmedical.news/news/breaking-new-fatal-respiratory-disease-that-causes-bilateral-pneumonia-detected-in-argentina-amidst-speculations-a-new-recombinant-virus-has-emerged[/url] or https://www.thailandmedical.news/news/breaking-new-fatal-respiratory-disease-that-causes-bilateral-pneumonia-detected-in-argentina-amidst-speculations-a-new-recombinant-virus-has-emerged also discussed in latest news...may be able to get further updates (twitter/flutrackers/other)  and put it there...

Out of the known six cases two died, three in ICU...at least two out of the six are HCW-ers. Tucumán-Argentina has high HIV, animal diseases, low CoVid-testing...The new-possible-variant would escape testing...

New update here [url]https://www.thailandmedical.news/news/updates-on-new-mysterious-fatal-pneumonia-viral-disease-in-argentina-7-more-hospitalized-and-one-more-died,-total-infected-13-and-total-deaths-3[/url] or https://www.thailandmedical.news/news/updates-on-new-mysterious-fatal-pneumonia-viral-disease-in-argentina-7-more-hospitalized-and-one-more-died,-total-infected-13-and-total-deaths-3  at least 8 healthcare workers infected...NO travel restrictions...[url]https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table[/url] or https://www.worldometers.info/coronavirus/weekly-trends/#weekly_table both cases and deaths from CoVid -60%...

-[url]https://www.thailandmedical.news/news/scientist-warn-that-outbreak-of-novel-zoonotic-avian-influenza-virus-ah3n8-in-poultry-in-china-could-lead-to-a-serious-human-pandemic[/url] or https://www.thailandmedical.news/news/scientist-warn-that-outbreak-of-novel-zoonotic-avian-influenza-virus-ah3n8-in-poultry-in-china-could-lead-to-a-serious-human-pandemic ;

link to [url]https://wwwnc.cdc.gov/eid/article/28/10/22-1067_article[/url] or https://wwwnc.cdc.gov/eid/article/28/10/22-1067_article

Abstract:

Zoonotic and pandemic influenza continue to pose threats to global public health. Pandemics arise when novel influenza A viruses, derived in whole or in part from animal or avian influenza viruses, adapt to transmit efficiently in a human population that has little population immunity to contain its onward transmission. Viruses of previous pandemic concern, such as influenza A(H7N9), arose from influenza A(H9N2) viruses established in domestic poultry acquiring a hemagglutinin and neuraminidase from influenza A viruses of aquatic waterfowl. We report a novel influenza A(H3N8) virus in chicken that has emerged in a similar manner and that has been recently reported to cause zoonotic disease. Although they are H3 subtype, these avian viruses are antigenically distant from contemporary human influenza A(H3N2) viruses, and there is little cross-reactive immunity in the human population. It is essential to heighten surveillance for these avian A(H3N8) viruses in poultry and in humans.

See also [url]https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H3N8[/url] or https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H3N8 ; H3N8 is a subtype of the species Influenza A virus that is endemic in birds, horses and dogs. It is the main cause of equine influenza and is also known as equine influenza virus. In 2011, it was reported to have been found in seals.[1] Cats have been experimentally infected with the virus, leading to clinical signs, shedding of the virus and infection of other cats.[2]

DJ; IF billions of cases of CoViD infections results in weakening human defense against disease flu may be a very major risk...on top of lots of other diseases; old-like TB and new diseases, outcome of virusses/bacteria finding new ways to infect humans...

-[url]https://www.coronaheadsup.com/europe/sweden/sweden-high-levels-of-coronavirus-in-gothenburgs-wastewater/[/url] or https://www.coronaheadsup.com/europe/sweden/sweden-high-levels-of-coronavirus-in-gothenburgs-wastewater/

“The percentage of viruses is about the same as in the first virus waves”.

The level of the coronavirus in the wastewater in Gothenburg is still elevated, reports Sweden’s Radio Vetenskapsradion.

According to the results, the percentage of viruses is about the same as in the first virus waves.

The measurements, carried out by the Sahlgrenska Academy at the University of Gothenburg, extend until August 28 and also show that the level of SARS-CoV-2 no longer drops to the bottom between rises.

According to the results, the curve for the measured virus levels in the wastewater also makes an upward turn in the last week.

Dagensmedicin.se report (in Swedish)

 

The Swedish Coronavirus dashboard is showing wastewater samples across the rest of Sweden are currently stable, but we will update this post with any new information as it appears. 

There may be some evidence of an underlaying increase in Covid cases in Sweden in this bi-weekly chart. Sweden’s Covid death rate appears to be increasing at quite a clip, and, after the summer solstice trough in mid-June, the beginning of the European winter wave can be clearly seen.

DJ, Russian cases +18% in worldometers, Sweden cases -26% (Ukraine -35% but testing there will be problematic...). [url]https://www.coronaheadsup.com/coronavirus/covid-19-when-do-the-winter-waves-start/[/url] or https://www.coronaheadsup.com/coronavirus/covid-19-when-do-the-winter-waves-start/ with schools/workplaces reopening we may see the early start of a winterwave of CoViD...potentially far worse then we have seen so far with some variants getting into the lungs and causing very severe disease. 

Vaccination campains may not be in time, miss some newer variants...only limited protection against infection...

End of part 1

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 02 2022 at 3:20am

part 2, 

Trying to get more on the Tucumán-Argentina story. Is there only spread in/linked to one healthcare facility ? With legionella not detected, could there be another-very local-cause of disease ? Lots of info is still unclear ...[url]https://en.wikipedia.org/wiki/Tucum%C3%A1n_Province[/url] or https://en.wikipedia.org/wiki/Tucum%C3%A1n_Province

Tucumán (Spanish pronunciation: [tukuˈman]) is the most densely populated, and the second-smallest by land area, of the provinces of Argentina.

Located in the northwest of the country, the province has the capital of San Miguel de Tucumán, often shortened to Tucumán. Neighboring provinces are, clockwise from the north: SaltaSantiago del Estero and Catamarca. It is nicknamed El Jardín de la República (The Garden of the Republic), as it is a highly productive agricultural area.

DJ Population of the province close to 1,5 million.Sugar, fruits main agriculture-meat only for local consumption...

So still lots of ???????????????

-MPX;








🧵 🐒🦠 #Pediatric #monkeypox 🇺🇸USA 🚨min. 70 children (0-19 yrs) w/ #monkeypox This is⬆️24 children (52% increase over last week's Aug 24th count of 46.)   Please see below for more details.

-

Roland Baker 2.0

@RolandBakerIII
 · 
The United States currently has 19,759 cases of monkeypox including 70 cases in those aged 0-19 & 151 ages 0-20. California is late updating data but is at 3,841 so far surpassing even Germany. Data: https://docs.google.com/spreadsheets/d/1EjA9usSK_WbK-RukPsW6YsKFtR3bhz2jlkPLkMl_fUE/

DJ [url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory has 52,342 confirmed cases, including suspected cases 61,105. Germany has 3,480 cases-so California-3,841 cases even more then Germany...

[url]https://www.telegraph.co.uk/news/2022/09/01/monkeypox-new-strain-found-uk/[/url] or https://www.telegraph.co.uk/news/2022/09/01/monkeypox-new-strain-found-uk/ ;

A new strain of monkeypox has been identified in the UK, health officials have announced.

The UK Health Security Agency (UKHSA) said that a person who had recently been to West Africa had contracted a genetically distinct variant of the virus to the one driving the UK outbreak

The individual was moved to the Royal Liverpool University Hospital, which is designated as a High Consequence Infectious Disease (HCID) facility.

Contact tracing is being carried out to track down if there are further infections. It remains unknown how the person caught monkeypox, and if they are male or female.

There are two major variants of the monkeypox virus, Clade I and Clade II, previously known as the Congo Basin and West African clade respectively. 

Clade I has a mortality rate of around one in 10, while the death rate for Clade II is around one in 100. 

Clade II, the less deadly variant, has two known sub-clades, known as Clade IIa and Clade IIb. The latter is behind the current UK and worldwide outbreak.

It remains unknown if the new imported case from West Africa is the first instance of someone on British soil having the more deadly version of the disease.

DJ-More info will soon get available....(as far as I know there have been at least 5 (sub)variants of MPX...with this latest one maybe being new for the UK but close to the one allready found in Africa...)

CoViD;








U.S. COVID update: Nearly 1,000 new deaths, some of them from backlogs - New cases: 117,428 - Average: 86,934 (-1,779) - States reporting: 37/50 - In hospital: 37,303 (-221) - In ICU: 4,399 (-67) - New deaths: 966 - Average: 557 (+27)

DJ Worldometers [url]https://www.worldometers.info/coronavirus/#main_table[/url] or https://www.worldometers.info/coronavirus/#main_table  puts US 71,334 new cases and 403 deaths. The US so far would have had 96,347,971 cases resulting in 1,071,420 deaths..(CFR just above 1% based on these numbers...). 








It might be surprising for  residents to know that three times as many individuals died from COVID-19 the last week of August 2022 (0.12 daily deaths per 100,000 population) as compared to the last week of August 2021 (0.04). This does not seem like progress.


Image

-so from june 2022 in LA county CoViD deaths above the 2021 numbers...








Once again, Zero-COVID as a health intervention will put more years on your life than practically any diet, exercise and vice abstention regime.

DJ [url]https://www.zerohedge.com/markets/chinas-life-expectancy-now-one-year-higher-us[/url] or https://www.zerohedge.com/markets/chinas-life-expectancy-now-one-year-higher-us ;

Life expectancy in the US has fallen for the second consecutive year as Covid-19 and overdoses increased mortality rates. An empire's death may start with its people, and as the world shifts, China, an emerging power, has a life expectancy that is above the US and widening. 

According to new data from the Centers for Disease Control and Prevention, Americans' life expectancy fell .9 years to 76.1 years in 2021 - the lowest since 1996.

The year prior, life expectancy dropped by 1.8 years.

The combined figures were the largest two-year decline since the 1920s. 

DJ; So in this pandemic "Zero-CoViD including NPI gives better outcomes...most countries try to keep public healthcare available for as many as possible...

💡2x BOOSTER SAVES LIVES—New CDC data shown today shows that 2 booster shots ⬇️lowered #COVID19 death rates by 📌14x (purple line) vs unvaccinated—plus amazingly, 2 boosters ⬇️deaths 📌3x vs 1 booster alone (blue). CDC soon to approve #BA5/4 booster software update—get it please!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote roni3470 Quote  Post ReplyReply Direct Link To This Post Posted: September 02 2022 at 8:44am

Dutch - I am seeing tweets that it is a flu, not covid in Argentina....have you found anything new on it?

NOW is the Season to Know

that Everything you Do

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 02 2022 at 11:28pm

roni3470-could you put a link to the flu-twitter ? I will follow the Argentina-Tucumán story in latest news...the major news by now has to be they still did not find the cause of this double pneumonia....Spread seems to be very limited so far...more background-info (on health, CoViD-previous infections, vaccines, MPX-possible links etc. (Argentina has 133 MPX cases) would be welcome-may be on the internet somewhere...). 

Also in latest news my opinion on the nuclear war/global political crisis; west- "global NATO" (10%) against the rest (90%) wars...

-[url]https://www.coronaheadsup.com/health/monkeypox/new-strain-of-monkeypox-detected-in-the-uk/[/url] or https://www.coronaheadsup.com/health/monkeypox/new-strain-of-monkeypox-detected-in-the-uk/

Monkeypox case linked with travel to West Africa identified.

The UKHSA has confirmed that an individual has been diagnosed with monkeypox linked to recent travel to West Africa.

Preliminary genomic sequencing conducted by UKHSA indicates that this case does not have the current outbreak strain circulating in the UK. The individual has been admitted to the High Consequence Infectious Disease (HCID) unit at the Royal Liverpool University Hospital in line with standing advice from the Advisory Committee on Dangerous Pathogens (ACDP).

Contact tracing of close contacts of the individual is underway. So far, no further linked cases have been identified.

-

**Based on the new WHO nomenclature, the monkeypox virus is comprised of two clades: Clade I (formerly Congo Basin (Central African) Clade) and Clade II (formerly West African Clade). Clade II consists of the subclades Clade IIa and Clade IIb, with the latter subclade referring mainly to the group of variants circulating in the 2022 global outbreak.

Clade IIb was declassified as an HCID in July 2022 following review by the Advisory Committee on Dangerous Pathogens (ACDP) and agreement by the UK 4 Nations public health agencies.

Future importations of monkeypox cases caused by Clade I (typically found in Central Africa) and Clade IIa (typically found in West Africa) will still be classified as HCIDs, as their clinical outcomes may be more severe than Clade IIb.

UK.gov: High consequence infectious diseases (HCID)

DJ...with some luck it may remain an isolated case...[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory including suspected MPX cases now 61,398 cases, 122 deaths (most in Africa). 

-[url]https://www.coronaheadsup.com/health/animals/preprint-susceptibility-of-alpaca-cattle-sheep-horse-goat-and-rabbit-to-intranasal-infection-with-sars-cov-2/[/url] or https://www.coronaheadsup.com/health/animals/preprint-susceptibility-of-alpaca-cattle-sheep-horse-goat-and-rabbit-to-intranasal-infection-with-sars-cov-2/ ;

“We report pilot studies to evaluate the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2.”.

Highlights:

  • None of the infected animals shed infectious virus via nasal, oral, or faecal routes
  • Viral RNA was detected in several animals.
  • Neutralizing antibody titres were low or non-existent one month following infection.
  • Several individual animals (1 calf, 2 goats, and one rabbit) had RT–PCR positive nasal and/or oral swabs,
  • Live virus was isolated from the trachea of one calf necropsied on 3 DPI
  • While several animals developed low-level neutralizing antibodies within 14 days of infection, the majority were seronegative by 28 DPI
  • None of the animals displayed any clinical signs of disease or fever following inoculation
  • The lack of shedding in alpacas, which are highly susceptible to MERS-CoV, suggests camelids are unlikely to serve as a source for a recombination event between MERS-CoV and SARS-CoV-2
  • These results suggest that domestic livestock species are poorly competent hosts for SARS-CoV-2 and are unlikely to contribute to disease transmission or epidemiology
  • No reason to believe that newer human-adapted variants are any more likely to replicate in these poorly susceptible species

DJ GOOD NEWS !!! Animal spread of CoViD-risks seem to be limited (at least for the CoViD-variants so far investigated...newer subvariants could change the picture somewhat...).

