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Scholarly Article Abstract: H5N6's Health Threat

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    Posted: August 16 2018 at 9:55pm

Clinical and immunological characteristics of human infections with H5N6 avian influenza virus
Yuhai Bi Shuguang Tan Yang Yang Gary Wong Min Zhao Qingchao Zhang Qiang Wang Xiaonan Zhao Liqiang Li Jing Yuan ... Show more
Clinical Infectious Diseases, ciy681,
16 August 2018
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H5N6 avian influenza virus (AIV) has caused sporadic, recurring outbreaks in China and Southeast Asia since 2013, with 19 human infections and 13 deaths. Seventeen of these infections occurred since December 2015, indicating a recent rise in the frequency of H5N6 cases.

To assess the relative threat of H5N6 virus to humans, we summarized and compared clinical data from patients infected with H5N6 (n=19) against data from two subtypes of major public health concern, H5N1 (n=53) and H7N9 (n=160). To assess immune responses indicative of prognosis, we compared concentrations of serum cytokines/chemokines in patients infected with H5N6, H5N1, H7N9 and 2009 pandemic H1N1 and characterized specific immune responses from one surviving and two non-surviving H5N6 patients.

H5N6 patients were found to have higher incidences of lymphopenia, and elevated alanine aminotransferase and lactate dehydrogenase levels compared to H5N1 and H7N9 patients. Hypercytokinemia was detected at substantially higher frequencies from H5N6 patients compared to those infected with other AIV subtypes. Evaluation of adaptive immunity showed that both humoral and cellular responses could be detected in the H5N6-infected survivor, but cellular responses were absent in the non-survivors. In addition, the surviving patient had lower concentrations of both pro- and anti-inflammatory cytokines/chemokines compared to the non-survivors.

Our results support that H5N6 virus could potentially be a major public health threat, and suggest it is possible that the earlier acquisition of cellular immunity and lower concentrations of cytokines/chemokines contributed to survival in our patient. Analysis of more patient samples will be needed to draw concrete conclusions.
AIVs, H5N6, clinical characteristics, humoral and cellular immunity

    anti-inflammatory agents cytokine immune response chemokines alanine transaminase asia, southeastern china disease outbreaks immunity, cellular influenza a virus, avian lymphopenia survivors infection lactate dehydrogenase public health medicine survival viruses pandemic influenza a virus, h1n1 subtype swine influenza swine-origin influenza virus influenza a virus, h7n9 subtype

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