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My 5 year old grandson in serious condition COV

Printed From: COVID-19 / South Africa Omicron Variant
Category: Main Forums
Forum Name: General Discussion
Forum Description: (General discussion regarding the coronavirus pandemic)
URL: http://www.avianflutalk.com/forum_posts.asp?TID=42099
Printed Date: March 28 2024 at 8:49am


Topic: My 5 year old grandson in serious condition COV
Posted By: Usk
Subject: My 5 year old grandson in serious condition COV
Date Posted: March 20 2020 at 4:33am

For those millions in this war who still think this isn’t a danger to the young and healthy get your head out of your****




Replies:
Posted By: EdwinSm,
Date Posted: March 20 2020 at 4:54am

((((((((((______)))))))))))) ___________  usk


(above is a virtual coronavirus hug, ie keeping a distance)



Posted By: Technophobe
Date Posted: March 20 2020 at 5:20am

We are worrying with you, Usk.

Chin up pal!



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How do you tell if a politician is lying?
His lips or pen are moving.


Posted By: BabyCat
Date Posted: March 20 2020 at 5:21am

Wow. It's affecting so many, closer and closer to all of us. Prayers for your family. 



Posted By: FluMom
Date Posted: March 20 2020 at 5:22am

So sorry, Prayers.  



Posted By: Usk
Date Posted: March 20 2020 at 5:43am

Thank you. We can’t go see him. His dad is in ICU with him. Just as support. They’re starting him  my grandson on cloniquine  the anti malary drug and steroids. He just got symptoms two days ago and they said his immune system went into hyperdrive



Posted By: Technophobe
Date Posted: March 20 2020 at 5:44am

Please keep us updated.



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How do you tell if a politician is lying?
His lips or pen are moving.


Posted By: ME163
Date Posted: March 20 2020 at 5:47am

Usk, my heart goes out to you.  I am praying for you..  Keep in touch.   



Posted By: hoosiermom22
Date Posted: March 20 2020 at 5:53am

Praying 🙏🏻 



Posted By: Tabitha111
Date Posted: March 20 2020 at 6:25am

To my fellow Virginian....hugs to you and so very sorry.  

I thought steroids were contraindicated in Covid19...but perhaps they are good for the little ones? Thank goodness they are starting him on Cloroquinine!



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'A man who does not think and plan long ahead will find trouble right at his door.'
--Confucius



Posted By: Technophobe
Date Posted: March 20 2020 at 6:30am

Steroids depress the immune system.  It sounds as if an overactive immune system is the problem this time.  



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How do you tell if a politician is lying?
His lips or pen are moving.


Posted By: Tabitha111
Date Posted: March 20 2020 at 7:10am

I think I just read a news story on your grandson on facebook! Oh my....




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'A man who does not think and plan long ahead will find trouble right at his door.'
--Confucius



Posted By: Sheep Lady
Date Posted: March 20 2020 at 7:16am

Prayers that his little body responds to treatment.  Praying for you all  Usk.



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Sheep Lady


Posted By: JellyMama
Date Posted: March 20 2020 at 7:19am

Please God, take care of this little boy and make him well.



Posted By: ViQueen24
Date Posted: March 20 2020 at 9:32am

Prayers for you all Usk.  Keep us updated.



Posted By: Usk
Date Posted: March 20 2020 at 9:37am

Read this resesrch pn Primates  and SARs. Hope it works

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Martin J Vincent, Eric Bergeron, [...], and Stuart T Nichol

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#__ffn_sectitle" style="box-sizing: border-box; color: rgb(100, 42, 143); - Additional article information

Abstract

Background

Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.