Also CoViD-19 recombination with MERS seems to be low-risk...not very likely !  Of course some species (minks, cat-likes) did show to be high risk. Bats may carry up to 30 corona-virusses...Sewage samples could indicate spread in mice, rats...

CoViD-19 looks like so far a human-host problem...

[url]https://www.thailandmedical.news/news/californian-diagnostics-company-incelldx-launches-first-diagnostic-test-for-long-covid-19-in-europe[/url] or https://www.thailandmedical.news/news/californian-diagnostics-company-incelldx-launches-first-diagnostic-test-for-long-covid-19-in-europe 

The TMN article mentions 3 billion CoViD cases...if 1-in-10 would still have symptoms after 6 months you have 300 million chronic CoViD cases...PTSD, other mental issues (depression, fear/phobia) could/should be included in the CoViD story...So a test for long/chronic CoViD may be just one of the (welcome) tools...

Maybe such kind of tests could also be developed for other chronic issues, chronic Q-fever (hundreds of cases in NL) ME-CFS, Lyme disease (the available tests are far from perfect). 

-No spread in domestic animals, chronic CoViD tests, Argentina pneumonia story seems limited...maybe finally some very welcome good news !

End of part 1

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part 2, twitter most;


Monkeypox Has Potential to Cause Heart Problems Patient in case study developed myocarditis following monkeypox infection Letter: https://acc.org/About-ACC/Press-Releases/2022/09/01/15/31/Monkeypox-Has-Potential-to-Cause-Heart-Problems Full report https://jacc.org/doi/10.1016/j.jaccas.2022.08.033

DJ, hearthproblems already increasing in lots of countries due to aging and overweight. CoViD(vaccines) and now MPX may make the hearthproblems even worse...








Mucosal immunity to SARS-CoV-2 after mRNA vaccination in naive individuals and individuals with pre-existing immunity. Now out in Nature Communications. Injected mRNA vaccines are not efficient in inducing mucosal immunity. We need new vaccines!

DJ, link to [url]https://www.nature.com/articles/s41467-022-32389-8[/url] or https://www.nature.com/articles/s41467-022-32389-8 ;

Abstract

Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.

Again-I am NOT an expert...one of my questions-following "pandemic news"- is what should/can I do ? Vaccines may be "far from perfect" still statistics indicate they offer protection against severe disease/death...with limited vaccine-risks. 








US policymakers: "China, you are short USDs.  We are going to weaponize the USD against you." China: "You're right.  In response, we are putting in a price floor on lithium.  Your lithium costs just rose by 10x; please pay in USD.  Now we are no longer short USDs."

-

G7: Let's put price caps on Russian oil to fight inflation Russia: No more gas for you

DJ, On Climate Collapse "politics hopes" are in "new technologies in need of development" to reduce CO2....The NATO-Russia war in Ukraine idea was "western sanctions will destroy Russia"...even with all the evidence sanctions are destroying us-we "the west" stick to sanctions...In this pandemic(s) "vaccines only" strategy resulted in variants evading vaccines/immunity...still "politics" stick to yet another not working strategy...

Repeating mistakes over and over is a sign of insanity...it is shocking to understand "our leaders are crazy"....The pharma-industry may run out of basic materials for production of medication....worsening the already bad healthcrisis...








If it's easy to do, now might be a good time to start looking at SGTF (S gene target failure) again in SARS-CoV-2 PCR diagnostics. BA.4/5 have the dropout - so if BA.2.75* goes up we'd see dropout decrease SGTF has been useful in the past as it's ~1-3 weeks ahead of sequences.

DJ, we may have the technology to pick up early signs of new variants increasing (also sewage samples help). But one of the problems is lack of testing/sampling so limited sequencing. A "mild" subvariant can mutate to a more dangerous one...[url]https://outbreak.info/situation-reports[/url] or https://outbreak.info/situation-reports ;

DJ Omicron B.1.1.529 has 334 subtypes, BA.2 has 138 subvariants, BA.5 79 subvariants, BA.2.75 now at 7 subtypes...so known "Omicron" variants number 558...with also other/older subvariants/recombinations...Weekly global deaths still around 14,000-with lots of CoViD deaths NOT included...

Media/politics going "post-pandemic" behave criminal !








Long COVID data keeps getting worse. This doesn’t even count those without severe disability but have acute events (including deadly ones) due to organ damage including blood clots, pulmonary embolism, stroke, etc.

and 






Katie Bach

@kathrynsbach
 · 
NEW REPORT: using updated data, I find that 2-4m Americans are not working due to #longcovid. This is costing us ~$170 billion annually in lost wages alone. A thread (1/) https://brookings.edu/research/new-data-shows-long-covid-is-keeping-as-many-as-4-million-people-out-of-work

DJ Simply ignoring this is disgusting ! This "policy" is NOT saving an economy but destroying it ! It was known that if you do not stop a pandemic it only gets worse...still "politics" did make such a bad choice...

On Pakistan;









We cannot solve our problems with the same thinking we used when we created them.
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DJ (hmmmm part 2 incomplete...again)...

-Main stories/crises;

-Climate [url]https://forum.arctic-sea-ice.net/index.php/topic,3721.700.html[/url] or https://forum.arctic-sea-ice.net/index.php/topic,3721.700.html September used to bring lowest point for Arctic Sea Ice however trend is lowest point moving up...could soon be in october...

[url]https://www.nhc.noaa.gov/gtwo.php?basin=atlc&fdays=5[/url] or https://www.nhc.noaa.gov/gtwo.php?basin=atlc&fdays=5 and [url]https://www.tropicaltidbits.com/storminfo/[/url] or https://www.tropicaltidbits.com/storminfo/ hurricanes/(super)typhoons will bring lots of rain/wind a.o. to East Asia, Mexico. Western Europe could face stormy weather later on next week...May end drought and heat here (tomorrow another 30C+ day-drought major problem)

A.o. [url]https://www.ventusky.com/[/url] or https://www.ventusky.com/ has tools to see where storms are going, (ant)arctic temperatures anomalies etc. 

-War-see latest news. In short DJ-I think Russia may preparing a major offensive to "end" Ukraine (War)...and gets hands free to kick out the US in the Middle East and East Asia-a.o. with help from Iran, China...The "west" wants war-the "west" gets war...

-Argentina/Tucumán [url]https://www.thailandmedical.news/news/breaking-doctors-at-eva-peron-hospital-in-tucuman-cry-foul-amidst-coverup-by-authorities-in-argentina-claiming-mysterious-fatal-pneumonia-is-legionell[/url] or https://www.thailandmedical.news/news/breaking-doctors-at-eva-peron-hospital-in-tucuman-cry-foul-amidst-coverup-by-authorities-in-argentina-claiming-mysterious-fatal-pneumonia-is-legionell another political cover-up ? (Also latest news-Legionella may NOT fit pattern of diseases-also cases NOT linked to "start"health care facility ???

-Monkeypox

DJ, [url]https://www.coronaheadsup.com/health/monkeypox/peru-first-south-american-lineage-of-monkeypox-identified/[/url] or https://www.coronaheadsup.com/health/monkeypox/peru-first-south-american-lineage-of-monkeypox-identified/ ;

The health authorities of Peru identified the first South American lineage of the virus that causes monkeypox, which has been designated B.1.6 by the International Scientific Committee “mpxv-lineages”, an official statement reported on Wednesday.

“This B.1.6 lineage corresponds to the first new and original lineage identified in the South American region, and is characterized by the nucleotide mutation G111029A, whose impact on the behavior of the virus is still under study,” said the Ministry of Health (Minsa).

The identification of this lineage of the virus was carried out by researchers from the Genomic Surveillance Team of the National Institute of Health (INS), who have sequenced 160 complete genomes, 122 of which correspond to the B.1.6 lineage, which come from Lima.

The Minsa added that the INS researchers observed that the B.1.6 lineage is not the only one present in the country, since so far “more than ten independent introductions” of the virus have been identified in the national territory.

“There are circulating lineages in some regions such as La Libertad and Arequipa that are still under investigation, which are different from B.1.6, predominant in Lima,” the official information remarked.

Noticiasbq.com report (in Spanish)

Yesterday [url]https://www.coronaheadsup.com/health/monkeypox/new-strain-of-monkeypox-detected-in-the-uk/[/url] or https://www.coronaheadsup.com/health/monkeypox/new-strain-of-monkeypox-detected-in-the-uk/ 

From [url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Outbreak_characteristics[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Outbreak_characteristics ;

The UK Human Animal Infections and Risk Surveillance (HAIRS) group[62] warned that the virus could reach wildlife and become endemic as a result.[63][64] There is a concern that if the ongoing outbreak is prolonged, it "could establish new ecological niches in wild animals" in regions outside of Africa.[59]

Scientists are investigating circulating lineages (and potential variants) of the monkeypox virus and are comparing them against the African endemic lineages.[65][66][unreliable source][67]

In July 2022, scientists reported that the window to be able to contain the outbreak is closing or has closed.[68][69]

An analysis of studies by a journalist indicates that "about 10-to-15% of cases have been hospitalized, mostly for pain and bacterial infections that can occur as a result of monkeypox lesions".[70] Studies published a month later, in August indicated hospitalizations of small cohorts of early patients were 8%[71] and 13%.[72]

DJ, MPX is going the way CoViD went; out of control...lots of (sub)variants with the potential to get even worse then CoViD. 








Sneaky virus! We already have a CDC PCR primer failure for a variant of monkeypox in California. If you have a negative result but strongly suspect monkeypox you're going to have to send samples in for testing for now.

DJ Doing a very good job in "following global developments"...twitter worth watching !

As more scientists around the world generate & share #monkeypox sequences, the international MPXV Lineage group has designated a further three lineages to help continue to classify monkeypox diversity. https://nextstrain.org/monkeypox/hmpxv1?f_lineage=B.1.6,B.1.7,B.1.8&label=clade:B.1&m=div

Link;[url]https://nextstrain.org/monkeypox/hmpxv1?f_lineage=B.1.6,B.1.7,B.1.8&label=clade:B.1&m=div[/url] or https://nextstrain.org/monkeypox/hmpxv1?f_lineage=B.1.6,B.1.7,B.1.8&label=clade:B.1&m=div (I am not an expert-but at least three subvariants of MPX-B.1.6, B.1.7 and B.1.8 with further subvariants...

-CoViD

[url]https://www.coronaheadsup.com/africa/india-more-than-2-million-children-orphaned-by-covid-19/[/url] or https://www.coronaheadsup.com/africa/india-more-than-2-million-children-orphaned-by-covid-19/

A project by Imperial College in London outlines the horrendous toll of the pandemic on children across the globe as millions are orphaned by the virus.

In India, more than 2 million children have been orphaned

In the United States, more than 200,000 children have been orphaned

DJ link [url]https://imperialcollegelondon.github.io/orphanhood_calculator/#/country/African[/url] or https://imperialcollegelondon.github.io/orphanhood_calculator/#/country/African Africa also over 2 million children lost their parents...global number likely over 10 million children...

From NL; 


ARGOSconsortium

@ARGOSamsterdam
 · 
Update: sequencing confirmed that 5/7 BA.2-like variants are BA.2.75.*. The other 2/7 are BA.5-variants with a S:L452Q mutation (a rare finding). The deviating sample was a delta-variant (AY.34). Also rare: last time we identified a delta variant was months ago.
Show this thread

also;

Even wat aangepast. BN.1 (BA.2.75.5.1) heeft net zijn naam toegewezen gekregen! 10 samples verspreid over de wereld, waarvan niet 1 maar 2 in Nederland. (Ik had er gisteren waarschijnlijk een over het hoofd gezien, omdat GISAID hem BA.2 noemde.)

DJ; 10 BN.1/BA.2.75.5.1 samples worldwide-2 of them in NL (One was named BA.2 by GISAID earlier). 








genuinely starting to wonder if BA.2 might have some combination of properties that makes it very prone to forming second gen variants (which just didnt ever materialise for the previous variants)

DJ-Pandemic perspective for coming months is very bad....

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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part 2-short-








The olfactory mucosa seems to harbor chronic infections in at least some individuals who test negative with NP swabs. If we were able to easily look elsewhere in the body, would we see persistent infection in other organs/locations as well?

-








I also wonder about other organs. We only know about the GI tract because it regularly ejects its contents in an easily testable form. But we know SARS-CoV-2 infects myriad other organs. Are they also subject to chronic infection?

link [url]https://www.science.org/doi/10.1126/scitranslmed.abf8396[/url] or https://www.science.org/doi/10.1126/scitranslmed.abf8396 ;

Sticking the nose into COVID-19

Patients with COVID-19 can develop loss of smell and/or taste. Unfortunately, the pathophysiology of these alterations remains unclear. Here, de Melo et al. examined the olfactory mucosa in patients with COVID-19 reporting loss of smell and detected SARS-CoV-2 viral particles and inflammation in multiple cell types in the olfactory neuroepithelium, including olfactory sensory neurons. Hamster infected with SARS-CoV-2 developed loss of smell that was associated with dissemination of the virus in the olfactory mucosa and CNS and with neuroinflammation. In four patients who developed persistent loss of smell, the authors detected lasting SARS-CoV-2 presence in the olfactory mucosa, suggesting that the prolonged relapsing anosmia in patients with COVID-19 could be due to persistent viral infection.

DJ..it is easy to catch the virus-hard to get rid of. May be hiding long time/different variants in all kind of places....

According to Caixin, 33 Chinese cities, including Tianjin and 7 provincial capitals, are now under partial or full lockdowns, affecting more than 65 million residents.

DJ, China, Russia keep dealing with CoViD serious...






