Click to Translate to English Click to Translate to French  Click to Translate to Spanish  Click to Translate to German  Click to Translate to Italian  Click to Translate to Japanese  Click to Translate to Chinese Simplified  Click to Translate to Korean  Click to Translate to Arabic  Click to Translate to Russian  Click to Translate to Portuguese  Click to Translate to Myanmar (Burmese)

PANDEMIC ALERT LEVEL
123456
Forum Home Forum Home > Main Forums > General Discussion
  New Posts New Posts RSS Feed - Pre-Pandemic covid antibody finding  Italy
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Online Discussion: Tracking new emerging diseases and the next pandemic since 2005; Coronavirus COVID-19 Pandemic Discussion Forum.

Pre-Pandemic covid antibody finding Italy

 Post Reply Post Reply
Author
Message
Pixie View Drop Down
Admin Group
Admin Group
Avatar

Joined: June 05 2006
Location: United States
Status: Offline
Points: 17313
Post Options Post Options   Thanks (0) Thanks(0)   Quote Pixie Quote  Post ReplyReply Direct Link To This Post Topic: Pre-Pandemic covid antibody finding Italy
    Posted: November 14 2020 at 2:09pm


https://journals.sagepub.com/doi/10.1177/0300891620974755


Unexpected detection of SARS-CoV-2 antibodies in the prepandemic period in Italy

Show all authors

Giovanni Apolone*, Emanuele Montomoli*, Alessandro Manenti, ...

First Published November 11, 2020 Research Article

CROSSMARK_Color_horizontal.svg

https://doi.org/10.1177/0300891620974755

Article information


Abstract

There are no robust data on the real onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and spread in the prepandemic period worldwide. We investigated the presence of SARS-CoV-2 receptor-binding domain (RBD)–specific antibodies in blood samples of 959 asymptomatic individuals enrolled in a prospective lung cancer screening trial between September 2019 and March 2020 to track the date of onset, frequency, and temporal and geographic variations across the Italian regions. SARS-CoV-2 RBD-specific antibodies were detected in 111 of 959 (11.6%) individuals, starting from September 2019 (14%), with a cluster of positive cases (>30%) in the second week of February 2020 and the highest number (53.2%) in Lombardy. This study shows an unexpected very early circulation of SARS-CoV-2 among asymptomatic individuals in Italy several months before the first patient was identified, and clarifies the onset and spread of the coronavirus disease 2019 (COVID-19) pandemic. Finding SARS-CoV-2 antibodies in asymptomatic people before the COVID-19 outbreak in Italy may reshape the history of pandemic.

Back to Top
Technophobe View Drop Down
Assistant Admin
Assistant Admin
Avatar

Joined: January 16 2014
Location: Scotland
Status: Online
Points: 84170
Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: November 14 2020 at 4:40pm

Well that does three things:........

It prompts a great theory as to why Italy was hit so hard at the beginning.

It makes Trump's shutting of the borders with China look really pointless, especially as there was no attempt to deal with the virus already inside the USA and minimal testing.

It makes China even more culpable for the worldwide spread, because it reveals the depth of its coverup.


ERCD
Back to Top
ksc View Drop Down
Adviser Group
Adviser Group


Joined: February 09 2020
Status: Offline
Points: 3735
Post Options Post Options   Thanks (0) Thanks(0)   Quote ksc Quote  Post ReplyReply Direct Link To This Post Posted: November 14 2020 at 4:55pm

...or the antibody test is registering false positives.

Back to Top
ksc View Drop Down
Adviser Group
Adviser Group


Joined: February 09 2020
Status: Offline
Points: 3735
Post Options Post Options   Thanks (0) Thanks(0)   Quote ksc Quote  Post ReplyReply Direct Link To This Post Posted: November 14 2020 at 4:59pm

Pre-existing coronavirus antibodies could help protect children against new pandemic strain

https://medicalxpress.com/news/2020-11-pre-existing-coronavirus-antibodies-children-pandemic.html

In their paper, published in Science today (Friday 6 November), the scientists found that some people, notably children, have antibodies reactive to SARS-CoV-2 in their blood, despite not ever having being infected with the virus. These antibodies are likely the result of exposure to other coronaviruses, which cause a common cold and which have structural similarities with SARS-CoV-2.

The researchers made this discovery while developing highly sensitive antibody tests for COVID-19. To see how well their assay tests were performing, they compared the blood of patients with COVID-19 to patients who had not had the disease. Surprisingly, they found that some people who had not been exposed to SARS-CoV-2 had antibodies in their blood which would recognize the virus. To confirm their findings, they analyzed over 300 blood samples collected before the pandemic, between 2011 and 2018.

Nearly all samples had antibodies that reacted with common cold coronaviruses, which was expected given how everyone has been exposed to these viruses at some point in their lives. However, a small fraction of adult donors, about 1 in 20, also had antibodies that cross-reacted with SARS-CoV-2, and this was not dependent on recent infection with a common cold coronavirus.

Notably, such cross-reactive antibodies were found much more frequently in blood samples taken from children aged 6 to 16.

Back to Top
 Post Reply Post Reply
  Share Topic   

Forum Jump Forum Permissions View Drop Down