Results

We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

Conclusion

Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

Keywords: severe acute respiratory syndrome coronavirus, chloroquine, inhibition, therapy

Background

Severe acute respiratory syndrome (SARS) is an emerging disease that was first reported in Guangdong Province, China, in late 2002. The disease rapidly spread to at least 30 countries within months of its first appearance, and concerted worldwide efforts led to the identification of the etiological agent as SARS coronavirus (SARS-CoV), a novel member of the family Coronaviridae [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B1" style="box-sizing: border-box; color: rgb(100, 42, 143); - 1 ]. Complete genome sequencing of SARS-CoV [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B2" style="box-sizing: border-box; color: rgb(100, 42, 143); - 2 , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B3" style="box-sizing: border-box; color: rgb(100, 42, 143); - 3 ] confirmed that this pathogen is not closely related to any of the previously established coronavirus groups. Budding of the SARS-CoV occurs in the Golgi apparatus [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B4" style="box-sizing: border-box; color: rgb(100, 42, 143); - 4 ] and results in the incorporation of the envelope spike glycoprotein into the virion. The spike glycoprotein is a type I membrane protein that facilitates viral attachment to the cellular receptor and initiation of infection, and angiotensin-converting enzyme-2 (ACE2) has been identified as a functional cellular receptor of SARS-CoV [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B5" style="box-sizing: border-box; color: rgb(100, 42, 143); - 5 ]. We have recently shown that the processing of the spike protein was effected by furin-like convertases and that inhibition of this cleavage by a specific inhibitor abrogated cytopathicity and significantly reduced the virus titer of SARS-CoV [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B6" style="box-sizing: border-box; color: rgb(100, 42, 143); - 6 ].



Posted By: Usk
Date Posted: March 20 2020 at 9:43am

Further in vivo evaluation of this drug against 2019-nCoV infection is recommended. Notably, two compounds remdesivir (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87) and chloroquine (EC50 = 1.13 μM; CC50 > 100 μM, SI > 88.50) potently blocked virus infection at low-micromolar concentration and showed high SI (Fig. 1a, b). Cite this article Wang, M., Cao, R., Zhang, L. et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 30, 269–271 (2020). https://doi.org/10.1038/s41422-020-0282-0 - https://doi.org/10.1038/s41422-020-0282-0



Posted By: Usk
Date Posted: March 20 2020 at 9:45am

Sorry when I get upset I do research to help calm myself

It looks like these docs know what to try first



Posted By: Usk
Date Posted: March 20 2020 at 9:46am

There is no known cure just things to try



Posted By: Technophobe
Date Posted: March 20 2020 at 10:01am

Thank you, Usk.  We are still with you.



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How do you tell if a politician is lying?
His lips or pen are moving.


Posted By: Usk
Date Posted: March 20 2020 at 10:06am

Thank you all for your support it is so very much appreciated 



Posted By: Technophobe
Date Posted: March 20 2020 at 10:13am

I  (and I know I'm not alone in this)  only wish I could do more, Usk.



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How do you tell if a politician is lying?
His lips or pen are moving.


Posted By: Newbie1A
Date Posted: March 20 2020 at 10:13am

Usk, my heart hurts for you, prayers for fast recovery for your grandson & strength for you and all who love him.  Long distance hugs to you and yours - please keep us all updated as best you can.



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If it's to be - it's up to me!


Posted By: kaye kaye
Date Posted: March 20 2020 at 1:16pm

Praying for a fast recovery  for the little guy.



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keep the joy


Posted By: KiwiMum
Date Posted: March 20 2020 at 1:58pm

 I'm so sorry to hear about your grandson, what terrible news. He's in my prayers for a full and speedy recovery.



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Those who got it wrong, for whatever reason, may feel defensive and retrench into a position that doesn’t accord with the facts.


Posted By: WitchMisspelled
Date Posted: March 20 2020 at 2:05pm

Usk, he's in my prayers for a full and speedy recovery.  Sending cyber hugs your way.  



Posted By: pheasant
Date Posted: March 20 2020 at 4:28pm

My family's praying as well for you all.



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The only thing we have to fear, is fear itself......FDR


Posted By: jacksdad
Date Posted: March 20 2020 at 5:33pm

I’m so sorry. Please let us know how he’s doing. We’re all thinking of him.





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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: roni3470
Date Posted: March 20 2020 at 6:58pm

I am so sorry to hear.  Praying for you and your family!