Yaneer Bar-Yam

@yaneerbaryam
 · 
"The Boss May Not Like It. But Millions of Workers Aren’t Coming Back to the Office. "Across the top 10 cities..occupancy rate of office buildings was only 43% recently...Before the pandemic, the rate was 99%.  https://barrons.com/articles/remote-work-return-to-the-office-51662050570

DJ, maybe those offices can turn into housing...housing often a major problem !

-[url]https://www.thehindu.com/sci-tech/science/new-sub-lineages-of-monkeypox-virus-emerge/article65842822.ece[/url] or https://www.thehindu.com/sci-tech/science/new-sub-lineages-of-monkeypox-virus-emerge/article65842822.ece ;

Despite a slow decline in cases globally, monkeypox cases continue to rise rapidly in Latin America

Global situation

As of September 2022, 10 countries account for a majority of cases (over 88%) — the U.S., Brazil, Peru, Canada, Spain, France, Germany, the U.K., Netherlands and Portugal. The disease has predominantly affected males aged between 30-43 years, although demographics have been found to differ between regions. For instance, in West and Central Africa, a larger number of cases are reported among younger individuals.

Declining in Europe

Despite an increase in the number of global cases for four consecutive weeks, the number of reported monkeypox virus infections across the world saw a decline by over 20% in the last week of August 2022. This decline is predominantly attributable to the decreasing number of reported cases in European countries.

Tracking variants

As genomic surveillance continues to provide opportunities to track the evolution of the monkeypox virus, the WHO has laid down the process of naming different variants of the virus taking into consideration the proposals put forward by scientists for a non-discriminatory nomenclature system. Following the new nomenclature, the monkeypox virus variant formerly known as the Congo Basin or Central African clade will be denoted as Clade I, while the former West African variant, which is the main circulating clade in the current outbreak, will be denoted as Clade II. Clade II of the monkeypox virus encompasses two subclades, denoted as Clade IIa and Clade IIb.

The continued genomic surveillance of monkeypox has now resulted in over 1,500 genomes available in the public domain which provides unique insights into the evolution and spread of the virus. At least two distinct lineages of the virus are known to be circulating in the present outbreak. The European outbreak was largely contributed by the IIb.B.1 lineage of virus, but a distinct but smaller lineage (IIb.A.2) presently encompassing genomes from India, the U.K., the U.S. and Thailand was also identified. This lineage has a possible origin predating the European outbreak and possibly had a cryptic spread for almost a year. The continued spread of the IIb.B.1 lineage which encompasses the majority of the genomes has resulted in many sub-lineages — over eight, including the recent one designated from Peru (B.1.6), the U.K. (B.1.7) and Germany(B.1.8).

The present monkeypox outbreak, while may have seen many learnings from the ongoing COVID-19 pandemic put to practice, has exposed many gaps as well. Even as case numbers are brought under control in European and North American countries, global efforts will be needed to contain the spread of the virus in regions such as Latin America and Africa.

DJ, Since MPX may spread via aerosols, surface, long incubation time it could become worse then CoViD. It may develop/mutate towards a more pox-like disease.

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
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DJ, 

Today liz truss "will win" the UK conservative party election-become the new UK-PM. She believes m.tatcher was a good UK-PM decades ago. As a reminder tatcher-good friend of fascist Chili dictator pinochet-did plunge the UK in an almost civil war with IRA actions increasing, a very violent minersstrike, poll-tax, race-riots...

Can truss do worse then bojo ? Yes she can ! 

There were hopes biden could undo damage trump did for the US....but from "don't test don't tell, NO Iran-deal to provoking wars-in my opinion biden at least in international politics may be even worse then the corrupt criminal trump did...

(DJ-I may not make friends this way; Is Putin a war criminal-YES, but so are Obama, Bush, Blair, BoJo and lots of western leaders involved in lots of other very bloody wars...Biden failed to restart talks with Russia on all kind of old arms agreements...The Ukraine war should have been avoided !!!). 

So pandemics;

[url]https://www.coronaheadsup.com/europe/sweden/sweden-covid-19-wave-forecasts-august-2022-to-november-2022/[/url] or https://www.coronaheadsup.com/europe/sweden/sweden-covid-19-wave-forecasts-august-2022-to-november-2022/ ;

Sweden’s Health Department has issued a document forecasting two likely scenarios for Covid-19 for the period August 2022 to November 2022.

“We have produced two scenarios that illustrate the continued spread of covid-19 during the period 20 August to 20 November 2022.

The results from both scenarios show an increase in the number of reported cases from the end of August before the number of reported cases decreases again. The peak falls at the end of September.

In scenario 0, there are approximately 5,000 reported cases at the peak, while the corresponding figure in scenario 1 is approximately 7,000 reported cases.”

 

Scenario 0 shows a wave of Covid cases for all ages in Sweden, starting in August 2022, peaking in late September 2022, and winding down in November 2022

-

Our take: Sweden has had fairly conventional winter waves in both 2020 and 2021. We’re not convinced about a wave starting in August and ending in November, but you can track it yourself with the updatable charts below.

DJ (then link to our world in data...I go for a global picture via [url]https://www.worldometers.info/coronavirus/weekly-trends/[/url] or https://www.worldometers.info/coronavirus/weekly-trends/ ). 

Point of course is that if you do NOT test-in a way-you may not have very good statistics. Sewage samples may provide good indications...[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time "self reporting of symptoms" also good indicator...An increase in Covid deaths in September 2022 could be a prelude to a winter wave that is even larger than those of 2020 and 2021…

DJ, Since we may have been in the CoViD pandemic for allmost three years-lots of proof CoViD was widespread around the globe september/october 2019-we may know new variants can make predictions/models very hard. Omicron-variants of concern (all named Omicron...maybe Omicron1 to ? may be an improvement) may be dominant. However older/other variants/recombinations also spread...both may hide in a host or spread in non-human hosts....

-[url]https://www.coronaheadsup.com/health/animals/deer/preprint-white-tailed-deer-still-harbouring-alpha-gamma-and-delta-variants-in-new-york/[/url] or https://www.coronaheadsup.com/health/animals/deer/preprint-white-tailed-deer-still-harbouring-alpha-gamma-and-delta-variants-in-new-york/ ;

Nine lineages including three major variants of concern Alpha, Gamma and Delta were detected in White-tailed deer samples in New York.

The SARS-CoV-2 sequences recovered in Season 1 were classified as B.1, B.1.1, B.1.2, B1.243, B.1.409, B.1.507 and Alpha, whereas in Season 2, B.1.1, B.1.2, B.1.517, Alpha, Gamma and Delta lineages were detected.

The Alpha variant was detected in multiple geographic locations in White-tailed deer across New York, in a time where there is no evidence that the virus was broadly circulating in humans in the state.

The time lapse between the peak of detection of Alpha and Gamma variants in humans and in White-tailed deer, suggest that these variants may have become established in White-tailed deer in New York

Detection of Alpha and Gamma variants in White-tailed deer long after their broad circulation in humans in New York suggests that White tailed deer may serve as a wildlife reservoir for SARS-CoV-2 variants of concern no longer circulating in humans. .

Preprint: White-tailed deer (Odocoileus virginianus) may serve as a wildlife reservoir for nearly extinct SARS-CoV-2 variants of concern

DJ...of course the problem is all kinds of variants may jump (direct or indirect-dog/cat eating dead deer) back to humans...

stop-the-spread, maybe a good idea ????

[url]https://www.thailandmedical.news/news/breaking-study-shows-that-one-third-of-post-covid-individuals-who-had-mild-symptoms-have-impaired-lung-function[/url] or https://www.thailandmedical.news/news/breaking-study-shows-that-one-third-of-post-covid-individuals-who-had-mild-symptoms-have-impaired-lung-function 

and 

[url]https://www.thailandmedical.news/news/alarming-new-study-data-validates-that-sars-cov-2-spike-proteins-damages-not-just-lung-cells-but-also-intestinal-cells-many-are-dying-slowly-and-silen[/url] or https://www.thailandmedical.news/news/alarming-new-study-data-validates-that-sars-cov-2-spike-proteins-damages-not-just-lung-cells-but-also-intestinal-cells-many-are-dying-slowly-and-silen 

DJ-A focus on "case-fatality-ratios" (CFR) and "claims CoViD hardly worse then the flu-so live with it" ignore long term damage. The number of "chronic CoViD cases" may be even higher then acute CoViD cases...But there is no clear definition..."Long CoViD patients often unable to fight" so politics ignores them "for the economy/profits"....Like politics ignores/uses climate collapse for profits...A greed based "civilization" will be short lived....








BA.2.75 in particular seems as if it’s evolving by following instructions from the  RBD escape calculator & ACE2 affinity heat map. The fastest lineages all have mutations at ≥1 of 346, 356, 444, 452, 486, & 490. 4/10 https://jbloomlab.github.io/SARS2_RBD_Ab_escape_maps/escape-calc/ https://jbloomlab.github.io/SARS-CoV-2-RBD_DMS_Omicron/RBD-heatmaps/


Image

1

4

21


DJ, CoViD cases soon will go up, MPX cases still going up in some regions-may mutate to a form worsening that pandemic. Polio, measles, flu, not yet making new headlines also will increase...

With an economy needed to have good public healthcare collapsing...

Outlook "Not Good"...vaccines may be of "limited help" with such a number of CoViD-variants and other diseases; exponential growth...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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part 2, 

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory Out of the 61,398 "suspected"MPX cases 19,354 are from the US. An important reason may be the US doing more testing & reporting then most other countries...but also the US may simply have more cases/spread. Public healthcare in the US simply is "not good enough"! Life expectency in the US is now under that of China, Cuba (very likely) and has been under that of Europe, Japan for a long time...The US has a major drugs and crime problem-unseen in any other "modern rich country"...the US is even exporting those problems....

Nancy Delagrave | Covid-Stop / Des N-95 pour tous

@RougeMatisse
 · 
Under what conditions would Monkeypox be the most infectious THROUGH the airborne route? Two ways. 1. At the beginning of the illness when the person is feverish and has a respiratory infection and often a sore throat. This phase is also called the prodromal phase.
Show this thread


Image

-

What is the other way Monkeypox would be the most infectious THROUGH the airborne route? 2. When the scabs fall off and we shake, move, or plump, the clothes, linens, or cushions where they have fallen. I have already shown👆🏼that an HCW was infected while changing bed linen.

DJ [url]https://en.wikipedia.org/wiki/Poxviridae[/url] or https://en.wikipedia.org/wiki/Poxviridae evolution;

The ancestor of the poxviruses is not known but structural studies suggest it may have been an adenovirus or a species related to both the poxviruses and the adenoviruses.[18]

Based on the genome organisation and DNA replication mechanism a phylogenetic relationships may exist between the rudiviruses (Rudiviridae) and the large eukaryal DNA viruses: the African swine fever virus (Asfarviridae), Chlorella viruses (Phycodnaviridae) and poxviruses (Poxviridae).[19]

The mutation rate in poxvirus genomes has been estimated to be 0.9–1.2 x 10−6 substitutions per site per year.[20] A second estimate puts this rate at 0.5–7 × 10−6 nucleotide substitutions per site per year.[21] A third estimate places the rate at 4–6 × 10−6.[22]

The last common ancestor of the extant poxviruses that infect vertebrates existed 0.5 million years ago. The genus Avipoxvirus diverged from the ancestor 249 ± 69 thousand years ago. The ancestor of the genus Orthopoxvirus was next to diverge from the other clades at 0.3 million years ago. A second estimate of this divergence time places this event at 166,000 ± 43,000 years ago.[21] The division of the Orthopoxvirus into the extant genera occurred ~14,000 years ago. The genus Leporipoxvirus diverged ~137,000 ± 35,000 years ago. This was followed by the ancestor of the genus Yatapoxvirus. The last common ancestor of the Capripoxvirus and Suipoxvirus diverged 111,000 ± 29,000 years ago.

An isolate from a fish – salmon gill poxvirus – appears to be the earliest branch in the Chordopoxvirinae.[23] A new systematic has been proposed recently after findings of a new squirrel poxvirus in Berlin, Germany.[24]

So maybe now MPX-risks/deaths may be "limited" but I think the potential is "high risk"...still "we"do not deal with it in that way...

-On the Tucumán-Argentina story;

15) At this point, Legionella or not—the Argentina 🇦🇷 health ministry has to take responsibility for their confusing messaging that they already tested multiple legionella strains that returned negative. They should have said awaiting more results on legionella.

DJ...another week maybe with more realistic info...(I believed they did find a new sort of legionella-missed earlier...but [url]https://www.thailandmedical.news/news/breaking-doctors-at-eva-peron-hospital-in-tucuman-cry-foul-amidst-coverup-by-authorities-in-argentina-claiming-mysterious-fatal-pneumonia-is-legionell[/url] or https://www.thailandmedical.news/news/breaking-doctors-at-eva-peron-hospital-in-tucuman-cry-foul-amidst-coverup-by-authorities-in-argentina-claiming-mysterious-fatal-pneumonia-is-legionell indicated that idea was to optimistic...more cases-possibly spread NOT linked to one location...). 

Did [url]https://www.worldometers.info/coronavirus/country/argentina/[/url] or https://www.worldometers.info/coronavirus/country/argentina/ simply stop reporting cases ? Brazil cases +33%...so there could be a CoViD-link ?????

[url]https://medicalxpress.com/news/2022-09-legionnaires-disease-life-argentina.html[/url] or https://medicalxpress.com/news/2022-09-legionnaires-disease-life-argentina.html ;

Legionnaires' disease has claimed a fifth life among patients and staff at a clinic in northern Argentina, provincial health officials announced Sunday.


The health ministry in Tucuman province had announced four earlier deaths on Saturday, all in the clinic in San Miguel de Tucuman, and said a total of 11 people had been infected by the rare, but severe, .

The latest death was that of a 64-year-old man with co-morbidities, officials said.

Of the six others infected, three remain in hospital and the others are being monitored at home, said Luis Medina Cruz, the Tucuman health minister.

Local officials said they are examining the clinic's water supply and air-conditioning system.

DJ...If "politics" decide "it is legionella", stop testing/reporting for CoViD ...main stream will go for legionella...even without science...

End of part 2

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DJ, 

UK next PM most likely even worse then bojo, denying climate change-not in words but in (lack of) actions..."live with the virus"-not doing anything to stop the healthcrisis other then spending cuts on the National Health Service...more war...

