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Tracking the next pandemic: Avian Flu Talk

"Puzzling" latest WHO Flu Fact Sheet

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    Posted: February 06 2006 at 8:15am
The Reporter (Addis Ababa)

February 4, 2006
Posted to the web February 6, 2006

"The World Health Organization (WHO) has issued a new fact sheet on
avian influenza, the first since the disease moved out of Asia into Europe.

The document summarizes the course of bird flu in its two-year spread
across Eurasia. In regard to the human cases that have
appeared in six nations, the fact sheet points out some puzzling
unknown factors. Human cases of disease have not appeared in
commercial poultry enterprises or culling operations, as might be
expected. Instead, the majority of cases have stricken previously
healthy children and young adults exposed to small flocks kept
indomestic settings.


Other bird species, including domestic poultry, develop disease when
infected with avian influenza viruses. In poultry, the viruses cause two
distinctly different form of disease one common and mild, the other rare
and highly lethal. In the mild form, signs of illness may be expressed only
as ruffled feathers, reduced egg production, or mild effects on the
respiratory system. Outbreaks can be so mild they escape detection
unless regular testing for viruses is in place.

In contrast, the second and far less common highly pathogenic form is
difficult to miss. First identified in Italy in 1878, highly pathogenic avian
influenza is characterized by sudden onset of severe disease, rapid
contagion, and a mortality rate that can approach 100% within 48 hours.
In this form of the disease, the virus not only affects the respiratory tract,
as in the mild form, but also invades multiple organs and tissues. The
resulting massive internal haemorrhaging has earned it the lay name of
"chicken Ebola".

For example, the highly pathogenic H5N1 virus can survive in bird faeces
for at least 35 days at low temperature (4 C). At a much higher
temperature (37 C), H5N1 viruses have been shown to survive, in faecal
samples, for six days.

The use of poor quality vaccines or vaccines that poorly match the
circulating virus strain may accelerate mutation of the virus. Poor quality
animal vaccines may also pose a risk for human health, as they may allow
infected birds to shed virus while still appearing to be disease-free."



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Edited by Rick
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