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NOW is the Season to Know

that Everything you Do

is Sacred


Posted By: BeachMama
Date Posted: March 20 2020 at 7:11pm

Usk, I know I can say nothing to make you truly feel better — but I am SO sorry. My family and I will be praying for your grandson every single day. 



Posted By: Gdeb
Date Posted: March 20 2020 at 7:39pm

Prayers for a speedy recovery. 



Posted By: Turboguy
Date Posted: March 20 2020 at 7:40pm

Originally posted by Usk Usk wrote:

For those millions in this war who still think this isn’t a danger to the young and healthy get your head out of your****


He should be able to make it through. Little kids are extraordinarily resilient. Good that he is in the hospital and fairly early on in this. When he makes it through he might have missed the worst of this.

Wish him and his parents luck.



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Liberals claim to want to give a hearing to other views, but then are shocked and offended to discover that there are other views. - William F. Buckley


Posted By: Usk
Date Posted: March 21 2020 at 6:26am

All your prayers and thoughts of support and  

HYDROXYCHLOROQUINE

Worked. He turned the corner last night breaking the 104 fever and his lungs except for right lower lobe is clear !!!  He should come home today to his house. Dad is still symptom free and so his is mom and older brother

Thank you again. They also used short z pac which I think is zythromycin and prednisone short 5 day course. Big sigh of relief!!



Posted By: Usk
Date Posted: March 21 2020 at 6:32am

Just saw it was you Turboguy. How are you?  We were worried you had not posted. So glad you are back!



Posted By: Gdeb
Date Posted: March 21 2020 at 7:11am

Great news, Usk!! 



Posted By: Technophobe
Date Posted: March 21 2020 at 7:32am

So glad!   Glad for my friend (you Usk) glad for the little boy and glad for everyone as the treatment works for everyone it appears.

Good new at last!



-------------
How do you tell if a politician is lying?
His lips or pen are moving.


Posted By: WitchMisspelled
Date Posted: March 21 2020 at 7:57am

I am so happy for you and your family Usk!  This is great news!



Posted By: EdwinSm,
Date Posted: March 21 2020 at 8:03am

Happy News.  



Posted By: LCfromFL
Date Posted: March 21 2020 at 8:10am

Originally posted by Usk Usk wrote:

All your prayers and thoughts of support and  

HYDROXYCHLOROQUINE

Worked. He turned the corner last night breaking the 104 fever and his lungs except for right lower lobe is clear !!!  He should come home today to his house. Dad is still symptom free and so his is mom and older brother

Thank you again. They also used short z pac which I think is zythromycin and prednisone short 5 day course. Big sigh of relief!!


This is FABULOUS news, Usk!!! Praying for continued recovery for him and protection for the rest of your family. 



Posted By: Sheep Lady
Date Posted: March 21 2020 at 9:38am

Praise God! Still praying for you all!



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Sheep Lady


Posted By: FluMom
Date Posted: March 21 2020 at 9:44am

Praise The Lord, he is better!



Posted By: BabyCat
Date Posted: March 21 2020 at 10:16am

   



Posted By: mwbab
Date Posted: March 21 2020 at 12:18pm

That is good news glad he is improving



Posted By: CST
Date Posted: March 21 2020 at 3:09pm

Prayers, for you little one.  




Posted By: Lakeman5
Date Posted: March 22 2020 at 6:08am

So glad he is getting beter!



Posted By: BeachMama
Date Posted: March 22 2020 at 7:20pm

Oh, Usk, I am so grateful and happy for you and your family!!!! Your precious grandson has been in our prayers! He will continue to be so. 



Posted By: Usk
Date Posted: March 23 2020 at 3:58am

Thank you all again. Rest of family still not sick and My grandson is playing and doing grrat. He gets tired easily and takes a nap but at least the cough is less deep now



Posted By: EdwinSm,
Date Posted: March 23 2020 at 4:12am

Good that he is "bouncing back" from the illness, and the others are still in good health.




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