Some good news;

[url]https://www.coronaheadsup.com/health/vaccine/cansinobio/china-covid-19-vaccine-administered-by-inhaler-approved/[/url] or https://www.coronaheadsup.com/health/vaccine/cansinobio/china-covid-19-vaccine-administered-by-inhaler-approved/ ;

China has granted CanSinoBIO approval for its Recombinant COVID-19 Vaccine for Inhalation to be used as a booster dose.

Press release:

CanSino Biologics Inc. (“CanSinoBIO”) (SSE: 688185, HKEX: 06185) announced that the National Medical Products Administration of China (“NMPA”) has granted the Company approval for its Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) for Inhalation (trade name: Convidecia Air) to be used as a booster dose. 

Utilizing the same adenovirus vector technological platform as the intramuscular version Convidecia, Convidecia Air provides a non-invasive option that uses a nebulizer to change liquid into an aerosol for inhalation through the mouth. Convidecia Air™ is needle-free and can effectively induce comprehensive immune protection in response to SARS-CoV-2 after just one breath.

CanSinoBIO received the approval of its clinical trial application for Convidecia Air in March 2021. Studies published in The Lancet indicated that Convidecia Air™ can induce strong humoral, cellular and mucosal immunity to achieve triple protection and effectively contain the infection and spread of the virus. 

Currently, CanSinoBIO has achieved steady production of various innovative vaccines and established a global supply chain, with a goal to continue to make quality vaccine products more accessible by the global population.

CanSino Biologics Inc Press release link

DJ, Nasal sprays have been investigated almost two years as a way of vaccination...oral/mouth-spray is welcome news...

[url]https://www.thailandmedical.news/news/breaking-the-world-s-first-truly-non-invasive-continuous-glucose-monitor,-glucorx-bioxensor-set-for-launch-in-europe-in-early-2023-[/url] or https://www.thailandmedical.news/news/breaking-the-world-s-first-truly-non-invasive-continuous-glucose-monitor,-glucorx-bioxensor-set-for-launch-in-europe-in-early-2023- ;DJ, CoViD is linked to an increase of diabetes...Better "tools" can also have indirect use (glucose level may provide info on other organs). Welcome-good-news !

[url]https://www.coronaheadsup.com/europe/netherlands/netherlands-five-scenarios-for-the-future-of-the-pandemic/[/url] or https://www.coronaheadsup.com/europe/netherlands/netherlands-five-scenarios-for-the-future-of-the-pandemic/  could be "good news" in the sense of at least taking CoViD/healthcrisis serious...It did NOT make headlines in NL...

The Netherlands has published a new guide to the future of the pandemic, laying out five possible scenarios for its evolution, including a worst-case scenario.

This is a weighty report – it’s nearly 150 pages long – and covers an awful lot of ground. It is possibly the first report we have read in the nearly three years of the coronavirus pandemic that tries to answer really thorny questions such as how to manage a potential societal collapse caused by an increasingly severe pandemic.

“Literature refers to the normalcy bias. This means that people tend to assume that everything will stay the same, even when there are clear signs that it is most likely not going to be the case. The inhabitants of Pompeii watched the eruption of Mount Vesuvius for hours without thinking of fleeing.”

Scenario V – the worst scenario (in part)

Mutations of the virus make COVID-19 more deadly. The virus is circulating worldwide and claims more victims every year, in all age categories. Everyone is potentially vulnerable.

People who have had the infection or have been vaccinated are only protected against severe COVID-19 for a limited time and quickly become susceptible to reinfection again. Vaccines are occasionally available, but the virus mutates faster than the vaccines can be developed, produced and used. After a number of years, the virus will become less intense and the pandemic may ‘extend’, but before that there may be severe outbreaks for a longer period of time, with everyone at risk of a serious or even fatal disease course.

DJ...politics will ignore it...Also the "worst case scenario" may see lots of diseases getting out of control-not "just" CoViD. NL has 1,166 MPX cases...increase for now slowing down...

Code black in healthcare

Healthcare is overwhelmed in this scenario. All conceivable treatment locations are used: recovery rooms, empty operating rooms, large halls or other improvised areas. People who work in care drop out; it is impossible to find enough staff. Healthcare ends up in code black. Due to the large numbers of patients and the great lack of staff, there is no place available for people who need acute care. This applies to people with a severe course of COVID-19, but also to people who, for example, have had a car accident or have a heart attack. This means that people diewho could have been saved in other situations. Ethically very difficult choices have to be made about who receives acute care and who does not.

DJ [url]https://nltimes.nl/2022/09/06/dutch-inflation-climbs-record-12[/url] or https://nltimes.nl/2022/09/06/dutch-inflation-climbs-record-12 Highest inflation in NL history was 11,1% in 1975...so now 12% is "major" also NOT in the "worst case scenario"..."Privatized hospitals" unable to pay for energy...

[url]https://nltimes.nl/2022/09/05/netherlands-must-prepare-society-future-covid-waves-advisory-bodies[/url] or https://nltimes.nl/2022/09/05/netherlands-must-prepare-society-future-covid-waves-advisory-bodies

We have to learn to live with the coronavirus, so the government must prepare society as soon as possible for the next phase of the pandemic, 14 agencies, including the Scientific Council for Government Policy (WRR), said in advice to the Cabinet. Among other things, the Netherlands must invest in good digital infrastructure so that the switch to online classes and medical consultations can happen smoothly in the event of a revival of the coronavirus.

“Thinking through scenarios is hardly happening in politics. The strength of this report is that these 14 organizations offer a very clear and extensive insight into the various domains,” a spokesperson for the WRR said to NOS. From education to human rights, there are recommendations for every theme in the report for five scenarios ranging from very favorable to worst case.

DJ, Present neo-liberal "government"planning to decrease spending on healthcare in the hundreds of millions €....

** Editors note:

Google translate seems to have confused the “worst scenario” for the “würst scenario” and simply ended up translating it as the “Sausage scenario”…

DJ...the link has a further link to the NL study in English...it may be a "good study" compared to total denial...It will NOT be used since "politics" does not want to know we are still in a worsening health/climate crisis...

[url]https://www.coronaheadsup.com/coronavirus/argentina-two-more-deaths-linked-to-pnuemonia-cluster-in-tucuman/[/url] or https://www.coronaheadsup.com/coronavirus/argentina-two-more-deaths-linked-to-pnuemonia-cluster-in-tucuman/ and [url]https://www.thailandmedical.news/news/latest-argentinian-mysterious-fatal-pneumonia-outbreak-that-authorities-claim-is-legionella-is-still-spreading-with-22-infections-and-6-deaths-so-far[/url] or https://www.thailandmedical.news/news/latest-argentinian-mysterious-fatal-pneumonia-outbreak-that-authorities-claim-is-legionella-is-still-spreading-with-22-infections-and-6-deaths-so-far DJ-Official "political" story still "legionella" I will try to find out more in "Latest News"...

[url]https://www.thailandmedical.news/news/ongoing-outbreak-of-new-strain-of-measles-that-causes-encephalitis-has-now-caused-the-deaths-of-698-children-in-zimbabwe-and-spreading-elsewhere[/url] or https://www.thailandmedical.news/news/ongoing-outbreak-of-new-strain-of-measles-that-causes-encephalitis-has-now-caused-the-deaths-of-698-children-in-zimbabwe-and-spreading-elsewhere this new type of measles also doing a lot of neurological/brain damage...(new) vaccines may stop spread/disease...(Politics rather invest in war-industry for profits...)

[url]https://www.thailandmedical.news/news/breaking-italian-study-claims-that-sars-cov-2-could-possibly-penetrate-the-skin-through-the-eccrine-sweat-glands[/url] or https://www.thailandmedical.news/news/breaking-italian-study-claims-that-sars-cov-2-could-possibly-penetrate-the-skin-through-the-eccrine-sweat-glands CoViD getting into the body via the skin....[url]https://www.mdpi.com/2218-273X/12/9/1212[/url] or https://www.mdpi.com/2218-273X/12/9/1212 ;

Abstract

The SARS-CoV-2 pandemic has disrupted global health systems and brought the entire globe to its knees. Although born as a disease of the respiratory system, COVID-19 can affect different parts of the body, including the skin. Reports of ongoing skin manifestations of COVID-19 have gradually multiplied, pushing researchers to investigate the etiopathogenic mechanisms underlying these phenomena in more depth. In an attempt to investigate the possible association between SARS-CoV-2, ACE2, TMPRSS2 and skin manifestations, we performed immunohistochemical investigations of the ACE2 receptor and TMPRSS2 in nine skin samples from SARS-CoV-2-positive patients compared to a cohort of healthy controls. Furthermore, after consulting public databases regarding ACE2 mRNA expression in various cell populations resident in the skin, we conducted a literature review aimed at outlining the current state of this topic. We did not find statistically different immuno-expression of ACE2 and TMPRSS2 between the group of SARS-CoV-2-positive patients (nine skin biopsies) and the control group. Regarding ACE2, major immunolabeling was present in the epidermal keratinocytes and, rarely, in the fibroblasts and in the adenomeres of the eccrine sweat glands. Regarding the immune expression of TMPRSS2, we found no significant differences between the two groups, with a weak immune staining only in some skin cytotypes. From the review of the literature, we isolated 35 relevant articles according to the inclusion criteria adopted. ACE2 appears to be a target of SARS-CoV-2, although, other receptor molecules may potentially be implicated, such as TMPRSS2. Future studies with large cases and different molecular investigative methods are needed to further elucidate the mechanisms underlying the skin manifestations of SARS-CoV-2. View Full-Text

DJ, should not be a major surprise...still "bad news"

-Summary;

Lots of diseases seem to be at a high level or spreading, CoViD, MPX at pandemic level, Polio, measles (very high R0 !) increasing risks. Flu H3N2(v), other types of flu could be on the brink of becoming major...

STOP THE SPREAD !!! Should be top of the list !

The focus may be to much (NL scenario's) on ONE disease while we are already in a "mega-mix" of diseases !

Also healthcare has been overstretched (and often underfunded-money going the wrong directions !)  for much to long. 

With diseases increasing healthcare capacity decreasing (sometimes close to collapse; exponential model 12,5 next step 25% capacity loss, next step/month ? 50% capacity loss, early 2023 100% capacity loss ????) 

Politics simply denying the exponential crisis/crises make matters worse...

Pandemics, infectious diseases, CAN END humans !!! Not taking that (climate collapse linked) risk serious only increasing the chance it WILL END humans !

End of part 1


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We live in interesting times; lots of news-limited time...


Europe is having *another* extreme wave of deaths. Covid Deaths / Million People Yes. On a log scale.

DJ...tech problem...








Omicron isn't mild in children- if you look at the overall impact - the average no. of deaths/month, and hospitalisations have been greater than in any prior year of the pandemic. This is a fact. Yet, we aren't offering <5 vaccines & making access for older children harder.



















[url]

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Yesterdays part 2 "had problems" sorry for that...also ran out of time "for improvements"...

DJ,

-Wars-see latest news; In my view there is a major risk of escalation;

-september 8 western sponsor meeting on increasing further support for Ukraine

-september 11 referendum in south Ukraine on joining Russia

My impression is "thousends" of "foreign fighters" involved in Ukraine-side of the war...Only way "Ukraine=the west" can win is NATO moving in. With no real perspective on talks escalation in Ukraine may be on its way...Also Middle East, East Asia may see escalation...

-On Tucumán-Argentina if I find new (twitter/flutrackers) info see latest news...

-CoViD;

[url]https://www.coronaheadsup.com/europe/netherlands/netherlands-covid-19-this-must-be-some-kind-of-mistake/[/url] or https://www.coronaheadsup.com/europe/netherlands/netherlands-covid-19-this-must-be-some-kind-of-mistake/ ;

It looks like a major error from whoever is inputting data into the Dutch Covid statistics feed, or perhaps at the OurWorldinData site.

At least, we sincerley hope it’s an error….

DJ Ourworldindata did show a sudden increase of NL CoViD-cases-most likely that info is "incorrect" may be some "updates coincided" resulting in an alarming statistic...[url]https://www.worldometers.info/coronavirus/weekly-trends/[/url] or https://www.worldometers.info/coronavirus/weekly-trends/ NL cases +2% (7,721 last week to 7,846 this week-as far as reported...it looks like "ourworldindata" missed lots of NL cases before september 6 and corrected that with 6,000+ cases all at once on one day...

Statistics can go wrong if you do not provide extra info when needed...but the point is NL cases +2%...we may see the effect of schools/workplaces reopening...still Europe cases -11% only Russia, Ukraine reporting higher increases then NL...


ARGOSconsortium

@ARGOSamsterdam
 · 
Update: sequencing confirmed that 5/7 BA.2-like variants are BA.2.75.*. The other 2/7 are BA.5-variants with a S:L452Q mutation (a rare finding). The deviating sample was a delta-variant (AY.34). Also rare: last time we identified a delta variant was months ago.

and









Even wat aangepast. BN.1 (BA.2.75.5.1) heeft net zijn naam toegewezen gekregen! 10 samples verspreid over de wereld, waarvan niet 1 maar 2 in Nederland. (Ik had er gisteren waarschijnlijk een over het hoofd gezien, omdat GISAID hem BA.2 noemde.)

may indicate NL "has some problems" BN.1/BA.2.75.5.1 2 out of 10 global detections in NL, 

Bij de CovSpectrum collections (gesorteerde lijst #24, goed onderhouden door !) zie je mooi dat de BA.2.75.2 van de niet al te kleine sublineages, het meeste groeivoordeel heeft. https://cov-spectrum.org/collections/24

also BA.2.75.2 may become a problem...[url]https://twitter.com/BertMulderCWZ[/url] or https://twitter.com/BertMulderCWZ (in Dutch) also mentioning 10% of HCW-ers (including doctors) ill, over 30% of healthcare demand in NL related to chronic/long CoViD...

