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PANDEMIC ALERT LEVEL
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Now tracking the new emerging South Africa Omicron Variant

What if

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4=laro View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 4=laro Quote  Post ReplyReply Direct Link To This Post Topic: What if
    Posted: November 20 2009 at 9:51pm
So much going on and no clear explanation.

One thing that crossed my mind:  The H1N1 was probably created using a sample from a woman who died in Alaska during the 1918 flu pandamic.  What if the people who were looking for the swine flu virus found a virus they thought was the killer flu from 1918 and it wasnt.  What if she was co-infected and the virus that survived was not the virus that killer her?

Sounds a little deep, but watching what is going on today, WELL, we have a swine flu virus that spreads easily but is not a big killer.  We have other viruses floating around along with it and they dont seem to be big killers either.  Everyone is comparing this flu pandamic to the 1918 pandamic but it seems to me we have the wrong virus.  Of course it could mutate but what if it cant, if it was lab created, some of the ingredents may have been left out and the virus cant mutate on its own.

What do you think?
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Mary008 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Mary008 Quote  Post ReplyReply Direct Link To This Post Posted: November 20 2009 at 11:55pm

hi... this type of discussion is quite interesting... better when we get away from all the Media/Blog spin.
 
 
 Everyone is comparing this flu pandamic to the 1918 pandamic but it seems to me we have the wrong virus.
 
how true.
 
 
you may be interested in this...
 
 
the nucleotide sequences of the 1918 polymerase genes have more synonymous differences than expected, suggesting evolutionary distance from known avian strains. Here we present sequence and phylogenetic analyses of the complete genome of the 1918 influenza virus4, 5, 6, 7, 8, and propose that the 1918 virus was not a reassortant virus (like those of the 1957 and 1968 pandemics9, 10), but more likely an entirely avian-like virus that adapted to humans. These data support prior phylogenetic studies suggesting that the 1918 virus was derived from an avian source11.
 
 
 
so people really shouldn't compare H1N1 2009 (reassortant in pigs)  to the 1918 virus.
 
 
 
A total of ten amino acid changes in the polymerase proteins consistently differentiate the 1918 and subsequent human influenza virus sequences from avian virus sequences. Notably, a number of the same changes have been found in recently circulating, highly pathogenic H5N1 viruses that have caused illness and death in humans and are feared to be the precursors of a new influenza pandemic. The sequence changes identified here may be important in the adaptation of influenza viruses to humans.
 
 
..........................
 
 
we need stricter controls on the creating and sharing of designer flu strains..
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(or the Baxter debacle will repeat)
 
 
 
The researchers divided the H5N1 strains into two groups: one that caused systemic lethal infection in the mice and one that was relatively benign. Mice are a good model for studying H5N1, Dr. Kawaoka says, because this virus affects mice and humans similarly.
 
 
Next, Dr. Kawaoka used a technology that allows him to genetically engineer "designer" influenza viruses from scratch. By systematically swapping the genes from the harmful and benign viruses, then testing how those engineered viruses affected mice, he discovered that the PB2 gene from the harmful group gives the virus its potency.
 
 
Then, through testing viruses that contained variations of this PB2 gene, he further identified a tiny change within the gene -- a change of just one unit of RNA -- that appears to be key to the virus's virulence.
 
The function of the PB2 gene is not completely understood, but scientists believe it codes for an enzyme that helps force the host cell's molecular machinery to make more viruses, Dr. Kawaoka explains.
(a good read)

http://www.unisci.com/stories/20013/0907015.htm

......
 
 
 
In the 1970's they actually thought the 1918 pandemic was...
 
(this was before genome sequencing)
 
 
A/Swine/1976/31-like        1918-1928
 
( A/NewJersey/8/76 (H1N1) swine influenza )
 
here
http://www.springerlink.com/content/374105m560188436/
 
 
 
.............

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Medclinician View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Medclinician Quote  Post ReplyReply Direct Link To This Post Posted: November 21 2009 at 4:39am
This has been posted, by me,  multiple times over the last two years. I have posted at least 5 threads on the use of Eskimo 1918 tissue to make a new virus at CDC. All my research over the last year and work has been lost..

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