[url]https://nltimes.nl/2022/09/05/netherlands-must-prepare-society-future-covid-waves-advisory-bodies[/url] or https://nltimes.nl/2022/09/05/netherlands-must-prepare-society-future-covid-waves-advisory-bodies and [url]https://coronadashboard.government.nl/landelijk/positief-geteste-mensen[/url] or https://coronadashboard.government.nl/landelijk/positief-geteste-mensen may not yet show  it but the "winterwave" for NL did get started...

NL did see lots of mass-events, travel...NL government/media act as if there are no pandemics...with also MPX, polio in sewage at a problematic (made) refugee center (NL government trying to stop refugees by creating inhumane conditions...). 

Also [url]https://www.coronaheadsup.com/europe/uk/uk-fresh-covid-19-wave-kicks-off/[/url] or https://www.coronaheadsup.com/europe/uk/uk-fresh-covid-19-wave-kicks-off/ ;

The ZOE Covid app is showing that cases have started to climb in Britain again – just as schoolkids head back to school after the summer break.

 

4th September 2022 – 112,816 new daily cases

3rd September 2022 – 109,765 new daily cases

DJ Worldometers has UK cases -85%...very unrealistic...[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time like sewage samples however may give early indications...

[url]https://www.thailandmedical.news/news/breaking-controversial-wuhan-lab-discovers-a-novel-dna-virus-in-rodents-the-virus-belongs-to-the-polyomaviruses-family-that-can-cause-tumors-in-humans[/url] or https://www.thailandmedical.news/news/breaking-controversial-wuhan-lab-discovers-a-novel-dna-virus-in-rodents-the-virus-belongs-to-the-polyomaviruses-family-that-can-cause-tumors-in-humans link to [url]https://www.virosin.org/article/doi/10.1016/j.virs.2022.06.001[/url] or https://www.virosin.org/article/doi/10.1016/j.virs.2022.06.001 ;

Abstract

Emergence and re-emergence of infectious diseases of wildlife origin have led pre-emptive pathogen surveillances in animals to be a public health priority. 

Rodents and shrews are among the most numerically abundant vertebrate taxa and are known as natural hosts of important zoonotic viruses. 

Many surveillance programs focused more on RNA viruses. In comparison, much less is known about DNA viruses harbored by these small mammals. 

To fill this knowledge gap, tissue specimens of 232 animals including 226 rodents, five shrews and one hedgehog were collected from 5 counties in Kenya and tested for the presence of DNA viruses belonging to 7 viral families by PCR. Diverse DNA sequences of adenoviruses, adeno-associated viruses, herpesviruses and polyomaviruses were detected. Phylogenetic analyses revealed that most of these viruses showed distinction from previously described viruses and formed new clusters. Furthermore, this is the first report of the discovery and full-length genome characterization of a polyomavirus in Lemniscomys species. 

This novel polyomavirus, named LsPyV KY187, has less than 60% amino acid sequence identity to the most related Glis glis polyomavirus 1 and Sciurus carolinensis polyomavirus 1 in both large and small T-antigen proteins and thus can be putatively allocated to a novel species within Betapolyomavirus. Our findings help us better understand the genetic diversity of DNA viruses in rodent and shrew populations in Kenya and provide new insights into the evolution of those DNA viruses in their small mammal reservoirs. It demonstrates the necessity of ongoing pathogen discovery studies targeting rodent-borne viruses in East Africa.

DJ The article also underlines the "limited knowledge" we have of spread of disease in/via rodents...If you want to get pandemics under control you need to know much more on also non-human hosts, asymptomatic spread etc. 

[url]https://www.thailandmedical.news/news/international-study-shows-high-doses-of-vitamin-b9-folic-acid-increases-covid-19-risk-and-also-covid-19-mortality-risk[/url] or https://www.thailandmedical.news/news/international-study-shows-high-doses-of-vitamin-b9-folic-acid-increases-covid-19-risk-and-also-covid-19-mortality-risk DJ-I think studies on interventions in diseases have to be very complex. What can help against one disease/sub-variant case may do harm in anther disease/subvariant case...

Again I am NOT an expert-just trying to make some sense...some people are helped with some medical interventions...other people-same background-may not react or show allergies...

-Another look at statistics [url]https://www.worldometers.info/coronavirus/weekly-trends/[/url] or https://www.worldometers.info/coronavirus/weekly-trends/ global cases -22%/deaths -24% with a lot of very poor/bad reporting...some countries only update numbers once a week making trends even more unrealistic-even as indicators;

Europe cases -11% deaths -22%

Asia cases -23%, deaths -10%

Africa cases +6%, deaths -40%

Oceania cases -21%, deaths -18%

North America cases -43%, deaths -44% 

South America cases -8%, deaths -26% 

End of part 1

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DJ, part 2,

I ended part 1 with a look at coViD-statistics, I expect cases/trends to go up the coming weeks. A decrease in testing/reporting, political denial, may not be able to produce enough lies to fully undo realism...[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory very likely further increasing-with statistics running behind the facts...

Some twitter;








The economy has recovered the *number* of jobs lost in the pandemic, but not the same ones. Jobs have moved to different industries. What surprises me most in this chart is the persistence of the Covid shock. Things did not go back to normal once lockdowns ended.

-[url]https://twitter.com/juliaonjobs/status/1567198338751303681/photo/1[/url] or https://twitter.com/juliaonjobs/status/1567198338751303681/photo/1 employment in public sector down, private sector up....








You spend ages waiting for approval for inhaled vaccines, then two come along at once.

link [url]https://www.independent.co.uk/news/ap-india-china-new-delhi-twitter-b2161031.html[/url] or https://www.independent.co.uk/news/ap-india-china-new-delhi-twitter-b2161031.html

India and China have cleared a new approach in COVID-19 vaccination — two needle-free options, one a squirt in the nose and the other inhaled through the mouth.

Regulators in India authorized Bharat Biotech's nasal version on Tuesday as an option for people who haven't yet been vaccinated.

DJ, "western" vaccines remain US-profit-dominated Moderna & Pfizer..."new"-needle needed vaccines...[url]https://www.livemint.com/news/covid19-update-new-variants-may-emerge-this-winter-says-eu-11662217556821.html[/url] or https://www.livemint.com/news/covid19-update-new-variants-may-emerge-this-winter-says-eu-11662217556821.html ;

According to details, the Pfizer version updated for the now-dominant BA.4 and 5 strains should be authorised in mid-September, while a similar Moderna jab is also in the pipeline.

"But these new Omicron-adapted jabs will largely be reserved for boosters for the elderly, the vulnerable, pregnant women and healthcare workers," Cavaleri said, adding most people will get the original vaccines that are designed to tackle the Wuhan strain of coronavirus.

"The original vaccines are still able to protect against severe Covid 19 disease and death, even if they are less effective at preventing infection," he said, adding, "It was 'not excluded' that new variants this winter might end up being closer to earlier Omicron strains that had now largely been overtaken by the BA.4 and 5 types."

DJ...I find it "strange" the "west"did close the doors for non-western vaccines...The larger the variaty of offered vaccines the more people may be willing to at least accept some form of vaccine...But also vaccines NEED to be part of a wider strategy...even the "best" present vaccines will not be able to get us out of this pandemic...

[url]https://theconversation.com/cutting-covid-isolation-and-mask-mandates-will-mean-more-damage-to-business-and-health-in-the-long-run-189862[/url] or https://theconversation.com/cutting-covid-isolation-and-mask-mandates-will-mean-more-damage-to-business-and-health-in-the-long-run-189862 (Australia);

From Friday September 9, the isolation requirements for people with COVID and no symptoms will be cut from seven days to five days. Masks will no longer be required on domestic flights.

While Australian Medical Association President Steve Robson called for the release of the science behind the National Cabinet decision, the change shows we are now rapidly pushing towards a “business-as-usual” pandemic. This political strategy requires the elimination of protections or restrictions, so that life and business can go “back to normal”.

But life is nowhere near normal. COVID is the third most common killer of Australians, with 11,746 deaths so far this year. And there is mounting evidence survivors of COVID face the risk of long-term health effects on the lungs, heart, brain and immune system.

In reality, there is no going back to normal now we are living with COVID.

DJ-Non pharma Interventions may-simply-do a better job then vaccines; STOP THE SPREAD !!!

Maybe two very simple basic ideas;

1. Disease triangle; 

Disease-transport-host....

Some disease (measles already a major problem in some area's) have a very high R0/spread-very easy to catch...other diseases (MERS, so far H5N1) have a very low R0...

Hosts in this story mainly human-hosts getting infected-with bats however a main source for Corona-virus diseases...other species being a reservoir (US deer) or possible "vector" spreading infections (pets, minks...)

Transport is getting the disease into the host...From spreading diseases all over the globe via travel, to mass infections via mass-events...

Vaccines may limit disease-but fail to stop the spread-resulting in variants that are getting better in evading immunity...

2. Exponential growth...

Basic doubling of numbers within a certain time...

In this CoViD pandemic not only cases, sub-variants grow but also other diseases-decrease of immunity-is a growing problem. 

Bloomberg gets it? “You’ve got the best part of 100 million to half a billion people in the world who are very changed in their capacity to respond to viruses... There’s no way that can mean business as normal for microbial ecology.”

-


Immune dysfunction left in Covid’s wake? -Worsening of disease symptoms. Ex: rashes caused by hand, foot and mouth -Transmitting pathogens more readily / differently -Emerging chronic carriers, who could become a “vessel for viral evolution.”

DJ link [url]https://www.bloomberg.com/news/newsletters/2022-09-05/kids-with-liver-damage-polio-monkeypox-tomato-flu-viruses-are-behaving-badly?sref=fnwLs0dR[/url] or https://www.bloomberg.com/news/newsletters/2022-09-05/kids-with-liver-damage-polio-monkeypox-tomato-flu-viruses-are-behaving-badly?sref=fnwLs0dR 

Why do "experts" miss this ? Tunnelvision-overspecialized, omly looking at one aspect-not getting the "big picture"...

Why do "politics" miss this ? Unwelcome news...so look the other way...like they do in climate collapse, fiat currencies...

Maybe people with history, social sciences etc. background may be getting the "big picture" earlier ? Lots of warnings also from scientists are being ignored...

In my view at present three major risks for human survival;

1-Wars getting out of control...in fact already happening...

2-Climate collapse...from mega droughts, extreme heat, wildfires, floods...also real now...

3-Pandemics; we only may be at the start of this global healthcrisis....

End of part 2

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 07 2022 at 10:58pm

DJ, 

-Argentina outbreak and nuclear war see latest news...

[url]https://www.thailandmedical.news/news/sars-cov-2-ba-2-75-variant-is-evolving-rapidly,-spawning-many-sub-lineages-like-the-ba-2-75-2-that-is-now-the-most-immune-evasive-variant-known[/url] or https://www.thailandmedical.news/news/sars-cov-2-ba-2-75-variant-is-evolving-rapidly,-spawning-many-sub-lineages-like-the-ba-2-75-2-that-is-now-the-most-immune-evasive-variant-known newer (sub)variants of CoViD may be even better in evading immunity/testing....

[url]https://github.com/cov-lineages/pango-designation/issues/963[/url] or https://github.com/cov-lineages/pango-designation/issues/963 ;

This variant is defined by S:R346T, S:F486S, S:D1199N and was first detected in India. Now it is present in 6 countries across 3 continents (expansion into Germany with todays GISAID upload). 11 seq on Usher as of 18.08.22. Sequences carrying S:D1199N where mentioned by @RajLABN in #918However the proposed sublineage is apparently distinct from those mentioned in #961 (i.e. #918#957#944). Sequence quality is fine but the sublineage currently clusters with a bunch of lower quality sequences with a lot of dropouts (see below).

So this subvariant named BA.2.75.2 [url]https://outbreak.info/situation-reports[/url] or https://outbreak.info/situation-reports the BA.2.75 branch growing fast 19 subvariants detected/sequenced in latest update...most likely many more....

Main reason why [url]https://www.worldometers.info/coronavirus/weekly-trends/[/url] or https://www.worldometers.info/coronavirus/weekly-trends/ cases/deaths linked to CoViD go down is everybody is so tired of it all....Governments, media, healthexperts seem to give up....so the public may notice there are many problems-lots of ill people...government etc. simply walk away...

[url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory also not updated yet...denial strategy ? 

-When you look at "the big picture" western countries moving into political [url]https://www.youtube.com/watch?v=ObCu1b0i01k[/url] or https://www.youtube.com/watch?v=ObCu1b0i01k The Duran on liz truss...UK-PM "parked to do worse" so bojo can return as "an improvement"....Economies-in the west-moving high speed into full depression...hyperinflation risks for most of the west (US,UK,EU)...More endless wars...

[url]https://www.euromomo.eu/graphs-and-maps[/url] or https://www.euromomo.eu/graphs-and-maps excess deaths simply getting worse then 2020, 2021...with autumn, winter bringing worse numbers...








Final stray throught - its now clear the jumping/variant/saltation evolution of SARS2 is an intrisic property of the virus - although we also see flu-like stepwise drift I think the 'variant evolution' will continue to be the main driver of variation going forwards.

DJ, we need urgently a better strategy to get out of this collapse....

To end with something positive-NL finally moving out of an ongoing heat wave...lots of rain today...so we may limit a drinking water problem...[url]https://www.nhc.noaa.gov/[/url] or https://www.nhc.noaa.gov/ (ex)hurricane Danielle may reach Spain/Europe next week as a "depression"..California [url]https://www.nhc.noaa.gov/refresh/graphics_ep2+shtml/054705.shtml?ero#contents[/url] or https://www.nhc.noaa.gov/refresh/graphics_ep2+shtml/054705.shtml?ero#contents may see Kay bringing flash floods...More storms in many places...

Enough for today-maybe part 2/twitter most later on...

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 08 2022 at 3:08am

part 2, 

[url]https://www.thailandmedical.news/news/new-covid-19-surge-has-started-in-uk-driven-by-ba-4-ba-4-6-bf-7-and-new-ba-5-subvariants-114,914-symptomatic-infections-in-the-last-24-hours[/url] or https://www.thailandmedical.news/news/new-covid-19-surge-has-started-in-uk-driven-by-ba-4-ba-4-6-bf-7-and-new-ba-5-subvariants-114,914-symptomatic-infections-in-the-last-24-hours both hospital cases, excess deaths increasing...NHS at/over breaking point but media-silence...

In [url]https://www.worldometers.info/coronavirus/[/url] or https://www.worldometers.info/coronavirus/ and [url]https://www.worldometers.info/coronavirus/country/uk/[/url] or https://www.worldometers.info/coronavirus/country/uk/ latest update from august 25...So "UK politics" decided the pandemic is over...nothing to see here...

[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time UK government already defunded ZOE...next step would be to call it "fake news" ? (Liz Truss appointed a climate change denier as minister of energy....so maybe health-secretary/minister also push further the "post-pandemic phantasy"...).

Here in NL-underlining this pandemic is the outcome of political disasters [url]https://nltimes.nl/2022/09/07/cabinet-moving-forward-heavily-criticized-healthcare-system-changes[/url] or https://nltimes.nl/2022/09/07/cabinet-moving-forward-heavily-criticized-healthcare-system-changes ;

According to the newspaper, the IZA boils down to people who are ill being more self-reliant in the future. They’ll have to find answers online or get a digital consultation with the GP instead of heading straight to the doctor’s office. They may have to travel further for the necessary care and pay more if they choose a healthcare provider outside their health insurer’s network. All of these points were criticized in the draft agreement and still exist in the final IZA, NRC said.

General practitioners' and district nurses’ budgets will still get cut. But health insurers must give GPs more time with patients from next year, a great wish of the general practitioners. And at the last minute, the Ministry promised to invest 48 million euros into the nursing sector.

Like in the UK also NL public healthcare being destroyed by neo-liberal "politicians" that see profits as #1...








However BA.2.75 isnt the only second generation BA.2 out there - 3 more such lineages have been identified in the past month or two - all are at low numbers of sequences currently (<50) but have troubling combos of potent antigenic mutations (particularly BJ.1 and BA.2.3.20).

Like in the UK in NL CoViD cases are going up...(Worldometers has NL cases going down because there only once/twice a week updates on numbers...). Of course if you simply not report cases one can claim "cases are going down"....








“Long Covid” isn’t some nebulous or psychosomatic thing. The virus hits the brains, lungs, kidneys, and hearts. Causes organ damage and fibrosis. Remains in tissues and causes ongoing inflammation. Hits lymphoid tissue in the gut.

Chronic CoViD = real...patients may get depressed with how "politics"deal with them...but that is ON TOP of chronic infections...

⬆️UPSWING—Wastewater data is showing that #SARSCoV2 virus concentrations are on the increase again. The flattening ==> upswing trend is seen nationwide. Good time to get the #BA5/#BA4 bivalent #booster shot asap. #COVID19 #CovidIsNotOver  https://biobot.io/data/

and 


#COVID19 #VariantDashboard - #UnitedStates  TOP lineages (15-DAY TRENDS): 
30.43% BA.5.2.1   
15.88% BA.5.2 
12.24% BA.5.1 
8.34% BA.4.6👀 
5.81% BA.5.5 
5.40% BA.5 
4.94% BA.5.6 
2.12% BA.4.1 
1.76% BE.1 
1.68% BF.5 


DJ, BA.2.75 at 0,75% in the US last 15 days...BA.2.75 in New York at 1,1%....








"Jeff Bezos had Amazon employees COVID testing other Amazon employees—I'll never see my sister again" -Tina Brown, sister of Poushawn Brown. Poushawn, 38, suddenly died in 2021 after COVID testing other employees for months. She was not given N95, face shield, or other PPE...

DJ, Governments have to serve the people NOT (only) the big companies....









1 in 5.4 people are now under EXTREME HEAT WARNINGS in the US today. Let that sink in. #ClimateEmergency #climatecrisis

and


Eric Feigl-Ding

@DrEricDing
 · 
⚠️FIRST TIME ON RECORD—Greenland just experienced its largest September melt event on record, the kind of melt typically seen in the middle of the summer. Usually ice stops melting in Greenland by Sept—except 2022. Look 👀 at that melting spike!!  https://washingtonpost.com/climate-environment/2022/09/06/greenland-ice-melt-heat-wave-summer/

DJ, Climate change and pandemics have lots of links...








We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 08 2022 at 11:40pm

DJ-twitter links stay a problem copying them....

-Main news yesterday of course was the death of [url]https://en.wikipedia.org/wiki/Elizabeth_II[/url] or https://en.wikipedia.org/wiki/Elizabeth_II 

[url]https://www.moonofalabama.org/2022/09/rip-liz-ii-1.html[/url] or https://www.moonofalabama.org/2022/09/rip-liz-ii-1.html ...most European "royals" have a lot of "dark family history"...

"king charles III" has no place in the modern world...head of states should be democraticly elected...not be top of an anti-democratic elite rulling a country for centuries....

As a "person" "Q.E.II" however may have been a symbol (not much more) of stability in a fast changing world...she became UK head of state during the Korean War...february 1952...died during the Ukraine War...her death may be linked to CoViD...(but smoking will also have been a factor). 

-[url]https://www.thailandmedical.news/news/meta-analysis-study-shows-that-antioxidant-supplements-like-vitamin-c,-vitamin-d,-selenium-and-zinc-does-help-in-covid-19-clinical-outcomes-[/url] or https://www.thailandmedical.news/news/meta-analysis-study-shows-that-antioxidant-supplements-like-vitamin-c,-vitamin-d,-selenium-and-zinc-does-help-in-covid-19-clinical-outcomes- link to [url]https://onlinelibrary.wiley.com/doi/10.1002/fsn3.3034[/url] or https://onlinelibrary.wiley.com/doi/10.1002/fsn3.3034 ;

Abstract

Coronavirus disease 2019 (COVID-19) is a newly emerging viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Oxidative stress appears to be a prominent contributor to the pathogenicity of SARS-CoV-2. Therefore, we carried out a systematic review of human observational and interventional studies to investigate the role of some antioxidants such as vitamins A, E, D, and C, selenium, zinc, and α-lipoic acid in the main clinical outcomes of subjects with COVID-19. Google Scholar, Cochrane Library, Web of Science, Scopus, and Medline were searched using Medical Subject Headings (MeSH) and non-MeSH terms without restrictions. Finally, 36 studies for vitamins C and D, selenium, and zinc were included in this systematic review; however, no eligible studies were found for vitamins A and E as well as α-lipoic acid. The results showed the promising role of vitamin C in inflammation, Horowitz index, and mortality; vitamin D in disease manifestations and severity, inflammatory markers, lung involvement, ventilation requirement, hospitalization, intensive care unit (ICU) admission, and mortality; selenium in cure rate and mortality; and zinc in ventilation requirement, hospitalization, ICU admission, biomarkers of inflammation and bacterial infection, and disease complications. 

In conclusion, it seems that antioxidants, especially vitamins C and D, selenium, and zinc, can improve multiple COVID-19 clinical outcomes. Nevertheless, more studies are necessary to affirm these results.

DJ...of course the conclusion may not be "that new" it offers hope for a strategy to limit CoViD-pandemic damage...supplements/healthy food (and healthy lifestyle) can make a difference...

New nasal/oral vaccines (India, China) also offer perspectives..."the west" sticking to (for profit) US moderna and pfizer...with some-higher risk-groups getting an updated version, others the old vaccine...DJ-I would welcome more competition, why the west is closing its doors for vaccines from India, China (even Russia, Iran/Cuba) if they are cheap and effective ? Pharma-protectionism ? (the above study was from Iran...reason some may boycot it...I would like to see Iran-Israel scientist cooperation in healthcare...). 

-[url]https://www.thailandmedical.news/news/breaking-study-shows-that-a-variety-of-sars-cov-2-variants-are-at-play-in-a-single-infection-current-approach-to-sequencing-and-reporting-variants-is-[/url] or https://www.thailandmedical.news/news/breaking-study-shows-that-a-variety-of-sars-cov-2-variants-are-at-play-in-a-single-infection-current-approach-to-sequencing-and-reporting-variants-is- wrong...

Some points from the article;

-Early nasal PCR tests "showing if someone recovered" simply ignored the virus may be in other parts of the body...Newer studies do see lots of variants could be even in one person for months (DJ-Stool sample testing may give better indications...but even using DIY/at home testing with a stick in your mouth insteda of the nose is advised against...). 

-Another "claim" was "it will get mild"...DJ-Why should it ? The only "goal" of the virus is to create as much new virus (via a host) as it can...that is what a virus does....!

-Lots of medication, anti-virals being promoted that made matters worse...variants better in evading immunity...

-DJ-I want to also include the claim "vaccines are low risk & safe"...I think vaccines saved many lives-at the cost of some lives...For some the vaccines used were high risk...Indications/info on that was ignored...further increasing "scepticism...". 

-Severity of disease -in this study- was linked to a MIX of variants, with also previous infections playing a role...So not "just one" variant as a dominant/deciding factor but far more complex...

The study [url]https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010200[/url] or https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010200 ;

Abstract

SARS-CoV-2 whole genome sequencing has played an important role in documenting the emergence of polymorphisms in the viral genome and its continuing evolution during the COVID-19 pandemic. 

Here we present data from over 360 patients to characterize the complex sequence diversity of individual infections identified during multiple variant surges (e.g., Alpha and Delta). Across our survey, we observed significantly increasing SARS-CoV-2 sequence diversity during the pandemic and frequent occurrence of multiple biallelic sequence polymorphisms in all infections. 

This sequence polymorphism shows that SARS-CoV-2 infections are heterogeneous mixtures. Convention for reporting microbial pathogens guides investigators to report a majority consensus sequence. 

In our study, we found that this approach would under-report sequence variation in all samples tested. 

As we find that this sequence heterogeneity is efficiently transmitted from donors to recipients, our findings illustrate that infection complexity must be monitored and reported more completely to understand SARS-CoV-2 infection and transmission dynamics. 

Many of the nucleotide changes that would not be reported in a majority consensus sequence have now been observed as lineage defining SNPs in Omicron BA.1 and/or BA.2 variants. 

This suggests that minority alleles in earlier SARS-CoV-2 infections may play an important role in the continuing evolution of new variants of concern.

DJ...we are moving into a third year of this pandemic...Billions of people will have had the virus and/or the vaccine...some did get reinfected more then once. Infection after vaccination may give a different picture (in severity of disease-in general the vaccine is supposed to limit infection). Ignoring patient-history may be a mistake...we only now may start to see the long term damage CoViD can bring...

"This sequence polymorphism shows that #SARSCoV2 infections are HETEROGENEOUS MIXTURES. Convention for reporting microbial pathogens guides investigators to report a majority CONSENSUS SEQUENCE. In our study, we found that this approach would under-report sequence variation...

and

Pandemic News

@mildanalyst
 · 
COVID-19 infection and transmission includes complex sequence diversity https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010200

as reactions (a.o.) on this very welcome US study...








Replying to 
its an interesting question - should say that the sequencing data for the previous hcovs is very incompletely (especially historically) but as far as we can tell they dont appear to do this same jumping evolution (though we could easily have missed it)

DJ, If there are the experts and finance a retro-spective study on older CoViD cases may give extra info...It may explain also regional differences, Brazil, South Africa CoViD developing in a different direction then in the EU, US, India, Russia or China...Does "zero-CoViD"in China at least "limit complexity"????

End of part 1 (may cut parts shorter if I include rwitter-tweets...). 

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DJ, Some wise words;

"By telling the public they are tired, the administration is lowering expectations, promising less, and excusing its own shortcomings..But given half-measures in public health will only prolong the pandemic, “people are tired” is also likely to be a self-fulfilling prophecy; 20/

-

"That’s why the message needs to change, reminding Americans we are resilient, compassionate, and capable of sacrifice. Instead of rationales for resignation, we need to hear what Winston Churchill supposedly said: “When you’re going through hell, keep going.”

If we want to "get out" do not stop ! Of course it would be better not "going through hell" but once you end up there, move on !!!


"In fact, pandemic fatigue is a reason to do more in public health policy—suppressing disease transmission as efficiently as possible to keep morale from fading. The tired-public hypothesis is also an excellent argument for implementing less-obtrusive interventions... 17/

DJ...I can not imagine anyone is realy enjoying this pandemic(s) ...even those making profits out of it must be getting tired of making profits this-high risk- way...They want the problem (and profits...) under control-not out of control...

From better ventilation indoors to better information, NPI, better (nasal/oral) vaccines...lots of actions are needed urgently ! 

When your house is on fire-with you in it-the last thing to do is sit down and say it is hopeless !!!








"recent polls suggest 70% of Americans see the pandemic optimistically—as “a problem, but manageable”—potentially suggesting widespread support for preventive measures. A poll last week found a majority of both Republicans & Democrats support vaccine&mask mandates in schools.15

and 









Stop Telling Americans That They’re “Tired of Covid” "Shifting responsibility for the pandemic onto individuals is bad policy—and risks becoming a self-fulfilling prophecy of doom.

Link; [url]https://www.thenation.com/article/society/covid-pandemic-cdc-fatigue/[/url] or https://www.thenation.com/article/society/covid-pandemic-cdc-fatigue/ ;

Since last winter, the Biden administration’s response to the Covid-19 pandemic—at its best never very inspiring—has continued giving up the ghost. Amid a record-breaking level of infections and deaths in the Omicron wave earlier this year, Americans saw the rollback of indoor masking mandates in many states—soon followed by the repeal of the federal mask mandate on public transportation. In February, the CDC reshaped its own guidelines about local Covid risk in a way that will permit the public to be blindsided by surges; last week, its guidance was loosened even further. Currently, the United States faces the recent emergence of a highly transmissible new variant, the prospect of 100 million new infections this fall, and the alarming news that one in five people who test positive will experience symptoms of long Covid. National Covid fatalities remain at “a horrible plateau.”

DJ..running away from problems most of the time results in bigger problems...

Music; [url]https://www.youtube.com/watch?v=xMaE6toi4mk[/url] or https://www.youtube.com/watch?v=xMaE6toi4mk The Clash - Should I Stay Or Should I Go....

End of part 2 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 09 2022 at 11:48pm

DJ, 

I take a look at "statistics"[url]https://www.worldometers.info/coronavirus/[/url] or https://www.worldometers.info/coronavirus/ less then 500,000 new cases reported...UK, Türkiye, Argentina, Israel, Belgium a.o. simply did not report cases...UK totally stopped reporting cases...[url]https://www.worldometers.info/coronavirus/weekly-trends/[/url] or https://www.worldometers.info/coronavirus/weekly-trends/ cases worldwide -21%, deaths -21% as well only give "limited indications"....58 countries report increase of cases...(11 of them reported no cases the week before...)

[url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time however indicating UK cases going up...

[url]https://www.youtube.com/watch?v=qJetNMAyw4M[/url] or https://www.youtube.com/watch?v=qJetNMAyw4M Tim Spector/ZOE;This week, Tim shares the latest on COVID rates namely that they're rising again according to our Health Study data, and shares some insights from our ongoing Blood Pressure Study.

DJ, Symptom-selfreporting, sewage-samples can give early indications on (symptomatic) spread...UK R0 1 moving up, 1 in 44 UK citizens have CoViD, 1-in-37 younger people...

Sore throat at 66% of cases report as symptom, headache54%, blocked nose 52%, cough-no phlegm 51%, runny nose 48%....altered smell 19%, loss of smell 13% (DJ both may indicate neurological issues...???indicators for longer term problems ????) 

"Redacted" [url]https://www.youtube.com/watch?v=OEL6HzVql_g[/url] or https://www.youtube.com/watch?v=OEL6HzVql_g on Israel findings on adverse effects of Pfizer-vaccines...

DJ-My goal is trying to find out how to deal with this pandemic...I think vaccines can protect-in general...However over 12 billion CoViD vaccines have been used...often a limited group did get 3 to 4 vaccines...and a lot of people did not get any vaccine...The global vaccination campain in this pandemic is "new" in human history...Lots of other vaccinations going on but in much lower numbers...Most vaccines may NOT be mRNA  but more "traditional ones" (using adeno-virus or dead covid-virus to start immunity...) 

The US has VAERS...to report "vaccine adverse effects"...however to report those effects you need to fill in a form asking questions most people can not answer...takes you up to an hour...

In Israel a study on adverse effects did not ask for neurological problem...( a drop-down digital form may have no room for reporting main problems - so easy to ignore major issues). 

The video (a.o.) claims lots of long lasting adverse effects, from menstruation, back pain, tinitus etc. simply are ignored...while boosters make it worse... And we see a next round of booster-vaccines for many countries...

DJ-Looking at statistics my impression is "death within 4 weeks after a positive CoViD-test" may have decreased due to vaccines...however...long term excess deaths is going up...also in age groups one would not expect to see such an increase of excess deaths....

Part of the explanation may be in long term health-issues of CoViD (possibly initial infection only giving no/mild symptoms...) however I do not have any real idea of how bad adverse effects of vaccines are...You are NOT allowed to ask questions (a facebook on adverse effects-3,000 members-was deleted by FB...). 

Astra-Zeneca was "stopped" because of "adverse effects", "lack of effectiveness against CoViD variants" (in South Africa)....DJ-I think the claim "big pharma" would see more profits if every one gets ill" may be "correct" to some level...but I would like governments to get the "profit from pandemics" element out...(like in most of the non-western world...Governments run the vaccines...do the major deals with big pharma...). 

One reason we may still be in this pandemic may be "profits" ....and I hate that idea...

Another reason is "lack of vaccine strategy"...vaccines are supposed to "stop the pandemic", NPI (masks, social distance etc.) all have been given up...Even when vaccines only -at best-limit disease...not STOP infection or spread....

So I can get another booster most likely within a month...I most likely will accept it because it may have "some use" against (short term) severe illness...but more and more I wonder what is the basic idea...why are we only sinking deeper into a healthcrisis-with data only getting worse, governments simply in denial of how serious things are...

End of part 1

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DJ, part 2,

In latest news I try to follow also developments in (European) economy/energy...The US may be able to support itself better for its energy needs then most of Europe is. Russia may use the "energy-weapon" in reaction to western/EU sanctions...Europe "has a problem" -but the seize of the problem is different for each country...NL did make a jump in renewables...producing more solar-energy (in % of its energy needs) then Spain does...Also wind-turbines-of better use in autumn-did increase in NL...

However "green renewable energy" has its limits...(we did see some time ago EU energy companies getting paid for taking energy-there was more solar/wind energy then demanded...) certainly in winter. Increasing LNG-port-capacity only has a use when you can increase LNG imports...

Lots of European countries did increase imports from Russian energy to be able to sanction Russian energy later on...for the short term that means energy in storage...

Lots of European countries did provide financial compensation for higher energy costs...raising inflation...There is a staff problem in getting more renewable, isolation-increase of energy efficiency steps being made...

The basic question -pandemic related- is how deep the economic crisis will get the coming months...One of my fears is medication may become problematic...increase of people dying from diseases now under medication control. 

For that-and lots of other-matters I would like to see an end to the Ukraine war as soon as possible....

-[url]https://www.coronaheadsup.com/coronavirus/research-omicron-variant-is-highly-likely-a-product-of-artificial-genetic-modification/[/url] or https://www.coronaheadsup.com/coronavirus/research-omicron-variant-is-highly-likely-a-product-of-artificial-genetic-modification/ ;

An extraordinary claim in a research paper just released: that the Omicron variant could be a product of artificial genetic modification.

A method to find a probability that a given bias of mutations occur naturally is proposed to test whether a newly detected virus is a product of natural evolution or artificial genetic modification.

The proposed method is applied to evaluate whether the Omicron variant strain of SARS-CoV-2, whose spike protein includes 29 N mutations and only one S mutation, can emerge through natural evolution. The result of binomial test based on the proposed model shows that the bias of N/S mutations in the Omicron spike can occur with a probability of 1.6 x 10^(-3) or less. Even with the conventional model where the probabilities of any kinds of mutations are all equal, the strong N/S mutation bias in the Omicron spike can occur with a probability of 3.7 x 10^(-3), which means that the Omicron variant is highly likely a product of artificial genetic modification.

Research paper: A probabilistic approach to evaluate the likelihood of artificial genetic modification and its application to SARS-CoV-2 Omicron variant

The theory that the Omicron variant might be artificial in nature is not as outlandish as it at first seems. There was a lot of speculation when the variant was first identified about its murky origins.

-

In December 2021, some even wondered whether the variant might have been intentionally created and then released as a type of self-spreading vaccine, presumably to counter the deadly Delta variant that had been prominent earlier that year. We can certainly think of a few nations across the globe where that sort of proposal might have been quietly entertained…

DJ...If you use a "statistical model" trying to calculate "chance for mutations" it would be good to realize;

-CoViD-infections may be in the billions...most in humans-most likely non-human cases (minks ! a.o.) in the millions...

-CoViD vaccinations over 12 billion...

-Most of spread/infections may not see testing/sequencing

Like the "claim" of SARS-2/CoViD19 "came from a Wuhan lab" the chances for SARS-1/2003 MERS getting another corona-risk may not need "lab-escape"...The same kind of statistics could find the Spanish Flu or Plague "had to be created"....So I am not convinced...

-[url]https://www.coronaheadsup.com/science/variants/omicron/ba-2-75-2/ba-2-75-2-the-most-immune-evasive-strain-we-have-tested-so-far/[/url] or https://www.coronaheadsup.com/science/variants/omicron/ba-2-75-2/ba-2-75-2-the-most-immune-evasive-strain-we-have-tested-so-far/ ;

A Twitter post from Covid researcher Yunlong Cao claims that Omicron BA.2.75.2 is “currently the most immune evasive strain we have tested so far”.

Yunlong Cao is a co-author of the recent preprint “Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75” which we covered in this post.

As of 8th September 2022, the research data from Yunlong Cao on BA.2.75.2 hasn’t yet been finalized or published. We will update this post when we have more news.

-

Given the extraordinary of ability of SARS-CoV-2 to constantly reinvent itself, we are convinced that there are still some very unpleasant surprises in store for humanity with this virus.

With SARS-CoV-2 testing largely abandoned, and with the most basic of mitigations phased out, a new variant that is deadlier than Delta and more transmissible than Omicron could cause casualties on a global scale as yet unseen in human history.

 

From this post

“Literature refers to the normalcy bias. This means that people tend to assume that everything will stay the same, even when there are clear signs that it is most likely not going to be the case. The inhabitants of Pompeii watched the eruption of Mount Vesuvius for hours without thinking of fleeing

DJ, Link has lots of twitters on [url]https://outbreak.info/situation-reports/ba.2.75*%20%5Bomicron%20(ba.2.75.x)%5D?loc&selected[/url] or https://outbreak.info/situation-reports/ba.2.75*%20%5Bomicron%20(ba.2.75.x)%5D?loc&selected ....Most likely (as expected in an exponential basic idea) CoViD-19 may now see over 1,000 subvariants...[url]https://github.com/cov-lineages/pango-designation/issues[/url] or https://github.com/cov-lineages/pango-designation/issues ......

DJ [url]https://www.thailandmedical.news/news/scientist-in-taiwan-report-that-a-new-sars-cov-2-ba-2-3-7-sub-variant-with-k97e-spike-mutation-is-causing-critical-neurological-illness-in-children[/url] or https://www.thailandmedical.news/news/scientist-in-taiwan-report-that-a-new-sars-cov-2-ba-2-3-7-sub-variant-with-k97e-spike-mutation-is-causing-critical-neurological-illness-in-children ....[url]https://www.ijidonline.com/article/S1201-9712(22)00500-8/fulltext[/url] or https://www.ijidonline.com/article/S1201-9712(22)00500-8/fulltext as link;

Highlights

  • COVID-19 infection can induce severe neurologic complications in children.
  • All sequences in this study belonged to the BA.2.3 lineage.
  • The sequences displayed a novel K97E mutation in the S protein.
  • Only mutations from Japan, the USA, and the Hong Kong showed a high correlation.
  • This strain appeared in April 2022 (coincided with the Omicron outbreak in Taiwan).

In my opinion the present pandemic strategy is making matters worse...STOP THE SPREAD !!! Vaccines will NOT be able to get us out of this pandemic without NPI !

-MPX [url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory countries simply stop reporting cases ? Denial as strategy...?

[url]https://www.thailandmedical.news/news/study-discovers-that-sars-cov-2-mpro-protein-disarms-some-of-the-human-immune-responses-by-cleaving-nemo-an-immune-signaling-protein[/url] or https://www.thailandmedical.news/news/study-discovers-that-sars-cov-2-mpro-protein-disarms-some-of-the-human-immune-responses-by-cleaving-nemo-an-immune-signaling-protein  link to [url]https://www.nature.com/articles/s41467-022-32922-9[/url] or https://www.nature.com/articles/s41467-022-32922-9 ;

In addition to its essential role in viral polyprotein processing, the SARS-CoV-2 3C-like protease (3CLpro) can cleave human immune signaling proteins, like NF-κB Essential Modulator (NEMO) and deregulate the host immune response. Here, in vitro assays show that SARS-CoV-2 3CLpro cleaves NEMO with fine-tuned efficiency. Analysis of the 2.50 Å resolution crystal structure of 3CLpro C145S bound to NEMO226–234 reveals subsites that tolerate a range of viral and host substrates through main chain hydrogen bonds while also enforcing specificity using side chain hydrogen bonds and hydrophobic contacts. Machine learning- and physics-based computational methods predict that variation in key binding residues of 3CLpro-NEMO helps explain the high fitness of SARS-CoV-2 in humans. We posit that cleavage of NEMO is an important piece of information to be accounted for, in the pathology of COVID-19.

DJ...CoViD-19 destroying immunity response...may give increase of all kinds of other diseases....


Cardiac events, strokes, pulmonary embolisms, seizures are among long covid consequences that are not being counted as Covid related. "Excess deaths"
Quote Tweet







Eric Feigl-Ding

@DrEricDing
 · 
Whoa—total EXCESS DEATHS to date across Europe* in 2022 now 📌exceeds both 2021 and 2020 at the same point! 👀 Unlike spikes—seems 2022 deaths are just steadily climbing—now passing prior pandemic years like tortoise 🐢 vs the hare 🐇. Worrisome. *38 Euromomo countries. #COVID19
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DJ..I need a break...[url]https://www.euromomo.eu/graphs-and-maps[/url] or https://www.euromomo.eu/graphs-and-maps more statistics (with their limits) on excess deaths...

End of part 2

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 10 2022 at 11:34pm

DJ, 

-In latest news I did write my view on the NATO-offensive, further escalation, in Ukraine...Nuclear War risks firther increased by the end of talks on a new Iran deal....

-A M7.6 earthquake hit Papua New Guinea...I did notice smaller quakes yesterday near Biak (Once a Dutch Navy station in "Netherlands New Guinea" till 1962) ...PNG has a small population, even a possible local tsunami often only brings limited damage...However if the quake was an M9,6 "the world would be shaking" and we could see a global tsunami...

Tropical storm "Kay" did help to end a wildfire in southern California...rains may bring mud-slides...Former hurricane Danielle may bring some bad weather to Spain early coming week...

[url]https://forum.arctic-sea-ice.net/index.php/board,3.0.html[/url] or https://forum.arctic-sea-ice.net/index.php/board,3.0.html Arctic/Greenland melt should worry us all...

-DJ-Yesterday I did get tired of the bad pandemic news...Even more new variants discussed on twitter...

If "exponential growth" was very simple the pandemic-as an example-could have claimed;

1 million lives in 2020

2 million lives in 2021

4 million lives in 2022...and would claim 

8 million lives in 2023,

16 million lives in 2024 etc...

However..it is NOT that simple;

-Vaccines do save lives (however some present vaccines may bring their own problems...)

-Non Pharma Intervention, masks, social distance, travel limitations, stop on mass events all "restrict freedom" even if they will save-on the long run-millions of lives...

-Diseases will increase, not only CoViD...MPX has to be related...Polio (New York emergency) etc. as well..

-On the background the economy is on its way to crash...collapse...

-Immunity is getting weaker (African Swine Fever showing up again in pigs...was a major global problem in 2018-20...may have been a possible "root" for CoViD...DJ-Time sequence, spread ASF was major in China...CoViD did get a start there...CoViD however may have started in Africa...)

-Oral (China) nasal (India) vaccines may see widescale use...however "the west" for profit reasons sticking to US big pharma...( The "profit-ideology" put above public health...). 

So-the depressing pandemic outlook is "bad"....If it did not kill more people then the Spanish Flu-in real numbers-it soon may do so...The over 6,5 million deaths is only an "official" tip of the iceberg...Double that number may give a more realistic number...so at least 13 million CoViD deaths..."Delta" in India may have killed over 5 million in India...however they never got tested...At the high end something like 40 million CoViD deaths ? 

Then you end up in discussions on what number of excess deaths are in reality CoViD linked ? How deathly is "long/chronic" CoViD ? How many people died after vaccination(s) from side-effects of far from perfect vaccines ? May be tens/hundreds of thousends ? 

Linked to this [url]https://www.coronaheadsup.com/health/immunocompromised/significant-long-term-alterations-in-t-cell-populations-in-hospitalised-covid-patients/[/url] or https://www.coronaheadsup.com/health/immunocompromised/significant-long-term-alterations-in-t-cell-populations-in-hospitalised-covid-patients/ ;

“We see similar effects on patients with a chronic HIV infection with increased level of exhausted CD57+ CD8+ T cells.”..

SARS-CoV-2 induces a long-term altered exhausted CD57+CD8+ T cell population

To investigate the magnitude of T cell impairment during SARS-CoV-2 infection and recovery, we measured the frequency of co-inhibitory markers that are normally upregulated during exhaustion and suppression on bulk CD3+, CD4+ and CD8+ T cell subsets. CD57 is a marker of terminally differentiated, non-proliferative T cells (senescence and exhaustion) and the frequency of CD57+CD4+ and CD57+CD8+ T cells increases with age as well as with cancer and chronic infections. Dimensionality reduction showed stronger CD57 expression across bulk CD3+ cells at all-time points.

Both CD4+ and CD8+ T cell populations were examined for expression of CD57 as shown by a representative pseudo color dot plot. We found no significant difference in the proportion of CD57+CD4+ T cells between COVID-19 patients and healthy controls. Interestingly, we observed a significant surge in the percentage of CD57+CD8+ T cells among COVID-19 patients at inclusion compared to healthy controls, which increased further by the 6 week time point and was sustained up until 6-7 months. Taken together, our data clearly shows a long-lasting effect on the CD8+ T cell population with increased level of exhausted CD57+ CD8+ T cells.

Linköping University research article: T cell perturbations persist for at least 6 months following hospitalization for COVID-19

Press release: Severe COVID-19 impairs the immune system for longer than 6 months

DJ, TMN Yesterday had [url]https://www.thailandmedical.news/news/study-discovers-that-sars-cov-2-mpro-protein-disarms-some-of-the-human-immune-responses-by-cleaving-nemo-an-immune-signaling-protein[/url] or https://www.thailandmedical.news/news/study-discovers-that-sars-cov-2-mpro-protein-disarms-some-of-the-human-immune-responses-by-cleaving-nemo-an-immune-signaling-protein ...CoViD19 likely weakening our immunity defense against other diseases...now science also may find proof. 

I think that is "very bad news"....

We should be doing all we can to get pandemics under control but we do not....So CoViD-19 may have started MPX...other diseases (flu ???) likely will follow and kill many more...

Of course one could claim the Spanish Flu killed between 2 and 5% of the global population over a hundred years ago...Even if CoViD killed around 40 million it would be around 0,5% of the present global population....DJ-my answer; so far....

Other diseases then CoViD (measles doing bad things a.o. in Zimbabwe, MPX has mutation-potential...H5N1 etc) may be able to kill much more people-certainly in combination of diseases...Do we start taking it serious when people drop dead on the street on a large scale ? 

My point; There is a lot we could do to STOP THE SPREAD but we are not doing it...

End of part 1...

We cannot solve our problems with the same thinking we used when we created them.
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DJ, part 2, 

WAR-early indications for further escalation-see latest news...

-[url]https://twitter.com/Jean__Fisch/status/1568107447482466305/photo/1[/url] or https://twitter.com/Jean__Fisch/status/1568107447482466305/photo/1 schools reopening=more CoViD cases in (in this statistic/photo) Belgian children....It will bring more MIS-C cases, no doubt increase other diseases...

Schools were supposed in many countries to increase ventilation...But nobody wanted/could pay for it..."besides getting CoViD would increase the immune response"-non sense...So spread in children is a "good way" to start further spread to (grand)parents, families...

-Let me look at some statistics to get a picture of exponential growth; 

[url]https://www.worldometers.info/coronavirus/worldwide-graphs/[/url] or https://www.worldometers.info/coronavirus/worldwide-graphs/ has a lot of statistics...

A look at reported CoViD deaths;

1 million at september 9 2020

2 million, january 5 2021

3 million, april 4 2021

4 million, june 30 2021

5 million, october 25 2021

6 million, february 27 2022

Current latest number 6,516,077

Another look; 1,956,509 deaths per january 1-2021, at january 1 2022 that number was 5,483,990...

[url]https://www.euromomo.eu/graphs-and-maps[/url] or https://www.euromomo.eu/graphs-and-maps provides excess deaths of all causes, including also heatwaves (also a massive killer !) For age 0-14, 15-44 it is clear 2022 is seeing (much) higher excess deaths, most likely older age groups did get vaccinated more, did see already higher numbers earlier...If you click on 2019 one can see 2020 did show already higher excess deaths...(if you also include 2018, 2017 the picture gets even more clear...). 

There will be other (WHO, (E)CDC etc) statistics on excess deaths...however they may NOT show exponential growth, why ? 

-Vaccines matter, 

-Those most at risk may have died,

-Non Pharma steps by many others (work from home, limiting contacts)

-Autumn/Winter statistics for the northern part of the globe still not here...it may be to early to see an exponential trend...

Also on country level [url]https://www.worldometers.info/coronavirus/country/brazil/[/url] or https://www.worldometers.info/coronavirus/country/brazil/  or [url]https://www.worldometers.info/coronavirus/country/germany/[/url] or https://www.worldometers.info/coronavirus/country/germany/ not such an exponential trend...

Diseases like the flu "self limit"; once you did get it you may have long term immunity...In a bad year up to 2 million flu deaths is seen as a pandemic -a normal year may see 400,000-600,000 flu deaths worldwide...So comparing flu with CoViD after 3 years-even a bad flu-would see 3x6=1,8 million deaths not 6,5 million as CoViD does...

So there are "limiting factors" on "exponential growth" of CoViD, most likely two major ones;

-vaccines and

-most at risk died already (partly due to other causes)...

However the idea of "it will get milder" on CoViD is wrong...Even Omicron (close to 1,000 subvariants...) is NOT getting milder...Vaccines may buy us time...

Economic collapse, climate crises increase excess deaths, combining chronc CoViD with a heatwave or a flood is very unwelcome...so those factors push excess deaths up...worsen also the long term outcome of CoViD...

DJ-Maybe there is a basic wrong idea; Only counting CoViD as cause of death within 4 weeks of a positive test may simply be wrong...it is far more complex !

End of part 2

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 11 2022 at 11:47pm

DJ, 

-War see latest news, escalation goes on...a war has no winners...

[url]https://www.coronaheadsup.com/science/vaccine-breakthrough/russia-eight-times-vaccinated-vladimir-zhirinovsky-dies-of-covid-19/[/url] or https://www.coronaheadsup.com/science/vaccine-breakthrough/russia-eight-times-vaccinated-vladimir-zhirinovsky-dies-of-covid-19/ ;

Vladimir Zhirinovsky said that in a year and a half he had shot himself eight times with different Covid-19 vaccines..

Ultranationalist Russian MP Vladimir Zhirinovsky died of Covid-19 in April 2022, despite admitting having vaccinated himself eight times against the disease using different vaccines.

“So I made eight injections and didn’t get sick, and if I had done four, then perhaps I would have been caught somewhere,” he said. According to the politician, re-vaccination is necessary when the level of antibodies decreases.

According to the Mash Telegram channel, Zhirinovsky was hospitalized due to bilateral pneumonia that began against the background of the coronavirus: 50-75% of his lungs were affected. An Interfax source also said that the damage to the lungs was serious.

Forumdaily.com report

Lenta.ru report

DJ [url]https://www.worldometers.info/coronavirus/weekly-trends/[/url] or https://www.worldometers.info/coronavirus/weekly-trends/ Russia cases +4%, deaths +2% 

[url]https://tass.com/coronavirus-outbreak-in-china[/url] or https://tass.com/coronavirus-outbreak-in-china reporting on CoViD in Russia (more info on variants would be welcome...). 

-[url]https://www.coronaheadsup.com/health/long-covid/norway-46-of-covid-infected-report-long-term-effects/[/url] or https://www.coronaheadsup.com/health/long-covid/norway-46-of-covid-infected-report-long-term-effects/ ;

“As many as 46 per cent of those who had been infected with Covid in our study report long-term effects.”.

A study by the University of Bergen and Haukeland University Hospital shows that more people suffer from long Covid than previously believed.

“As many as 46 per cent of those who had been infected with Covid in our study report long-term effects, which is a very large amount,” professor and infectious medicine specialist Nina Langeland at the University of Bergen told TV2.

Overall, 46% had persisting symptoms 12 months after COVID-19. Compared with controls, adult cases had a high risk of fatigue, memory problems, concentration problems, and dyspnea.

The prevalence of memory problems increased overall from 6 to 18 months and among women.

ScienceNorway.no report

Study: Symptom Burden and Immune Dynamics 6 to 18 Months Following Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection (SARS-CoV-2): A Case-control Study

DJ, the definition of "long/chronic CoViD" goes from healthissues after 4 weeks...some still stick to an idea CoViD is over after 4 weeks-people dying later can not die from CoViD in that view...to 4, 6, 12 months...

Also 46% of cases still with problems after a year; can they return to their jobs ? Maybe only part time ? Or do they even need help in their households ? 

The chronic CoViD story reminds me of ME-CFS...[url]https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome[/url] or https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome My idea on ME-CFS is there may have been a link to infection(s), sort of post-viral syndrome...Mental aspects (depression, fear) come on top of it when there is not enough support...Mourning over loss of quality of life, acceptance of that loss are aspects...Long/chronc CoViD patients may benefit from contacts with other "patients" running into the same kind of problems...Legal support also can help to at least have some form of income...

Auto-immune issues, chronic fatigue-immunity deficiency syndrome is also seen in chronic CoViD cases...There by now most likely will be more chronic CoViD cases then acute ones...

-Polio

[url]https://www.coronaheadsup.com/health/polio/usa-state-of-emergency-declared-in-new-york-over-polio/[/url] or https://www.coronaheadsup.com/health/polio/usa-state-of-emergency-declared-in-new-york-over-polio/ ;

New York’s governor, Kathy Hochul, declared a state of emergency over polio on September 9th 2022 after the virus was detected in the wastewater of yet another county in the New York City area.

The latest detection involved a wastewater sample collected last month in Nassau county on Long Island.

  • The sample identified in Nassau County was collected in August.
  • Of the 57 positive samples of concern, 50 samples have been found to be genetically linked to the individual case of paralytic polio among a Rockland County resident.
  • Of the 50 samples, 31 samples were collected in Rockland County, 13 samples were collected in Orange County, 6 samples were collected in Sullivan County, and 1 sample was collected in Nassau County.
  • Of the 31 samples identified in Rockland County, 2 were collected in May, 3 were collected in June, 9 were collected in July, and 17 were collected in August.
  • Of the 12 samples identified in Orange County, 2 were collected in June, 5 were collected in July, and 5 in August.
  • Of the 6 samples identified in Sullivan County, 2 were collected in July and 4 were collected in August.
  • 7 positive samples of concern, 1 collected in April from Orange County and 2 collected in June and 4 collected in July from New York City have also been identified. While at this time, these samples have not been genetically linked to the individual case in Rockland County, sequencing analysis characterizes these samples as either a vaccine-derived poliovirus (1, collected in New York City in July) or variants of the revertant polio Sabin type 2 poliovirus (6, 3 collected in July and 2 collected in June in New York City; 1 collected in April in Orange County). Both of these types of polioviruses can cause illness, including paralysis, in humans.

CNBC report

NYSDOH wastewater surveillance report

BBC report

DJ, Polio may be widespread...in most cases it will remain with no or mild symptoms, only a small % develop serious disease/long lasting problems...

-MPX, I don't know [url]https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory[/url] or https://en.wikipedia.org/wiki/2022_monkeypox_outbreak#Cases_per_country_and_territory is this still getting updated ? 

In the Americas the percent of monkeypox cases was zero on PAHO's epidemiological week (EW) 22 but has slowly climbed to 3.0% (117) by EW 31. PAHO notes that in Brazil 6.4% of cases are female. Numbers are climbing both in relative terms and absolute numbers.

DJ-he also reported Jordan did see the first case of MPX...I expected MPX cases to increase due to schools/workplaces reopening...Increase of spread via aerosols, surfaces...decrease of sexual transfer...Will become a major problem "soon" because the MPX virus can also cause infections in a.o. the brain...

-Another look at [url]https://www.worldometers.info/coronavirus/weekly-trends/[/url] or https://www.worldometers.info/coronavirus/weekly-trends/  global cases going down-most because of lack of testing/reporting...However ;

Vietnam cases +33%, deaths +13%

Poland cases +24%, deaths -20% (Slovenia cases +27%, Slovakia cases +23%...central Europe increase of cases...)

Nigeria cases +27%

Venezuela cases +23%

France cases +10%

South Africa cases +9% (it is winter there now...) 

There are 51 countries reporting an increase of cases...

The UK simply stopped reporting (most) cases [url]https://health-study.joinzoe.com/data#levels-over-time[/url] or https://health-study.joinzoe.com/data#levels-over-time self-reporting of symptoms indicate cases going up there. Also lots of places have sewage samples indicating cases going up...the new wave(s) of CoViD have started...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein
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